hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04825.1
Complex Portal: CPX-24752
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF4G1 | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | 5 | UniProt NCBI |
| EIF4G3 | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | 5 | UniProt NCBI |
| EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | 5 | UniProt NCBI |
| EIF4E | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | 5 | UniProt NCBI |
| EIF4EBP2 | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | 5 | UniProt NCBI |
| EIF4E1B | Eukaryotic translation initiation factor 4E type 1B | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP107 | 1.47436756702e-10 | 0.833333333333 | EIF4E EIF4G3 EIF4EBP2 EIF4G1 EIF4EBP1 | Translation factors |
| GO:0045182 | 7.92035700763e-09 | 1.0 | EIF4EBP1 EIF4EBP2 EIF4G1 EIF4G3 EIF4E EIF4E1B | translation regulator activity |
| WP:WP4566 | 5.71139447148e-08 | 0.666666666667 | EIF4E EIF4G3 EIF4G1 EIF4EBP1 | Translation inhibitors in chronically activated PDGFRA cells |
| GO:0016281 | 2.81924903404e-07 | 0.666666666667 | EIF4G3 EIF4G1 EIF4E1B EIF4E | eukaryotic translation initiation factor 4F complex |
| GO:0034518 | 7.17391174374e-07 | 0.666666666667 | EIF4G3 EIF4G1 EIF4E1B EIF4E | RNA cap binding complex |
| GO:0006413 | 5.18706281503e-06 | 0.833333333333 | EIF4E EIF4G3 EIF4EBP2 EIF4G1 EIF4EBP1 | translational initiation |
| GO:0031369 | 6.90936487191e-06 | 0.666666666667 | EIF4EBP2 EIF4EBP1 EIF4G1 EIF4E | translation initiation factor binding |
| REAC:R-HSA-166208 | 1.42587173715e-05 | 0.5 | EIF4EBP1 EIF4G1 EIF4E | mTORC1-mediated signalling |
| GO:0003743 | 5.33450584461e-05 | 0.666666666667 | EIF4G3 EIF4G1 EIF4E1B EIF4E | translation initiation factor activity |
| REAC:R-HSA-165159 | 7.49011945156e-05 | 0.5 | EIF4EBP1 EIF4G1 EIF4E | MTOR signalling |
| CORUM:5253 | 0.000102488289015 | 0.333333333333 | EIF4G1 EIF4E | MNK1-eIF4F complex |
| GO:0008190 | 0.00010757157937 | 0.5 | EIF4EBP1 EIF4G1 EIF4EBP2 | eukaryotic initiation factor 4E binding |
| KEGG:01521 | 0.0001275988674 | 0.5 | EIF4EBP1 EIF4E EIF4E1B | EGFR tyrosine kinase inhibitor resistance |
| KEGG:04211 | 0.000167761438495 | 0.5 | EIF4EBP1 EIF4E EIF4E1B | Longevity regulating pathway |
| REAC:R-HSA-72662 | 0.000239738718613 | 0.5 | EIF4EBP1 EIF4G1 EIF4E | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| KEGG:04066 | 0.00030754918341 | 0.5 | EIF4EBP1 EIF4E EIF4E1B | HIF-1 signaling pathway |
| REAC:R-HSA-1169408 | 0.000320288872929 | 0.5 | EIF4G3 EIF4G1 EIF4E | ISG15 antiviral mechanism |
| GO:0008135 | 0.000359278119226 | 0.666666666667 | EIF4G3 EIF4G1 EIF4E1B EIF4E | translation factor activity, RNA binding |
| GO:0006446 | 0.000380685722162 | 0.666666666667 | EIF4EBP2 EIF4G3 EIF4G1 EIF4EBP1 | regulation of translational initiation |
| REAC:R-HSA-1169410 | 0.000417052782963 | 0.5 | EIF4G3 EIF4G1 EIF4E | Antiviral mechanism by IFN-stimulated genes |
| GO:0006417 | 0.000579540333421 | 0.833333333333 | EIF4E EIF4G3 EIF4EBP2 EIF4G1 EIF4EBP1 | regulation of translation |
| WP:WP4549 | 0.000585504009181 | 0.5 | EIF4EBP2 EIF4G1 EIF4E | Fragile X syndrome |
| KEGG:04910 | 0.000635578637107 | 0.5 | EIF4EBP1 EIF4E EIF4E1B | Insulin signaling pathway |
| GO:0090079 | 0.000792088897246 | 0.666666666667 | EIF4G3 EIF4G1 EIF4E1B EIF4E | translation regulator activity, nucleic acid binding |
| KEGG:04150 | 0.00103019356944 | 0.5 | EIF4EBP1 EIF4E EIF4E1B | mTOR signaling pathway |
| GO:0034248 | 0.00132854414204 | 0.833333333333 | EIF4E EIF4G3 EIF4EBP2 EIF4G1 EIF4EBP1 | regulation of amide metabolic process |
| WP:WP516 | 0.00153714048185 | 0.333333333333 | EIF4EBP1 EIF4E | Hypertrophy model |
| GO:0000339 | 0.00156505859778 | 0.5 | EIF4G3 EIF4E EIF4E1B | RNA cap binding |
| REAC:R-HSA-72613 | 0.00185327127259 | 0.5 | EIF4EBP1 EIF4G1 EIF4E | Eukaryotic Translation Initiation |
| REAC:R-HSA-72737 | 0.00185327127259 | 0.5 | EIF4EBP1 EIF4G1 EIF4E | Cap-dependent Translation Initiation |
| WP:WP3879 | 0.00210864528598 | 0.333333333333 | EIF4EBP1 EIF4E | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| GO:0010608 | 0.00412670158187 | 0.833333333333 | EIF4E EIF4G3 EIF4EBP2 EIF4G1 EIF4EBP1 | post-transcriptional regulation of gene expression |
| REAC:R-HSA-913531 | 0.00604240808777 | 0.5 | EIF4G3 EIF4G1 EIF4E | Interferon Signaling |
| WP:WP3932 | 0.00666912471972 | 0.5 | EIF4EBP1 EIF4E EIF4E1B | Focal adhesion PI3K Akt mTOR signaling pathway |
| REAC:R-HSA-429947 | 0.0070977267476 | 0.333333333333 | EIF4G1 EIF4E | Deadenylation of mRNA |
| KEGG:04151 | 0.00734849685315 | 0.5 | EIF4EBP1 EIF4E EIF4E1B | PI3K-Akt signaling pathway |
| WP:WP4172 | 0.00867989635729 | 0.5 | EIF4EBP1 EIF4E EIF4E1B | PI3K Akt signaling pathway |
| KEGG:05416 | 0.0103053165388 | 0.333333333333 | EIF4G3 EIF4G1 | Viral myocarditis |
| WP:WP585 | 0.0127325196108 | 0.333333333333 | EIF4EBP1 EIF4E | Interferon type I signaling pathways |
| GO:0006412 | 0.018956843244 | 0.833333333333 | EIF4E EIF4G3 EIF4EBP2 EIF4G1 EIF4EBP1 | translation |
| GO:0043043 | 0.0219515252556 | 0.833333333333 | EIF4E EIF4G3 EIF4EBP2 EIF4G1 EIF4EBP1 | peptide biosynthetic process |
| WP:WP2034 | 0.0226781844519 | 0.333333333333 | EIF4EBP1 EIF4E | Leptin signaling pathway |
| WP:WP4674 | 0.0240332707265 | 0.333333333333 | EIF4EBP1 EIF4E | Head and neck squamous cell carcinoma |
| REAC:R-HSA-72766 | 0.0266429590673 | 0.5 | EIF4EBP1 EIF4G1 EIF4E | Translation |
| WP:WP4806 | 0.0306106562527 | 0.333333333333 | EIF4EBP1 EIF4E | EGFR tyrosine kinase inhibitor resistance |
| REAC:R-HSA-429914 | 0.0379731829042 | 0.333333333333 | EIF4G1 EIF4E | Deadenylation-dependent mRNA decay |
| REAC:R-HSA-72649 | 0.0437202891307 | 0.333333333333 | EIF4G1 EIF4E | Translation initiation complex formation |
| REAC:R-HSA-72702 | 0.0437202891307 | 0.333333333333 | EIF4G1 EIF4E | Ribosomal scanning and start codon recognition |
| WP:WP2263 | 0.0442314519914 | 0.333333333333 | EIF4EBP1 EIF4E1B | Androgen receptor network in prostate cancer |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EIF4E | EIF4G3 | 0.999 | 0.21 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| EIF4E | EIF4EBP2 | 0.998 | 0.124 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| EIF4EBP1 | EIF4E | 0.998 | 0.1384 |
mutually_exclusive (A6NMX2)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| EIF4E | EIF4G1 | 0.997 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| EIF4E1B | EIF4E | 0.982 |
mutually_exclusive (Q13541)
structurally_consistent (dimer) |
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF4EBP1 | EIF4EBP2 | 0.982 | 0.042 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM fraction |
| EIF4E1B | EIF4EBP1 | 0.977 |
mutually_exclusive (P06730)
structurally_consistent (dimer) |
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF4EBP1 | EIF4G3 | 0.908 | 0.148 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4E1B | EIF4EBP2 | 0.904 |
mutually_exclusive (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4G3 | EIF4EBP2 | 0.902 | 0.03 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM WMM_only |
| EIF4G1 | EIF4G3 | 0.786 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | ||
| EIF4G1 | EIF4EBP2 | 0.756 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| EIF4E1B | EIF4G3 | 0.675 | bioplex3_WMM WMM_only | ||
| EIF4E1B | EIF4G1 | 0.245 |
mutually_exclusive (P06730)
|
bioplex3_WMM WMM_only | |
| EIF4EBP1 | EIF4G1 | 0.188 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes