hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04827.1
Complex Portal: CPX-21593
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ILK | Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (Beta-integrin-linked kinase) (ILK-1) (ILK-2) (p59ILK) | 5 | UniProt NCBI |
| LIMS2 | LIM and senescent cell antigen-like-containing domain protein 2 (LIM-like protein 2) (Particularly interesting new Cys-His protein 2) (PINCH-2) | 5 | UniProt NCBI |
| PARVG | Gamma-parvin | 5 | UniProt NCBI |
| LIMS1 | LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48) | 5 | UniProt NCBI |
| PARVB | Beta-parvin (Affixin) | 5 | UniProt NCBI |
| RSU1 | Ras suppressor protein 1 (RSP-1) (Rsu-1) | 4 | UniProt NCBI |
| PXN | Paxillin | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-446353 | 1.86122718525e-15 | 0.857142857143 | LIMS1 LIMS2 PXN PARVB ILK RSU1 | Cell-extracellular matrix interactions |
| REAC:R-HSA-446728 | 1.56148526259e-11 | 0.857142857143 | LIMS1 LIMS2 PXN PARVB ILK RSU1 | Cell junction organization |
| REAC:R-HSA-1500931 | 1.42640394509e-10 | 0.857142857143 | LIMS1 LIMS2 PXN PARVB ILK RSU1 | Cell-Cell communication |
| REAC:R-HSA-446388 | 2.49703862656e-10 | 0.571428571429 | PXN RSU1 LIMS1 PARVB | Regulation of cytoskeletal remodeling and cell spreading by IPP complex components |
| GO:0034446 | 6.6205971092e-09 | 0.857142857143 | LIMS1 LIMS2 PXN PARVG ILK PARVB | substrate adhesion-dependent cell spreading |
| GO:0031589 | 1.1257173191e-08 | 1.0 | LIMS1 LIMS2 PXN PARVB PARVG ILK RSU1 | cell-substrate adhesion |
| GO:0005925 | 2.30729354274e-07 | 1.0 | LIMS1 LIMS2 PXN PARVB PARVG ILK RSU1 | focal adhesion |
| GO:0030055 | 2.64933046223e-07 | 1.0 | LIMS1 LIMS2 PXN PARVB PARVG ILK RSU1 | cell-substrate junction |
| GO:0070161 | 1.11756958291e-05 | 1.0 | LIMS1 LIMS2 PXN PARVB PARVG ILK RSU1 | anchoring junction |
| KEGG:04510 | 3.36951270138e-05 | 0.571428571429 | ILK PXN PARVB PARVG | Focal adhesion |
| WP:WP306 | 5.84781371e-05 | 0.571428571429 | ILK PXN PARVB PARVG | Focal adhesion |
| CORUM:6920 | 6.1565588648e-05 | 0.285714285714 | ILK LIMS2 | ILK-LIMS2-PARVA complex |
| CORUM:6919 | 6.1565588648e-05 | 0.285714285714 | ILK LIMS1 | ILK-LIMS1-PARVA complex |
| CORUM:5498 | 6.1565588648e-05 | 0.285714285714 | ILK PARVB | ILK-PARVB-ARHGEF6 complex |
| GO:0007155 | 0.000187334808196 | 1.0 | LIMS1 LIMS2 PXN PARVB PARVG ILK RSU1 | cell adhesion |
| REAC:R-HSA-446343 | 0.000228551860007 | 0.285714285714 | ILK PXN | Localization of the PINCH-ILK-PARVIN complex to focal adhesions |
| GO:0010811 | 0.000835286748042 | 0.571428571429 | ILK RSU1 LIMS1 LIMS2 | positive regulation of cell-substrate adhesion |
| GO:0030054 | 0.000952363989281 | 1.0 | LIMS1 LIMS2 PXN PARVB PARVG ILK RSU1 | cell junction |
| GO:0010810 | 0.0130287098618 | 0.571428571429 | ILK RSU1 LIMS1 LIMS2 | regulation of cell-substrate adhesion |
| GO:1900026 | 0.0200035679209 | 0.428571428571 | ILK LIMS1 LIMS2 | positive regulation of substrate adhesion-dependent cell spreading |
| KEGG:05100 | 0.0287602683365 | 0.285714285714 | ILK PXN | Bacterial invasion of epithelial cells |
| WP:WP2572 | 0.0332242517043 | 0.285714285714 | ILK LIMS1 | Primary focal segmental glomerulosclerosis FSGS |
| CORUM:4025 | 0.0499958217778 | 0.142857142857 | PARVB | ACTN1-PARVB complex |
| CORUM:6510 | 0.0499958217778 | 0.142857142857 | ILK | ILK-SERCA2A-PLN complex |
| CORUM:6927 | 0.0499958217778 | 0.142857142857 | PXN | Robo4-paxillin complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ILK | PARVB | 1.0 | 0.092 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () bioplex3_HCT116 fraction | |
| ILK | RSU1 | 1.0 | 0.864 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction | |
| ILK | LIMS1 | 1.0 | 0.166 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 fraction | |
| PARVB | RSU1 | 1.0 | 0.062 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction | |
| LIMS1 | RSU1 | 1.0 | 0.138 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| PARVG | LIMS1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| LIMS1 | PARVB | 0.999 | 0.108 |
mutually_exclusive (Q9NVD7)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| PARVG | RSU1 | 0.999 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ILK | PARVG | 0.998 | 0.068 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| LIMS2 | RSU1 | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RSU1 | PXN | 0.985 | 0.082 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PARVB | PXN | 0.981 | 0.074 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| ILK | PXN | 0.978 | 0.146 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| LIMS1 | PXN | 0.908 | 0.128 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ILK | LIMS2 | 0.633 | bioplex3_WMM WMM_only | ||
| LIMS2 | LIMS1 | 0.616 | bioplex3_WMM WMM_only | ||
| LIMS2 | PARVB | 0.329 | bioplex3_WMM WMM_only |
Related Complexes