hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04842.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AP1S1 | AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin) | 5 | UniProt NCBI |
| AP1B1 | AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) | 5 | UniProt NCBI |
| AP1M1 | AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7476 | 9.35474852325e-10 | 1.0 | AP1S1 AP1M1 AP1B1 | AP1B1-AP1G2-AP1M-1AP1S1 complex |
| CORUM:36 | 1.30966479326e-08 | 1.0 | AP1S1 AP1M1 AP1B1 | AP1 adaptor complex |
| CORUM:144 | 1.96449718988e-08 | 1.0 | AP1S1 AP1M1 AP1B1 | Gamma-BAR-AP1 complex |
| REAC:R-HSA-164940 | 5.59922569377e-08 | 1.0 | AP1S1 AP1M1 AP1B1 | Nef mediated downregulation of MHC class I complex cell surface expression |
| REAC:R-HSA-164938 | 6.20580847727e-07 | 1.0 | AP1S1 AP1M1 AP1B1 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| REAC:R-HSA-164952 | 1.36481126286e-06 | 1.0 | AP1S1 AP1M1 AP1B1 | The role of Nef in HIV-1 replication and disease pathogenesis |
| REAC:R-HSA-432720 | 2.5457812821e-06 | 1.0 | AP1S1 AP1M1 AP1B1 | Lysosome Vesicle Biogenesis |
| GO:0030121 | 1.15344049292e-05 | 1.0 | AP1S1 AP1M1 AP1B1 | AP-1 adaptor complex |
| REAC:R-HSA-432722 | 1.1573599509e-05 | 1.0 | AP1S1 AP1M1 AP1B1 | Golgi Associated Vesicle Biogenesis |
| KEGG:04142 | 1.58086646471e-05 | 1.0 | AP1S1 AP1M1 AP1B1 | Lysosome |
| GO:0030130 | 2.11464090368e-05 | 1.0 | AP1S1 AP1M1 AP1B1 | clathrin coat of trans-Golgi network vesicle |
| REAC:R-HSA-199992 | 2.55418012064e-05 | 1.0 | AP1S1 AP1M1 AP1B1 | trans-Golgi Network Vesicle Budding |
| GO:0012510 | 3.49876949518e-05 | 1.0 | AP1S1 AP1M1 AP1B1 | trans-Golgi network transport vesicle membrane |
| KEGG:05170 | 6.16221404209e-05 | 1.0 | AP1S1 AP1M1 AP1B1 | Human immunodeficiency virus 1 infection |
| GO:0030131 | 7.84339535184e-05 | 1.0 | AP1S1 AP1M1 AP1B1 | clathrin adaptor complex |
| GO:1903232 | 7.84339535184e-05 | 1.0 | AP1S1 AP1M1 AP1B1 | melanosome assembly |
| REAC:R-HSA-2132295 | 0.000121377214977 | 1.0 | AP1S1 AP1M1 AP1B1 | MHC class II antigen presentation |
| GO:0060155 | 0.000127839654632 | 1.0 | AP1S1 AP1M1 AP1B1 | platelet dense granule organization |
| REAC:R-HSA-162909 | 0.00014826283035 | 1.0 | AP1S1 AP1M1 AP1B1 | Host Interactions of HIV factors |
| GO:0030140 | 0.000314889254566 | 1.0 | AP1S1 AP1M1 AP1B1 | trans-Golgi network transport vesicle |
| GO:0030125 | 0.000351222630093 | 1.0 | AP1S1 AP1M1 AP1B1 | clathrin vesicle coat |
| HP:0011967 | 0.000354217072454 | 0.666666666667 | AP1S1 AP1B1 | Decreased circulating copper concentration |
| HP:0010837 | 0.000455401167586 | 0.666666666667 | AP1S1 AP1B1 | Decreased circulating ceruloplasmin concentration |
| GO:0030119 | 0.000629105668845 | 1.0 | AP1S1 AP1M1 AP1B1 | AP-type membrane coat adaptor complex |
| GO:0032438 | 0.000686297093286 | 1.0 | AP1S1 AP1M1 AP1B1 | melanosome organization |
| GO:0048753 | 0.000686297093286 | 1.0 | AP1S1 AP1M1 AP1B1 | pigment granule organization |
| HP:0033144 | 0.000695688281083 | 0.666666666667 | AP1S1 AP1B1 | Abnormal circulating ceruloplasmin concentration |
| GO:0033363 | 0.000810868666521 | 1.0 | AP1S1 AP1M1 AP1B1 | secretory granule organization |
| REAC:R-HSA-162906 | 0.000828046157745 | 1.0 | AP1S1 AP1M1 AP1B1 | HIV Infection |
| GO:0030118 | 0.000878441055398 | 1.0 | AP1S1 AP1M1 AP1B1 | clathrin coat |
| HP:0010836 | 0.00115089028102 | 0.666666666667 | AP1S1 AP1B1 | Abnormal circulating copper concentration |
| GO:0030660 | 0.00136394338287 | 1.0 | AP1S1 AP1M1 AP1B1 | Golgi-associated vesicle membrane |
| HP:0001406 | 0.00193466002352 | 0.666666666667 | AP1S1 AP1B1 | Intrahepatic cholestasis |
| HP:0031865 | 0.00216216836724 | 0.666666666667 | AP1S1 AP1B1 | Abnormal liver physiology |
| GO:0033059 | 0.00252170927764 | 1.0 | AP1S1 AP1M1 AP1B1 | cellular pigmentation |
| GO:0030120 | 0.0028124724019 | 1.0 | AP1S1 AP1M1 AP1B1 | vesicle coat |
| GO:0005798 | 0.00503611343216 | 1.0 | AP1S1 AP1M1 AP1B1 | Golgi-associated vesicle |
| GO:0043473 | 0.00597828207479 | 1.0 | AP1S1 AP1M1 AP1B1 | pigmentation |
| GO:0110010 | 0.00842684400117 | 0.666666666667 | AP1S1 AP1B1 | basolateral protein secretion |
| HP:0011030 | 0.00888120343534 | 0.666666666667 | AP1S1 AP1B1 | Abnormal blood transition element cation concentration |
| GO:0048475 | 0.0101882437539 | 1.0 | AP1S1 AP1M1 AP1B1 | coated membrane |
| GO:0030117 | 0.0101882437539 | 1.0 | AP1S1 AP1M1 AP1B1 | membrane coat |
| GO:0032588 | 0.0116771431902 | 1.0 | AP1S1 AP1M1 AP1B1 | trans-Golgi network membrane |
| GO:0030665 | 0.0120707547584 | 1.0 | AP1S1 AP1M1 AP1B1 | clathrin-coated vesicle membrane |
| REAC:R-HSA-199991 | 0.0145539954891 | 1.0 | AP1S1 AP1M1 AP1B1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.017135828319 | 1.0 | AP1S1 AP1M1 AP1B1 | Vesicle-mediated transport |
| REAC:R-HSA-1280218 | 0.0226639223828 | 1.0 | AP1S1 AP1M1 AP1B1 | Adaptive Immune System |
| GO:0030658 | 0.023732518742 | 1.0 | AP1S1 AP1M1 AP1B1 | transport vesicle membrane |
| REAC:R-HSA-9824446 | 0.0269033233908 | 1.0 | AP1S1 AP1M1 AP1B1 | Viral Infection Pathways |
| GO:0030136 | 0.0468435252984 | 1.0 | AP1S1 AP1M1 AP1B1 | clathrin-coated vesicle |
| GO:0030662 | 0.0498541011049 | 1.0 | AP1S1 AP1M1 AP1B1 | coated vesicle membrane |
| REAC:R-HSA-5663205 | 0.0499835710674 | 1.0 | AP1S1 AP1M1 AP1B1 | Infectious disease |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| AP1M1 | AP1B1 | 1.0 | 0.434 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction |
| AP1S1 | AP1B1 | 0.985 | 0.112 |
mutually_exclusive (O43747)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM fraction |
| AP1S1 | AP1M1 | 0.98 | 0.248 | hein_WMM bioplex3_WMM youn_WMM fraction |
Related Complexes