hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04859.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DNAJA1 | DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) | 5 | UniProt NCBI |
| CAPS | Calcyphosin (Calcyphosine) | 5 | UniProt NCBI |
| TUBB6 | Tubulin beta-6 chain (Tubulin beta class V) | 5 | UniProt NCBI |
| TUBB | Tubulin beta chain (Tubulin beta-5 chain) | 5 | UniProt NCBI |
| CAD | Multifunctional protein CAD (Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase) [Includes: Glutamine-dependent carbamoyl phosphate synthase (EC 6.3.5.5); Glutamine amidotransferase (GATase) (GLNase) (EC 3.5.1.2); Ammonium-dependent carbamoyl phosphate synthase (CPS) (CPSase) (EC 6.3.4.16); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)] | 5 | UniProt NCBI |
| RPS27 | Small ribosomal subunit protein eS27 (40S ribosomal protein S27) (Metallopan-stimulin 1) (MPS-1) | 5 | UniProt NCBI |
| TUBA4B | Putative tubulin-like protein alpha-4B (EC 3.6.5.-) (Alpha-tubulin 4B) | 3 | UniProt NCBI |
| EML2 | Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-68877 | 0.000438960882413 | 0.5 | RPS27 TUBB6 TUBA4B TUBB | Mitotic Prometaphase |
| WP:WP2359 | 0.00048410935602 | 0.375 | TUBB6 TUBA4B TUBB | Parkin ubiquitin proteasomal system pathway |
| REAC:R-HSA-3371497 | 0.000499872649354 | 0.375 | DNAJA1 TUBA4B TUBB6 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand |
| REAC:R-HSA-380320 | 0.00263138488572 | 0.375 | TUBB6 TUBA4B TUBB | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-9648025 | 0.00521333144783 | 0.375 | TUBB6 TUBA4B RPS27 | EML4 and NUDC in mitotic spindle formation |
| REAC:R-HSA-2500257 | 0.00639902621489 | 0.375 | TUBB6 TUBA4B RPS27 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-68886 | 0.00662679219127 | 0.5 | RPS27 TUBB6 TUBA4B TUBB | M Phase |
| REAC:R-HSA-5663220 | 0.00830150872147 | 0.375 | TUBB6 TUBA4B RPS27 | RHO GTPases Activate Formins |
| REAC:R-HSA-190840 | 0.00849789009901 | 0.25 | TUBB6 TUBA4B | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane |
| REAC:R-HSA-190872 | 0.00949504138694 | 0.25 | TUBB6 TUBA4B | Transport of connexons to the plasma membrane |
| REAC:R-HSA-389977 | 0.0140328389809 | 0.25 | TUBB6 TUBA4B | Post-chaperonin tubulin folding pathway |
| REAC:R-HSA-389960 | 0.0166306183768 | 0.25 | TUBB6 TUBA4B | Formation of tubulin folding intermediates by CCT/TriC |
| REAC:R-HSA-9619483 | 0.0166306183768 | 0.25 | TUBB6 TUBA4B | Activation of AMPK downstream of NMDARs |
| HPA:0210873 | 0.0169879513029 | 0.375 | DNAJA1 CAPS EML2 | fallopian tube; ciliated cells (ciliary rootlets)[High] |
| REAC:R-HSA-190861 | 0.0209373692109 | 0.25 | TUBB6 TUBA4B | Gap junction assembly |
| HPA:0210881 | 0.0212630673333 | 0.5 | DNAJA1 EML2 CAPS CAD | fallopian tube; ciliated cells (tip of cilia)[>=Low] |
| REAC:R-HSA-69278 | 0.0220129016806 | 0.5 | RPS27 TUBB6 TUBA4B TUBB | Cell Cycle, Mitotic |
| REAC:R-HSA-2467813 | 0.0223294751293 | 0.375 | TUBB6 TUBA4B RPS27 | Separation of Sister Chromatids |
| REAC:R-HSA-9668328 | 0.0224821270291 | 0.25 | TUBB6 TUBA4B | Sealing of the nuclear envelope (NE) by ESCRT-III |
| REAC:R-HSA-5626467 | 0.0224821270291 | 0.25 | TUBB6 TUBA4B | RHO GTPases activate IQGAPs |
| REAC:R-HSA-5617833 | 0.0241789966573 | 0.375 | TUBB6 TUBA4B TUBB | Cilium Assembly |
| REAC:R-HSA-69275 | 0.0241789966573 | 0.375 | TUBB6 TUBA4B TUBB | G2/M Transition |
| REAC:R-HSA-453274 | 0.0249460207152 | 0.375 | TUBB6 TUBA4B TUBB | Mitotic G2-G2/M phases |
| HPA:0500112 | 0.0262861553076 | 0.625 | DNAJA1 EML2 TUBB CAD TUBB6 | soft tissue 1; chondrocytes[>=Medium] |
| REAC:R-HSA-389958 | 0.0274432906045 | 0.25 | TUBB6 TUBA4B | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| WP:WP2272 | 0.0277732439303 | 0.25 | TUBB6 TUBB | Pathogenic Escherichia coli infection |
| KEGG:04540 | 0.0316509404433 | 0.25 | TUBB6 TUBB | Gap junction |
| HPA:0210883 | 0.0329272554011 | 0.375 | DNAJA1 CAPS EML2 | fallopian tube; ciliated cells (tip of cilia)[High] |
| REAC:R-HSA-8955332 | 0.0388325640363 | 0.25 | TUBB6 TUBA4B | Carboxyterminal post-translational modifications of tubulin |
| REAC:R-HSA-9609736 | 0.0388325640363 | 0.25 | TUBB6 TUBA4B | Assembly and cell surface presentation of NMDA receptors |
| REAC:R-HSA-68882 | 0.0394646436185 | 0.375 | TUBB6 TUBA4B RPS27 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.0399900120065 | 0.375 | TUBB6 TUBA4B RPS27 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-190828 | 0.0409204105231 | 0.25 | TUBB6 TUBA4B | Gap junction trafficking |
| REAC:R-HSA-157858 | 0.04306231829 | 0.25 | TUBB6 TUBA4B | Gap junction trafficking and regulation |
| REAC:R-HSA-9646399 | 0.0452582424141 | 0.25 | TUBB6 TUBA4B | Aggrephagy |
| REAC:R-HSA-1640170 | 0.0491409220523 | 0.5 | RPS27 TUBB6 TUBA4B TUBB | Cell Cycle |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DNAJA1 | TUBB | 0.999 | 0.374 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| TUBB | CAD | 0.998 | 0.352 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| TUBB6 | TUBB | 0.996 | 0.982 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| RPS27 | TUBB6 | 0.99 | 0.256 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM |
| RPS27 | TUBB | 0.99 | 0.49 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM treiber_WMM |
| TUBB | EML2 | 0.989 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TUBB6 | EML2 | 0.987 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CAPS | TUBB6 | 0.956 | 0.3 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| CAPS | TUBB | 0.952 | 0.306608695652 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| RPS27 | CAD | 0.934 | 0.162 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| DNAJA1 | TUBB6 | 0.867 | 0.298 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM |
| DNAJA1 | RPS27 | 0.823 | 0.238 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| DNAJA1 | CAD | 0.506 | 0.23 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| RPS27 | EML2 | 0.308 | bioplex3_WMM WMM_only | |
| CAPS | EML2 | 0.252 | bioplex_WMM bioplex3_WMM WMM_only | |
| DNAJA1 | EML2 | 0.242 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| CAD | EML2 | 0.215 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| TUBB6 | CAD | 0.102 | 0.272 | hein_WMM bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| DNAJA1 | CAPS | 0.019 | 0.14 | bioplex_WMM bioplex3_WMM WMM_only |
| RPS27 | CAPS | 0.013 | 0.148 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| CAPS | CAD | 0.005 | 0.1 | bioplex3_HEK293 WMM_only |
Related Complexes