hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04886.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PRIM1 | DNA primase small subunit (EC 2.7.7.102) (DNA primase 49 kDa subunit) (p49) | 5 | UniProt NCBI |
| POLA1 | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | 5 | UniProt NCBI |
| NLGN4Y | Neuroligin-4, Y-linked (Neuroligin Y) | 5 | UniProt NCBI |
| C15orf39 | Uncharacterized protein C15orf39 | 3 | UniProt NCBI |
| POLA2 | DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1100 | 1.12081835382e-08 | 0.6 | POLA2 PRIM1 POLA1 | DNA polymerase alpha-primase complex |
| REAC:R-HSA-68952 | 1.7467401872e-07 | 0.6 | POLA2 PRIM1 POLA1 | DNA replication initiation |
| CORUM:1107 | 2.35251050842e-07 | 0.6 | POLA2 PRIM1 POLA1 | DNA synthesome core complex |
| CORUM:1098 | 3.36038420171e-07 | 0.6 | POLA2 PRIM1 POLA1 | DNA synthesome complex (13 subunits) |
| CORUM:1108 | 8.00644851437e-07 | 0.6 | POLA2 PRIM1 POLA1 | DNA synthesome complex (15 subunits) |
| REAC:R-HSA-174430 | 8.91627220919e-07 | 0.6 | POLA2 PRIM1 POLA1 | Telomere C-strand synthesis initiation |
| REAC:R-HSA-113501 | 8.91627220919e-07 | 0.6 | POLA2 PRIM1 POLA1 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| CORUM:1099 | 1.018897882e-06 | 0.6 | POLA2 PRIM1 POLA1 | DNA synthesome complex (17 subunits) |
| CORUM:1111 | 1.018897882e-06 | 0.6 | POLA2 PRIM1 POLA1 | DNA synthesome complex (17 subunits) |
| REAC:R-HSA-69166 | 1.13468173222e-06 | 0.6 | POLA2 PRIM1 POLA1 | Removal of the Flap Intermediate |
| REAC:R-HSA-69091 | 1.13468173222e-06 | 0.6 | POLA2 PRIM1 POLA1 | Polymerase switching |
| REAC:R-HSA-69109 | 1.13468173222e-06 | 0.6 | POLA2 PRIM1 POLA1 | Leading Strand Synthesis |
| REAC:R-HSA-69183 | 1.41820648707e-06 | 0.6 | POLA2 PRIM1 POLA1 | Processive synthesis on the lagging strand |
| REAC:R-HSA-69186 | 3.55148388129e-06 | 0.6 | POLA2 PRIM1 POLA1 | Lagging Strand Synthesis |
| REAC:R-HSA-113510 | 4.79663279828e-06 | 0.6 | POLA2 PRIM1 POLA1 | E2F mediated regulation of DNA replication |
| KEGG:03030 | 6.64052632759e-06 | 0.6 | POLA2 PRIM1 POLA1 | DNA replication |
| REAC:R-HSA-174411 | 8.09488316343e-06 | 0.6 | POLA2 PRIM1 POLA1 | Polymerase switching on the C-strand of the telomere |
| GO:0005658 | 9.61003071434e-06 | 0.6 | POLA2 PRIM1 POLA1 | alpha DNA polymerase:primase complex |
| GO:0006269 | 9.61003071434e-06 | 0.6 | POLA2 PRIM1 POLA1 | DNA replication, synthesis of RNA primer |
| WP:WP466 | 1.3807096837e-05 | 0.6 | POLA2 PRIM1 POLA1 | DNA replication |
| REAC:R-HSA-69190 | 1.54330255969e-05 | 0.6 | POLA2 PRIM1 POLA1 | DNA strand elongation |
| REAC:R-HSA-68962 | 1.69745830215e-05 | 0.6 | POLA2 PRIM1 POLA1 | Activation of the pre-replicative complex |
| REAC:R-HSA-174417 | 1.861537069e-05 | 0.6 | POLA2 PRIM1 POLA1 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-180786 | 6.46704304154e-05 | 0.6 | POLA2 PRIM1 POLA1 | Extension of Telomeres |
| REAC:R-HSA-9710421 | 0.000111649199751 | 0.6 | POLA2 PRIM1 POLA1 | Defective pyroptosis |
| REAC:R-HSA-9645723 | 0.000375711265178 | 0.6 | POLA2 PRIM1 POLA1 | Diseases of programmed cell death |
| CORUM:1003 | 0.00038189088864 | 0.4 | POLA1 POLA2 | RC complex (Replication competent complex) |
| REAC:R-HSA-157579 | 0.000499618531598 | 0.6 | POLA2 PRIM1 POLA1 | Telomere Maintenance |
| REAC:R-HSA-69239 | 0.000844385297839 | 0.6 | POLA2 PRIM1 POLA1 | Synthesis of DNA |
| REAC:R-HSA-73886 | 0.00102719141084 | 0.6 | POLA2 PRIM1 POLA1 | Chromosome Maintenance |
| GO:0042575 | 0.00109385703544 | 0.6 | POLA2 PRIM1 POLA1 | DNA polymerase complex |
| REAC:R-HSA-69206 | 0.00110198471879 | 0.6 | POLA2 PRIM1 POLA1 | G1/S Transition |
| GO:0043601 | 0.00147736290187 | 0.6 | POLA2 PRIM1 POLA1 | nuclear replisome |
| REAC:R-HSA-69002 | 0.00159480598718 | 0.6 | POLA2 PRIM1 POLA1 | DNA Replication Pre-Initiation |
| REAC:R-HSA-453279 | 0.00159480598718 | 0.6 | POLA2 PRIM1 POLA1 | Mitotic G1 phase and G1/S transition |
| GO:0030894 | 0.00194127795747 | 0.6 | POLA2 PRIM1 POLA1 | replisome |
| REAC:R-HSA-69242 | 0.00201875981781 | 0.6 | POLA2 PRIM1 POLA1 | S Phase |
| REAC:R-HSA-69306 | 0.00264594341422 | 0.6 | POLA2 PRIM1 POLA1 | DNA Replication |
| GO:0006270 | 0.00475337188383 | 0.6 | POLA2 PRIM1 POLA1 | DNA replication initiation |
| GO:0043596 | 0.00875197805683 | 0.6 | POLA2 PRIM1 POLA1 | nuclear replication fork |
| WP:WP45 | 0.0117576408425 | 0.4 | PRIM1 POLA2 | G1 to S cell cycle control |
| WP:WP2446 | 0.0212523049113 | 0.4 | PRIM1 POLA1 | Retinoblastoma gene in cancer |
| GO:0005657 | 0.0417184596383 | 0.6 | POLA2 PRIM1 POLA1 | replication fork |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PRIM1 | POLA2 | 0.999 | 0.81 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM fraction |
| PRIM1 | NLGN4Y | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PRIM1 | POLA1 | 0.994 | 0.818 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM fraction |
| POLA1 | POLA2 | 0.979 | 0.84 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| C15orf39 | POLA2 | 0.971 | 0.054 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PRIM1 | C15orf39 | 0.969 | 0.078 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| POLA1 | C15orf39 | 0.928 | 0.09 | hein_WMM bioplex3_WMM WMM_only |
Related Complexes