hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04912.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TUBA1C | Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | 5 | UniProt NCBI |
| TUBAL3 | Tubulin alpha chain-like 3 (EC 3.6.5.-) | 5 | UniProt NCBI |
| TCP11L2 | T-complex protein 11-like protein 2 | 4 | UniProt NCBI |
| NFXL1 | NF-X1-type zinc finger protein NFXL1 (Ovarian zinc finger protein) (hOZFP) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-190840 | 0.00156635412759 | 0.5 | TUBA1C TUBAL3 | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane |
| REAC:R-HSA-190872 | 0.00175047124894 | 0.5 | TUBA1C TUBAL3 | Transport of connexons to the plasma membrane |
| REAC:R-HSA-389977 | 0.00258893271292 | 0.5 | TUBA1C TUBAL3 | Post-chaperonin tubulin folding pathway |
| WP:WP2272 | 0.00299043061896 | 0.5 | TUBA1C TUBAL3 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-9619483 | 0.00306932002175 | 0.5 | TUBA1C TUBAL3 | Activation of AMPK downstream of NMDARs |
| REAC:R-HSA-389960 | 0.00306932002175 | 0.5 | TUBA1C TUBAL3 | Formation of tubulin folding intermediates by CCT/TriC |
| REAC:R-HSA-190861 | 0.00386628370571 | 0.5 | TUBA1C TUBAL3 | Gap junction assembly |
| REAC:R-HSA-9668328 | 0.00415229579539 | 0.5 | TUBA1C TUBAL3 | Sealing of the nuclear envelope (NE) by ESCRT-III |
| REAC:R-HSA-5626467 | 0.00415229579539 | 0.5 | TUBA1C TUBAL3 | RHO GTPases activate IQGAPs |
| REAC:R-HSA-389958 | 0.00507136546841 | 0.5 | TUBA1C TUBAL3 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| WP:WP2359 | 0.00578263137464 | 0.5 | TUBA1C TUBAL3 | Parkin ubiquitin proteasomal system pathway |
| KEGG:04540 | 0.00619374956043 | 0.5 | TUBA1C TUBAL3 | Gap junction |
| REAC:R-HSA-9609736 | 0.00718390333861 | 0.5 | TUBA1C TUBAL3 | Assembly and cell surface presentation of NMDA receptors |
| REAC:R-HSA-8955332 | 0.00718390333861 | 0.5 | TUBA1C TUBAL3 | Carboxyterminal post-translational modifications of tubulin |
| REAC:R-HSA-190828 | 0.007571530532 | 0.5 | TUBA1C TUBAL3 | Gap junction trafficking |
| REAC:R-HSA-157858 | 0.0079693038543 | 0.5 | TUBA1C TUBAL3 | Gap junction trafficking and regulation |
| REAC:R-HSA-9646399 | 0.00837722051003 | 0.5 | TUBA1C TUBAL3 | Aggrephagy |
| REAC:R-HSA-437239 | 0.0105688559686 | 0.5 | TUBA1C TUBAL3 | Recycling pathway of L1 |
| REAC:R-HSA-6811436 | 0.012504459305 | 0.5 | TUBA1C TUBAL3 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-3371497 | 0.0135329645116 | 0.5 | TUBA1C TUBAL3 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand |
| REAC:R-HSA-983189 | 0.0146019089592 | 0.5 | TUBA1C TUBAL3 | Kinesins |
| KEGG:04210 | 0.0177164397058 | 0.5 | TUBA1C TUBAL3 | Apoptosis |
| KEGG:04145 | 0.0214296747035 | 0.5 | TUBA1C TUBAL3 | Phagosome |
| REAC:R-HSA-2995410 | 0.022534212454 | 0.5 | TUBA1C TUBAL3 | Nuclear Envelope (NE) Reassembly |
| REAC:R-HSA-438064 | 0.0232149434748 | 0.5 | TUBA1C TUBAL3 | Post NMDA receptor activation events |
| KEGG:04530 | 0.0237566589162 | 0.5 | TUBA1C TUBAL3 | Tight junction |
| REAC:R-HSA-1445148 | 0.0239057396727 | 0.5 | TUBA1C TUBAL3 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| REAC:R-HSA-9663891 | 0.0282617295192 | 0.5 | TUBA1C TUBAL3 | Selective autophagy |
| REAC:R-HSA-8852276 | 0.0290229039331 | 0.5 | TUBA1C TUBAL3 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| REAC:R-HSA-442755 | 0.0321680026233 | 0.5 | TUBA1C TUBAL3 | Activation of NMDA receptors and postsynaptic events |
| KEGG:04814 | 0.0322340970049 | 0.5 | TUBA1C TUBAL3 | Motor proteins |
| KEGG:05130 | 0.0334335704012 | 0.5 | TUBA1C TUBAL3 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-390466 | 0.0363250695065 | 0.5 | TUBA1C TUBAL3 | Chaperonin-mediated protein folding |
| REAC:R-HSA-380320 | 0.0407325822829 | 0.5 | TUBA1C TUBAL3 | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-391251 | 0.0425656343513 | 0.5 | TUBA1C TUBAL3 | Protein folding |
| REAC:R-HSA-6811434 | 0.0434971593242 | 0.5 | TUBA1C TUBAL3 | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-6807878 | 0.046351696636 | 0.5 | TUBA1C TUBAL3 | COPI-mediated anterograde transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TUBA1C | TCP11L2 | 0.997 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| TUBAL3 | TCP11L2 | 0.978 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TUBA1C | NFXL1 | 0.954 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| TUBAL3 | TUBA1C | 0.95 | 0.97 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| TCP11L2 | NFXL1 | 0.585 | bioplex_WMM bioplex3_WMM WMM_only | |
| TUBAL3 | NFXL1 | 0.041 | 0.126 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes