hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04917.1
Complex Portal: CPX-23663
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ARAF | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | 5 | UniProt NCBI |
| BRAF | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | 5 | UniProt NCBI |
| KRAS | GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed] | 5 | UniProt NCBI |
| KSR1 | Kinase suppressor of Ras 1 (EC 2.7.11.1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4928 | 3.87329686614e-05 | 1.0 | KRAS KSR1 | MAPK pathway in congenital thyroid cancer |
| KEGG:04625 | 0.00058037380927 | 1.0 | KRAS KSR1 | C-type lectin receptor signaling pathway |
| REAC:R-HSA-6802955 | 0.00120125951175 | 1.0 | KRAS KSR1 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802949 | 0.00120125951175 | 1.0 | KRAS KSR1 | Signaling by RAS mutants |
| REAC:R-HSA-6802946 | 0.00120125951175 | 1.0 | KRAS KSR1 | Signaling by moderate kinase activity BRAF mutants |
| REAC:R-HSA-9649948 | 0.00120125951175 | 1.0 | KRAS KSR1 | Signaling downstream of RAS mutants |
| WP:WP231 | 0.00148377064565 | 1.0 | KRAS KSR1 | TNF alpha signaling pathway |
| KEGG:04014 | 0.00273702337615 | 1.0 | KRAS KSR1 | Ras signaling pathway |
| REAC:R-HSA-6802957 | 0.00424627295404 | 1.0 | KRAS KSR1 | Oncogenic MAPK signaling |
| WP:WP4223 | 0.00456751084292 | 1.0 | KRAS KSR1 | Ras signaling |
| CORUM:5918 | 0.0249718442457 | 0.5 | KSR1 | KSR1 homo-oligomer complex |
| REAC:R-HSA-5673001 | 0.0385804228396 | 1.0 | KRAS KSR1 | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.0400465404229 | 1.0 | KRAS KSR1 | MAPK1/MAPK3 signaling |
| CORUM:5921 | 0.0499419797295 | 0.5 | KSR1 | KSR1-BRAF-MEK complex |
| HP:0011321 | 0.0499436884913 | 0.5 | KRAS | Left unilambdoid synostosis |
| HP:0100955 | 0.0499436884913 | 0.5 | KRAS | Giant cell granuloma of mandible |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| BRAF | ARAF | 0.989 | 0.078 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| KSR1 | BRAF | 0.985 | 0.11 | hein_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| KRAS | BRAF | 0.981 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| KSR1 | ARAF | 0.959 | 0.074 | hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| KRAS | ARAF | 0.087 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes