hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04919.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PDK1 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) | 5 | UniProt NCBI |
| PDHX | Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX) | 5 | UniProt NCBI |
| PDK3 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3) | 5 | UniProt NCBI |
| PDK2 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII) | 5 | UniProt NCBI |
| PDHA1 | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) | 5 | UniProt NCBI |
| PDHB | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1) | 5 | UniProt NCBI |
| DLAT | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-204174 | 1.27698634199e-13 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | Regulation of pyruvate dehydrogenase (PDH) complex |
| GO:0006086 | 2.2691065e-12 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | acetyl-CoA biosynthetic process from pyruvate |
| REAC:R-HSA-70268 | 4.16616794075e-12 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | Pyruvate metabolism |
| REAC:R-HSA-5362517 | 1.2743464183e-11 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | Signaling by Retinoic Acid |
| GO:0006085 | 5.57191707223e-11 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | acetyl-CoA biosynthetic process |
| REAC:R-HSA-71406 | 7.59806873486e-11 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | Pyruvate metabolism and Citric Acid (TCA) cycle |
| GO:0006084 | 5.92308831628e-10 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | acetyl-CoA metabolic process |
| GO:0071616 | 4.51968196359e-09 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | acyl-CoA biosynthetic process |
| GO:0035384 | 4.51968196359e-09 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | thioester biosynthetic process |
| GO:0034030 | 1.54182545094e-08 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | ribonucleoside bisphosphate biosynthetic process |
| GO:0033866 | 1.54182545094e-08 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | nucleoside bisphosphate biosynthetic process |
| GO:0034033 | 1.54182545094e-08 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | purine nucleoside bisphosphate biosynthetic process |
| REAC:R-HSA-1428517 | 3.16392999894e-08 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0006637 | 1.77907089057e-07 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | acyl-CoA metabolic process |
| GO:0035383 | 1.77907089057e-07 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | thioester metabolic process |
| REAC:R-HSA-9006931 | 2.15038697685e-07 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | Signaling by Nuclear Receptors |
| GO:0006090 | 3.52753783753e-07 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | pyruvate metabolic process |
| GO:0034032 | 5.80297190308e-07 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | purine nucleoside bisphosphate metabolic process |
| GO:0033865 | 5.80297190308e-07 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | nucleoside bisphosphate metabolic process |
| GO:0033875 | 5.80297190308e-07 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | ribonucleoside bisphosphate metabolic process |
| GO:0044272 | 2.67973063947e-06 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | sulfur compound biosynthetic process |
| GO:0050812 | 3.84440695359e-06 | 0.6 | PDK1 PDK2 PDK3 | regulation of acyl-CoA biosynthetic process |
| GO:0010510 | 3.84440695359e-06 | 0.6 | PDK1 PDK2 PDK3 | regulation of acetyl-CoA biosynthetic process from pyruvate |
| GO:0009152 | 6.71183379666e-06 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | purine ribonucleotide biosynthetic process |
| GO:0009260 | 8.9004423659e-06 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | ribonucleotide biosynthetic process |
| GO:0004740 | 9.61003071434e-06 | 0.6 | PDK1 PDK2 PDK3 | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
| GO:0046390 | 1.06522796203e-05 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | ribose phosphate biosynthetic process |
| GO:0006164 | 1.62580436396e-05 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | purine nucleotide biosynthetic process |
| GO:0072522 | 1.85772293741e-05 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | purine-containing compound biosynthetic process |
| GO:0009165 | 2.78328719987e-05 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | nucleotide biosynthetic process |
| GO:1901293 | 3.06422269678e-05 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | nucleoside phosphate biosynthetic process |
| GO:0045254 | 3.362820138e-05 | 0.6 | PDHX PDK2 PDHA1 | pyruvate dehydrogenase complex |
| GO:0005967 | 3.362820138e-05 | 0.6 | PDHX PDK2 PDHA1 | mitochondrial pyruvate dehydrogenase complex |
| GO:0006790 | 5.97436292687e-05 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | sulfur compound metabolic process |
| GO:0042762 | 0.000115261178119 | 0.6 | PDK1 PDK2 PDK3 | regulation of sulfur metabolic process |
| GO:0009150 | 0.000221831775662 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | purine ribonucleotide metabolic process |
| GO:0009259 | 0.000259735617241 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | ribonucleotide metabolic process |
| WP:WP5050 | 0.000264396631677 | 0.4 | PDK1 PDHA1 | TCA cycle in senescence |
| GO:0019693 | 0.000311878876809 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | ribose phosphate metabolic process |
| GO:1900371 | 0.000436807598019 | 0.6 | PDK1 PDK2 PDK3 | regulation of purine nucleotide biosynthetic process |
| GO:0030808 | 0.000436807598019 | 0.6 | PDK1 PDK2 PDK3 | regulation of nucleotide biosynthetic process |
| GO:0006163 | 0.000586751252526 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | purine nucleotide metabolic process |
| GO:0072521 | 0.000721513819175 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | purine-containing compound metabolic process |
| GO:0005759 | 0.000778003322929 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | mitochondrial matrix |
| GO:0032787 | 0.000890730616832 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | monocarboxylic acid metabolic process |
| KEGG:05415 | 0.000905384445946 | 0.6 | PDK3 PDK2 PDHA1 | Diabetic cardiomyopathy |
| GO:0009117 | 0.000934818284299 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | nucleotide metabolic process |
| HP:0500231 | 0.000961529670085 | 0.4 | PDHX PDHA1 | Abnormal CSF pyruvate family amino acid concentration |
| GO:0006753 | 0.00100420679152 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | nucleoside phosphate metabolic process |
| GO:0090407 | 0.00109030437564 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | organophosphate biosynthetic process |
| WP:WP4206 | 0.0011148137474 | 0.4 | PDK1 PDHA1 | Hereditary leiomyomatosis and renal cell carcinoma pathway |
| GO:0055086 | 0.00183357328508 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | nucleobase-containing small molecule metabolic process |
| GO:1901137 | 0.00205545864443 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | carbohydrate derivative biosynthetic process |
| HP:0002928 | 0.00288300984678 | 0.4 | PDHX PDHA1 | Decreased activity of the pyruvate dehydrogenase complex |
| REAC:R-HSA-1430728 | 0.00423241276191 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | Metabolism |
| WP:WP5220 | 0.00433647105223 | 0.4 | PDHX PDHA1 | Metabolic reprogramming in pancreatic cancer |
| REAC:R-HSA-389661 | 0.00454605723789 | 0.4 | PDHX PDHA1 | Glyoxylate metabolism and glycine degradation |
| GO:0097411 | 0.00468200720083 | 0.4 | PDK1 PDK3 | hypoxia-inducible factor-1alpha signaling pathway |
| GO:0019752 | 0.00618316242146 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | carboxylic acid metabolic process |
| GO:0043436 | 0.00698585237284 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | oxoacid metabolic process |
| GO:0006082 | 0.00709889029368 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | organic acid metabolic process |
| HP:0500184 | 0.00768171284681 | 0.4 | PDHX PDHA1 | Abnormal CSF amino acid concentration |
| REAC:R-HSA-162582 | 0.00823431736973 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | Signal Transduction |
| HP:0500183 | 0.00870474912182 | 0.4 | PDHX PDHA1 | Abnormal CSF carboxylic acid concentration |
| GO:0043604 | 0.00918533309693 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | amide biosynthetic process |
| KEGG:05230 | 0.00996128881886 | 0.4 | PDK1 PDHA1 | Central carbon metabolism in cancer |
| GO:0019637 | 0.0162053403278 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | organophosphate metabolic process |
| WP:WP3925 | 0.0197951791935 | 0.4 | PDHX PDHA1 | Amino acid metabolism |
| KEGG:04066 | 0.0217595858915 | 0.4 | PDK1 PDHA1 | HIF-1 signaling pathway |
| GO:1901135 | 0.0227982065196 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | carbohydrate derivative metabolic process |
| GO:0010906 | 0.0264997162634 | 0.6 | PDK1 PDK2 PDK3 | regulation of glucose metabolic process |
| GO:0019217 | 0.0294915925302 | 0.6 | PDK1 PDK2 PDK3 | regulation of fatty acid metabolic process |
| GO:1900542 | 0.0310683011928 | 0.6 | PDK1 PDK2 PDK3 | regulation of purine nucleotide metabolic process |
| GO:0006140 | 0.0327001087246 | 0.6 | PDK1 PDK2 PDK3 | regulation of nucleotide metabolic process |
| GO:0043603 | 0.0398244546538 | 1.0 | PDK1 PDHA1 PDK2 PDK3 PDHX | amide metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PDHA1 | PDHB | 1.0 | 0.958 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| PDHA1 | DLAT | 1.0 | 0.718 | hein_WMM bioplex_WMM Guru bioplex3_WMM youn_WMM fraction |
| PDHB | DLAT | 1.0 | 0.694 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM fraction |
| PDK3 | DLAT | 0.999 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| PDK1 | PDK2 | 0.999 | 0.058 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| PDK3 | PDK1 | 0.999 | 0.278 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () |
| PDK3 | PDHB | 0.999 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM treiber_WMM |
| PDHX | PDHA1 | 0.998 | 0.684 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PDK3 | PDHX | 0.998 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PDHX | DLAT | 0.997 | 0.652 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PDK3 | PDHA1 | 0.997 | 0.18 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM treiber_WMM |
| PDHA1 | PDK2 | 0.996 | 0.204 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PDK3 | PDK2 | 0.996 | 0.088 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PDK1 | PDHA1 | 0.996 | 0.29 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| PDK2 | DLAT | 0.994 | 0.236 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PDHX | PDK2 | 0.994 | 0.07 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PDHX | PDHB | 0.991 | 0.568 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM |
| PDK1 | PDHX | 0.984 | 0.218 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PDK1 | PDHB | 0.964 | 0.429538461538 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PDHB | PDK2 | 0.957 | 0.354 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PDK1 | DLAT | 0.924 | 0.3708 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
Related Complexes