hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_04919.1

Complex Portal: CPX-16656

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
PDK1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)	5	UniProt NCBI
PDHX	Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)	5	UniProt NCBI
PDK3	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)	5	UniProt NCBI
PDK2	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)	5	UniProt NCBI
PDHA1	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)	5	UniProt NCBI
PDHB	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)	5	UniProt NCBI
DLAT	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-204174	1.27698634199e-13	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	Regulation of pyruvate dehydrogenase (PDH) complex
GO:0006086	2.2691065e-12	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	acetyl-CoA biosynthetic process from pyruvate
REAC:R-HSA-70268	4.16616794075e-12	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	Pyruvate metabolism
REAC:R-HSA-5362517	1.2743464183e-11	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	Signaling by Retinoic Acid
GO:0006085	5.57191707223e-11	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	acetyl-CoA biosynthetic process
REAC:R-HSA-71406	7.59806873486e-11	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	Pyruvate metabolism and Citric Acid (TCA) cycle
GO:0006084	5.92308831628e-10	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	acetyl-CoA metabolic process
GO:0071616	4.51968196359e-09	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	acyl-CoA biosynthetic process
GO:0035384	4.51968196359e-09	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	thioester biosynthetic process
GO:0034030	1.54182545094e-08	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	ribonucleoside bisphosphate biosynthetic process
GO:0033866	1.54182545094e-08	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	nucleoside bisphosphate biosynthetic process
GO:0034033	1.54182545094e-08	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	purine nucleoside bisphosphate biosynthetic process
REAC:R-HSA-1428517	3.16392999894e-08	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	The citric acid (TCA) cycle and respiratory electron transport
GO:0006637	1.77907089057e-07	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	acyl-CoA metabolic process
GO:0035383	1.77907089057e-07	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	thioester metabolic process
REAC:R-HSA-9006931	2.15038697685e-07	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	Signaling by Nuclear Receptors
GO:0006090	3.52753783753e-07	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	pyruvate metabolic process
GO:0034032	5.80297190308e-07	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	purine nucleoside bisphosphate metabolic process
GO:0033865	5.80297190308e-07	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	nucleoside bisphosphate metabolic process
GO:0033875	5.80297190308e-07	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	ribonucleoside bisphosphate metabolic process
GO:0044272	2.67973063947e-06	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	sulfur compound biosynthetic process
GO:0050812	3.84440695359e-06	0.6	PDK2 PDK1 PDK3	regulation of acyl-CoA biosynthetic process
GO:0010510	3.84440695359e-06	0.6	PDK2 PDK1 PDK3	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0009152	6.71183379666e-06	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	purine ribonucleotide biosynthetic process
GO:0009260	8.9004423659e-06	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	ribonucleotide biosynthetic process
GO:0004740	9.61003071434e-06	0.6	PDK2 PDK1 PDK3	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0046390	1.06522796203e-05	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	ribose phosphate biosynthetic process
GO:0006164	1.62580436396e-05	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	purine nucleotide biosynthetic process
GO:0072522	1.85772293741e-05	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	purine-containing compound biosynthetic process
GO:0009165	2.78328719987e-05	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	nucleotide biosynthetic process
GO:1901293	3.06422269678e-05	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	nucleoside phosphate biosynthetic process
GO:0045254	3.362820138e-05	0.6	PDK2 PDHX PDHA1	pyruvate dehydrogenase complex
GO:0005967	3.362820138e-05	0.6	PDK2 PDHX PDHA1	mitochondrial pyruvate dehydrogenase complex
GO:0006790	5.97436292687e-05	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	sulfur compound metabolic process
GO:0042762	0.000115261178119	0.6	PDK2 PDK1 PDK3	regulation of sulfur metabolic process
GO:0009150	0.000221831775662	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	purine ribonucleotide metabolic process
GO:0009259	0.000259735617241	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	ribonucleotide metabolic process
WP:WP5050	0.000264396631677	0.4	PDK1 PDHA1	TCA cycle in senescence
GO:0019693	0.000311878876809	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	ribose phosphate metabolic process
GO:1900371	0.000436807598019	0.6	PDK2 PDK1 PDK3	regulation of purine nucleotide biosynthetic process
GO:0030808	0.000436807598019	0.6	PDK2 PDK1 PDK3	regulation of nucleotide biosynthetic process
GO:0006163	0.000586751252526	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	purine nucleotide metabolic process
GO:0072521	0.000721513819175	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	purine-containing compound metabolic process
GO:0005759	0.000778003322929	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	mitochondrial matrix
GO:0032787	0.000890730616832	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	monocarboxylic acid metabolic process
KEGG:05415	0.000905384445946	0.6	PDK2 PDK3 PDHA1	Diabetic cardiomyopathy
GO:0009117	0.000934818284299	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	nucleotide metabolic process
HP:0500231	0.000961529670085	0.4	PDHX PDHA1	Abnormal CSF pyruvate family amino acid concentration
GO:0006753	0.00100420679152	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	nucleoside phosphate metabolic process
GO:0090407	0.00109030437564	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	organophosphate biosynthetic process
WP:WP4206	0.0011148137474	0.4	PDK1 PDHA1	Hereditary leiomyomatosis and renal cell carcinoma pathway
GO:0055086	0.00183357328508	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	nucleobase-containing small molecule metabolic process
GO:1901137	0.00205545864443	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	carbohydrate derivative biosynthetic process
HP:0002928	0.00288300984678	0.4	PDHX PDHA1	Decreased activity of the pyruvate dehydrogenase complex
REAC:R-HSA-1430728	0.00423241276191	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	Metabolism
WP:WP5220	0.00433647105223	0.4	PDHX PDHA1	Metabolic reprogramming in pancreatic cancer
REAC:R-HSA-389661	0.00454605723789	0.4	PDHX PDHA1	Glyoxylate metabolism and glycine degradation
GO:0097411	0.00468200720083	0.4	PDK1 PDK3	hypoxia-inducible factor-1alpha signaling pathway
GO:0019752	0.00618316242146	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	carboxylic acid metabolic process
GO:0043436	0.00698585237284	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	oxoacid metabolic process
GO:0006082	0.00709889029368	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	organic acid metabolic process
HP:0500184	0.00768171284681	0.4	PDHX PDHA1	Abnormal CSF amino acid concentration
REAC:R-HSA-162582	0.00823431736973	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	Signal Transduction
HP:0500183	0.00870474912182	0.4	PDHX PDHA1	Abnormal CSF carboxylic acid concentration
GO:0043604	0.00918533309693	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	amide biosynthetic process
KEGG:05230	0.00996128881886	0.4	PDK1 PDHA1	Central carbon metabolism in cancer
GO:0019637	0.0162053403278	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	organophosphate metabolic process
WP:WP3925	0.0197951791935	0.4	PDHX PDHA1	Amino acid metabolism
KEGG:04066	0.0217595858915	0.4	PDK1 PDHA1	HIF-1 signaling pathway
GO:1901135	0.0227982065196	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	carbohydrate derivative metabolic process
GO:0010906	0.0264997162634	0.6	PDK2 PDK1 PDK3	regulation of glucose metabolic process
GO:0019217	0.0294915925302	0.6	PDK2 PDK1 PDK3	regulation of fatty acid metabolic process
GO:1900542	0.0310683011928	0.6	PDK2 PDK1 PDK3	regulation of purine nucleotide metabolic process
GO:0006140	0.0327001087246	0.6	PDK2 PDK1 PDK3	regulation of nucleotide metabolic process
GO:0043603	0.0398244546538	1.0	PDHA1 PDK2 PDK3 PDK1 PDHX	amide metabolic process

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
PDHA1	PDHB	1.0	0.958	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM
PDHA1	DLAT	1.0	0.718		hein_WMM bioplex_WMM Guru bioplex3_WMM youn_WMM fraction
PDHB	DLAT	1.0	0.694		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM fraction
PDK3	DLAT	0.999	0.118	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
PDK1	PDK2	0.999	0.058	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein ()
PDK3	PDK1	0.999	0.278	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein ()
PDK3	PDHB	0.999	0.124	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM treiber_WMM
PDHX	PDHA1	0.998	0.684		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDK3	PDHX	0.998	0.06	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDHX	DLAT	0.997	0.652		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDK3	PDHA1	0.997	0.18	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM treiber_WMM
PDHA1	PDK2	0.996	0.204		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
PDK3	PDK2	0.996	0.088	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDK1	PDHA1	0.996	0.29		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
PDK2	DLAT	0.994	0.236	structurally_consistent (dimer)	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
PDHX	PDK2	0.994	0.07		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
PDHX	PDHB	0.991	0.568		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM
PDK1	PDHX	0.984	0.218		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDK1	PDHB	0.964	0.429538461538		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDHB	PDK2	0.957	0.354	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDK1	DLAT	0.924	0.3708		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM

Related Complexes

Genename	Complexes
PDK1	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHX	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDK3	huMAP3_00016.1 huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDK2	huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHA1	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHB	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
DLAT	huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_04919.1

Complex Portal: CPX-16656