hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04931.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) | 5 | UniProt NCBI |
| RRM1 | Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit) | 5 | UniProt NCBI |
| FBXO48 | F-box only protein 48 (F-box protein 48) | 2 | UniProt NCBI |
| HROB | Homologous recombination OB-fold protein | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4584 | 0.000198998246169 | 0.5 | RRM1 RRM2B | Biomarkers for pyrimidine metabolism disorders |
| WP:WP4225 | 0.000390164573598 | 0.5 | RRM1 RRM2B | Pyrimidine metabolism and related diseases |
| KEGG:00240 | 0.00247340401034 | 0.5 | RRM1 RRM2B | Pyrimidine metabolism |
| GO:0000731 | 0.0025122894873 | 0.75 | RRM1 RRM2B HROB | DNA synthesis involved in DNA repair |
| REAC:R-HSA-499943 | 0.00258893271292 | 0.5 | RRM1 RRM2B | Interconversion of nucleotide di- and triphosphates |
| KEGG:00480 | 0.0030591266514 | 0.5 | RRM1 RRM2B | Glutathione metabolism |
| KEGG:00983 | 0.00551283411821 | 0.5 | RRM1 RRM2B | Drug metabolism - other enzymes |
| KEGG:01232 | 0.00601982850302 | 0.5 | RRM1 RRM2B | Nucleotide metabolism |
| GO:0004748 | 0.00842684400117 | 0.5 | RRM1 RRM2B | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| GO:0061731 | 0.00842684400117 | 0.5 | RRM1 RRM2B | ribonucleoside-diphosphate reductase activity |
| GO:0005971 | 0.00842684400117 | 0.5 | RRM1 RRM2B | ribonucleoside-diphosphate reductase complex |
| KEGG:00230 | 0.0118173906169 | 0.5 | RRM1 RRM2B | Purine metabolism |
| GO:0070318 | 0.0168521501606 | 0.5 | RRM1 RRM2B | positive regulation of G0 to G1 transition |
| GO:0016728 | 0.0280843539964 | 0.5 | RRM1 RRM2B | oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor |
| REAC:R-HSA-15869 | 0.0297941212351 | 0.5 | RRM1 RRM2B | Metabolism of nucleotides |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RRM2B | RRM1 | 0.979 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RRM1 | FBXO48 | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RRM1 | HROB | 0.958 | 0.086 | hein_WMM bioplex3_WMM WMM_only |
| RRM2B | FBXO48 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | |
| RRM2B | HROB | 0.027 | 0.026 | bioplex3_WMM WMM_only |
Related Complexes