hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_04932.1

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
THOC5	THO complex subunit 5 homolog (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90)	5	UniProt NCBI
POLDIP3	Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR)	5	UniProt NCBI
THOC6	THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58)	5	UniProt NCBI
THOC3	THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45)	5	UniProt NCBI
ALYREF	THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF)	5	UniProt NCBI
DDX39A	ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49)	5	UniProt NCBI
THOC2	THO complex subunit 2 (Tho2) (hTREX120)	5	UniProt NCBI
SARNP	SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29)	5	UniProt NCBI
ZC3H11A	Zinc finger CCCH domain-containing protein 11A	5	UniProt NCBI
KIF1C	Kinesin-like protein KIF1C	5	UniProt NCBI
THOC1	THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) (p84N5) (hTREX84)	5	UniProt NCBI
DDX39B	Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein)	5	UniProt NCBI
FYTTD1	UAP56-interacting factor (Forty-two-three domain-containing protein 1) (Protein 40-2-3)	5	UniProt NCBI
THOC7	THO complex subunit 7 homolog (Functional spliceosome-associated protein 24) (fSAP24) (Ngg1-interacting factor 3-like protein 1-binding protein 1) (NIF3L1-binding protein 1) (hTREX30)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-72187	7.8739048009e-27	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	mRNA 3'-end processing
REAC:R-HSA-73856	4.7866064386e-26	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	RNA Polymerase II Transcription Termination
REAC:R-HSA-159236	1.90755234032e-25	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	Transport of Mature mRNA derived from an Intron-Containing Transcript
REAC:R-HSA-72202	9.17664025389e-25	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	Transport of Mature Transcript to Cytoplasm
GO:0006406	1.61569905927e-23	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	mRNA export from nucleus
GO:0000346	2.35000207272e-23	0.692307692308	THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC3 THOC5 THOC1	transcription export complex
GO:0051028	5.04034223544e-23	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	mRNA transport
GO:0006405	4.31285407096e-22	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	RNA export from nucleus
CORUM:770	3.41633304177e-21	0.538461538462	THOC3 THOC1 THOC7 THOC2 DDX39B THOC5 THOC6	TREX complex
GO:0050657	8.11425626104e-21	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	nucleic acid transport
GO:0050658	8.11425626104e-21	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	RNA transport
GO:0051236	1.15117076629e-20	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	establishment of RNA localization
GO:0006403	2.38073450157e-19	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	RNA localization
GO:0051168	2.84203880887e-19	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	nuclear export
GO:0015931	5.17876253869e-19	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	nucleobase-containing compound transport
GO:0044417	3.04053640717e-18	0.538461538462	THOC3 THOC1 THOC7 THOC2 DDX39B THOC5 THOC6	translocation of molecules into host
GO:0046784	3.04053640717e-18	0.538461538462	THOC3 THOC1 THOC7 THOC2 DDX39B THOC5 THOC6	viral mRNA export from host cell nucleus
REAC:R-HSA-72203	5.18186529345e-18	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	Processing of Capped Intron-Containing Pre-mRNA
CORUM:6160	7.12988705817e-18	0.461538461538	THOC1 THOC7 THOC2 THOC3 THOC5 THOC6	hTREX84 complex
GO:0051169	2.07179763993e-16	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	nuclear transport
GO:0006913	2.07179763993e-16	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	nucleocytoplasmic transport
GO:0000445	6.34559948177e-15	0.461538461538	THOC1 THOC7 THOC2 THOC3 THOC5 THOC6	THO complex part of transcription export complex
GO:0000347	6.34559948177e-15	0.461538461538	THOC1 THOC7 THOC2 THOC3 THOC5 THOC6	THO complex
CORUM:774	1.302095624e-14	0.384615384615	THOC5 THOC1 THOC7 THOC6 THOC2	THO complex
REAC:R-HSA-8953854	3.42387314874e-13	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	Metabolism of RNA
KEGG:03013	5.78422747799e-11	0.538461538462	THOC3 THOC1 THOC7 THOC2 DDX39B THOC5 THOC6	Nucleocytoplasmic transport
GO:0046907	9.27213332445e-11	1.0	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A KIF1C THOC1	intracellular transport
REAC:R-HSA-73857	1.65411861959e-10	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	RNA Polymerase II Transcription
CORUM:351	5.01369344129e-10	0.538461538462	THOC3 THOC1 THOC7 THOC2 DDX39B THOC5 THOC6	Spliceosome
REAC:R-HSA-74160	7.4329437e-10	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	Gene expression (Transcription)
GO:0051649	2.40658347659e-09	1.0	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A KIF1C THOC1	establishment of localization in cell
GO:0071705	1.45232640697e-08	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	nitrogen compound transport
GO:0051701	1.20374400696e-07	0.538461538462	THOC3 THOC1 THOC7 THOC2 DDX39B THOC5 THOC6	biological process involved in interaction with host
GO:0071702	1.63343219066e-07	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	organic substance transport
GO:0016607	1.47823656785e-06	0.615384615385	POLDIP3 THOC1 THOC7 SARNP FYTTD1 DDX39A DDX39B THOC6	nuclear speck
GO:0051641	2.83155234815e-06	1.0	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A KIF1C THOC1	cellular localization
GO:0044403	5.82309370293e-06	0.538461538462	THOC3 THOC1 THOC7 THOC2 DDX39B THOC5 THOC6	biological process involved in symbiotic interaction
GO:0033036	1.72034341977e-05	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	macromolecule localization
GO:0006810	1.98084347196e-05	1.0	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A KIF1C THOC1	transport
GO:0051234	6.48725531739e-05	1.0	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A KIF1C THOC1	establishment of localization
GO:0000781	6.96555758049e-05	0.461538461538	THOC1 THOC7 THOC2 THOC3 THOC5 THOC6	chromosome, telomeric region
GO:0016973	0.000111659150534	0.307692307692	POLDIP3 ZC3H11A SARNP THOC2	poly(A)+ mRNA export from nucleus
KEGG:03040	0.000196510562353	0.307692307692	THOC3 DDX39B THOC1 THOC2	Spliceosome
GO:2000002	0.000274621184043	0.230769230769	THOC5 THOC1 DDX39B	negative regulation of DNA damage checkpoint
GO:0051179	0.000476839492153	1.0	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A KIF1C THOC1	localization
GO:0016604	0.000822508680251	0.615384615385	POLDIP3 THOC1 THOC7 SARNP FYTTD1 DDX39A DDX39B THOC6	nuclear body
GO:1901977	0.00153551162834	0.230769230769	THOC5 THOC1 DDX39B	negative regulation of cell cycle checkpoint
GO:0140513	0.00213464356125	0.692307692308	THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC3 THOC5 THOC1	nuclear protein-containing complex
HPA:0380513	0.00257047225823	0.538461538462	ZC3H11A SARNP THOC2 FYTTD1 DDX39B THOC3 KIF1C	placenta; decidual cells[High]
GO:0098687	0.00778132039846	0.461538461538	THOC1 THOC7 THOC2 THOC3 THOC5 THOC6	chromosomal region
GO:0003723	0.0165832809285	0.692307692308	POLDIP3 ZC3H11A SARNP THOC2 DDX39B THOC5 DDX39A KIF1C FYTTD1	RNA binding
GO:0005654	0.0261351282479	0.923076923077	POLDIP3 FYTTD1 THOC3 THOC6 ZC3H11A THOC7 SARNP THOC2 DDX39B THOC5 DDX39A THOC1	nucleoplasm
HPA:0060103	0.0346862806731	0.538461538462	POLDIP3 ZC3H11A SARNP THOC2 FYTTD1 THOC3 DDX39B	bronchus; respiratory epithelial cells[High]
GO:2000001	0.0362257557392	0.230769230769	THOC5 THOC1 DDX39B	regulation of DNA damage checkpoint

Edges

Protein 1	Protein 2	Score	ProteomeHD
THOC6	THOC1	1.0	0.902
THOC7	THOC1	1.0	0.55
THOC3	THOC5	1.0	0.318
THOC3	THOC1	1.0	0.326
THOC3	THOC7	1.0	0.1
THOC6	THOC5	1.0	0.876
THOC6	THOC7	1.0	0.526
THOC6	THOC3	1.0	0.342
THOC2	THOC1	1.0	0.856
THOC5	THOC1	1.0	0.946
THOC2	THOC5	1.0	0.846
THOC6	THOC2	1.0	0.874
THOC7	THOC5	1.0	0.522
THOC3	THOC2	1.0	0.46
DDX39A	THOC5	1.0	0.206
DDX39B	THOC5	1.0	0.356
THOC2	THOC7	1.0	0.332
ZC3H11A	THOC1	0.999	0.362
THOC1	SARNP	0.999	0.282
THOC2	SARNP	0.999	0.344
DDX39A	THOC1	0.999	0.078
THOC5	SARNP	0.999	0.326
THOC2	DDX39B	0.999	0.458
THOC6	DDX39B	0.999	0.408
THOC3	ZC3H11A	0.999	0.098
THOC6	SARNP	0.998	0.176
POLDIP3	THOC5	0.998	0.25
ZC3H11A	THOC7	0.998	0.132
ZC3H11A	THOC2	0.998	0.486
DDX39B	THOC1	0.998	0.382
ZC3H11A	THOC5	0.998	0.362
DDX39A	DDX39B	0.998	0.446
ZC3H11A	FYTTD1	0.998	0.14
THOC1	FYTTD1	0.997	0.116
ZC3H11A	SARNP	0.997	0.378
THOC5	FYTTD1	0.997	0.094
THOC6	DDX39A	0.997	0.164
POLDIP3	THOC7	0.997	0.3
POLDIP3	SARNP	0.997	0.408
THOC7	SARNP	0.997	0.412
DDX39B	SARNP	0.997	0.736
THOC2	FYTTD1	0.997	0.208
POLDIP3	THOC1	0.997	0.526
ZC3H11A	DDX39A	0.996	0.184
DDX39A	SARNP	0.996	0.394
DDX39B	THOC7	0.996	0.242
ZC3H11A	DDX39B	0.996	0.308
THOC6	ZC3H11A	0.995	0.356
THOC7	FYTTD1	0.995	0.106
SARNP	FYTTD1	0.995	0.262
ALYREF	THOC1	0.993	0.331
THOC3	SARNP	0.992	0.1
POLDIP3	THOC6	0.992	0.304
KIF1C	THOC1	0.992	0.068
ALYREF	ZC3H11A	0.991	0.534
ZC3H11A	KIF1C	0.991	0.036
POLDIP3	FYTTD1	0.99	0.194
DDX39A	THOC2	0.989	0.174
ALYREF	THOC2	0.988	0.674
KIF1C	FYTTD1	0.988	0.022
ALYREF	THOC5	0.987	0.298
THOC7	KIF1C	0.986	0.04
KIF1C	SARNP	0.986	0.174
THOC3	DDX39B	0.986	0.238
THOC6	FYTTD1	0.985	0.248
DDX39A	KIF1C	0.985	0.092
THOC3	ALYREF	0.984	0.246
THOC3	FYTTD1	0.984	0.048
ALYREF	DDX39B	0.983	0.816
ALYREF	THOC7	0.979	0.242
DDX39A	FYTTD1	0.977	0.098
POLDIP3	ZC3H11A	0.976	0.478
POLDIP3	THOC2	0.975	0.562
POLDIP3	ALYREF	0.974	0.484
THOC3	DDX39A	0.974	0.128
DDX39A	THOC7	0.973	0.168
ALYREF	DDX39A	0.972	0.406
POLDIP3	KIF1C	0.969	0.106
DDX39B	KIF1C	0.964	0.166
ALYREF	FYTTD1	0.962	0.13685
ALYREF	SARNP	0.962	0.62
THOC6	ALYREF	0.949	0.284
DDX39B	FYTTD1	0.937	0.09
THOC2	KIF1C	0.922	0.056
POLDIP3	DDX39B	0.917	0.266
POLDIP3	THOC3	0.914	0.234
POLDIP3	DDX39A	0.866	0.3
THOC6	KIF1C	0.862	0.04
KIF1C	THOC5	0.803	0.072
ALYREF	KIF1C	0.757	0.088
THOC3	KIF1C	0.342	0.1

Related Complexes

Genename	Complexes
THOC5	huMAP3_02553.1 huMAP3_02771.1 huMAP3_04932.1 huMAP3_05846.1 huMAP3_07273.1 huMAP3_08111.1 huMAP3_08233.1 huMAP3_08963.1 huMAP3_09101.1 huMAP3_09226.1 huMAP3_09583.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
POLDIP3	huMAP3_00031.1 huMAP3_02553.1 huMAP3_04023.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_06628.1 huMAP3_07273.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09643.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
THOC6	huMAP3_00936.1 huMAP3_04023.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_06572.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
THOC3	huMAP3_00936.1 huMAP3_02019.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_06572.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1 huMAP3_14379.1
ALYREF	huMAP3_00936.1 huMAP3_04023.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_06572.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09156.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
DDX39A	huMAP3_01665.1 huMAP3_02019.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_05995.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09225.1 huMAP3_09226.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
THOC2	huMAP3_01665.1 huMAP3_02019.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_05696.1 huMAP3_05995.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09225.1 huMAP3_09226.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
SARNP	huMAP3_02771.1 huMAP3_04334.1 huMAP3_04932.1 huMAP3_07273.1 huMAP3_08111.1 huMAP3_08233.1 huMAP3_08302.1 huMAP3_09101.1 huMAP3_09225.1 huMAP3_09226.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
ZC3H11A	huMAP3_01665.1 huMAP3_02019.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_05696.1 huMAP3_05846.1 huMAP3_05995.1 huMAP3_08302.1 huMAP3_08820.1 huMAP3_09101.1 huMAP3_09156.1 huMAP3_09226.1 huMAP3_09552.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10564.1 huMAP3_10789.1
KIF1C	huMAP3_02179.1 huMAP3_02771.1 huMAP3_04334.1 huMAP3_04932.1 huMAP3_06629.1 huMAP3_07298.1 huMAP3_08111.1 huMAP3_08340.1 huMAP3_08963.1 huMAP3_09101.1 huMAP3_09226.1 huMAP3_09457.1 huMAP3_09507.1 huMAP3_09583.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10359.1 huMAP3_10789.1 huMAP3_11021.1 huMAP3_12548.1 huMAP3_13489.1
THOC1	huMAP3_02553.1 huMAP3_02771.1 huMAP3_03454.1 huMAP3_04932.1 huMAP3_05165.1 huMAP3_07273.1 huMAP3_07755.1 huMAP3_08111.1 huMAP3_08233.1 huMAP3_08963.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09583.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
DDX39B	huMAP3_01665.1 huMAP3_02019.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_05846.1 huMAP3_05995.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09225.1 huMAP3_09226.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
FYTTD1	huMAP3_02837.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09943.1 huMAP3_09960.1 huMAP3_10299.1 huMAP3_10789.1
THOC7	huMAP3_02019.1 huMAP3_02553.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_06628.1 huMAP3_07273.1 huMAP3_08111.1 huMAP3_08159.1 huMAP3_08233.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_04932.1