hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04935.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 (11-DH) (11-beta-HSD1) (EC 1.1.1.146) (7-oxosteroid reductase) (EC 1.1.1.201) (Corticosteroid 11-beta-dehydrogenase isozyme 1) (Short chain dehydrogenase/reductase family 26C member 1) | 5 | UniProt NCBI |
| HSD17B2 | 17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) | 5 | UniProt NCBI |
| INSR | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04913 | 0.000102418907518 | 1.0 | HSD17B2 INSR | Ovarian steroidogenesis |
| WP:WP496 | 0.0435328773163 | 0.5 | HSD17B2 | Steroid biosynthesis |
| WP:WP3634 | 0.049750157242 | 0.5 | INSR | Insulin signaling in adipocytes normal condition |
| WP:WP3635 | 0.049750157242 | 0.5 | INSR | Insulin signaling in adipocytes diabetic condition |
| WP:WP5320 | 0.049750157242 | 0.5 | HSD17B2 | Male steroid hormones in cardiomyocyte energy metabolism |
| HP:0004914 | 0.0499436884913 | 0.5 | INSR | Recurrent infantile hypoglycemia |
| HP:0012684 | 0.0499436884913 | 0.5 | INSR | Abnormal pineal volume |
| HP:0012686 | 0.0499436884913 | 0.5 | INSR | Increased pineal volume |
| HP:0034384 | 0.0499436884913 | 0.5 | INSR | Elevated circulating insulin:C-peptide ratio |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HSD17B2 | INSR | 0.98 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HSD11B1 | INSR | 0.957 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes