hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04946.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DCTN2 | Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin) | 5 | UniProt NCBI |
| ACTR1B | Beta-centractin (Actin-related protein 1B) (ARP1B) | 5 | UniProt NCBI |
| DCTN4 | Dynactin subunit 4 (Dyn4) (Dynactin subunit p62) | 5 | UniProt NCBI |
| ACTR10 | Actin-related protein 10 (Actin-related protein 11) (hARP11) | 4 | UniProt NCBI |
| DCTN6 | Dynactin subunit 6 (Dynactin subunit p27) (Protein WS-3) | 5 | UniProt NCBI |
| DCTN5 | Dynactin subunit 5 (Dynactin subunit p25) | 5 | UniProt NCBI |
| DEFB127 | Beta-defensin 127 (Beta-defensin 27) (DEFB-27) (Defensin, beta 127) | 5 | UniProt NCBI |
| CPVL | Probable serine carboxypeptidase CPVL (EC 3.4.16.-) (Carboxypeptidase, vitellogenic-like) (Vitellogenic carboxypeptidase-like protein) (VCP-like protein) (hVLP) | 4 | UniProt NCBI |
| ACTR1A | Alpha-centractin (Centractin) (ARP1) (Actin-RPV) (Centrosome-associated actin homolog) | 5 | UniProt NCBI |
| DCTN3 | Dynactin subunit 3 (Dynactin complex subunit 22 kDa subunit) (p22) | 5 | UniProt NCBI |
| PDGFD | Platelet-derived growth factor D (PDGF-D) (Iris-expressed growth factor) (Spinal cord-derived growth factor B) (SCDGF-B) [Cleaved into: Platelet-derived growth factor D, latent form (PDGFD latent form); Platelet-derived growth factor D, receptor-binding form (PDGFD receptor-binding form)] | 5 | UniProt NCBI |
| DCTN1 | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005869 | 4.80327387602e-22 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR1B ACTR10 ACTR1A DCTN5 DCTN2 | dynactin complex |
| REAC:R-HSA-6811436 | 1.3872342729e-15 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR10 DCTN5 DCTN1 ACTR1A DCTN2 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-3371497 | 1.94352538305e-15 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR10 DCTN5 DCTN1 ACTR1A DCTN2 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand |
| REAC:R-HSA-2132295 | 5.78683725193e-15 | 0.75 | DCTN4 DCTN3 DCTN6 ACTR1B ACTR10 ACTR1A DCTN1 DCTN5 DCTN2 | MHC class II antigen presentation |
| KEGG:04814 | 2.24465195149e-14 | 0.75 | DCTN4 DCTN3 DCTN6 ACTR1B ACTR10 ACTR1A DCTN1 DCTN5 DCTN2 | Motor proteins |
| WP:WP5376 | 3.07911442833e-13 | 0.5 | DCTN1 DCTN4 DCTN6 DCTN3 DCTN5 DCTN2 | 17p13 3 YWHAE copy number variation |
| REAC:R-HSA-6807878 | 3.38796307596e-13 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR10 DCTN5 DCTN1 ACTR1A DCTN2 | COPI-mediated anterograde transport |
| KEGG:05132 | 4.36775701558e-13 | 0.75 | DCTN4 DCTN3 DCTN6 ACTR1B ACTR10 ACTR1A DCTN1 DCTN5 DCTN2 | Salmonella infection |
| GO:0005875 | 1.69469352144e-12 | 0.75 | DCTN4 DCTN3 DCTN6 ACTR1B ACTR10 ACTR1A DCTN1 DCTN5 DCTN2 | microtubule associated complex |
| KEGG:05016 | 2.4735093187e-12 | 0.75 | DCTN4 DCTN3 DCTN6 ACTR1B ACTR10 ACTR1A DCTN1 DCTN5 DCTN2 | Huntington disease |
| REAC:R-HSA-8856688 | 3.18537896692e-12 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR10 DCTN5 DCTN1 ACTR1A DCTN2 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-199977 | 8.97417487511e-12 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR10 DCTN5 DCTN1 ACTR1A DCTN2 | ER to Golgi Anterograde Transport |
| KEGG:05014 | 1.24964580083e-11 | 0.75 | DCTN4 DCTN3 DCTN6 ACTR1B ACTR10 ACTR1A DCTN1 DCTN5 DCTN2 | Amyotrophic lateral sclerosis |
| REAC:R-HSA-948021 | 4.03882050167e-11 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR10 DCTN5 DCTN1 ACTR1A DCTN2 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-6811442 | 1.02837897041e-10 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR10 DCTN5 DCTN1 ACTR1A DCTN2 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| KEGG:05022 | 1.14328705269e-10 | 0.75 | DCTN4 DCTN3 DCTN6 ACTR1B ACTR10 ACTR1A DCTN1 DCTN5 DCTN2 | Pathways of neurodegeneration - multiple diseases |
| REAC:R-HSA-446203 | 2.25333750613e-09 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR10 DCTN5 DCTN1 ACTR1A DCTN2 | Asparagine N-linked glycosylation |
| KEGG:04962 | 4.81017088183e-09 | 0.416666666667 | DCTN1 DCTN4 DCTN5 DCTN2 DCTN6 | Vasopressin-regulated water reabsorption |
| WP:WP5085 | 1.08116457671e-08 | 0.416666666667 | DCTN1 DCTN4 DCTN5 DCTN2 DCTN6 | Vasopressin regulated water reabsorption |
| REAC:R-HSA-1280218 | 4.13681172018e-08 | 0.75 | DCTN4 DCTN3 DCTN6 ACTR1B ACTR10 ACTR1A DCTN1 DCTN5 DCTN2 | Adaptive Immune System |
| REAC:R-HSA-199991 | 6.22841230648e-07 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR10 DCTN5 DCTN1 ACTR1A DCTN2 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 9.56782809885e-07 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR10 DCTN5 DCTN1 ACTR1A DCTN2 | Vesicle-mediated transport |
| REAC:R-HSA-2262752 | 3.89232740475e-06 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR10 DCTN5 DCTN1 ACTR1A DCTN2 | Cellular responses to stress |
| GO:0015629 | 4.0330163084e-06 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR1B ACTR10 ACTR1A DCTN5 DCTN2 | actin cytoskeleton |
| REAC:R-HSA-8953897 | 4.19832213909e-06 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR10 DCTN5 DCTN1 ACTR1A DCTN2 | Cellular responses to stimuli |
| REAC:R-HSA-168256 | 5.90035829962e-06 | 0.833333333333 | DCTN4 ACTR1A DCTN3 DCTN6 ACTR1B ACTR10 DEFB127 DCTN1 DCTN5 DCTN2 | Immune System |
| GO:0005813 | 7.38097818076e-05 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR1B DCTN5 DCTN1 ACTR1A DCTN2 | centrosome |
| REAC:R-HSA-597592 | 0.000246563276175 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR10 DCTN5 DCTN1 ACTR1A DCTN2 | Post-translational protein modification |
| GO:0005815 | 0.000281176090774 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR1B DCTN5 DCTN1 ACTR1A DCTN2 | microtubule organizing center |
| GO:0015630 | 0.000327277052765 | 0.75 | DCTN4 DCTN3 DCTN6 ACTR1B ACTR10 ACTR1A DCTN1 DCTN5 DCTN2 | microtubule cytoskeleton |
| REAC:R-HSA-392499 | 0.0029832414005 | 0.666666666667 | DCTN4 DCTN3 DCTN6 ACTR10 DCTN5 DCTN1 ACTR1A DCTN2 | Metabolism of proteins |
| REAC:R-HSA-380259 | 0.00510802930332 | 0.25 | ACTR1A DCTN2 DCTN3 | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-380284 | 0.00510802930332 | 0.25 | ACTR1A DCTN2 DCTN3 | Loss of proteins required for interphase microtubule organization from the centrosome |
| REAC:R-HSA-8854518 | 0.00584044581838 | 0.25 | ACTR1A DCTN2 DCTN3 | AURKA Activation by TPX2 |
| REAC:R-HSA-380270 | 0.00844506693194 | 0.25 | ACTR1A DCTN2 DCTN3 | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-380287 | 0.00844506693194 | 0.25 | ACTR1A DCTN2 DCTN3 | Centrosome maturation |
| REAC:R-HSA-2565942 | 0.010175973432 | 0.25 | ACTR1A DCTN2 DCTN3 | Regulation of PLK1 Activity at G2/M Transition |
| GO:0005856 | 0.0117703736413 | 0.75 | DCTN4 DCTN3 DCTN6 ACTR1B ACTR10 ACTR1A DCTN1 DCTN5 DCTN2 | cytoskeleton |
| REAC:R-HSA-380320 | 0.0129690076343 | 0.25 | ACTR1A DCTN2 DCTN3 | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-5620912 | 0.0143054151355 | 0.25 | ACTR1A DCTN2 DCTN3 | Anchoring of the basal body to the plasma membrane |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| DCTN4 | DCTN5 | 1.0 | 0.508 |
| ACTR1B | DCTN5 | 1.0 | 0.15 |
| ACTR1B | DCTN4 | 1.0 | 0.172 |
| DCTN4 | DCTN6 | 1.0 | 0.32 |
| DCTN5 | DCTN3 | 1.0 | 0.73 |
| DCTN6 | DCTN5 | 1.0 | 0.638 |
| ACTR1B | ACTR10 | 1.0 | 0.096 |
| ACTR10 | ACTR1A | 1.0 | 0.47 |
| ACTR10 | DCTN5 | 1.0 | 0.3 |
| DCTN2 | ACTR1A | 1.0 | 0.854 |
| DCTN4 | ACTR10 | 1.0 | 0.898 |
| DCTN5 | ACTR1A | 1.0 | 0.518 |
| DCTN2 | DCTN4 | 1.0 | 0.628 |
| ACTR1A | DCTN1 | 1.0 | |
| ACTR1B | DCTN6 | 1.0 | 0.116 |
| DCTN6 | DCTN3 | 1.0 | 0.574 |
| DCTN2 | DCTN5 | 1.0 | 0.586 |
| DCTN2 | DCTN1 | 1.0 | |
| DCTN4 | DCTN1 | 1.0 | |
| DCTN4 | ACTR1A | 1.0 | 0.736 |
| ACTR1B | DCTN1 | 1.0 | |
| ACTR10 | DCTN6 | 1.0 | 0.182 |
| ACTR10 | DCTN3 | 1.0 | 0.726 |
| DCTN5 | DCTN1 | 1.0 | |
| DCTN4 | DCTN3 | 1.0 | 0.908 |
| DCTN3 | DCTN1 | 1.0 | |
| DCTN6 | ACTR1A | 1.0 | 0.268 |
| DCTN2 | ACTR1B | 1.0 | 0.348 |
| DCTN2 | ACTR10 | 1.0 | 0.434 |
| DCTN6 | DCTN1 | 0.999 | |
| ACTR1A | DCTN3 | 0.999 | 0.92 |
| ACTR10 | DCTN1 | 0.999 | |
| DCTN2 | DCTN3 | 0.999 | 0.912 |
| DCTN2 | DCTN6 | 0.999 | 0.452 |
| ACTR1B | ACTR1A | 0.999 | 0.274 |
| DCTN5 | PDGFD | 0.998 | |
| ACTR1B | DCTN3 | 0.998 | 0.262 |
| CPVL | DCTN5 | 0.998 | 0.024 |
| CPVL | ACTR1B | 0.998 | 0.05 |
| CPVL | DCTN6 | 0.997 | 0.074 |
| CPVL | DCTN2 | 0.995 | 0.128 |
| DCTN6 | PDGFD | 0.989 | |
| DCTN2 | DEFB127 | 0.969 | |
| DCTN6 | DEFB127 | 0.968 | |
| CPVL | ACTR10 | 0.957 | 0.06 |
| DCTN3 | PDGFD | 0.946 | |
| ACTR10 | DEFB127 | 0.946 | |
| ACTR1A | PDGFD | 0.924 | |
| CPVL | DCTN4 | 0.912 | 0.036 |
| DEFB127 | ACTR1A | 0.91 | |
| DCTN2 | PDGFD | 0.894 | |
| DCTN4 | DEFB127 | 0.887 | |
| CPVL | ACTR1A | 0.88 | 0.068 |
| CPVL | DCTN1 | 0.877 | |
| DCTN4 | PDGFD | 0.863 | |
| PDGFD | DCTN1 | 0.855 | |
| ACTR10 | PDGFD | 0.819 | |
| ACTR1B | PDGFD | 0.794 | |
| DCTN5 | DEFB127 | 0.792 | |
| CPVL | DCTN3 | 0.779 | 0.028 |
| ACTR1B | DEFB127 | 0.704 | |
| DEFB127 | DCTN3 | 0.674 | |
| DEFB127 | DCTN1 | 0.171 | |
| CPVL | PDGFD | 0.036 | |
| CPVL | DEFB127 | 0.003 |
Related Complexes