hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04951.1
Complex Portal: CPX-21307
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ADAM22 | Disintegrin and metalloproteinase domain-containing protein 22 (ADAM 22) (Metalloproteinase-disintegrin ADAM22-3) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) | 5 | UniProt NCBI |
| LGI1 | Leucine-rich glioma-inactivated protein 1 (Epitempin-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7395 | 1.70876175213e-06 | 1.0 | LGI1 ADAM22 | ADAM22-LGI1 complex |
| REAC:R-HSA-5682910 | 7.68942788458e-05 | 1.0 | LGI1 ADAM22 | LGI-ADAM interactions |
| HP:0002266 | 0.00191723068589 | 1.0 | LGI1 ADAM22 | Focal clonic seizure |
| HP:0007334 | 0.00266566833332 | 1.0 | LGI1 ADAM22 | Bilateral tonic-clonic seizure with focal onset |
| HP:0020221 | 0.00710844888886 | 1.0 | LGI1 ADAM22 | Clonic seizure |
| HP:0011153 | 0.0143057533888 | 1.0 | LGI1 ADAM22 | Focal motor seizure |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ADAM22 | LGI1 | 0.984 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes