hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04977.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AEBP2 | Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2) | 5 | UniProt NCBI |
| EED | Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1) | 5 | UniProt NCBI |
| PHF19 | PHD finger protein 19 (Polycomb-like protein 3) (hPCL3) | 5 | UniProt NCBI |
| EZH1 | Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1) | 5 | UniProt NCBI |
| SUZ12 | Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog) | 5 | UniProt NCBI |
| JARID2 | Protein Jumonji (Jumonji/ARID domain-containing protein 2) | 5 | UniProt NCBI |
| EZH2 | Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6) | 5 | UniProt NCBI |
| EPOP | Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28) | 4 | UniProt NCBI |
| MTF2 | Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2) | 5 | UniProt NCBI |
| SKIDA1 | SKI/DACH domain-containing protein 1 (Protein DLN-1) | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03083 | 1.56382143673e-18 | 0.9 | PHF19 EPOP EED JARID2 AEBP2 EZH2 EZH1 MTF2 SUZ12 | Polycomb repressive complex |
| WP:WP2916 | 4.78050621907e-18 | 0.7 | EED EZH1 EZH2 AEBP2 JARID2 MTF2 SUZ12 | Interactome of polycomb repressive complex 2 PRC2 |
| GO:0035098 | 3.64471100416e-16 | 0.7 | PHF19 EED EZH1 EZH2 AEBP2 SUZ12 MTF2 | ESC/E(Z) complex |
| GO:0035097 | 1.9195845146e-13 | 0.8 | PHF19 EED JARID2 AEBP2 EZH2 EZH1 MTF2 SUZ12 | histone methyltransferase complex |
| REAC:R-HSA-212300 | 4.43791385175e-13 | 0.7 | PHF19 EED JARID2 EZH2 AEBP2 SUZ12 MTF2 | PRC2 methylates histones and DNA |
| GO:0034708 | 3.67365536752e-12 | 0.8 | PHF19 EED JARID2 AEBP2 EZH2 EZH1 MTF2 SUZ12 | methyltransferase complex |
| GO:0031519 | 5.70026207713e-12 | 0.7 | PHF19 EED EZH1 EZH2 AEBP2 SUZ12 MTF2 | PcG protein complex |
| CORUM:7304 | 8.06664600281e-12 | 0.4 | PHF19 EZH2 EED SUZ12 | HIC1-PCL3L-PCR2 complex |
| CORUM:974 | 4.03199797571e-11 | 0.4 | SUZ12 EZH2 AEBP2 EED | EED-EZH2 complex |
| REAC:R-HSA-212165 | 7.46968105355e-10 | 0.7 | PHF19 EED JARID2 EZH2 AEBP2 SUZ12 MTF2 | Epigenetic regulation of gene expression |
| CORUM:6910 | 1.68385473419e-08 | 0.3 | PHF19 EED EZH2 | EED-EZH2-PHF19 complex |
| CORUM:105 | 1.68264493604e-07 | 0.3 | SUZ12 EED EZH2 | Polycomb repressive complex 2 (PRC 2) |
| GO:0003682 | 3.22773530178e-07 | 0.8 | PHF19 EPOP EED JARID2 EZH2 EZH1 SUZ12 MTF2 | chromatin binding |
| HP:0001814 | 2.26002310037e-06 | 0.3 | SUZ12 EED EZH2 | Deep-set nails |
| GO:0042054 | 3.07418766755e-06 | 0.5 | EZH1 JARID2 EZH2 EED SUZ12 | histone methyltransferase activity |
| WP:WP2369 | 5.95314833593e-06 | 0.4 | EZH1 EZH2 AEBP2 EED | Histone modifications |
| REAC:R-HSA-3214841 | 2.12861862485e-05 | 0.4 | SUZ12 EZH2 AEBP2 EED | PKMTs methylate histone lysines |
| CORUM:5521 | 3.07577115383e-05 | 0.2 | EED EZH2 | EED-EZH polycomb complex |
| CORUM:5502 | 3.07577115383e-05 | 0.2 | EED EZH2 | EED-EZH-YY1 polycomb complex |
| WP:WP5366 | 3.50558212031e-05 | 0.4 | EZH1 JARID2 EED SUZ12 | NF1 copy number variation syndrome |
| GO:0008276 | 4.69143992236e-05 | 0.5 | EZH1 JARID2 EZH2 EED SUZ12 | protein methyltransferase activity |
| HP:0010300 | 4.95955738443e-05 | 0.3 | SUZ12 EED EZH2 | Abnormally low-pitched voice |
| WP:WP2853 | 7.2498749015e-05 | 0.4 | JARID2 MTF2 AEBP2 EZH2 | Endoderm differentiation |
| HP:0002002 | 7.65104937643e-05 | 0.4 | SUZ12 EZH2 EED JARID2 | Deep philtrum |
| HP:0001816 | 8.19991586848e-05 | 0.3 | SUZ12 EED EZH2 | Thin nail |
| WP:WP4204 | 9.1293952863e-05 | 0.3 | SUZ12 EED EZH2 | Tumor suppressor activity of SMARCB1 |
| CORUM:1177 | 9.22394575203e-05 | 0.2 | EED EZH2 | Polycomb repressive complex 4 |
| CORUM:7375 | 9.22394575203e-05 | 0.2 | SUZ12 EZH2 | BRD7-EZH2-SUZ12 complex |
| WP:WP4553 | 0.0001114513301 | 0.3 | SUZ12 EED EZH2 | FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma |
| GO:1990234 | 0.000126088226089 | 0.8 | PHF19 EED JARID2 AEBP2 EZH2 EZH1 MTF2 SUZ12 | transferase complex |
| GO:0046976 | 0.0002304395259 | 0.3 | EZH1 EZH2 JARID2 | histone H3K27 methyltransferase activity |
| REAC:R-HSA-8953750 | 0.000329743401167 | 0.3 | SUZ12 EED EZH2 | Transcriptional Regulation by E2F6 |
| GO:0001222 | 0.00081226844944 | 0.4 | SUZ12 MTF2 EED EZH2 | transcription corepressor binding |
| HP:0001176 | 0.000909359373616 | 0.3 | SUZ12 EED EZH2 | Large hands |
| HP:0001769 | 0.000909359373616 | 0.3 | SUZ12 EED EZH2 | Broad foot |
| REAC:R-HSA-74160 | 0.000973001799799 | 0.7 | PHF19 EED JARID2 EZH2 AEBP2 SUZ12 MTF2 | Gene expression (Transcription) |
| GO:0008168 | 0.00120381036173 | 0.5 | EZH1 JARID2 EZH2 EED SUZ12 | methyltransferase activity |
| REAC:R-HSA-8943724 | 0.00159905965802 | 0.3 | SUZ12 EED EZH2 | Regulation of PTEN gene transcription |
| GO:0016741 | 0.00161934942174 | 0.5 | EZH1 JARID2 EZH2 EED SUZ12 | transferase activity, transferring one-carbon groups |
| HP:0001548 | 0.00188406714163 | 0.3 | SUZ12 EED EZH2 | Overgrowth |
| GO:0140993 | 0.00195464990261 | 0.5 | EZH1 JARID2 EZH2 EED SUZ12 | histone modifying activity |
| REAC:R-HSA-9710421 | 0.00196402430394 | 0.3 | SUZ12 EED EZH2 | Defective pyroptosis |
| GO:0140513 | 0.00205875531072 | 0.8 | PHF19 EED JARID2 AEBP2 EZH2 EZH1 MTF2 SUZ12 | nuclear protein-containing complex |
| GO:0044877 | 0.00293647708351 | 0.8 | PHF19 EPOP EED JARID2 EZH2 EZH1 SUZ12 MTF2 | protein-containing complex binding |
| REAC:R-HSA-4839726 | 0.00391020339039 | 0.4 | SUZ12 EZH2 AEBP2 EED | Chromatin organization |
| REAC:R-HSA-3247509 | 0.00391020339039 | 0.4 | SUZ12 EZH2 AEBP2 EED | Chromatin modifying enzymes |
| HP:0000337 | 0.00395469549896 | 0.4 | SUZ12 EZH2 EED JARID2 | Broad forehead |
| HP:5200005 | 0.00520371988663 | 0.3 | SUZ12 EED EZH2 | Abnormal pitch |
| REAC:R-HSA-9645723 | 0.00655835959712 | 0.3 | SUZ12 EED EZH2 | Diseases of programmed cell death |
| HP:0000995 | 0.00684185418075 | 0.3 | SUZ12 EED EZH2 | Melanocytic nevus |
| HP:0005616 | 0.00720578778026 | 0.3 | SUZ12 EED EZH2 | Accelerated skeletal maturation |
| WP:WP2857 | 0.00723895082243 | 0.3 | JARID2 AEBP2 MTF2 | Mesodermal commitment pathway |
| HP:0012785 | 0.00724480497691 | 0.4 | SUZ12 EZH2 EED JARID2 | Flexion contracture of finger |
| HP:0034681 | 0.00738581804496 | 0.4 | SUZ12 EZH2 EED JARID2 | Finger joint contracture |
| HP:5200010 | 0.00797162805718 | 0.3 | SUZ12 EED EZH2 | Abnormal Intonation |
| WP:WP4239 | 0.00812075814624 | 0.3 | SUZ12 EED EZH2 | Epithelial to mesenchymal transition in colorectal cancer |
| REAC:R-HSA-5617472 | 0.01035862204 | 0.3 | SUZ12 EED EZH2 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| REAC:R-HSA-5619507 | 0.01035862204 | 0.3 | SUZ12 EED EZH2 | Activation of HOX genes during differentiation |
| HP:0001800 | 0.0105878524491 | 0.3 | SUZ12 EED EZH2 | Hypoplastic toenails |
| REAC:R-HSA-2559580 | 0.010653587202 | 0.3 | SUZ12 EED EZH2 | Oxidative Stress Induced Senescence |
| HP:0002213 | 0.0120854462771 | 0.3 | SUZ12 EED EZH2 | Fine hair |
| HP:0031434 | 0.0120854462771 | 0.3 | SUZ12 EED EZH2 | Abnormal prosody |
| HP:0009473 | 0.0132902397142 | 0.4 | SUZ12 EZH2 EED JARID2 | Joint contracture of the hand |
| REAC:R-HSA-9609690 | 0.0150034597897 | 0.3 | SUZ12 EED EZH2 | HCMV Early Events |
| GO:0001221 | 0.0163585481162 | 0.4 | SUZ12 MTF2 EED EZH2 | transcription coregulator binding |
| HP:0011304 | 0.0180739979836 | 0.3 | SUZ12 EED EZH2 | Broad thumb |
| HP:0001582 | 0.0194678741188 | 0.3 | SUZ12 EED EZH2 | Redundant skin |
| REAC:R-HSA-6807070 | 0.0213069607025 | 0.3 | SUZ12 EED EZH2 | PTEN Regulation |
| HP:0001852 | 0.0232586243067 | 0.3 | SUZ12 EED EZH2 | Sandal gap |
| HP:0000311 | 0.0240708430057 | 0.3 | SUZ12 EED EZH2 | Round face |
| REAC:R-HSA-9609646 | 0.0247610923631 | 0.3 | SUZ12 EED EZH2 | HCMV Infection |
| GO:1902494 | 0.0260248958425 | 0.8 | PHF19 EED JARID2 AEBP2 EZH2 EZH1 MTF2 SUZ12 | catalytic complex |
| HP:0100360 | 0.0312423457582 | 0.4 | SUZ12 EZH2 EED JARID2 | Upper-limb joint contracture |
| HP:0010624 | 0.0322365869344 | 0.3 | SUZ12 EED EZH2 | Aplastic/hypoplastic toenail |
| HP:0001609 | 0.0322365869344 | 0.3 | SUZ12 EED EZH2 | Hoarse voice |
| HP:0009768 | 0.0332426017963 | 0.3 | SUZ12 EED EZH2 | Broad phalanges of the hand |
| KEGG:00310 | 0.0343628308557 | 0.2 | EZH1 EZH2 | Lysine degradation |
| HP:0000278 | 0.040329336928 | 0.4 | SUZ12 EZH2 EED JARID2 | Retrognathia |
| REAC:R-HSA-2559583 | 0.0459825497062 | 0.3 | SUZ12 EED EZH2 | Cellular Senescence |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EED | EZH2 | 1.0 | 0.15 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction |
| SUZ12 | EZH2 | 1.0 | 0.632 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction |
| EED | SUZ12 | 1.0 | 0.482 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () |
| AEBP2 | SUZ12 | 1.0 | 0.158 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AEBP2 | EED | 1.0 | 0.132 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| EZH2 | EPOP | 1.0 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| PHF19 | EED | 0.999 | 0.146 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| PHF19 | EZH1 | 0.999 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PHF19 | SUZ12 | 0.999 | 0.088 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AEBP2 | EZH2 | 0.999 | 0.136 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| PHF19 | EZH2 | 0.999 | 0.158 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SUZ12 | EPOP | 0.999 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| AEBP2 | JARID2 | 0.998 | 0.116 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AEBP2 | EZH1 | 0.998 | 0.14 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| JARID2 | EZH2 | 0.998 | 0.066 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| EED | EPOP | 0.998 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| PHF19 | EPOP | 0.997 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EZH1 | SUZ12 | 0.997 | 0.218 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SUZ12 | JARID2 | 0.993 | 0.22 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM fraction |
| AEBP2 | EPOP | 0.991 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| EED | MTF2 | 0.991 | 0.26 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| SUZ12 | MTF2 | 0.989 | 0.234 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SUZ12 | SKIDA1 | 0.988 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| EED | EZH1 | 0.988 | 0.394 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| JARID2 | EPOP | 0.986 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| MTF2 | SKIDA1 | 0.984 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| EZH1 | JARID2 | 0.982 | 0.08 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| EZH1 | MTF2 | 0.982 | 0.282 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| EZH2 | MTF2 | 0.979 | 0.112 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| EZH1 | EPOP | 0.977 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| PHF19 | AEBP2 | 0.976 | 0.106 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PHF19 | MTF2 | 0.975 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| EED | JARID2 | 0.974 | 0.11 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| EZH1 | EZH2 | 0.965 | 0.344 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| EZH1 | SKIDA1 | 0.962 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| EED | SKIDA1 | 0.954 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PHF19 | JARID2 | 0.953 | 0.108 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| AEBP2 | MTF2 | 0.946 | 0.226 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| EPOP | MTF2 | 0.944 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| EZH2 | SKIDA1 | 0.937 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PHF19 | SKIDA1 | 0.905 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| JARID2 | MTF2 | 0.879 | 0.098 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes