hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04997.1
Complex Portal: CPX-21894
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TCAIM | T-cell activation inhibitor, mitochondrial (Tolerance associated gene-1 protein) (TOAG-1) | 3 | UniProt NCBI |
| DLD | Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) | 5 | UniProt NCBI |
| OGDH | 2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7267 | 2.05032700758e-05 | 0.666666666667 | DLD OGDH | KAT2A-Oxoglutarate dehydrogenase complex |
| KEGG:00785 | 0.00011671046881 | 0.666666666667 | DLD OGDH | Lipoic acid metabolism |
| WP:WP2453 | 0.000135842423213 | 0.666666666667 | DLD OGDH | TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc |
| WP:WP78 | 0.000173183276299 | 0.666666666667 | DLD OGDH | TCA cycle aka Krebs or citric acid cycle |
| KEGG:00020 | 0.00033164208966 | 0.666666666667 | DLD OGDH | Citrate cycle (TCA cycle) |
| KEGG:01210 | 0.00033164208966 | 0.666666666667 | DLD OGDH | 2-Oxocarboxylic acid metabolism |
| REAC:R-HSA-71064 | 0.000374861161166 | 0.666666666667 | DLD OGDH | Lysine catabolism |
| HP:0012401 | 0.000986522412937 | 0.666666666667 | DLD OGDH | Abnormal urine alpha-ketoglutarate concentration |
| REAC:R-HSA-71403 | 0.00143063482691 | 0.666666666667 | DLD OGDH | Citric acid cycle (TCA cycle) |
| REAC:R-HSA-389661 | 0.00204339075673 | 0.666666666667 | DLD OGDH | Glyoxylate metabolism and glycine degradation |
| WP:WP3925 | 0.00384048220995 | 0.666666666667 | DLD OGDH | Amino acid metabolism |
| KEGG:01200 | 0.00406958776216 | 0.666666666667 | DLD OGDH | Carbon metabolism |
| WP:WP4932 | 0.00514316015145 | 0.666666666667 | DLD OGDH | 7q11 23 copy number variation syndrome |
| GO:0106077 | 0.00842684400117 | 0.666666666667 | DLD OGDH | histone succinylation |
| GO:0018335 | 0.00842684400117 | 0.666666666667 | DLD OGDH | protein succinylation |
| REAC:R-HSA-71406 | 0.00902065028483 | 0.666666666667 | DLD OGDH | Pyruvate metabolism and Citric Acid (TCA) cycle |
| GO:0045252 | 0.0294899169624 | 0.666666666667 | DLD OGDH | oxoglutarate dehydrogenase complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DLD | OGDH | 0.995 | 0.478 |
mutually_exclusive (Q9ULD0)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| TCAIM | DLD | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TCAIM | OGDH | 0.934 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes