hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05007.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAML1 | Mastermind-like protein 1 (Mam-1) | 5 | UniProt NCBI |
| RBPJ | Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:3113 | 5.12628525639e-06 | 1.0 | MAML1 RBPJ | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2897 | 5.12628525639e-06 | 1.0 | MAML1 RBPJ | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2890 | 5.12628525639e-06 | 1.0 | MAML1 RBPJ | RBPJ-NOTCH1-MAML1 complex |
| REAC:R-HSA-2197563 | 3.58839967947e-05 | 1.0 | MAML1 RBPJ | NOTCH2 intracellular domain regulates transcription |
| WP:WP3845 | 7.2783930122e-05 | 1.0 | MAML1 RBPJ | Canonical and non canonical Notch signaling |
| REAC:R-HSA-210744 | 9.39818963671e-05 | 1.0 | MAML1 RBPJ | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| REAC:R-HSA-8941856 | 9.39818963671e-05 | 1.0 | MAML1 RBPJ | RUNX3 regulates NOTCH signaling |
| CORUM:2639 | 0.000112778275641 | 1.0 | MAML1 RBPJ | HES1 promoter-Notch enhancer complex |
| REAC:R-HSA-9013695 | 0.000179419983974 | 1.0 | MAML1 RBPJ | NOTCH4 Intracellular Domain Regulates Transcription |
| KEGG:04330 | 0.000183378615366 | 1.0 | MAML1 RBPJ | Notch signaling pathway |
| REAC:R-HSA-9793380 | 0.000261440548076 | 1.0 | MAML1 RBPJ | Formation of paraxial mesoderm |
| REAC:R-HSA-9013508 | 0.000324664732905 | 1.0 | MAML1 RBPJ | NOTCH3 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-350054 | 0.000394723964742 | 1.0 | MAML1 RBPJ | Notch-HLH transcription pathway |
| WP:WP61 | 0.000402652619272 | 1.0 | MAML1 RBPJ | Notch signaling pathway |
| KEGG:04658 | 0.000439100744773 | 1.0 | MAML1 RBPJ | Th1 and Th2 cell differentiation |
| REAC:R-HSA-1980145 | 0.000471618243588 | 1.0 | MAML1 RBPJ | Signaling by NOTCH2 |
| REAC:R-HSA-186712 | 0.000512628525639 | 1.0 | MAML1 RBPJ | Regulation of beta-cell development |
| REAC:R-HSA-9758941 | 0.00113803532692 | 1.0 | MAML1 RBPJ | Gastrulation |
| REAC:R-HSA-9012852 | 0.00126619245833 | 1.0 | MAML1 RBPJ | Signaling by NOTCH3 |
| REAC:R-HSA-2122947 | 0.00133283416666 | 1.0 | MAML1 RBPJ | NOTCH1 Intracellular Domain Regulates Transcription |
| GO:0007221 | 0.00140460216025 | 1.0 | MAML1 RBPJ | positive regulation of transcription of Notch receptor target |
| GO:0002193 | 0.00140460216025 | 1.0 | MAML1 RBPJ | MAML1-RBP-Jkappa- ICN1 complex |
| REAC:R-HSA-2644602 | 0.00184717145405 | 1.0 | MAML1 RBPJ | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644603 | 0.00184717145405 | 1.0 | MAML1 RBPJ | Signaling by NOTCH1 in Cancer |
| REAC:R-HSA-2894862 | 0.00184717145405 | 1.0 | MAML1 RBPJ | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| REAC:R-HSA-2644606 | 0.00184717145405 | 1.0 | MAML1 RBPJ | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| REAC:R-HSA-2894858 | 0.00184717145405 | 1.0 | MAML1 RBPJ | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| REAC:R-HSA-1980143 | 0.00292369135789 | 1.0 | MAML1 RBPJ | Signaling by NOTCH1 |
| REAC:R-HSA-9013694 | 0.00449062588459 | 1.0 | MAML1 RBPJ | Signaling by NOTCH4 |
| REAC:R-HSA-1912408 | 0.00486997099357 | 1.0 | MAML1 RBPJ | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-8878159 | 0.00654113998715 | 1.0 | MAML1 RBPJ | Transcriptional regulation by RUNX3 |
| KEGG:05165 | 0.00700203931066 | 1.0 | MAML1 RBPJ | Human papillomavirus infection |
| REAC:R-HSA-1912422 | 0.00715287669441 | 1.0 | MAML1 RBPJ | Pre-NOTCH Expression and Processing |
| REAC:R-HSA-157118 | 0.0353816208396 | 1.0 | MAML1 RBPJ | Signaling by NOTCH |
| CORUM:2907 | 0.0499419797295 | 0.5 | RBPJ | RBP-Jkappa-Notch1 complex |
| CORUM:2908 | 0.0499419797295 | 0.5 | RBPJ | RBP-Jkappa-SHARP complex |
| CORUM:2946 | 0.0499419797295 | 0.5 | RBPJ | YY1-Notch1-RBP-Jkappa complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAML1 | RBPJ | 0.998 | 0.076 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
Related Complexes