hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05011.1

Complex Portal: CPX-22324

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
CLEC4G	C-type lectin domain family 4 member G (Liver and lymph node sinusoidal endothelial cell C-type lectin) (LSECtin)	5	UniProt NCBI
AP4S1	AP-4 complex subunit sigma-1 (AP-4 adaptor complex subunit sigma-1) (Adaptor-related protein complex 4 subunit sigma-1) (Sigma-1 subunit of AP-4) (Sigma-4-adaptin) (Sigma4-adaptin)	5	UniProt NCBI
TEPSIN	AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin)	5	UniProt NCBI
AP4M1	AP-4 complex subunit mu-1 (AP-4 adaptor complex mu subunit) (Adaptor-related protein complex 4 subunit mu-1) (Mu subunit of AP-4) (Mu-adaptin-related protein 2) (mu-ARP2) (Mu4-adaptin) (mu4)	5	UniProt NCBI
AP4E1	AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin)	5	UniProt NCBI
AP4B1	AP-4 complex subunit beta-1 (AP-4 adaptor complex subunit beta) (Adaptor-related protein complex 4 subunit beta-1) (Beta subunit of AP-4) (Beta4-adaptin)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:67	9.60315000334e-13	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	AP4 adaptor complex
GO:0030124	3.94689465137e-10	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	AP-4 adaptor complex
HP:5200020	1.27431287521e-09	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormal interest in others
HP:0100962	1.27431287521e-09	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Shyness
HP:0008807	2.93680214472e-08	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Acetabular dysplasia
HP:0002464	3.62741681089e-08	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Spastic dysarthria
HP:0010803	4.43302350384e-08	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Everted upper lip vermilion
REAC:R-HSA-432720	5.91891333952e-08	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Lysosome Vesicle Biogenesis
HP:0007020	1.24000644513e-07	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Progressive spastic paraplegia
HP:0002816	2.47683758208e-07	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Genu recurvatum
HP:0002761	3.99586953938e-07	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Generalized joint hypermobility
HP:0025502	3.99586953938e-07	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Overweight
HP:0010500	4.46548193681e-07	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Hyperextensibility of the knee
HP:0000297	7.46166611169e-07	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Facial hypotonia
REAC:R-HSA-199992	1.32087543833e-06	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	trans-Golgi Network Vesicle Budding
GO:0032588	2.50014146384e-06	0.833333333333	AP4M1 AP4S1 AP4B1 AP4E1 TEPSIN	trans-Golgi network membrane
KEGG:04142	3.66118278132e-06	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Lysosome
GO:0031904	5.88640060552e-06	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	endosome lumen
HP:0003170	7.72911213095e-06	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormal acetabulum morphology
HP:0034670	8.15172897372e-06	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormal knee physiology
GO:0030119	2.05958456954e-05	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	AP-type membrane coat adaptor complex
HP:0002307	2.08253116225e-05	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Drooling
HP:0000646	2.26206838432e-05	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Amblyopia
HP:0001258	2.5527884612e-05	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Spastic paraplegia
HP:0003781	2.87061332109e-05	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Excessive salivation
HP:0002515	3.09835596569e-05	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Waddling gait
HP:0010550	6.39011315576e-05	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Paraplegia
HP:0002518	6.39011315576e-05	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormal periventricular white matter morphology
HP:0012433	9.43697491582e-05	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormal social behavior
HP:0000341	0.000127691719331	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Narrow forehead
HP:0012472	0.00013813645411	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Eclabion
GO:0005802	0.000204308337956	0.833333333333	AP4M1 AP4S1 AP4B1 AP4E1 TEPSIN	trans-Golgi network
HP:0100755	0.000205019199447	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormality of salivation
HP:0002465	0.00020987742036	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Poor speech
HP:0000414	0.00020987742036	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Bulbous nose
HP:0010551	0.000326358841257	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Paraplegia/paraparesis
HP:0000154	0.000340206764848	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Wide mouth
HP:0002061	0.000400032634721	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Lower limb spasticity
HP:0000280	0.000449812260346	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Coarse facial features
GO:0098791	0.000459997596769	0.833333333333	AP4M1 AP4S1 AP4B1 AP4E1 TEPSIN	Golgi apparatus subcompartment
HP:0002352	0.000476369190142	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Leukoencephalopathy
HP:0000322	0.000649630195048	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Short philtrum
HP:0031432	0.000810945831704	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Restricted or repetitive behaviors or interests
HP:0000733	0.000810945831704	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormal repetitive mannerisms
GO:0030117	0.000870570917794	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	membrane coat
GO:0048475	0.000870570917794	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	coated membrane
HP:0031828	0.00103228693258	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormal superficial reflex
HP:0003487	0.00103228693258	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Babinski sign
HP:0002355	0.00109824486598	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Difficulty walking
HP:0000301	0.00145544132918	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormality of facial musculature
HP:0031815	0.00145544132918	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormal oral physiology
HP:0002120	0.00207646369353	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Cerebral cortical atrophy
HP:0001763	0.00215907002281	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Pes planus
HP:0010864	0.00251421996371	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Intellectual disability, severe
HP:0001384	0.00267436793474	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormal hip joint morphology
HP:0000436	0.00287644304207	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormal nasal tip morphology
HP:0034353	0.00339206501528	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Appendicular spasticity
HP:0002815	0.00355126374061	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormality of the knee
HP:0001762	0.00359191818431	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Talipes equinovarus
HP:0011337	0.0044801952368	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormality of mouth size
HP:0007256	0.00513919491307	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormal pyramidal sign
HP:0001272	0.0054109367211	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Cerebellar atrophy
HP:0011339	0.00592684823973	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormality of upper lip vermillion
REAC:R-HSA-199991	0.00605429919172	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Membrane Trafficking
HP:0004324	0.00635274834011	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Increased body weight
HP:0001883	0.00647850981782	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Talipes
HP:0005656	0.00673558058778	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Positional foot deformity
HP:0002079	0.00693330736043	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Hypoplasia of the corpus callosum
REAC:R-HSA-5653656	0.00750133147239	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Vesicle-mediated transport
HP:0004302	0.0078404361426	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Functional motor deficit
HP:0011799	0.00851820869182	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormality of facial soft tissue
HP:0010549	0.0088330267897	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Weakness due to upper motor neuron dysfunction
HP:0001332	0.0101795325916	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Dystonia
HP:0001382	0.0123751293622	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Joint hypermobility
HP:0003272	0.0126854625769	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormal hip bone morphology
HP:0007663	0.0136512113701	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Reduced visual acuity
HP:0100021	0.014698352718	0.5	AP4S1 AP4E1 AP4M1	Cerebral palsy
HP:0001260	0.0173996902388	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Dysarthria
HP:0002644	0.0197536366037	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormal pelvic girdle bone morphology
HP:0001319	0.0212041745435	0.5	AP4M1 AP4B1 AP4E1	Neonatal hypotonia
HP:0002059	0.0288139256305	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Cerebral atrophy
HP:0007369	0.0328460948675	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Atrophy/Degeneration affecting the cerebrum
HP:0100491	0.0337001736215	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormality of lower limb joint
REAC:R-HSA-432722	0.03659902859	0.333333333333	AP4E1 AP4B1	Golgi Associated Vesicle Biogenesis
HP:0000288	0.0375147870502	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Abnormality of the philtrum
HP:0007370	0.0494403483522	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	Aplasia/Hypoplasia of the corpus callosum
HP:0000218	0.0494403483522	0.666666666667	AP4S1 AP4B1 AP4E1 AP4M1	High palate

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
AP4E1	TEPSIN	1.0	0.138		hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116
AP4S1	AP4B1	1.0	0.172	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM
AP4E1	AP4B1	1.0	0.284	mutually_exclusive (Q9Y587)	hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM
AP4M1	AP4E1	1.0	0.17	mutually_exclusive (Q9Y587)	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM
AP4M1	TEPSIN	1.0	0.078		hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116
AP4M1	AP4B1	0.999	0.18	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
AP4S1	AP4M1	0.999	0.112	mutually_exclusive (Q9Y6B7) structurally_consistent (dimer)	hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM
AP4S1	AP4E1	0.999	0.166342857143	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM
AP4B1	TEPSIN	0.998	0.172	mutually_exclusive (Q9Y587)	hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
AP4S1	TEPSIN	0.998	0.126	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
CLEC4G	TEPSIN	0.986			bioplex3_HEK293 bioplex3_WMM WMM_only
AP4B1	CLEC4G	0.415			bioplex3_WMM WMM_only
AP4E1	CLEC4G	0.278			bioplex3_WMM WMM_only
AP4M1	CLEC4G	0.278			bioplex3_WMM WMM_only
AP4S1	CLEC4G	0.274			bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
CLEC4G	huMAP3_03145.1 huMAP3_05011.1 huMAP3_05347.1 huMAP3_08005.1 huMAP3_09871.1 huMAP3_10461.1 huMAP3_11003.1 huMAP3_12731.1 huMAP3_12768.1 huMAP3_12927.1
AP4S1	huMAP3_01388.1 huMAP3_03145.1 huMAP3_05011.1 huMAP3_08618.1 huMAP3_09871.1 huMAP3_11003.1 huMAP3_12731.1 huMAP3_12768.1 huMAP3_12927.1
TEPSIN	huMAP3_03145.1 huMAP3_04613.1 huMAP3_05011.1 huMAP3_05347.1 huMAP3_06260.1 huMAP3_08005.1 huMAP3_09871.1 huMAP3_10461.1 huMAP3_10741.1 huMAP3_11003.1 huMAP3_12731.1 huMAP3_12768.1 huMAP3_12927.1
AP4M1	huMAP3_01388.1 huMAP3_03145.1 huMAP3_05011.1 huMAP3_08005.1 huMAP3_09871.1 huMAP3_11003.1 huMAP3_12731.1 huMAP3_12768.1 huMAP3_12927.1
AP4E1	huMAP3_01388.1 huMAP3_03145.1 huMAP3_05011.1 huMAP3_08618.1 huMAP3_09871.1 huMAP3_11003.1 huMAP3_12731.1 huMAP3_12768.1 huMAP3_12927.1
AP4B1	huMAP3_01388.1 huMAP3_05011.1 huMAP3_08618.1 huMAP3_09871.1 huMAP3_11003.1 huMAP3_12731.1 huMAP3_12768.1 huMAP3_12864.1 huMAP3_12927.1 huMAP3_13753.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05011.1

Complex Portal: CPX-22324