hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05036.1
Complex Portal: CPX-23472
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MPP3 | MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3) | 5 | UniProt NCBI |
| DLG4 | Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) | 5 | UniProt NCBI |
| KIF26B | Kinesin-like protein KIF26B | 4 | UniProt NCBI |
| CASK | Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog) | 5 | UniProt NCBI |
| PXDC1 | PX domain-containing protein 1 | 2 | UniProt NCBI |
| DLG1 | Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) | 5 | UniProt NCBI |
| PATJ | InaD-like protein (Inadl protein) (hINADL) (Channel-interacting PDZ domain-containing protein) (Pals1-associated tight junction protein) (Protein associated to tight junctions) | 5 | UniProt NCBI |
| MPP7 | MAGUK p55 subfamily member 7 | 5 | UniProt NCBI |
| LIN7B | Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2) | 5 | UniProt NCBI |
| LIN7C | Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9609736 | 5.45063220907e-09 | 0.5 | LIN7B CASK DLG4 LIN7C DLG1 | Assembly and cell surface presentation of NMDA receptors |
| CORUM:6263 | 1.68385473419e-08 | 0.3 | DLG1 MPP7 LIN7C | MPP7-DLG1-LIN7C complex |
| GO:0097025 | 2.76191861336e-08 | 0.4 | DLG1 MPP7 LIN7C LIN7B | MPP7-DLG1-LIN7 complex |
| GO:0005911 | 6.94211896642e-08 | 0.8 | DLG1 MPP3 DLG4 LIN7B LIN7C PATJ CASK MPP7 | cell-cell junction |
| REAC:R-HSA-6794362 | 1.30230627724e-07 | 0.5 | LIN7B CASK DLG4 LIN7C DLG1 | Protein-protein interactions at synapses |
| REAC:R-HSA-442755 | 2.57935569353e-07 | 0.5 | LIN7B CASK DLG4 LIN7C DLG1 | Activation of NMDA receptors and postsynaptic events |
| GO:0045197 | 1.12828086728e-06 | 0.5 | LIN7B DLG1 DLG4 LIN7C PATJ | establishment or maintenance of epithelial cell apical/basal polarity |
| GO:0035088 | 1.683076869e-06 | 0.5 | LIN7B DLG1 DLG4 LIN7C PATJ | establishment or maintenance of apical/basal cell polarity |
| GO:0061245 | 1.683076869e-06 | 0.5 | LIN7B DLG1 DLG4 LIN7C PATJ | establishment or maintenance of bipolar cell polarity |
| REAC:R-HSA-6794361 | 4.29630226864e-06 | 0.4 | CASK DLG4 LIN7C LIN7B | Neurexins and neuroligins |
| GO:0005912 | 4.93566709462e-06 | 0.6 | DLG1 MPP3 DLG4 LIN7B LIN7C MPP7 | adherens junction |
| REAC:R-HSA-112314 | 8.076274077e-06 | 0.5 | LIN7B CASK DLG4 LIN7C DLG1 | Neurotransmitter receptors and postsynaptic signal transmission |
| GO:0007163 | 1.36137497528e-05 | 0.6 | DLG1 DLG4 LIN7B LIN7C PATJ MPP7 | establishment or maintenance of cell polarity |
| GO:0070161 | 1.93845265376e-05 | 0.8 | DLG1 MPP3 DLG4 LIN7B LIN7C PATJ CASK MPP7 | anchoring junction |
| REAC:R-HSA-112315 | 2.8312603313e-05 | 0.5 | LIN7B CASK DLG4 LIN7C DLG1 | Transmission across Chemical Synapses |
| CORUM:3209 | 3.07577115383e-05 | 0.2 | CASK DLG1 | LIN2-SAP97 complex |
| GO:0097016 | 4.61210427592e-05 | 0.3 | DLG1 LIN7C LIN7B | L27 domain binding |
| REAC:R-HSA-212676 | 7.36319907643e-05 | 0.3 | CASK LIN7C LIN7B | Dopamine Neurotransmitter Release Cycle |
| CORUM:1448 | 9.22394575203e-05 | 0.2 | CASK DLG1 | LIN2-LIN7-SAP97 complex |
| CORUM:617 | 9.22394575203e-05 | 0.2 | CASK LIN7C | CASK-LIN7C-APBA1 complex |
| CORUM:6260 | 9.22394575203e-05 | 0.2 | DLG1 MPP7 | MPP7-DLG1-LIN7A complex |
| CORUM:3207 | 0.000184411585051 | 0.2 | CASK DLG1 | LIN2-LIN7-SAP97-MINT1 complex |
| REAC:R-HSA-112316 | 0.000190797095052 | 0.5 | LIN7B CASK DLG4 LIN7C DLG1 | Neuronal System |
| REAC:R-HSA-112310 | 0.000464190455184 | 0.3 | CASK LIN7C LIN7B | Neurotransmitter release cycle |
| GO:0016323 | 0.000786675339155 | 0.5 | LIN7B CASK DLG4 LIN7C DLG1 | basolateral plasma membrane |
| CORUM:848 | 0.000859331699025 | 0.2 | PATJ MPP7 | RICH1/AMOT polarity complex, Flag-Amot precipitated |
| GO:0098590 | 0.000910637781525 | 0.7 | DLG1 MPP3 LIN7B LIN7C PATJ CASK DLG4 | plasma membrane region |
| REAC:R-HSA-451306 | 0.00101671361746 | 0.2 | DLG1 DLG4 | Ionotropic activity of kainate receptors |
| REAC:R-HSA-451308 | 0.00101671361746 | 0.2 | DLG1 DLG4 | Activation of Ca-permeable Kainate Receptor |
| GO:0009925 | 0.00151840106916 | 0.5 | LIN7B CASK DLG4 LIN7C DLG1 | basal plasma membrane |
| GO:0045178 | 0.00189523613818 | 0.5 | LIN7B CASK DLG4 LIN7C DLG1 | basal part of cell |
| REAC:R-HSA-447038 | 0.00213354034849 | 0.2 | DLG1 DLG4 | NrCAM interactions |
| WP:WP5417 | 0.00225531384444 | 0.3 | CASK DLG4 DLG1 | Cell lineage map for neuronal differentiation |
| GO:0030054 | 0.00291655424765 | 0.8 | DLG1 MPP3 DLG4 LIN7B LIN7C PATJ CASK MPP7 | cell junction |
| KEGG:04390 | 0.00560546698078 | 0.3 | DLG1 DLG4 PATJ | Hippo signaling pathway |
| REAC:R-HSA-442982 | 0.00922174626729 | 0.2 | DLG1 DLG4 | Ras activation upon Ca2+ influx through NMDA receptor |
| REAC:R-HSA-438066 | 0.0137668647983 | 0.2 | DLG1 DLG4 | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-9617324 | 0.0137668647983 | 0.2 | DLG1 DLG4 | Negative regulation of NMDA receptor-mediated neuronal transmission |
| REAC:R-HSA-8849932 | 0.0154820698392 | 0.2 | DLG1 DLG4 | Synaptic adhesion-like molecules |
| REAC:R-HSA-9620244 | 0.0154820698392 | 0.2 | DLG1 DLG4 | Long-term potentiation |
| REAC:R-HSA-442742 | 0.0233407803855 | 0.2 | DLG1 DLG4 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| REAC:R-HSA-451326 | 0.0233407803855 | 0.2 | DLG1 DLG4 | Activation of kainate receptors upon glutamate binding |
| REAC:R-HSA-399719 | 0.0302795201711 | 0.2 | DLG1 DLG4 | Trafficking of AMPA receptors |
| REAC:R-HSA-399721 | 0.0302795201711 | 0.2 | DLG1 DLG4 | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| CORUM:6321 | 0.0499436884912 | 0.1 | DLG4 | DLG4-DLGAP1-SHANK3 complex |
| CORUM:1909 | 0.0499436884912 | 0.1 | DLG4 | APC-DLG4 complex |
| CORUM:4869 | 0.0499436884912 | 0.1 | DLG1 | beta(1)-AR receptosome (ADRB1-SAP97-AKAP79-PRKAR2A) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DLG1 | LIN7C | 1.0 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM | ||
| MPP7 | LIN7C | 0.999 | 0.078 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| CASK | LIN7C | 0.999 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | ||
| MPP3 | LIN7C | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PXDC1 | LIN7C | 0.998 | 0.17 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| DLG1 | LIN7B | 0.997 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CASK | LIN7B | 0.997 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CASK | DLG1 | 0.997 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| LIN7B | LIN7C | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| DLG1 | MPP7 | 0.996 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| CASK | MPP7 | 0.995 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| MPP7 | LIN7B | 0.995 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PXDC1 | LIN7B | 0.994 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| KIF26B | LIN7C | 0.994 | 0.124 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| MPP3 | LIN7B | 0.991 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CASK | PXDC1 | 0.991 | hein_WMM bioplex_WMM bioplex3_WMM hein () | ||
| KIF26B | MPP7 | 0.984 | 0.102 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| DLG4 | LIN7C | 0.982 | 0.178 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MPP3 | PXDC1 | 0.967 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KIF26B | DLG1 | 0.967 | hein_WMM bioplex_WMM bioplex3_WMM hein () | ||
| MPP3 | CASK | 0.96 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MPP3 | MPP7 | 0.958 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MPP3 | DLG1 | 0.958 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PXDC1 | DLG1 | 0.95 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KIF26B | LIN7B | 0.937 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| DLG4 | MPP3 | 0.902 | bioplex3_WMM WMM_only | ||
| PXDC1 | MPP7 | 0.888 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only | |
| KIF26B | CASK | 0.88 | hein_WMM bioplex_WMM bioplex3_WMM hein () | ||
| KIF26B | PXDC1 | 0.691 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| DLG4 | LIN7B | 0.64 | bioplex3_WMM WMM_only | ||
| DLG4 | CASK | 0.633 | bioplex3_WMM WMM_only | ||
| DLG4 | DLG1 | 0.633 | bioplex3_WMM WMM_only | ||
| DLG4 | PXDC1 | 0.616 | 0.096 | bioplex3_WMM WMM_only | |
| MPP3 | KIF26B | 0.583 | bioplex_WMM bioplex3_WMM WMM_only | ||
| DLG4 | MPP7 | 0.45 | 0.096 | bioplex3_WMM WMM_only | |
| DLG4 | KIF26B | 0.214 | 0.186 | bioplex3_WMM WMM_only |
Related Complexes