hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05041.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| COPS5 | COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1) | 5 | UniProt NCBI |
| FBXO17 | F-box only protein 17 (F-box only protein 26) | 5 | UniProt NCBI |
| COPS7B | COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b) | 5 | UniProt NCBI |
| APPBP2 | Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) (Protein interacting with APP tail 1) | 5 | UniProt NCBI |
| COPS8 | COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8) | 5 | UniProt NCBI |
| KLHDC3 | Kelch domain-containing protein 3 (Testis intracellular mediator protein) | 5 | UniProt NCBI |
| COPS2 | COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15) | 5 | UniProt NCBI |
| COPS7A | COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a) | 5 | UniProt NCBI |
| NEDD8 | NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8) | 5 | UniProt NCBI |
| COPS3 | COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3) | 5 | UniProt NCBI |
| COPS6 | COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP) | 5 | UniProt NCBI |
| COPS4 | COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2174 | 1.36535689455e-20 | 0.583333333333 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS8 | COP9 signalosome complex |
| GO:0000338 | 2.16042107362e-20 | 0.666666666667 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS7B COPS8 | protein deneddylation |
| CORUM:2179 | 6.14226580289e-20 | 0.583333333333 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS8 | CNS-P53 complex |
| GO:0045116 | 6.14425318082e-19 | 0.75 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS8 NEDD8 COPS7B COPS3 | protein neddylation |
| CORUM:728 | 1.35008452096e-18 | 0.583333333333 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS8 | CSA-POLIIa complex |
| CORUM:727 | 1.35008452096e-18 | 0.583333333333 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS8 | CSA complex |
| CORUM:726 | 1.35008452096e-18 | 0.583333333333 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS8 | DDB2 complex |
| GO:2000434 | 3.6206988023e-17 | 0.666666666667 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS7B COPS8 | regulation of protein neddylation |
| REAC:R-HSA-5696394 | 1.26731597234e-16 | 0.666666666667 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS7B COPS8 | DNA Damage Recognition in GG-NER |
| REAC:R-HSA-8856825 | 7.48490732509e-16 | 0.75 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS8 NEDD8 COPS7B COPS3 | Cargo recognition for clathrin-mediated endocytosis |
| REAC:R-HSA-6781823 | 1.94352538305e-15 | 0.666666666667 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS7B COPS8 | Formation of TC-NER Pre-Incision Complex |
| GO:0008180 | 5.02277539725e-15 | 0.666666666667 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS7B COPS8 | COP9 signalosome |
| REAC:R-HSA-8951664 | 1.06920399634e-14 | 0.833333333333 | COPS6 COPS2 COPS7A COPS5 FBXO17 COPS8 NEDD8 COPS7B COPS4 COPS3 | Neddylation |
| REAC:R-HSA-8856828 | 2.03751362177e-14 | 0.75 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS8 NEDD8 COPS7B COPS3 | Clathrin-mediated endocytosis |
| REAC:R-HSA-6781827 | 5.40130073854e-14 | 0.666666666667 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS7B COPS8 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-5696399 | 1.0109862502e-13 | 0.666666666667 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS7B COPS8 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-5696398 | 8.9678925666e-13 | 0.666666666667 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS7B COPS8 | Nucleotide Excision Repair |
| GO:0070646 | 3.02771250521e-11 | 0.666666666667 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS7B COPS8 | protein modification by small protein removal |
| WP:WP4352 | 8.42316385179e-11 | 0.666666666667 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS7B COPS8 | Ciliary landscape |
| WP:WP5381 | 5.65767158059e-10 | 0.583333333333 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS8 | Smith Magenis and Potocki Lupski syndrome copy number variation |
| REAC:R-HSA-73894 | 4.21811827771e-09 | 0.666666666667 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS7B COPS8 | DNA Repair |
| REAC:R-HSA-199991 | 1.10752972311e-08 | 0.75 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS8 NEDD8 COPS7B COPS3 | Membrane Trafficking |
| GO:1903320 | 1.52963787902e-08 | 0.666666666667 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS7B COPS8 | regulation of protein modification by small protein conjugation or removal |
| GO:1901873 | 1.73906483316e-08 | 0.666666666667 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS7B COPS8 | regulation of post-translational protein modification |
| REAC:R-HSA-5653656 | 1.80117986504e-08 | 0.75 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS8 NEDD8 COPS7B COPS3 | Vesicle-mediated transport |
| REAC:R-HSA-597592 | 2.68259416842e-07 | 0.833333333333 | COPS6 COPS2 COPS7A COPS5 FBXO17 COPS8 NEDD8 COPS7B COPS4 COPS3 | Post-translational protein modification |
| GO:0032446 | 2.56822563414e-06 | 0.75 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS8 NEDD8 COPS7B COPS3 | protein modification by small protein conjugation |
| GO:0070647 | 6.20693835324e-06 | 0.75 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS8 NEDD8 COPS7B COPS3 | protein modification by small protein conjugation or removal |
| REAC:R-HSA-392499 | 6.66011767075e-06 | 0.833333333333 | COPS6 COPS2 COPS7A COPS5 FBXO17 COPS8 NEDD8 COPS7B COPS4 COPS3 | Metabolism of proteins |
| GO:0043687 | 1.11464692915e-05 | 0.75 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS8 NEDD8 COPS7B COPS3 | post-translational protein modification |
| GO:0019538 | 0.00144972977038 | 1.0 | COPS6 COPS2 APPBP2 COPS5 FBXO17 COPS8 NEDD8 COPS7A COPS7B KLHDC3 COPS4 COPS3 | protein metabolic process |
| GO:0031399 | 0.00286576210675 | 0.666666666667 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS7B COPS8 | regulation of protein modification process |
| GO:0051246 | 0.0115040535194 | 0.75 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS8 NEDD8 COPS7B COPS3 | regulation of protein metabolic process |
| GO:1901564 | 0.0161866064871 | 1.0 | COPS6 COPS2 APPBP2 COPS5 FBXO17 COPS8 NEDD8 COPS7A COPS7B KLHDC3 COPS4 COPS3 | organonitrogen compound metabolic process |
| GO:0140513 | 0.0197270317597 | 0.666666666667 | COPS4 COPS2 COPS7A COPS5 COPS6 COPS3 COPS7B COPS8 | nuclear protein-containing complex |
| REAC:R-HSA-9013422 | 0.0420840222149 | 0.166666666667 | COPS2 COPS4 | RHOBTB1 GTPase cycle |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| COPS7B | COPS6 | 1.0 | 0.764 |
| COPS8 | COPS6 | 1.0 | 0.844 |
| COPS7B | COPS2 | 1.0 | 0.668 |
| COPS3 | COPS6 | 1.0 | 0.884 |
| COPS5 | COPS2 | 1.0 | 0.958 |
| COPS7B | COPS8 | 1.0 | 0.534 |
| COPS8 | COPS7A | 1.0 | 0.23 |
| COPS2 | COPS6 | 1.0 | 0.962 |
| APPBP2 | COPS2 | 1.0 | 0.098 |
| COPS3 | COPS4 | 1.0 | 0.94 |
| COPS7A | COPS6 | 0.999 | 0.648 |
| COPS8 | COPS2 | 0.999 | 0.588 |
| COPS5 | COPS6 | 0.999 | 0.96 |
| COPS5 | COPS8 | 0.999 | 0.808 |
| COPS7A | COPS3 | 0.999 | 0.462 |
| COPS5 | COPS7B | 0.999 | 0.572 |
| COPS2 | COPS3 | 0.999 | 0.952 |
| COPS6 | COPS4 | 0.999 | 0.982 |
| COPS2 | COPS4 | 0.999 | 0.96 |
| COPS5 | COPS3 | 0.999 | 0.898 |
| APPBP2 | COPS8 | 0.999 | 0.132 |
| COPS8 | COPS4 | 0.999 | 0.892 |
| COPS8 | COPS3 | 0.999 | 0.666 |
| COPS7A | COPS4 | 0.999 | 0.278 |
| COPS7B | COPS3 | 0.999 | 0.412 |
| COPS7B | COPS4 | 0.999 | 0.472 |
| COPS5 | COPS4 | 0.999 | 0.964 |
| COPS2 | COPS7A | 0.999 | 0.59 |
| NEDD8 | COPS8 | 0.998 | 0.21 |
| NEDD8 | COPS2 | 0.998 | 0.38 |
| COPS5 | COPS7A | 0.998 | 0.644 |
| COPS5 | FBXO17 | 0.997 | 0.118 |
| FBXO17 | COPS7B | 0.997 | 0.054 |
| COPS7B | APPBP2 | 0.997 | 0.136 |
| FBXO17 | COPS2 | 0.996 | 0.134 |
| NEDD8 | KLHDC3 | 0.996 | 0.12 |
| FBXO17 | COPS8 | 0.996 | 0.082 |
| APPBP2 | COPS3 | 0.996 | 0.066 |
| NEDD8 | COPS3 | 0.994 | 0.33 |
| FBXO17 | COPS6 | 0.994 | 0.146 |
| COPS7B | COPS7A | 0.993 | 0.248 |
| FBXO17 | COPS4 | 0.993 | 0.1 |
| NEDD8 | COPS6 | 0.992 | 0.256 |
| FBXO17 | COPS7A | 0.99 | 0.054 |
| FBXO17 | COPS3 | 0.99 | 0.086 |
| KLHDC3 | COPS2 | 0.988 | 0.196 |
| NEDD8 | COPS7A | 0.982 | 0.212 |
| KLHDC3 | COPS3 | 0.979 | 0.068 |
| NEDD8 | COPS4 | 0.977 | 0.306 |
| APPBP2 | COPS4 | 0.972 | 0.09 |
| KLHDC3 | COPS6 | 0.972 | 0.186 |
| APPBP2 | COPS7A | 0.967 | 0.154 |
| KLHDC3 | COPS7A | 0.964 | 0.078 |
| COPS8 | KLHDC3 | 0.962 | 0.108 |
| COPS7B | KLHDC3 | 0.959 | 0.066 |
| APPBP2 | KLHDC3 | 0.957 | 0.138 |
| COPS5 | APPBP2 | 0.955 | 0.108 |
| COPS5 | KLHDC3 | 0.942 | 0.278 |
| APPBP2 | COPS6 | 0.936 | 0.186 |
| FBXO17 | APPBP2 | 0.904 | 0.098 |
| KLHDC3 | COPS4 | 0.804 | 0.074 |
| FBXO17 | KLHDC3 | 0.766 | 0.114 |
| NEDD8 | COPS7B | 0.55 | 0.096 |
| NEDD8 | COPS5 | 0.53 | 0.36 |
| NEDD8 | FBXO17 | 0.288 | 0.15 |
| NEDD8 | APPBP2 | 0.155 | 0.108 |
Related Complexes