hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05041.1

Complex Portal: CPX-20429

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
COPS5	COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)	5	UniProt NCBI
FBXO17	F-box only protein 17 (F-box only protein 26)	5	UniProt NCBI
COPS7B	COP9 signalosome complex subunit 7b (SGN7b) (Signalosome subunit 7b) (JAB1-containing signalosome subunit 7b)	5	UniProt NCBI
APPBP2	Amyloid protein-binding protein 2 (Amyloid beta precursor protein-binding protein 2) (APP-BP2) (Protein interacting with APP tail 1)	5	UniProt NCBI
COPS8	COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8)	5	UniProt NCBI
KLHDC3	Kelch domain-containing protein 3 (Testis intracellular mediator protein)	5	UniProt NCBI
COPS2	COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15)	5	UniProt NCBI
COPS7A	COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a)	5	UniProt NCBI
NEDD8	NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)	5	UniProt NCBI
COPS3	COP9 signalosome complex subunit 3 (SGN3) (Signalosome subunit 3) (JAB1-containing signalosome subunit 3)	5	UniProt NCBI
COPS6	COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP)	5	UniProt NCBI
COPS4	COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:2174	1.36535689455e-20	0.583333333333	COPS3 COPS7A COPS6 COPS5 COPS8 COPS4 COPS2	COP9 signalosome complex
GO:0000338	2.16042107362e-20	0.666666666667	COPS3 COPS7A COPS8 COPS7B COPS5 COPS6 COPS4 COPS2	protein deneddylation
CORUM:2179	6.14226580289e-20	0.583333333333	COPS3 COPS7A COPS6 COPS5 COPS8 COPS4 COPS2	CNS-P53 complex
GO:0045116	6.14425318082e-19	0.75	COPS7A COPS7B COPS8 COPS2 COPS5 COPS6 COPS3 COPS4 NEDD8	protein neddylation
CORUM:728	1.35008452096e-18	0.583333333333	COPS3 COPS7A COPS6 COPS5 COPS8 COPS4 COPS2	CSA-POLIIa complex
CORUM:727	1.35008452096e-18	0.583333333333	COPS3 COPS7A COPS6 COPS5 COPS8 COPS4 COPS2	CSA complex
CORUM:726	1.35008452096e-18	0.583333333333	COPS3 COPS7A COPS6 COPS5 COPS8 COPS4 COPS2	DDB2 complex
GO:2000434	3.6206988023e-17	0.666666666667	COPS3 COPS7A COPS8 COPS7B COPS5 COPS6 COPS4 COPS2	regulation of protein neddylation
REAC:R-HSA-5696394	1.26731597234e-16	0.666666666667	COPS3 COPS7A COPS8 COPS7B COPS5 COPS6 COPS4 COPS2	DNA Damage Recognition in GG-NER
REAC:R-HSA-8856825	7.48490732509e-16	0.75	COPS7A COPS7B COPS8 COPS2 COPS5 COPS6 COPS3 COPS4 NEDD8	Cargo recognition for clathrin-mediated endocytosis
REAC:R-HSA-6781823	1.94352538305e-15	0.666666666667	COPS3 COPS7A COPS8 COPS7B COPS5 COPS6 COPS4 COPS2	Formation of TC-NER Pre-Incision Complex
GO:0008180	5.02277539725e-15	0.666666666667	COPS3 COPS7A COPS8 COPS7B COPS5 COPS6 COPS4 COPS2	COP9 signalosome
REAC:R-HSA-8951664	1.06920399634e-14	0.833333333333	COPS7B COPS7A COPS8 FBXO17 NEDD8 COPS5 COPS6 COPS3 COPS4 COPS2	Neddylation
REAC:R-HSA-8856828	2.03751362177e-14	0.75	COPS7A COPS7B COPS8 COPS2 COPS5 COPS6 COPS3 COPS4 NEDD8	Clathrin-mediated endocytosis
REAC:R-HSA-6781827	5.40130073854e-14	0.666666666667	COPS3 COPS7A COPS8 COPS7B COPS5 COPS6 COPS4 COPS2	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
REAC:R-HSA-5696399	1.0109862502e-13	0.666666666667	COPS3 COPS7A COPS8 COPS7B COPS5 COPS6 COPS4 COPS2	Global Genome Nucleotide Excision Repair (GG-NER)
REAC:R-HSA-5696398	8.9678925666e-13	0.666666666667	COPS3 COPS7A COPS8 COPS7B COPS5 COPS6 COPS4 COPS2	Nucleotide Excision Repair
GO:0070646	3.02771250521e-11	0.666666666667	COPS3 COPS7A COPS8 COPS7B COPS5 COPS6 COPS4 COPS2	protein modification by small protein removal
WP:WP4352	8.42316385179e-11	0.666666666667	COPS3 COPS7A COPS8 COPS7B COPS5 COPS6 COPS4 COPS2	Ciliary landscape
WP:WP5381	5.65767158059e-10	0.583333333333	COPS3 COPS7A COPS6 COPS5 COPS8 COPS4 COPS2	Smith Magenis and Potocki Lupski syndrome copy number variation
REAC:R-HSA-73894	4.21811827771e-09	0.666666666667	COPS3 COPS7A COPS8 COPS7B COPS5 COPS6 COPS4 COPS2	DNA Repair
REAC:R-HSA-199991	1.10752972311e-08	0.75	COPS7A COPS7B COPS8 COPS2 COPS5 COPS6 COPS3 COPS4 NEDD8	Membrane Trafficking
GO:1903320	1.52963787902e-08	0.666666666667	COPS3 COPS7A COPS8 COPS7B COPS5 COPS6 COPS4 COPS2	regulation of protein modification by small protein conjugation or removal
GO:1901873	1.73906483316e-08	0.666666666667	COPS3 COPS7A COPS8 COPS7B COPS5 COPS6 COPS4 COPS2	regulation of post-translational protein modification
REAC:R-HSA-5653656	1.80117986504e-08	0.75	COPS7A COPS7B COPS8 COPS2 COPS5 COPS6 COPS3 COPS4 NEDD8	Vesicle-mediated transport
REAC:R-HSA-597592	2.68259416842e-07	0.833333333333	COPS7B COPS7A COPS8 FBXO17 NEDD8 COPS5 COPS6 COPS3 COPS4 COPS2	Post-translational protein modification
GO:0032446	2.56822563414e-06	0.75	COPS7A COPS7B COPS8 COPS2 COPS5 COPS6 COPS3 COPS4 NEDD8	protein modification by small protein conjugation
GO:0070647	6.20693835324e-06	0.75	COPS7A COPS7B COPS8 COPS2 COPS5 COPS6 COPS3 COPS4 NEDD8	protein modification by small protein conjugation or removal
REAC:R-HSA-392499	6.66011767075e-06	0.833333333333	COPS7B COPS7A COPS8 FBXO17 NEDD8 COPS5 COPS6 COPS3 COPS4 COPS2	Metabolism of proteins
GO:0043687	1.11464692915e-05	0.75	COPS7A COPS7B COPS8 COPS2 COPS5 COPS6 COPS3 COPS4 NEDD8	post-translational protein modification
GO:0019538	0.00144972977038	1.0	COPS7B FBXO17 COPS8 COPS7A APPBP2 COPS2 COPS5 COPS6 COPS3 COPS4 NEDD8 KLHDC3	protein metabolic process
GO:0031399	0.00286576210675	0.666666666667	COPS3 COPS7A COPS8 COPS7B COPS5 COPS6 COPS4 COPS2	regulation of protein modification process
GO:0051246	0.0115040535194	0.75	COPS7A COPS7B COPS8 COPS2 COPS5 COPS6 COPS3 COPS4 NEDD8	regulation of protein metabolic process
GO:1901564	0.0161866064871	1.0	COPS7B FBXO17 COPS8 COPS7A APPBP2 COPS2 COPS5 COPS6 COPS3 COPS4 NEDD8 KLHDC3	organonitrogen compound metabolic process
GO:0140513	0.0197270317597	0.666666666667	COPS3 COPS7A COPS8 COPS7B COPS5 COPS6 COPS4 COPS2	nuclear protein-containing complex
REAC:R-HSA-9013422	0.0420840222149	0.166666666667	COPS4 COPS2	RHOBTB1 GTPase cycle

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
COPS7B	COPS6	1.0	0.764
COPS8	COPS6	1.0	0.844
COPS7B	COPS2	1.0	0.668	structurally_consistent (dimer)
COPS3	COPS6	1.0	0.884	structurally_consistent (Q96EF6) structurally_consistent (dimer)
COPS5	COPS2	1.0	0.958
COPS7B	COPS8	1.0	0.534	structurally_consistent (P61201) structurally_consistent (dimer)
COPS8	COPS7A	1.0	0.23
COPS2	COPS6	1.0	0.962
APPBP2	COPS2	1.0	0.098
COPS3	COPS4	1.0	0.94
COPS7A	COPS6	0.999	0.648
COPS8	COPS2	0.999	0.588	mutually_exclusive (Q53RE8) structurally_consistent (dimer)
COPS5	COPS6	0.999	0.96
COPS5	COPS8	0.999	0.808
COPS7A	COPS3	0.999	0.462	structurally_consistent (dimer)
COPS5	COPS7B	0.999	0.572
COPS2	COPS3	0.999	0.952	structurally_consistent (dimer)
COPS6	COPS4	0.999	0.982	structurally_consistent (dimer)
COPS2	COPS4	0.999	0.96	structurally_consistent (Q13618)
COPS5	COPS3	0.999	0.898
APPBP2	COPS8	0.999	0.132
COPS8	COPS4	0.999	0.892	structurally_consistent (dimer)
COPS8	COPS3	0.999	0.666	structurally_consistent (dimer)
COPS7A	COPS4	0.999	0.278	structurally_consistent (dimer)
COPS7B	COPS3	0.999	0.412	structurally_consistent (dimer)
COPS7B	COPS4	0.999	0.472	structurally_consistent (dimer)
COPS5	COPS4	0.999	0.964
COPS2	COPS7A	0.999	0.59	structurally_consistent (dimer)
NEDD8	COPS8	0.998	0.21	structurally_consistent (Q9BQ90)
NEDD8	COPS2	0.998	0.38
COPS5	COPS7A	0.998	0.644
COPS5	FBXO17	0.997	0.118
FBXO17	COPS7B	0.997	0.054
COPS7B	APPBP2	0.997	0.136	structurally_consistent (Q9UNS2)
FBXO17	COPS2	0.996	0.134
NEDD8	KLHDC3	0.996	0.12	structurally_consistent (Q92905) structurally_consistent (dimer)
FBXO17	COPS8	0.996	0.082
APPBP2	COPS3	0.996	0.066	structurally_consistent (dimer)
NEDD8	COPS3	0.994	0.33	structurally_consistent (Q9BQ90)
FBXO17	COPS6	0.994	0.146	structurally_consistent (dimer)
COPS7B	COPS7A	0.993	0.248	mutually_exclusive (Q9BT78) structurally_consistent (dimer)
FBXO17	COPS4	0.993	0.1	structurally_consistent (dimer)
NEDD8	COPS6	0.992	0.256	structurally_consistent (Q9BT78)
FBXO17	COPS7A	0.99	0.054	structurally_consistent (dimer)
FBXO17	COPS3	0.99	0.086	structurally_consistent (dimer)
KLHDC3	COPS2	0.988	0.196
NEDD8	COPS7A	0.982	0.212	mutually_exclusive (Q9BT78)
KLHDC3	COPS3	0.979	0.068	structurally_consistent (dimer)
NEDD8	COPS4	0.977	0.306	structurally_consistent (dimer)
APPBP2	COPS4	0.972	0.09
KLHDC3	COPS6	0.972	0.186
APPBP2	COPS7A	0.967	0.154	structurally_consistent (Q9UNS2)
KLHDC3	COPS7A	0.964	0.078	structurally_consistent (Q9UNS2)
COPS8	KLHDC3	0.962	0.108	structurally_consistent (dimer)
COPS7B	KLHDC3	0.959	0.066	structurally_consistent (Q9UNS2)
APPBP2	KLHDC3	0.957	0.138
COPS5	APPBP2	0.955	0.108
COPS5	KLHDC3	0.942	0.278	structurally_consistent (dimer)
APPBP2	COPS6	0.936	0.186
FBXO17	APPBP2	0.904	0.098
KLHDC3	COPS4	0.804	0.074
FBXO17	KLHDC3	0.766	0.114
NEDD8	COPS7B	0.55	0.096
NEDD8	COPS5	0.53	0.36	structurally_consistent (dimer)
NEDD8	FBXO17	0.288	0.15	structurally_consistent (Q9BT78)
NEDD8	APPBP2	0.155	0.108

Related Complexes

Genename	Complexes
COPS5	huMAP3_05041.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
FBXO17	huMAP3_05041.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
COPS7B	huMAP3_05041.1 huMAP3_05816.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
APPBP2	huMAP3_05041.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
COPS8	huMAP3_05041.1 huMAP3_05816.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
KLHDC3	huMAP3_05041.1 huMAP3_05215.1 huMAP3_05816.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_10626.1 huMAP3_14528.1
COPS2	huMAP3_05041.1 huMAP3_05816.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
COPS7A	huMAP3_05041.1 huMAP3_05816.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
NEDD8	huMAP3_04750.1 huMAP3_05041.1 huMAP3_05816.1 huMAP3_05894.1 huMAP3_08550.1 huMAP3_08919.1 huMAP3_09779.1 huMAP3_09980.1 huMAP3_14528.1
COPS3	huMAP3_05041.1 huMAP3_05816.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
COPS6	huMAP3_05041.1 huMAP3_05816.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1
COPS4	huMAP3_05041.1 huMAP3_07590.1 huMAP3_08550.1 huMAP3_09779.1 huMAP3_14528.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05041.1

Complex Portal: CPX-20429