hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05054.1
Complex Portal: CPX-24466
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WIPF1 | WAS/WASL-interacting protein family member 1 (Protein PRPL-2) (Wiskott-Aldrich syndrome protein-interacting protein) (WASP-interacting protein) | 5 | UniProt NCBI |
| WIPF3 | WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16 homolog) | 4 | UniProt NCBI |
| WASL | Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) | 5 | UniProt NCBI |
| ARHGEF10L | Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5663213 | 8.38346160394e-06 | 0.75 | WIPF3 WIPF1 WASL | RHO GTPases Activate WASPs and WAVEs |
| REAC:R-HSA-9664417 | 3.27872895639e-05 | 0.75 | WIPF3 WIPF1 WASL | Leishmania phagocytosis |
| REAC:R-HSA-9664422 | 3.27872895639e-05 | 0.75 | WIPF3 WIPF1 WASL | FCGR3A-mediated phagocytosis |
| REAC:R-HSA-9664407 | 3.27872895639e-05 | 0.75 | WIPF3 WIPF1 WASL | Parasite infection |
| REAC:R-HSA-2029482 | 3.87912301308e-05 | 0.75 | WIPF3 WIPF1 WASL | Regulation of actin dynamics for phagocytic cup formation |
| KEGG:05135 | 8.42717414951e-05 | 0.75 | WIPF3 WIPF1 WASL | Yersinia infection |
| REAC:R-HSA-9012999 | 9.49629216168e-05 | 1.0 | WIPF3 ARHGEF10L WIPF1 WASL | RHO GTPase cycle |
| REAC:R-HSA-2029480 | 0.000106339832101 | 0.75 | WIPF3 WIPF1 WASL | Fcgamma receptor (FCGR) dependent phagocytosis |
| KEGG:05130 | 0.000250261342721 | 0.75 | WIPF3 WIPF1 WASL | Pathogenic Escherichia coli infection |
| REAC:R-HSA-9013148 | 0.000453862022785 | 0.75 | WIPF3 WIPF1 WASL | CDC42 GTPase cycle |
| REAC:R-HSA-9658195 | 0.000571445331233 | 0.75 | WIPF3 WIPF1 WASL | Leishmania infection |
| REAC:R-HSA-9824443 | 0.000571445331233 | 0.75 | WIPF3 WIPF1 WASL | Parasitic Infection Pathways |
| REAC:R-HSA-194315 | 0.000624339554915 | 1.0 | WIPF3 ARHGEF10L WIPF1 WASL | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.000681855532791 | 1.0 | WIPF3 ARHGEF10L WIPF1 WASL | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| KEGG:04144 | 0.000687966939719 | 0.75 | WIPF3 WIPF1 WASL | Endocytosis |
| REAC:R-HSA-9013149 | 0.000897810107574 | 0.75 | WIPF3 WIPF1 WASL | RAC1 GTPase cycle |
| REAC:R-HSA-195258 | 0.00591360366085 | 0.75 | WIPF3 WIPF1 WASL | RHO GTPase Effectors |
| GO:0007015 | 0.0138903594981 | 1.0 | WIPF3 ARHGEF10L WIPF1 WASL | actin filament organization |
| CORUM:2513 | 0.0249718442456 | 0.25 | WASL | N-WASp homomer complex |
| CORUM:2297 | 0.049938562206 | 0.25 | WASL | ABI1-WASL complex |
| CORUM:2510 | 0.049938562206 | 0.25 | WIPF1 | ZAP70-CRKL-WIPF1-WAS complex |
| CORUM:2511 | 0.049938562206 | 0.25 | WIPF1 | CRKL-WIPF1-WAS complex |
| CORUM:6213 | 0.049938562206 | 0.25 | WIPF1 | DOCK8-WIP-WASp complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| WIPF1 | WASL | 0.997 | 0.13 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| WIPF3 | WASL | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ARHGEF10L | WASL | 0.989 | 0.1 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| WIPF1 | WIPF3 | 0.785 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes