hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05058.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NSFL1C | NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47) | 5 | UniProt NCBI |
| UBXN2A | UBX domain-containing protein 2A (UBX domain-containing protein 4) | 5 | UniProt NCBI |
| UBXN2B | UBX domain-containing protein 2B (NSFL1 cofactor p37) (p97 cofactor p37) | 5 | UniProt NCBI |
| VCF1 | Protein VCF1 (VCP nuclear cofactor family member 1) | 3 | UniProt NCBI |
| ASPSCR1 | Tether containing UBX domain for GLUT4 (Alveolar soft part sarcoma chromosomal region candidate gene 1 protein) (Alveolar soft part sarcoma locus) (Renal papillary cell carcinoma protein 17) (UBX domain-containing protein 9) | 5 | UniProt NCBI |
| VCP | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | 5 | UniProt NCBI |
| VCPKMT | Protein N-lysine methyltransferase METTL21D (EC 2.1.1.-) (Methyltransferase-like protein 21D) (VCP lysine methyltransferase) (VCP-KMT) (Valosin-containing protein lysine methyltransferase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04141 | 0.00211181505065 | 0.428571428571 | NSFL1C UBXN2A VCP | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-8876725 | 0.00455853850403 | 0.285714285714 | VCPKMT VCP | Protein methylation |
| GO:0031468 | 0.00677983410628 | 0.428571428571 | NSFL1C UBXN2A UBXN2B | nuclear membrane reassembly |
| WP:WP5202 | 0.00877446561805 | 0.285714285714 | NSFL1C VCP | Alstrom syndrome |
| GO:1990730 | 0.00983221512175 | 0.285714285714 | NSFL1C VCP | VCP-NSFL1C complex |
| GO:1904780 | 0.00983221512175 | 0.285714285714 | NSFL1C UBXN2B | negative regulation of protein localization to centrosome |
| REAC:R-HSA-9013407 | 0.0212237900738 | 0.285714285714 | NSFL1C VCP | RHOH GTPase cycle |
| GO:0046604 | 0.0294899169624 | 0.285714285714 | NSFL1C UBXN2B | positive regulation of mitotic centrosome separation |
| GO:0071763 | 0.0329865610647 | 0.428571428571 | NSFL1C UBXN2A UBXN2B | nuclear membrane organization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| VCP | UBXN2A | 0.999 | 0.2655 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| VCP | UBXN2B | 0.999 | 0.3 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ASPSCR1 | NSFL1C | 0.999 | 0.064 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ASPSCR1 | UBXN2A | 0.998 | 0.0766666666667 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| VCPKMT | VCP | 0.998 | 0.242 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ASPSCR1 | VCF1 | 0.997 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| UBXN2B | VCF1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NSFL1C | UBXN2A | 0.997 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| UBXN2A | UBXN2B | 0.997 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| NSFL1C | VCF1 | 0.995 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| VCP | NSFL1C | 0.994 | 0.532 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| VCP | ASPSCR1 | 0.993 | 0.171 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| UBXN2A | VCF1 | 0.99 | bioplex_WMM bioplex3_WMM WMM_only | |
| ASPSCR1 | UBXN2B | 0.989 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| VCP | VCF1 | 0.978 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| NSFL1C | UBXN2B | 0.945 | 0.1296 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 |
| VCPKMT | VCF1 | 0.49 | bioplex_WMM bioplex3_WMM WMM_only | |
| VCPKMT | UBXN2A | 0.49 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only |
| VCPKMT | ASPSCR1 | 0.252 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only |
| VCPKMT | NSFL1C | 0.219 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes