hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05061.1
Complex Portal: CPX-10790
Confidence: Extremely High
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1) | 5 | UniProt NCBI |
PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1) | 5 | UniProt NCBI |
PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta) | 5 | UniProt NCBI |
PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | 5 | UniProt NCBI |
PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta) | 5 | UniProt NCBI |
PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK) | 5 | UniProt NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
WP:WP4582 | 4.90223997047e-18 | 1.0 | PIK3R3 PIK3CD PIK3R1 PIK3R2 PIK3CB PIK3CA | Cancer immunotherapy by CTLA4 blockade |
GO:0005943 | 2.58853125713e-17 | 1.0 | PIK3R3 PIK3CD PIK3R1 PIK3R2 PIK3CB PIK3CA | phosphatidylinositol 3-kinase complex, class IA |
GO:0097651 | 2.58853125713e-17 | 1.0 | PIK3R3 PIK3CD PIK3R1 PIK3R2 PIK3CB PIK3CA | phosphatidylinositol 3-kinase complex, class I |
WP:WP3879 | 2.8789518372e-16 | 1.0 | PIK3R3 PIK3CD PIK3R1 PIK3R2 PIK3CB PIK3CA | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
REAC:R-HSA-912631 | 3.68865704141e-16 | 1.0 | PIK3R3 PIK3CD PIK3R1 PIK3R2 PIK3CB PIK3CA | Regulation of signaling by CBL |
REAC:R-HSA-912526 | 7.37731408283e-16 | 1.0 | PIK3R3 PIK3CD PIK3R1 PIK3R2 PIK3CB PIK3CA | Interleukin receptor SHC signaling |
KEGG:04960 | 2.27300376694e-15 | 1.0 | PIK3R3 PIK3CD PIK3R1 PIK3R2 PIK3CB PIK3CA | Aldosterone-regulated sodium reabsorption |
KEGG:04973 | 6.21354687271e-15 | 1.0 | PIK3R3 PIK3CD PIK3R1 PIK3R2 PIK3CB PIK3CA | Carbohydrate digestion and absorption |
WP:WP3937 | 7.13532699701e-15 | 1.0 | PIK3R3 PIK3CD PIK3R1 PIK3R2 PIK3CB PIK3CA | Microglia pathogen phagocytosis pathway |
REAC:R-HSA-8853659 | 8.07250602523e-15 | 1.0 | PIK3R3 PIK3CD PIK3R1 PIK3R2 PIK3CB PIK3CA | RET signaling |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
---|---|---|---|---|---|
PIK3CA | PIK3R3 | 1.0 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | ||
PIK3CB | PIK3R1 | 0.999 | 0.23 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () fraction | |
PIK3CB | PIK3R3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
PIK3CA | PIK3R1 | 0.998 | 0.164 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
PIK3CA | PIK3R2 | 0.998 | 0.295459408904 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
PIK3CD | PIK3R3 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
PIK3CD | PIK3R1 | 0.997 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
PIK3CB | PIK3CA | 0.996 | 0.21 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
PIK3R2 | PIK3R1 | 0.995 | 0.31 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | |
PIK3R2 | PIK3R3 | 0.994 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM |
Related Complexes