hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05061.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) (Serine/threonine protein kinase PIK3CB) (EC 2.7.11.1) | 5 | UniProt NCBI |
| PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1) | 5 | UniProt NCBI |
| PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta) | 5 | UniProt NCBI |
| PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta) | 5 | UniProt NCBI |
| PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK) | 5 | UniProt NCBI |
| PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4582 | 4.90223997047e-18 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Cancer immunotherapy by CTLA4 blockade |
| GO:0005943 | 2.58853125713e-17 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | phosphatidylinositol 3-kinase complex, class IA |
| GO:0097651 | 2.58853125713e-17 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | phosphatidylinositol 3-kinase complex, class I |
| WP:WP3879 | 2.8789518372e-16 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| REAC:R-HSA-912631 | 3.68865704141e-16 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Regulation of signaling by CBL |
| REAC:R-HSA-912526 | 7.37731408283e-16 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Interleukin receptor SHC signaling |
| KEGG:04960 | 2.27300376694e-15 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Aldosterone-regulated sodium reabsorption |
| KEGG:04973 | 6.21354687271e-15 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Carbohydrate digestion and absorption |
| WP:WP3937 | 7.13532699701e-15 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Microglia pathogen phagocytosis pathway |
| REAC:R-HSA-8853659 | 8.07250602523e-15 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | RET signaling |
| REAC:R-HSA-451927 | 1.50576385893e-14 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Interleukin-2 family signaling |
| KEGG:04930 | 1.72124236649e-14 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Type II diabetes mellitus |
| KEGG:04923 | 2.33375654195e-14 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Regulation of lipolysis in adipocytes |
| KEGG:04929 | 3.1179743273e-14 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | GnRH secretion |
| WP:WP4539 | 3.74514792944e-14 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Synaptic signaling pathways associated with autism spectrum disorder |
| REAC:R-HSA-512988 | 4.4356100923e-14 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| KEGG:04370 | 6.8941215815e-14 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | VEGF signaling pathway |
| KEGG:05213 | 7.79335483126e-14 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Endometrial cancer |
| KEGG:04664 | 8.78825119269e-14 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Fc epsilon RI signaling pathway |
| KEGG:04213 | 9.88678259178e-14 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Longevity regulating pathway - multiple species |
| REAC:R-HSA-1660499 | 1.45979744413e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Synthesis of PIPs at the plasma membrane |
| KEGG:05221 | 1.72482519693e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Acute myeloid leukemia |
| WP:WP4205 | 1.9252567036e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | MET in type 1 papillary renal cell carcinoma |
| WP:WP4155 | 1.9252567036e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Endometrial cancer |
| REAC:R-HSA-2219530 | 2.16037676721e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Constitutive Signaling by Aberrant PI3K in Cancer |
| KEGG:04917 | 2.35327882207e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Prolactin signaling pathway |
| KEGG:05218 | 2.35327882207e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Melanoma |
| WP:WP5293 | 2.390503788e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Acute myeloid leukemia |
| WP:WP4685 | 2.65611532e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Melanoma |
| WP:WP1403 | 2.94587335491e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | AMP activated protein kinase signaling |
| KEGG:05211 | 3.16193112517e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Renal cell carcinoma |
| KEGG:05230 | 3.82023481845e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Central carbon metabolism in cancer |
| KEGG:04662 | 4.18993496217e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | B cell receptor signaling pathway |
| KEGG:05223 | 4.18993496217e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Non-small cell lung cancer |
| KEGG:05214 | 4.18993496217e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Glioma |
| KEGG:04750 | 4.58897638713e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Inflammatory mediator regulation of TRP channels |
| KEGG:01524 | 5.01919292343e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Platinum drug resistance |
| WP:WP4255 | 5.2946152577e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Non small cell lung cancer |
| KEGG:05212 | 5.98091240666e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Pancreatic cancer |
| WP:WP1544 | 6.36004474888e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | MicroRNAs in cardiomyocyte hypertrophy |
| GO:0005942 | 6.54898408055e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | phosphatidylinositol 3-kinase complex |
| KEGG:01521 | 7.09150325302e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:05220 | 7.09150325302e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Chronic myeloid leukemia |
| KEGG:04012 | 8.36885477065e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | ErbB signaling pathway |
| KEGG:05100 | 8.36885477065e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Bacterial invasion of epithelial cells |
| KEGG:05210 | 9.83242209556e-13 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Colorectal cancer |
| KEGG:05235 | 1.15033150026e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:04211 | 1.24235802028e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Longevity regulating pathway |
| KEGG:01522 | 1.34043891662e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Endocrine resistance |
| KEGG:04914 | 1.34043891662e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Progesterone-mediated oocyte maturation |
| KEGG:05231 | 1.44488870233e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Choline metabolism in cancer |
| WP:WP4806 | 1.47471838172e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:04070 | 1.67421378361e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Phosphatidylinositol signaling system |
| KEGG:04625 | 1.67421378361e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | C-type lectin receptor signaling pathway |
| WP:WP4263 | 1.72183335379e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Pancreatic adenocarcinoma pathway |
| WP:WP673 | 1.72183335379e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | ErbB signaling pathway |
| KEGG:04670 | 1.79977981738e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Leukocyte transendothelial migration |
| KEGG:05146 | 1.79977981738e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Amoebiasis |
| KEGG:05222 | 1.79977981738e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Small cell lung cancer |
| KEGG:04620 | 1.93309684089e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Toll-like receptor signaling pathway |
| KEGG:04933 | 1.93309684089e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | AGE-RAGE signaling pathway in diabetic complications |
| WP:WP75 | 2.00252867496e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Toll like receptor signaling pathway |
| KEGG:05142 | 2.0745429512e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Chagas disease |
| REAC:R-HSA-1483255 | 2.12410345031e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | PI Metabolism |
| KEGG:04725 | 2.22450991153e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Cholinergic synapse |
| KEGG:04666 | 2.38340347664e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Fc gamma R-mediated phagocytosis |
| KEGG:05215 | 2.38340347664e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Prostate cancer |
| REAC:R-HSA-6811558 | 2.51852652295e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| KEGG:04915 | 2.72966537707e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Estrogen signaling pathway |
| REAC:R-HSA-2219528 | 2.97217415752e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | PI3K/AKT Signaling in Cancer |
| WP:WP4658 | 3.08303669231e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Small cell lung cancer |
| KEGG:04668 | 3.32699300102e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | TNF signaling pathway |
| KEGG:04931 | 4.0294818242e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Insulin resistance |
| KEGG:04611 | 4.0294818242e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Platelet activation |
| KEGG:04066 | 4.2894483935e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | HIF-1 signaling pathway |
| REAC:R-HSA-199418 | 4.41219796908e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Negative regulation of the PI3K/AKT network |
| KEGG:04722 | 4.56324297181e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Neurotrophin signaling pathway |
| KEGG:04935 | 4.56324297181e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Growth hormone synthesis, secretion and action |
| KEGG:04071 | 5.47350842925e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Sphingolipid signaling pathway |
| KEGG:04660 | 5.47350842925e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | T cell receptor signaling pathway |
| KEGG:04919 | 6.16065883811e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Thyroid hormone signaling pathway |
| WP:WP710 | 6.72381429869e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | DNA damage response only ATM dependent |
| WP:WP4787 | 7.14405269236e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Osteoblast differentiation and related diseases |
| KEGG:04926 | 7.32519199624e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Relaxin signaling pathway |
| KEGG:04650 | 7.75190220961e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Natural killer cell mediated cytotoxicity |
| WP:WP4829 | 9.19241856844e-12 | 0.833333333333 | PIK3CA PIK3R1 PIK3R3 PIK3CB PIK3R2 | mBDNF and proBDNF regulation of GABA neurotransmission |
| KEGG:04152 | 9.67181841548e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | AMPK signaling pathway |
| KEGG:04068 | 9.67181841548e-12 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | FoxO signaling pathway |
| KEGG:05135 | 1.07711127614e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Yersinia infection |
| KEGG:04380 | 1.07711127614e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Osteoclast differentiation |
| WP:WP3844 | 1.10302722329e-11 | 0.833333333333 | PIK3CA PIK3R1 PIK3R3 PIK3CB PIK3R2 | PI3K AKT mTOR signaling pathway and therapeutic opportunities in prostate cancer |
| KEGG:04072 | 1.13586280029e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Phospholipase D signaling pathway |
| KEGG:05418 | 1.1972607895e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Fluid shear stress and atherosclerosis |
| KEGG:04210 | 1.39829130399e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Apoptosis |
| KEGG:04550 | 1.39829130399e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Signaling pathways regulating pluripotency of stem cells |
| WP:WP3915 | 1.41492551568e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Angiopoietin like protein 8 regulatory pathway |
| WP:WP4217 | 1.5742373961e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Ebola virus infection in host |
| REAC:R-HSA-114604 | 1.60149771012e-11 | 0.833333333333 | PIK3CA PIK3R1 PIK3R3 PIK3CB PIK3R2 | GPVI-mediated activation cascade |
| KEGG:05162 | 1.70940888015e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Measles |
| KEGG:05017 | 1.79559756318e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Spinocerebellar ataxia |
| KEGG:04910 | 1.88537744134e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Insulin signaling pathway |
| KEGG:05224 | 1.97886723182e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Breast cancer |
| WP:WP3929 | 2.0390577925e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Chemokine signaling pathway |
| WP:WP4630 | 2.25450200665e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Measles virus infection |
| KEGG:04630 | 2.39240303497e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | JAK-STAT signaling pathway |
| KEGG:05160 | 2.39240303497e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Hepatitis C |
| KEGG:05226 | 2.39240303497e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Gastric cancer |
| WP:WP51 | 2.87747225205e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Regulation of actin cytoskeleton |
| KEGG:04062 | 3.43746021006e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Chemokine signaling pathway |
| KEGG:04932 | 3.43746021006e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Non-alcoholic fatty liver disease |
| WP:WP4239 | 3.4736181799e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Epithelial to mesenchymal transition in colorectal cancer |
| KEGG:04218 | 3.59137633887e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Cellular senescence |
| GO:0046854 | 3.97064904803e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | phosphatidylinositol phosphate biosynthetic process |
| KEGG:05164 | 4.26574188467e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Influenza A |
| WP:WP4396 | 4.36027332076e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Nonalcoholic fatty liver disease |
| WP:WP4666 | 4.36027332076e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Hepatitis B infection |
| KEGG:05161 | 5.04248004732e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Hepatitis B |
| KEGG:05206 | 5.04248004732e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | MicroRNAs in cancer |
| KEGG:04150 | 5.04248004732e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | mTOR signaling pathway |
| REAC:R-HSA-198203 | 5.07705636973e-11 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | PI3K/AKT activation |
| KEGG:04613 | 5.25405263672e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Neutrophil extracellular trap formation |
| WP:WP481 | 5.66572532243e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Insulin signaling |
| WP:WP4566 | 5.79685782819e-11 | 0.833333333333 | PIK3CA PIK3R1 PIK3R3 PIK3CB PIK3R2 | Translation inhibitors in chronically activated PDGFRA cells |
| KEGG:04360 | 6.42622555813e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Axon guidance |
| WP:WP4223 | 6.70525294749e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Ras signaling |
| KEGG:04140 | 6.95239973135e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Autophagy - animal |
| KEGG:04024 | 7.51399563157e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | cAMP signaling pathway |
| KEGG:05225 | 7.80866212692e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Hepatocellular carcinoma |
| KEGG:05207 | 9.08549177605e-11 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Chemical carcinogenesis - receptor activation |
| REAC:R-HSA-9027276 | 1.01530006227e-10 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3CD | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) |
| KEGG:04015 | 1.01533679739e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Rap1 signaling pathway |
| KEGG:05167 | 1.09218193342e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:04510 | 1.30575386149e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Focal adhesion |
| KEGG:05417 | 1.66232245688e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Lipid and atherosclerosis |
| KEGG:05169 | 1.66232245688e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Epstein-Barr virus infection |
| KEGG:05415 | 1.77792942775e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Diabetic cardiomyopathy |
| KEGG:05205 | 1.77792942775e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Proteoglycans in cancer |
| WP:WP306 | 1.80969616958e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Focal adhesion |
| KEGG:04014 | 1.90015995973e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Ras signaling pathway |
| KEGG:05203 | 2.02931422142e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Viral carcinogenesis |
| KEGG:05163 | 2.46147374381e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Human cytomegalovirus infection |
| KEGG:05170 | 2.54045151099e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Human immunodeficiency virus 1 infection |
| KEGG:04810 | 2.70475291739e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Regulation of actin cytoskeleton |
| KEGG:05166 | 2.96774709659e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-2730905 | 3.04523297384e-10 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Role of LAT2/NTAL/LAB on calcium mobilization |
| REAC:R-HSA-9673767 | 3.04523297384e-10 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants |
| REAC:R-HSA-9673770 | 3.04523297384e-10 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Signaling by PDGFRA extracellular domain mutants |
| KEGG:05171 | 3.35125647473e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Coronavirus disease - COVID-19 |
| KEGG:05208 | 3.35125647473e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Chemical carcinogenesis - reactive oxygen species |
| REAC:R-HSA-1483257 | 5.14902023189e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Phospholipid metabolism |
| KEGG:05131 | 6.8056313596e-10 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Shigellosis |
| WP:WP2059 | 1.04865960878e-09 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Alzheimer 39 s disease and miRNA effects |
| WP:WP5124 | 1.04865960878e-09 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Alzheimer 39 s disease |
| KEGG:05020 | 1.08106444785e-09 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Prion disease |
| WP:WP2261 | 1.52519194658e-09 | 0.833333333333 | PIK3CA PIK3R1 PIK3R2 PIK3CB PIK3CD | Glioblastoma signaling pathways |
| GO:0052742 | 1.81606603046e-09 | 0.833333333333 | PIK3CA PIK3R1 PIK3R3 PIK3CB PIK3CD | phosphatidylinositol kinase activity |
| REAC:R-HSA-210993 | 1.97831742843e-09 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Tie2 Signaling |
| WP:WP5420 | 2.19834835619e-09 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | ADHD and autism ASD linked metabolic pathways and SNP |
| REAC:R-HSA-1257604 | 2.61739309821e-09 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | PIP3 activates AKT signaling |
| KEGG:04151 | 2.76004935166e-09 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | PI3K-Akt signaling pathway |
| WP:WP4172 | 2.76059772708e-09 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | PI3K Akt signaling pathway |
| KEGG:05165 | 3.26161264788e-09 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Human papillomavirus infection |
| REAC:R-HSA-9669938 | 3.44861810508e-09 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | Signaling by KIT in disease |
| REAC:R-HSA-9671555 | 3.44861810508e-09 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Signaling by PDGFR in disease |
| REAC:R-HSA-9670439 | 3.44861810508e-09 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants |
| REAC:R-HSA-9006335 | 5.61509006183e-09 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3CD | Signaling by Erythropoietin |
| REAC:R-HSA-9006925 | 6.17695829337e-09 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Intracellular signaling by second messengers |
| GO:0006661 | 6.68301683123e-09 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | phosphatidylinositol biosynthetic process |
| REAC:R-HSA-389357 | 7.01809336055e-09 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | CD28 dependent PI3K/Akt signaling |
| KEGG:05010 | 7.85696921525e-09 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Alzheimer disease |
| REAC:R-HSA-373753 | 8.66845929073e-09 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Nephrin family interactions |
| REAC:R-HSA-2029485 | 8.66845929073e-09 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Role of phospholipids in phagocytosis |
| REAC:R-HSA-201556 | 1.05936223437e-08 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Signaling by ALK |
| REAC:R-HSA-2424491 | 1.05936223437e-08 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | DAP12 signaling |
| KEGG:05168 | 1.24681593458e-08 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Herpes simplex virus 1 infection |
| GO:0046488 | 1.73454724604e-08 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | phosphatidylinositol metabolic process |
| GO:0001727 | 2.03314862263e-08 | 0.833333333333 | PIK3CA PIK3R1 PIK3R3 PIK3CB PIK3CD | lipid kinase activity |
| REAC:R-HSA-186763 | 2.16411786968e-08 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Downstream signal transduction |
| WP:WP524 | 2.30981983981e-08 | 0.666666666667 | PIK3CA PIK3R2 PIK3CB PIK3CD | G13 signaling pathway |
| WP:WP4262 | 2.47308537057e-08 | 0.833333333333 | PIK3CA PIK3R1 PIK3R3 PIK3CD PIK3R2 | Breast cancer pathway |
| REAC:R-HSA-109704 | 2.5402076735e-08 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | PI3K Cascade |
| WP:WP4564 | 2.61750871586e-08 | 0.666666666667 | PIK3CA PIK3R3 PIK3CB PIK3CD | Neural crest cell migration during development |
| GO:0016303 | 2.76161616937e-08 | 0.666666666667 | PIK3CA PIK3R3 PIK3CB PIK3CD | 1-phosphatidylinositol-3-kinase activity |
| WP:WP4565 | 3.32392897727e-08 | 0.666666666667 | PIK3CA PIK3R3 PIK3CB PIK3CD | Neural crest cell migration in cancer |
| REAC:R-HSA-2172127 | 3.43699391828e-08 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | DAP12 interactions |
| REAC:R-HSA-389356 | 3.43699391828e-08 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | CD28 co-stimulation |
| GO:0019898 | 3.62345930083e-08 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | extrinsic component of membrane |
| REAC:R-HSA-112399 | 3.96532736613e-08 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | IRS-mediated signalling |
| KEGG:05200 | 4.04564876536e-08 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Pathways in cancer |
| REAC:R-HSA-5663202 | 4.72771122339e-08 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Diseases of signal transduction by growth factor receptors and second messengers |
| REAC:R-HSA-2428924 | 5.91891333952e-08 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | IGF1R signaling cascade |
| REAC:R-HSA-2428928 | 5.91891333952e-08 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | IRS-related events triggered by IGF1R |
| REAC:R-HSA-2404192 | 5.91891333952e-08 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| REAC:R-HSA-449147 | 7.00967449411e-08 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Signaling by Interleukins |
| REAC:R-HSA-74751 | 8.51756800425e-08 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Insulin receptor signalling cascade |
| REAC:R-HSA-1433557 | 8.51756800425e-08 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | Signaling by SCF-KIT |
| WP:WP395 | 1.00527533776e-07 | 0.666666666667 | PIK3CA PIK3R1 PIK3CD PIK3R2 | IL 4 signaling pathway |
| GO:0046474 | 1.01736747098e-07 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | glycerophospholipid biosynthetic process |
| GO:0043491 | 1.89708148828e-07 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO:0008654 | 2.23111733564e-07 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | phospholipid biosynthetic process |
| REAC:R-HSA-422475 | 2.29492826104e-07 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Axon guidance |
| WP:WP5191 | 2.31467026157e-07 | 0.5 | PIK3CA PIK3CB PIK3CD | Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution |
| GO:0045017 | 2.77996964393e-07 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | glycerolipid biosynthetic process |
| REAC:R-HSA-186797 | 2.80989308113e-07 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Signaling by PDGF |
| REAC:R-HSA-9675108 | 2.86284035167e-07 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Nervous system development |
| WP:WP2037 | 4.31044765976e-07 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Prolactin signaling pathway |
| WP:WP4674 | 5.15463585691e-07 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Head and neck squamous cell carcinoma |
| REAC:R-HSA-388841 | 5.69863130112e-07 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | Costimulation by the CD28 family |
| WP:WP3932 | 5.73812004279e-07 | 0.833333333333 | PIK3CA PIK3R1 PIK3R2 PIK3CB PIK3CD | Focal adhesion PI3K Akt mTOR signaling pathway |
| REAC:R-HSA-76002 | 7.51133595426e-07 | 0.833333333333 | PIK3CA PIK3R1 PIK3R3 PIK3CB PIK3R2 | Platelet activation, signaling and aggregation |
| REAC:R-HSA-74752 | 8.04336027921e-07 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Signaling by Insulin receptor |
| REAC:R-HSA-9009391 | 8.04336027921e-07 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | Extra-nuclear estrogen signaling |
| GO:0006650 | 8.11129727973e-07 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | glycerophospholipid metabolic process |
| REAC:R-HSA-1280215 | 9.39784923341e-07 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Cytokine Signaling in Immune system |
| REAC:R-HSA-556833 | 9.68023729521e-07 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Metabolism of lipids |
| REAC:R-HSA-1280218 | 1.58206520823e-06 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Adaptive Immune System |
| REAC:R-HSA-2029480 | 2.05309631721e-06 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Fcgamma receptor (FCGR) dependent phagocytosis |
| GO:0061695 | 2.14939412651e-06 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | transferase complex, transferring phosphorus-containing groups |
| REAC:R-HSA-9013404 | 2.64348795346e-06 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | RAC2 GTPase cycle |
| WP:WP4659 | 2.67704255195e-06 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | Gastrin signaling pathway |
| GO:0006644 | 2.72313737492e-06 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | phospholipid metabolic process |
| GO:0046486 | 2.96109352328e-06 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | glycerolipid metabolic process |
| WP:WP4483 | 3.13601886583e-06 | 0.5 | PIK3CA PIK3CB PIK3CD | Relationship between inflammation COX 2 and EGFR |
| REAC:R-HSA-4420097 | 3.20062837424e-06 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-202424 | 3.51005707347e-06 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Downstream TCR signaling |
| REAC:R-HSA-194138 | 4.57361233129e-06 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Signaling by VEGF |
| REAC:R-HSA-187037 | 4.97663696861e-06 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-202733 | 6.10041360214e-06 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Cell surface interactions at the vascular wall |
| REAC:R-HSA-1500931 | 6.34619634179e-06 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Cell-Cell communication |
| REAC:R-HSA-202403 | 7.12815324682e-06 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | TCR signaling |
| REAC:R-HSA-1266738 | 7.19708522974e-06 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Developmental Biology |
| WP:WP2533 | 8.03768746193e-06 | 0.5 | PIK3CA PIK3CB PIK3CD | Glycerophospholipid biosynthetic pathway |
| REAC:R-HSA-2454202 | 8.58891112799e-06 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Fc epsilon receptor (FCERI) signaling |
| WP:WP4481 | 9.00082228875e-06 | 0.5 | PIK3CA PIK3CB PIK3CD | Resistin as a regulator of inflammation |
| REAC:R-HSA-166520 | 9.56649817153e-06 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Signaling by NTRKs |
| WP:WP4871 | 1.36192169576e-05 | 0.5 | PIK3CA PIK3CB PIK3CD | Kisspeptin kisspeptin receptor system in the ovary |
| REAC:R-HSA-416476 | 1.67659998e-05 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | G alpha (q) signalling events |
| CORUM:3133 | 1.70876175213e-05 | 0.333333333333 | PIK3CA PIK3R1 | Phosphatidylinositol 3-kinase (PIK3CA, PIK3R1) |
| GO:0035005 | 1.92180881975e-05 | 0.5 | PIK3CA PIK3CB PIK3CD | 1-phosphatidylinositol-4-phosphate 3-kinase activity |
| REAC:R-HSA-9680350 | 2.30646071149e-05 | 0.5 | PIK3CA PIK3CB PIK3R1 | Signaling by CSF1 (M-CSF) in myeloid cells |
| REAC:R-HSA-9006934 | 2.37398291815e-05 | 0.833333333333 | PIK3CA PIK3R1 PIK3R3 PIK3CB PIK3R2 | Signaling by Receptor Tyrosine Kinases |
| GO:0007169 | 2.6425732472e-05 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | transmembrane receptor protein tyrosine kinase signaling pathway |
| WP:WP5411 | 3.14733202476e-05 | 0.5 | PIK3CA PIK3CB PIK3CD | Phosphatidyl inositol phosphate pathway |
| WP:WP286 | 3.14733202476e-05 | 0.5 | PIK3R2 PIK3CD PIK3R1 | IL 3 signaling pathway |
| WP:WP4971 | 3.14733202476e-05 | 0.5 | PIK3CA PIK3CB PIK3CD | Phosphoinositides metabolism |
| GO:0090407 | 3.1791215881e-05 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | organophosphate biosynthetic process |
| REAC:R-HSA-1266695 | 3.48992434538e-05 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | Interleukin-7 signaling |
| REAC:R-HSA-9013149 | 3.56561563648e-05 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | RAC1 GTPase cycle |
| WP:WP585 | 5.70141452182e-05 | 0.5 | PIK3R2 PIK3CD PIK3R1 | Interferon type I signaling pathways |
| REAC:R-HSA-109582 | 6.28463206651e-05 | 0.833333333333 | PIK3CA PIK3R1 PIK3R3 PIK3CB PIK3R2 | Hemostasis |
| REAC:R-HSA-8939211 | 6.71951661694e-05 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | ESR-mediated signaling |
| WP:WP2032 | 7.1781176044e-05 | 0.5 | PIK3CA PIK3R1 PIK3R2 | Thyroid stimulating hormone TSH signaling pathway |
| KEGG:00562 | 8.60988412763e-05 | 0.5 | PIK3CA PIK3CB PIK3CD | Inositol phosphate metabolism |
| GO:0008610 | 8.77454088933e-05 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | lipid biosynthetic process |
| HP:0030381 | 0.000108046320019 | 0.333333333333 | PIK3R1 PIK3CD | Increased proportion of transitional B cells |
| HP:0030379 | 0.000108046320019 | 0.333333333333 | PIK3R1 PIK3CD | Abnormal proportion of transitional B cells |
| REAC:R-HSA-5673001 | 0.000118221861411 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.000127366123378 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | MAPK1/MAPK3 signaling |
| REAC:R-HSA-1643685 | 0.000200456644481 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Disease |
| REAC:R-HSA-9006931 | 0.000213812028272 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | Signaling by Nuclear Receptors |
| REAC:R-HSA-5683057 | 0.000220816183191 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | MAPK family signaling cascades |
| GO:0036092 | 0.0002304395259 | 0.5 | PIK3CA PIK3CB PIK3CD | phosphatidylinositol-3-phosphate biosynthetic process |
| REAC:R-HSA-8851907 | 0.00025805759528 | 0.333333333333 | PIK3CA PIK3R1 | MET activates PI3K/AKT signaling |
| REAC:R-HSA-9028335 | 0.00025805759528 | 0.333333333333 | PIK3CA PIK3R1 | Activated NTRK2 signals through PI3K |
| GO:0001775 | 0.000322644200636 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | cell activation |
| HP:0011956 | 0.000324079809263 | 0.333333333333 | PIK3R1 PIK3CD | Intestinal lymphoid nodular hyperplasia |
| GO:0007167 | 0.000341510408951 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | enzyme-linked receptor protein signaling pathway |
| REAC:R-HSA-9603381 | 0.000387015749065 | 0.333333333333 | PIK3CA PIK3R1 | Activated NTRK3 signals through PI3K |
| REAC:R-HSA-168256 | 0.000431398594432 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Immune System |
| REAC:R-HSA-1250342 | 0.000541723162524 | 0.333333333333 | PIK3CA PIK3R1 | PI3K events in ERBB4 signaling |
| REAC:R-HSA-1430728 | 0.000579637081746 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Metabolism |
| GO:0008286 | 0.000619048899658 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | insulin receptor signaling pathway |
| GO:0044255 | 0.000671930884891 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | cellular lipid metabolic process |
| GO:0030183 | 0.000684451996602 | 0.666666666667 | PIK3R2 PIK3R1 PIK3CD PIK3R3 | B cell differentiation |
| GO:0046935 | 0.000698569295426 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | 1-phosphatidylinositol-3-kinase regulator activity |
| REAC:R-HSA-5655291 | 0.000722165722116 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by FGFR4 in disease |
| GO:0019637 | 0.000813040004126 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | organophosphate metabolic process |
| WP:WP22 | 0.000914914863609 | 0.333333333333 | PIK3R2 PIK3R1 | IL 9 signaling pathway |
| REAC:R-HSA-388396 | 0.00103654049852 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | GPCR downstream signalling |
| GO:1990234 | 0.00110852393468 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | transferase complex |
| REAC:R-HSA-1963642 | 0.00116019984728 | 0.333333333333 | PIK3CA PIK3R1 | PI3K events in ERBB2 signaling |
| REAC:R-HSA-5654710 | 0.00116019984728 | 0.333333333333 | PIK3CA PIK3R1 | PI-3K cascade:FGFR3 |
| GO:0042110 | 0.00128678619231 | 0.833333333333 | PIK3CA PIK3R1 PIK3R3 PIK3CD PIK3R2 | T cell activation |
| REAC:R-HSA-162582 | 0.00128853291586 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | Signal Transduction |
| WP:WP205 | 0.00136659658622 | 0.333333333333 | PIK3R2 PIK3R1 | IL 7 signaling pathway |
| REAC:R-HSA-9012999 | 0.00137431571924 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | RHO GTPase cycle |
| REAC:R-HSA-5654689 | 0.0014177632075 | 0.333333333333 | PIK3CA PIK3R1 | PI-3K cascade:FGFR1 |
| HP:0031693 | 0.00161951205762 | 0.333333333333 | PIK3R1 PIK3CD | Severe Epstein Barr virus infection |
| REAC:R-HSA-5654720 | 0.00170100530318 | 0.333333333333 | PIK3CA PIK3R1 | PI-3K cascade:FGFR4 |
| REAC:R-HSA-5637810 | 0.00170100530318 | 0.333333333333 | PIK3CA PIK3R1 | Constitutive Signaling by EGFRvIII |
| REAC:R-HSA-5637812 | 0.00170100530318 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by EGFRvIII in Cancer |
| REAC:R-HSA-5654695 | 0.00170100530318 | 0.333333333333 | PIK3CA PIK3R1 | PI-3K cascade:FGFR2 |
| REAC:R-HSA-372790 | 0.0017378916004 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | Signaling by GPCR |
| GO:0071495 | 0.00193018044108 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | cellular response to endogenous stimulus |
| REAC:R-HSA-9034015 | 0.00200991204249 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by NTRK3 (TRKC) |
| REAC:R-HSA-9703648 | 0.00200991204249 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by FLT3 ITD and TKD mutants |
| REAC:R-HSA-9665348 | 0.00200991204249 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by ERBB2 ECD mutants |
| REAC:R-HSA-5655332 | 0.002344469338 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by FGFR3 in disease |
| REAC:R-HSA-5654708 | 0.002344469338 | 0.333333333333 | PIK3CA PIK3R1 | Downstream signaling of activated FGFR3 |
| REAC:R-HSA-180292 | 0.002344469338 | 0.333333333333 | PIK3CA PIK3R1 | GAB1 signalosome |
| GO:0006629 | 0.00250973705538 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | lipid metabolic process |
| REAC:R-HSA-5654696 | 0.00309047926945 | 0.333333333333 | PIK3CA PIK3R1 | Downstream signaling of activated FGFR2 |
| REAC:R-HSA-1839117 | 0.00309047926945 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by cytosolic FGFR1 fusion mutants |
| REAC:R-HSA-9703465 | 0.00309047926945 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by FLT3 fusion proteins |
| REAC:R-HSA-1236382 | 0.00309047926945 | 0.333333333333 | PIK3CA PIK3R1 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| REAC:R-HSA-5637815 | 0.00309047926945 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| REAC:R-HSA-5654716 | 0.00309047926945 | 0.333333333333 | PIK3CA PIK3R1 | Downstream signaling of activated FGFR4 |
| REAC:R-HSA-5654687 | 0.00309047926945 | 0.333333333333 | PIK3CA PIK3R1 | Downstream signaling of activated FGFR1 |
| GO:0098796 | 0.00312436057741 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | membrane protein complex |
| GO:0009719 | 0.00322757972864 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | response to endogenous stimulus |
| WP:WP3972 | 0.00326040131097 | 0.333333333333 | PIK3CA PIK3R1 | PDGFR beta pathway |
| KEGG:05132 | 0.00355441751449 | 0.5 | PIK3CA PIK3CB PIK3CD | Salmonella infection |
| HP:0002007 | 0.00388628767281 | 0.666666666667 | PIK3CA PIK3R1 PIK3CD PIK3R2 | Frontal bossing |
| REAC:R-HSA-9664565 | 0.00393892248474 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by ERBB2 KD Mutants |
| REAC:R-HSA-9006115 | 0.00393892248474 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by NTRK2 (TRKB) |
| HP:0011218 | 0.00401779642285 | 0.666666666667 | PIK3CA PIK3R1 PIK3CD PIK3R2 | Abnormal shape of the frontal region |
| HP:0430000 | 0.00406236038394 | 0.666666666667 | PIK3CA PIK3R1 PIK3CD PIK3R2 | Abnormal frontal bone morphology |
| REAC:R-HSA-1227990 | 0.00440152140132 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by ERBB2 in Cancer |
| WP:WP127 | 0.0046606239013 | 0.333333333333 | PIK3R2 PIK3R1 | IL 5 signaling pathway |
| GO:0032869 | 0.00470234449591 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | cellular response to insulin stimulus |
| HP:0025352 | 0.00485499013014 | 0.333333333333 | PIK3CA PIK3R2 | Typically de novo |
| HP:0031692 | 0.00485499013014 | 0.333333333333 | PIK3R1 PIK3CD | Severe cytomegalovirus infection |
| HP:0200117 | 0.00485499013014 | 0.333333333333 | PIK3R1 PIK3CD | Recurrent upper and lower respiratory tract infections |
| HP:0011110 | 0.00485499013014 | 0.333333333333 | PIK3R1 PIK3CD | Recurrent tonsillitis |
| WP:WP244 | 0.00497042421358 | 0.333333333333 | PIK3R2 PIK3R1 | Alpha 6 beta 4 signaling pathway |
| REAC:R-HSA-1643713 | 0.00540340354533 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by EGFR in Cancer |
| REAC:R-HSA-983695 | 0.00594265866298 | 0.333333333333 | PIK3R1 PIK3CD | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| WP:WP4558 | 0.00595923834675 | 0.333333333333 | PIK3CA PIK3R1 | Overview of interferons mediated signaling pathway |
| WP:WP2828 | 0.00595923834675 | 0.333333333333 | PIK3R2 PIK3R1 | Bladder cancer |
| GO:0032868 | 0.0063111355837 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | response to insulin |
| GO:0042113 | 0.00649203481341 | 0.666666666667 | PIK3R2 PIK3R1 PIK3CD PIK3R3 | B cell activation |
| WP:WP2332 | 0.00703705758996 | 0.333333333333 | PIK3R2 PIK3R1 | Interleukin 11 signaling pathway |
| REAC:R-HSA-9682385 | 0.0070977267476 | 0.333333333333 | PIK3CA PIK3R1 | FLT3 signaling in disease |
| REAC:R-HSA-1839124 | 0.0070977267476 | 0.333333333333 | PIK3CA PIK3R1 | FGFR1 mutant receptor activation |
| GO:0046649 | 0.00723959301982 | 0.833333333333 | PIK3CA PIK3R1 PIK3R3 PIK3CD PIK3R2 | lymphocyte activation |
| WP:WP364 | 0.00741608411471 | 0.333333333333 | PIK3R2 PIK3R1 | IL6 signaling pathway |
| HP:0032170 | 0.00841070885474 | 0.333333333333 | PIK3R1 PIK3CD | Severe varicella zoster infection |
| REAC:R-HSA-194315 | 0.0087987737143 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | Signaling by Rho GTPases |
| WP:WP61 | 0.00945912219359 | 0.333333333333 | PIK3R2 PIK3R1 | Notch signaling pathway |
| GO:0001784 | 0.00949259421943 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | phosphotyrosine residue binding |
| REAC:R-HSA-9716542 | 0.00959411672385 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| GO:0043542 | 0.00969847453123 | 0.666666666667 | PIK3CA PIK3R3 PIK3CB PIK3CD | endothelial cell migration |
| REAC:R-HSA-5654741 | 0.00971370123257 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by FGFR3 |
| WP:WP2018 | 0.0103452582733 | 0.333333333333 | PIK3R2 PIK3R1 | RANKL RANK signaling pathway |
| REAC:R-HSA-5655302 | 0.0104313293282 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by FGFR1 in disease |
| REAC:R-HSA-5654743 | 0.0104313293282 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by FGFR4 |
| GO:0030217 | 0.0107239945371 | 0.666666666667 | PIK3R2 PIK3R1 PIK3CD PIK3R3 | T cell differentiation |
| WP:WP195 | 0.0112707123684 | 0.333333333333 | PIK3R2 PIK3R1 | IL 1 signaling pathway |
| REAC:R-HSA-5655253 | 0.0119428487471 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by FGFR2 in disease |
| WP:WP304 | 0.0127325196108 | 0.333333333333 | PIK3R2 PIK3R1 | Kit receptor signaling pathway |
| REAC:R-HSA-5654736 | 0.0127367120473 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by FGFR1 |
| REAC:R-HSA-9607240 | 0.0127367120473 | 0.333333333333 | PIK3CA PIK3R1 | FLT3 Signaling |
| GO:0038084 | 0.0136563164499 | 0.5 | PIK3CA PIK3CB PIK3CD | vascular endothelial growth factor signaling pathway |
| WP:WP5072 | 0.0137560784303 | 0.333333333333 | PIK3R2 PIK3R1 | Modulators of TCR signaling and T cell activation |
| GO:0141124 | 0.0151451423504 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | intracellular signaling cassette |
| GO:0071375 | 0.0153056641383 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | cellular response to peptide hormone stimulus |
| REAC:R-HSA-9696273 | 0.0170865043842 | 0.333333333333 | PIK3R2 PIK3R1 | RND1 GTPase cycle |
| REAC:R-HSA-9013420 | 0.0170865043842 | 0.333333333333 | PIK3R2 PIK3R1 | RHOU GTPase cycle |
| WP:WP69 | 0.0182415379951 | 0.333333333333 | PIK3R2 PIK3R1 | T cell receptor signaling pathway |
| GO:0016773 | 0.018781111661 | 0.833333333333 | PIK3CA PIK3R1 PIK3R3 PIK3CB PIK3CD | phosphotransferase activity, alcohol group as acceptor |
| REAC:R-HSA-9696270 | 0.019003715544 | 0.333333333333 | PIK3R2 PIK3R1 | RND2 GTPase cycle |
| WP:WP3303 | 0.019460492062 | 0.333333333333 | PIK3CA PIK3R1 | RAC1 PAK1 p38 MMP2 pathway |
| GO:0045321 | 0.019672929333 | 0.833333333333 | PIK3CA PIK3R1 PIK3R3 PIK3CD PIK3R2 | leukocyte activation |
| REAC:R-HSA-9696264 | 0.0200002568185 | 0.333333333333 | PIK3R2 PIK3R1 | RND3 GTPase cycle |
| HP:0040218 | 0.020461457105 | 0.333333333333 | PIK3R1 PIK3CD | Reduced natural killer cell count |
| WP:WP5094 | 0.0220152039288 | 0.333333333333 | PIK3R2 PIK3R1 | Orexin receptor pathway |
| REAC:R-HSA-9035034 | 0.0220691409046 | 0.333333333333 | PIK3R2 PIK3R1 | RHOF GTPase cycle |
| WP:WP5087 | 0.0221664611486 | 0.5 | PIK3CA PIK3CB PIK3CD | Pleural mesothelioma |
| HP:0025539 | 0.0226111656051 | 0.333333333333 | PIK3R1 PIK3CD | Abnormal B cell subset distribution |
| WP:WP2034 | 0.0226781844519 | 0.333333333333 | PIK3R2 PIK3R1 | Leptin signaling pathway |
| REAC:R-HSA-1227986 | 0.0231414557883 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by ERBB2 |
| REAC:R-HSA-1236394 | 0.0231414557883 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by ERBB4 |
| GO:0045309 | 0.0235785344663 | 0.5 | PIK3R2 PIK3R3 PIK3R1 | protein phosphorylated amino acid binding |
| WP:WP3888 | 0.0239700907162 | 0.5 | PIK3CA PIK3R1 PIK3R2 | VEGFA VEGFR2 signaling |
| REAC:R-HSA-177929 | 0.0242390006211 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by EGFR |
| GO:0016301 | 0.0266728271518 | 0.833333333333 | PIK3CA PIK3R1 PIK3R3 PIK3CB PIK3CD | kinase activity |
| WP:WP5098 | 0.0268597929621 | 0.333333333333 | PIK3R1 PIK3CD | T cell activation SARS CoV 2 |
| WP:WP23 | 0.0283311425678 | 0.333333333333 | PIK3R2 PIK3R1 | B cell receptor signaling pathway |
| GO:0043434 | 0.0292377969225 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | response to peptide hormone |
| HPA:0500651 | 0.0304891194196 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | soft tissue 1; fibroblasts[>=Low] |
| GO:1901653 | 0.0309639973592 | 0.666666666667 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | cellular response to peptide |
| REAC:R-HSA-9725370 | 0.0313533174732 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by ALK fusions and activated point mutants |
| REAC:R-HSA-9700206 | 0.0313533174732 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by ALK in cancer |
| REAC:R-HSA-1226099 | 0.0313533174732 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by FGFR in disease |
| HP:0040089 | 0.0322780794397 | 0.333333333333 | PIK3R1 PIK3CD | Abnormal natural killer cell count |
| HP:0002721 | 0.0323291457974 | 0.5 | PIK3CA PIK3CD PIK3R1 | Immunodeficiency |
| REAC:R-HSA-9013405 | 0.0326270815028 | 0.333333333333 | PIK3R2 PIK3R1 | RHOD GTPase cycle |
| WP:WP138 | 0.0329770277677 | 0.333333333333 | PIK3R2 PIK3R1 | Androgen receptor signaling pathway |
| REAC:R-HSA-168249 | 0.0338175140237 | 0.666666666667 | PIK3CA PIK3R1 PIK3CB PIK3R2 | Innate Immune System |
| REAC:R-HSA-9013409 | 0.0352499509777 | 0.333333333333 | PIK3R2 PIK3R1 | RHOJ GTPase cycle |
| HPA:0530721 | 0.0362409368932 | 1.0 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 PIK3R3 | spleen; cells in white pulp[>=Low] |
| GO:0010631 | 0.0379514736875 | 0.666666666667 | PIK3CA PIK3R3 PIK3CB PIK3CD | epithelial cell migration |
| REAC:R-HSA-5654738 | 0.0379731829042 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by FGFR2 |
| GO:0090132 | 0.0386403705075 | 0.666666666667 | PIK3CA PIK3R3 PIK3CB PIK3CD | epithelium migration |
| HP:0031691 | 0.0406481036194 | 0.333333333333 | PIK3R1 PIK3CD | Severe viral infection |
| GO:0090130 | 0.0414897534761 | 0.666666666667 | PIK3CA PIK3R3 PIK3CB PIK3CD | tissue migration |
| GO:0001781 | 0.042122686785 | 0.333333333333 | PIK3CB PIK3CD | neutrophil apoptotic process |
| GO:0033029 | 0.042122686785 | 0.333333333333 | PIK3CB PIK3CD | regulation of neutrophil apoptotic process |
| GO:0033031 | 0.042122686785 | 0.333333333333 | PIK3CB PIK3CD | positive regulation of neutrophil apoptotic process |
| GO:0035924 | 0.0421653429605 | 0.5 | PIK3CA PIK3CB PIK3CD | cellular response to vascular endothelial growth factor stimulus |
| HP:0012176 | 0.0436511011886 | 0.333333333333 | PIK3R1 PIK3CD | Abnormal natural killer cell morphology |
| HP:0100765 | 0.0436511011886 | 0.333333333333 | PIK3R1 PIK3CD | Abnormality of the tonsils |
| REAC:R-HSA-9013026 | 0.0467439411123 | 0.333333333333 | PIK3R2 PIK3R1 | RHOB GTPase cycle |
| HP:0003496 | 0.0467604957305 | 0.333333333333 | PIK3R1 PIK3CD | Increased circulating IgM level |
| GO:0030098 | 0.0476561097968 | 0.666666666667 | PIK3R2 PIK3R1 PIK3CD PIK3R3 | lymphocyte differentiation |
| REAC:R-HSA-190236 | 0.048293243222 | 0.333333333333 | PIK3CA PIK3R1 | Signaling by FGFR |
| WP:WP3931 | 0.0489911417376 | 0.333333333333 | PIK3R2 PIK3CD | Embryonic stem cell pluripotency pathways |
| CORUM:2574 | 0.0499436884912 | 0.166666666667 | PIK3R1 | CD19-VAV1-PIK3R1 complex |
| CORUM:7361 | 0.0499436884912 | 0.166666666667 | PIK3R1 | ARAF-PIK3R1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PIK3CA | PIK3R3 | 1.0 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| PIK3CB | PIK3R1 | 0.999 | 0.23 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () fraction |
| PIK3CB | PIK3R3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PIK3CA | PIK3R1 | 0.998 | 0.164 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| PIK3CA | PIK3R2 | 0.998 | 0.295459408904 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| PIK3CD | PIK3R3 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PIK3CD | PIK3R1 | 0.997 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| PIK3CB | PIK3CA | 0.996 | 0.21 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PIK3R2 | PIK3R1 | 0.995 | 0.31 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PIK3R2 | PIK3R3 | 0.994 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| PIK3CB | PIK3R2 | 0.992 | 0.350883495146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PIK3R3 | PIK3R1 | 0.979 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| PIK3CA | PIK3CD | 0.869 | 0.196 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PIK3CB | PIK3CD | 0.838 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PIK3CD | PIK3R2 | 0.141 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes