hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05070.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TLDC2 | TLD domain-containing protein 2 (TBC/LysM-associated domain-containing protein 2) | 2 | UniProt NCBI |
| ATP6V1G3 | V-type proton ATPase subunit G 3 (V-ATPase subunit G 3) (V-ATPase 13 kDa subunit 3) (Vacuolar proton pump subunit G 3) | 4 | UniProt NCBI |
| ATP6V1A | V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha) | 5 | UniProt NCBI |
| ATP6V1C1 | V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04966 | 6.07335157092e-07 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | Collecting duct acid secretion |
| REAC:R-HSA-77387 | 4.59102468944e-06 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | Insulin receptor recycling |
| REAC:R-HSA-917977 | 4.59102468944e-06 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | Transferrin endocytosis and recycling |
| KEGG:05110 | 4.86072516083e-06 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | Vibrio cholerae infection |
| REAC:R-HSA-1222556 | 6.29837429836e-06 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | ROS and RNS production in phagocytes |
| KEGG:04721 | 1.17128735206e-05 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | Synaptic vesicle cycle |
| KEGG:05120 | 1.35902422006e-05 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:05323 | 1.71467161414e-05 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | Rheumatoid arthritis |
| REAC:R-HSA-917937 | 3.0932996971e-05 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | Iron uptake and transport |
| REAC:R-HSA-9639288 | 3.27872895639e-05 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | Amino acids regulate mTORC1 |
| REAC:R-HSA-74752 | 5.2908776296e-05 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | Signaling by Insulin receptor |
| KEGG:00190 | 0.000100732661973 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | Oxidative phosphorylation |
| KEGG:04145 | 0.000127763882829 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | Phagosome |
| KEGG:04150 | 0.000180381602802 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | mTOR signaling pathway |
| REAC:R-HSA-983712 | 0.000432467117837 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | Ion channel transport |
| GO:0016471 | 0.000591522022343 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | vacuolar proton-transporting V-type ATPase complex |
| GO:0033176 | 0.000680215375943 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | proton-transporting V-type ATPase complex |
| REAC:R-HSA-9711097 | 0.00081494341463 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | Cellular response to starvation |
| KEGG:05165 | 0.00141764261548 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | Human papillomavirus infection |
| WP:WP4917 | 0.00188599942343 | 0.5 | ATP6V1A ATP6V1C1 | Proximal tubule transport |
| GO:0016469 | 0.00508133939815 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | proton-transporting two-sector ATPase complex |
| REAC:R-HSA-9006934 | 0.0183118305735 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-382551 | 0.0342552713859 | 0.75 | ATP6V1C1 ATP6V1G3 ATP6V1A | Transport of small molecules |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ATP6V1C1 | ATP6V1A | 0.991 | 0.29 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| TLDC2 | ATP6V1A | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ATP6V1G3 | ATP6V1A | 0.974 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATP6V1C1 | TLDC2 | 0.957 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes