hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05114.1
Complex Portal: CPX-18417
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CTNNA2 | Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein) | 5 | UniProt NCBI |
| ZFP82 | Zinc finger protein 82 homolog (Zfp-82) (Zinc finger protein 545) | 3 | UniProt NCBI |
| CTNNBIP1 | Beta-catenin-interacting protein 1 (Inhibitor of beta-catenin and Tcf-4) | 5 | UniProt NCBI |
| CDH2 | Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325) | 5 | UniProt NCBI |
| APC | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) | 5 | UniProt NCBI |
| CTNNB1 | Catenin beta-1 (Beta-catenin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6206 | 5.12628525639e-06 | 0.5 | CTNNBIP1 CTNNB1 | ICAT-AR-beta-catenin complex |
| REAC:R-HSA-525793 | 0.00282403231951 | 0.5 | CTNNA2 CTNNB1 | Myogenesis |
| KEGG:05213 | 0.00331074310373 | 0.5 | CTNNA2 CTNNB1 | Endometrial cancer |
| WP:WP4155 | 0.00405547408869 | 0.5 | CTNNA2 CTNNB1 | Endometrial cancer |
| WP:WP2118 | 0.00434689671613 | 0.5 | CTNNA2 CTNNB1 | Arrhythmogenic right ventricular cardiomyopathy |
| KEGG:05412 | 0.0056793701001 | 0.5 | CTNNA2 CTNNB1 | Arrhythmogenic right ventricular cardiomyopathy |
| REAC:R-HSA-3769402 | 0.00643909852192 | 0.5 | CTNNBIP1 CTNNB1 | Deactivation of the beta-catenin transactivating complex |
| WP:WP4336 | 0.00685264055756 | 0.5 | CTNNBIP1 CTNNB1 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| KEGG:05100 | 0.00710024614077 | 0.5 | CTNNA2 CTNNB1 | Bacterial invasion of epithelial cells |
| WP:WP4258 | 0.00862655865142 | 0.5 | CTNNBIP1 CTNNB1 | lncRNA in canonical Wnt signaling and colorectal cancer |
| KEGG:04670 | 0.00909742323246 | 0.5 | CTNNA2 CTNNB1 | Leukocyte transendothelial migration |
| KEGG:04520 | 0.00909742323246 | 0.5 | CTNNA2 CTNNB1 | Adherens junction |
| WP:WP428 | 0.0127805971611 | 0.5 | CTNNBIP1 CTNNB1 | Wnt signaling |
| WP:WP2858 | 0.0165681999049 | 0.5 | CTNNA2 CTNNB1 | Ectoderm differentiation |
| KEGG:05226 | 0.0211069184789 | 0.5 | CTNNA2 CTNNB1 | Gastric cancer |
| CORUM:5262 | 0.0249718442456 | 0.25 | CTNNB1 | TCF4-CTNNB1 complex |
| CORUM:6336 | 0.0249718442456 | 0.25 | CTNNB1 | CTNNB1-DNMT1 complex |
| CORUM:5281 | 0.0249718442456 | 0.25 | CTNNB1 | Cell-cell junction complex (CDH1-CTNNB1) |
| KEGG:04390 | 0.02620193588 | 0.5 | CTNNA2 CTNNB1 | Hippo signaling pathway |
| KEGG:04310 | 0.0276522587106 | 0.5 | CTNNBIP1 CTNNB1 | Wnt signaling pathway |
| CORUM:4096 | 0.049938562206 | 0.25 | CTNNB1 | CTNNA1-CTNNB1 complex |
| CORUM:521 | 0.049938562206 | 0.25 | CTNNB1 | Polycystin-1-E-cadherin-beta-catenin complex |
| CORUM:1816 | 0.049938562206 | 0.25 | CTNNB1 | JUN-TCF4-CTNNB1 complex |
| CORUM:3004 | 0.049938562206 | 0.25 | CTNNB1 | APC-AXIN1-CTNNB1 complex |
| CORUM:3155 | 0.049938562206 | 0.25 | CTNNB1 | TFC4-CTNNB1 complex |
| CORUM:7312 | 0.049938562206 | 0.25 | CTNNB1 | CTNNB1-ESR1 complex |
| CORUM:6961 | 0.049938562206 | 0.25 | CTNNB1 | CTNNB1-GID8 complex |
| CORUM:6680 | 0.049938562206 | 0.25 | CTNNB1 | CTNNB1-GLIS2 complex |
| CORUM:6655 | 0.049938562206 | 0.25 | CTNNB1 | CTNNB1-TBX5-YAP1 complex |
| CORUM:6364 | 0.049938562206 | 0.25 | CTNNB1 | OVOL2-beta-catenin-TCF4 complex |
| CORUM:6362 | 0.049938562206 | 0.25 | CTNNB1 | PDLIM1-E-cadherin-beta-catenin complex |
| CORUM:6359 | 0.049938562206 | 0.25 | CTNNB1 | RHAMM-beta-catenin complex |
| CORUM:6339 | 0.049938562206 | 0.25 | CTNNB1 | beta-catenin-B-cell lymphoma 9 protein complex |
| CORUM:4095 | 0.049938562206 | 0.25 | CTNNB1 | CTNNAL1-CTNNB1 complex |
| CORUM:6334 | 0.049938562206 | 0.25 | CTNNB1 | Afadin-beta-catenin complex |
| CORUM:6269 | 0.049938562206 | 0.25 | CTNNB1 | DLL1-CTNNB1-CDH2 complex |
| CORUM:5261 | 0.049938562206 | 0.25 | CTNNB1 | TCF4-CTNNB1-EP300 complex |
| CORUM:5264 | 0.049938562206 | 0.25 | CTNNB1 | TCF4-CTNNB1-CREBBP complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CTNNA2 | CTNNB1 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction | |
| CTNNBIP1 | CTNNB1 | 0.999 | 0.094 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| APC | CTNNB1 | 0.999 | 0.258 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| CTNNBIP1 | APC | 0.993 | 0.218 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CTNNA2 | CTNNBIP1 | 0.99 |
structurally_consistent (P35222)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ZFP82 | CTNNB1 | 0.983 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CDH2 | CTNNB1 | 0.98 | 0.366 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| ZFP82 | CTNNBIP1 | 0.905 | bioplex3_WMM WMM_only | ||
| CTNNA2 | APC | 0.594 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CTNNA2 | ZFP82 | 0.179 |
structurally_consistent (P35222)
|
bioplex3_WMM WMM_only | |
| CTNNA2 | CDH2 | 0.131 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ZFP82 | APC | 0.102 | bioplex3_WMM WMM_only | ||
| CDH2 | APC | 0.091 | 0.226 | bioplex_WMM bioplex3_WMM WMM_only | |
| CTNNBIP1 | CDH2 | 0.076 | 0.126 |
mutually_exclusive (P35222)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ZFP82 | CDH2 | 0.062 | bioplex3_WMM WMM_only |
Related Complexes