hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05118.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FADD | FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity) | 5 | UniProt NCBI |
| TNFRSF10B | Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262) | 5 | UniProt NCBI |
| NDFIP1 | NEDD4 family-interacting protein 1 (Breast cancer-associated protein SGA-1M) (NEDD4 WW domain-binding protein 5) (Putative MAPK-activating protein PM13) (Putative NF-kappa-B-activating protein 164) (Putative NFKB and MAPK-activating protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-75158 | 0.000143154936711 | 0.666666666667 | TNFRSF10B FADD | TRAIL signaling |
| REAC:R-HSA-3371378 | 0.000306718584473 | 0.666666666667 | TNFRSF10B FADD | Regulation by c-FLIP |
| REAC:R-HSA-69416 | 0.000306718584473 | 0.666666666667 | TNFRSF10B FADD | Dimerization of procaspase-8 |
| REAC:R-HSA-5218900 | 0.000306718584473 | 0.666666666667 | TNFRSF10B FADD | CASP8 activity is inhibited |
| REAC:R-HSA-140534 | 0.000531572756485 | 0.666666666667 | TNFRSF10B FADD | Caspase activation via Death Receptors in the presence of ligand |
| REAC:R-HSA-5357769 | 0.0011650518872 | 0.666666666667 | TNFRSF10B FADD | Caspase activation via extrinsic apoptotic signalling pathway |
| REAC:R-HSA-5675482 | 0.00296224002415 | 0.666666666667 | TNFRSF10B FADD | Regulation of necroptotic cell death |
| REAC:R-HSA-5213460 | 0.00296224002415 | 0.666666666667 | TNFRSF10B FADD | RIPK1-mediated regulated necrosis |
| WP:WP254 | 0.00296720799434 | 0.666666666667 | TNFRSF10B FADD | Apoptosis |
| WP:WP1772 | 0.00338983502479 | 0.666666666667 | TNFRSF10B FADD | Apoptosis modulation and signaling |
| KEGG:04210 | 0.00542112539104 | 0.666666666667 | TNFRSF10B FADD | Apoptosis |
| KEGG:04217 | 0.00706776241177 | 0.666666666667 | TNFRSF10B FADD | Necroptosis |
| KEGG:05164 | 0.00780874825616 | 0.666666666667 | TNFRSF10B FADD | Influenza A |
| REAC:R-HSA-5218859 | 0.00937397262456 | 0.666666666667 | TNFRSF10B FADD | Regulated Necrosis |
| KEGG:05130 | 0.0102516009655 | 0.666666666667 | TNFRSF10B FADD | Pathogenic Escherichia coli infection |
| KEGG:05132 | 0.0188728482722 | 0.666666666667 | TNFRSF10B FADD | Salmonella infection |
| CORUM:5861 | 0.0249718442456 | 0.333333333333 | FADD | FAS-FADD-CASP10 complex |
| GO:0036462 | 0.0393180950424 | 0.666666666667 | TNFRSF10B FADD | TRAIL-activated apoptotic signaling pathway |
| CORUM:5856 | 0.0499402709677 | 0.333333333333 | FADD | AK2-FADD-caspase-10 (AFAC10) complex |
| CORUM:5859 | 0.0499402709677 | 0.333333333333 | FADD | FAS-FADD-CASP8-CASP10 complex |
| CORUM:5860 | 0.0499402709677 | 0.333333333333 | FADD | DISC complex (FAS, FADD, CASP8) |
| CORUM:5473 | 0.0499402709677 | 0.333333333333 | FADD | DISC complex (FAS, FADD, CASP8) |
| CORUM:5991 | 0.0499402709677 | 0.333333333333 | FADD | LRRK2-FADD-CASP8 complex |
| CORUM:6158 | 0.0499402709677 | 0.333333333333 | TNFRSF10B | TRIAL-DR5 complex |
| CORUM:6175 | 0.0499402709677 | 0.333333333333 | FADD | Caspase-10-SUMO-FADD/Drp1 complex |
| CORUM:5800 | 0.0499402709677 | 0.333333333333 | FADD | DISC complex (FAS, FADD, CASP8) |
| CORUM:5808 | 0.0499402709677 | 0.333333333333 | FADD | DISC complex (CD95, FADD, CASP8) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TNFRSF10B | FADD | 0.983 | 0.07 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TNFRSF10B | NDFIP1 | 0.98 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| FADD | NDFIP1 | 0.053 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes