hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05174.1

Complex Portal: CPX-23353

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
GTF2H2C	General transcription factor IIH subunit 2-like protein (General transcription factor IIH polypeptide 2-like protein)	4	UniProt NCBI
GTF2H2	General transcription factor IIH subunit 2 (Basic transcription factor 2 44 kDa subunit) (BTF2 p44) (General transcription factor IIH polypeptide 2) (TFIIH basal transcription factor complex p44 subunit)	5	UniProt NCBI
GTF2H4	General transcription factor IIH subunit 4 (Basic transcription factor 2 52 kDa subunit) (BTF2 p52) (General transcription factor IIH polypeptide 4) (TFIIH basal transcription factor complex p52 subunit)	5	UniProt NCBI
CDK7	Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)	5	UniProt NCBI
ERCC2	General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD) (EC 3.6.4.12) (Basic transcription factor 2 80 kDa subunit) (BTF2 p80) (CXPD) (DNA excision repair protein ERCC-2) (DNA repair protein complementing XP-D cells) (TFIIH basal transcription factor complex 80 kDa subunit) (TFIIH 80 kDa subunit) (TFIIH p80) (Xeroderma pigmentosum group D-complementing protein)	5	UniProt NCBI
GTF2H1	General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit)	5	UniProt NCBI
ERCC3	General transcription and DNA repair factor IIH helicase subunit XPB (TFIIH subunit XPB) (EC 3.6.4.12) (Basic transcription factor 2 89 kDa subunit) (BTF2 p89) (DNA excision repair protein ERCC-3) (DNA repair protein complementing XP-B cells) (TFIIH basal transcription factor complex 89 kDa subunit) (TFIIH 89 kDa subunit) (TFIIH p89) (Xeroderma pigmentosum group B-complementing protein)	5	UniProt NCBI
GTF2H5	General transcription factor IIH subunit 5 (General transcription factor IIH polypeptide 5) (TFB5 ortholog) (TFIIH basal transcription factor complex TTD-A subunit) (TFIIH subunit p8)	5	UniProt NCBI
CCNH	Cyclin-H (MO15-associated protein) (p34) (p37)	5	UniProt NCBI
GTF2H3	General transcription factor IIH subunit 3 (Basic transcription factor 2 34 kDa subunit) (BTF2 p34) (General transcription factor IIH polypeptide 3) (TFIIH basal transcription factor complex p34 subunit)	5	UniProt NCBI
MNAT1	CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005675	3.69959944008e-33	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	transcription factor TFIIH holo complex
CORUM:1009	5.97970892236e-33	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	TFIIH transcription factor complex
CORUM:1029	5.97970892236e-33	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	TFIIH transcription factor complex
GO:0000439	4.50272081853e-30	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	transcription factor TFIIH core complex
CORUM:107	4.366981426e-29	0.818181818182	ERCC2 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	TFIIH transcription factor complex
CORUM:1036	4.366981426e-29	0.818181818182	ERCC2 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	TFIIH transcription factor complex
GO:0032806	5.1782060163e-29	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	carboxy-terminal domain protein kinase complex
REAC:R-HSA-77075	1.23800207354e-25	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA Pol II CTD phosphorylation and interaction with CE
REAC:R-HSA-167160	1.23800207354e-25	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
REAC:R-HSA-72086	3.05821221316e-25	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	mRNA Capping
REAC:R-HSA-73863	1.03339052842e-24	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA Polymerase I Transcription Termination
REAC:R-HSA-167158	1.50301981185e-24	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Formation of the HIV-1 Early Elongation Complex
REAC:R-HSA-113418	1.50301981185e-24	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Formation of the Early Elongation Complex
KEGG:03022	5.13583794523e-24	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Basal transcription factors
WP:WP4753	1.79864088033e-23	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Nucleotide excision repair
REAC:R-HSA-167200	3.4260621446e-23	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Formation of HIV-1 elongation complex containing HIV-1 Tat
REAC:R-HSA-167246	3.4260621446e-23	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Tat-mediated elongation of the HIV-1 transcript
REAC:R-HSA-167169	3.4260621446e-23	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	HIV Transcription Elongation
REAC:R-HSA-5696395	3.4260621446e-23	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Formation of Incision Complex in GG-NER
REAC:R-HSA-167152	5.77656061216e-23	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Formation of HIV elongation complex in the absence of HIV Tat
REAC:R-HSA-76042	7.42654322551e-23	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA Polymerase II Transcription Initiation And Promoter Clearance
REAC:R-HSA-73779	7.42654322551e-23	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
REAC:R-HSA-167161	7.42654322551e-23	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	HIV Transcription Initiation
REAC:R-HSA-75953	7.42654322551e-23	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA Polymerase II Transcription Initiation
REAC:R-HSA-167162	7.42654322551e-23	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA Polymerase II HIV Promoter Escape
REAC:R-HSA-73776	7.42654322551e-23	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA Polymerase II Promoter Escape
REAC:R-HSA-73762	1.20526901268e-22	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA Polymerase I Transcription Initiation
KEGG:03420	2.38784573177e-22	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Nucleotide excision repair
REAC:R-HSA-6781823	3.68118796566e-22	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Formation of TC-NER Pre-Incision Complex
GO:0016591	4.72641717829e-22	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA polymerase II, holoenzyme
REAC:R-HSA-75955	1.00451938154e-21	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA Polymerase II Transcription Elongation
REAC:R-HSA-112382	1.00451938154e-21	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Formation of RNA Pol II elongation complex
REAC:R-HSA-6796648	2.09716910702e-21	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	TP53 Regulates Transcription of DNA Repair Genes
REAC:R-HSA-6782210	2.97188661695e-21	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Gap-filling DNA repair synthesis and ligation in TC-NER
REAC:R-HSA-6782135	3.52201602256e-21	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Dual incision in TC-NER
WP:WP5114	5.81770748407e-21	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Nucleotide excision repair in xeroderma pigmentosum
REAC:R-HSA-167172	6.75881034318e-21	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Transcription of the HIV genome
GO:0055029	1.65718124384e-20	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	nuclear DNA-directed RNA polymerase complex
WP:WP405	1.86999435606e-20	0.818181818182	ERCC2 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Eukaryotic transcription initiation
GO:0000428	1.87948604485e-20	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	DNA-directed RNA polymerase complex
REAC:R-HSA-6781827	2.54862974182e-20	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
GO:0030880	2.71885153476e-20	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA polymerase complex
REAC:R-HSA-73772	3.34669505605e-20	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA Polymerase I Promoter Escape
REAC:R-HSA-674695	3.34669505605e-20	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA Polymerase II Pre-transcription Events
REAC:R-HSA-5696399	5.64888503997e-20	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Global Genome Nucleotide Excision Repair (GG-NER)
REAC:R-HSA-427413	2.09831077472e-19	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	NoRC negatively regulates rRNA expression
REAC:R-HSA-5250941	2.91822129038e-19	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Negative epigenetic regulation of rRNA expression
REAC:R-HSA-73854	3.24963395797e-19	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA Polymerase I Promoter Clearance
REAC:R-HSA-73864	3.61453512824e-19	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA Polymerase I Transcription
WP:WP4946	5.79906267675e-19	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	DNA repair pathways full network
GO:1902554	6.26360500405e-19	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	serine/threonine protein kinase complex
REAC:R-HSA-5696398	8.97898732377e-19	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Nucleotide Excision Repair
GO:1902911	2.66215195428e-18	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	protein kinase complex
REAC:R-HSA-162599	6.16876012398e-18	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Late Phase of HIV Life Cycle
REAC:R-HSA-162587	1.53691793773e-17	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	HIV Life Cycle
REAC:R-HSA-212165	1.04058231563e-16	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Epigenetic regulation of gene expression
GO:0090575	1.57961193131e-16	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA polymerase II transcription regulator complex
REAC:R-HSA-162906	1.43420003203e-15	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	HIV Infection
GO:0061695	4.46842690212e-15	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	transferase complex, transferring phosphorus-containing groups
CORUM:1037	5.52460635237e-15	0.454545454545	GTF2H1 ERCC3 GTF2H3 GTF2H2 GTF2H4	TFIIH transcription factor core complex
REAC:R-HSA-73894	3.91520429429e-14	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	DNA Repair
CORUM:103	6.13235285753e-14	0.545454545455	ERCC2 GTF2H4 GTF2H3 GTF2H2 GTF2H1 ERCC3	RNA polymerase II holoenzyme complex
REAC:R-HSA-5696400	6.75587681606e-14	0.636363636364	ERCC2 GTF2H5 GTF2H4 GTF2H3 GTF2H2 GTF2H1 ERCC3	Dual Incision in GG-NER
GO:0005667	8.44623191434e-14	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	transcription regulator complex
REAC:R-HSA-3700989	1.0715032096e-13	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Transcriptional Regulation by TP53
CORUM:2825	1.22575055659e-13	0.545454545455	ERCC2 GTF2H4 GTF2H3 GTF2H2 GTF2H1 ERCC3	BRCA1-RNA polymerase II complex
CORUM:1030	1.15314319164e-11	0.363636363636	ERCC2 MNAT1 CDK7 CCNH	CAK-ERCC2 complex
CORUM:2660	1.15314319164e-11	0.363636363636	ERCC2 MNAT1 CDK7 CCNH	CAK-ERCC2 complex
REAC:R-HSA-8953854	1.29240071289e-10	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Metabolism of RNA
REAC:R-HSA-9824446	1.70071804589e-10	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Viral Infection Pathways
GO:1990234	4.48299201665e-10	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	transferase complex
GO:0140535	8.47360827415e-10	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	intracellular protein-containing complex
GO:0005669	1.24868613204e-09	0.545454545455	ERCC2 GTF2H5 GTF2H4 GTF2H3 GTF2H2 ERCC3	transcription factor TFIID complex
REAC:R-HSA-5663205	1.33926658569e-09	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Infectious disease
GO:0006289	1.51865816572e-09	0.636363636364	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 GTF2H2 ERCC3	nucleotide-excision repair
REAC:R-HSA-212436	7.37775532608e-09	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Generic Transcription Pathway
GO:0070516	8.68316823302e-09	0.363636363636	ERCC2 MNAT1 CDK7 CCNH	CAK-ERCC2 complex
CORUM:1008	2.10621603952e-08	0.272727272727	CCNH CDK7 MNAT1	CAK complex (Cdk-activating kinase complex)
CORUM:1010	2.10621603952e-08	0.272727272727	CCNH CDK7 MNAT1	CAK complex (Cdk-activating kinase complex)
REAC:R-HSA-73857	2.20543046166e-08	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA Polymerase II Transcription
GO:0140513	2.22565858581e-08	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	nuclear protein-containing complex
REAC:R-HSA-74160	7.69459173595e-08	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Gene expression (Transcription)
GO:0006281	1.15485918395e-07	0.818181818182	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 GTF2H2 GTF2H1 ERCC3 MNAT1	DNA repair
REAC:R-HSA-1643685	2.95397320054e-07	0.909090909091	ERCC2 GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	Disease
CORUM:2657	4.20724492332e-07	0.272727272727	CCNH CDK7 MNAT1	ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex
GO:1902494	7.89780451133e-07	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	catalytic complex
GO:0006974	3.99649436403e-06	0.818181818182	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 GTF2H2 GTF2H1 ERCC3 MNAT1	DNA damage response
GO:0006366	5.21186456064e-06	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	transcription by RNA polymerase II
GO:0006259	6.96856840347e-06	0.818181818182	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 GTF2H2 GTF2H1 ERCC3 MNAT1	DNA metabolic process
GO:0000438	1.58598067776e-05	0.272727272727	GTF2H3 GTF2H2 GTF2H4	core TFIIH complex portion of holo TFIIH complex
GO:0070985	1.58598067776e-05	0.272727272727	CCNH CDK7 MNAT1	transcription factor TFIIK complex
GO:0019907	1.58598067776e-05	0.272727272727	CCNH CDK7 MNAT1	cyclin-dependent protein kinase activating kinase holoenzyme complex
HP:0410219	2.46100865792e-05	0.272727272727	ERCC2 ERCC3 GTF2H5	Hypoplasia of mandible relative to maxilla
HP:0007381	2.46100865792e-05	0.272727272727	ERCC2 ERCC3 GTF2H5	Congenital exfoliative erythroderma
CORUM:1007	3.41979277617e-05	0.181818181818	CCNH CDK7	CAK core complex (Cdk-activating kinase core complex)
HP:0045055	3.51428278464e-05	0.272727272727	ERCC2 ERCC3 GTF2H5	Tiger tail banding
HP:0001809	4.83015426938e-05	0.272727272727	ERCC2 ERCC3 GTF2H5	Split nail
HP:0007587	6.43756062764e-05	0.272727272727	ERCC2 ERCC3 GTF2H5	Numerous pigmented freckles
HP:0002562	6.43756062764e-05	0.272727272727	ERCC2 ERCC3 GTF2H5	Low-set nipples
HP:0006538	8.36539154996e-05	0.272727272727	ERCC2 ERCC3 GTF2H5	Recurrent bronchopulmonary infections
HP:0025428	8.36539154996e-05	0.272727272727	ERCC2 ERCC3 GTF2H5	Bronchospasm
HP:0025548	0.000106424889478	0.272727272727	ERCC2 ERCC3 GTF2H5	Increased mean corpuscular hemoglobin concentration
GO:0006351	0.000127015524712	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	DNA-templated transcription
HP:0003079	0.000132976469997	0.272727272727	ERCC2 ERCC3 GTF2H5	Defective DNA repair after ultraviolet radiation damage
HP:0007034	0.000132976469997	0.272727272727	ERCC2 ERCC3 GTF2H5	Generalized hyperreflexia
GO:0032774	0.000142880142753	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA biosynthetic process
HP:0001598	0.000163596121967	0.272727272727	ERCC2 ERCC3 GTF2H5	Concave nail
REAC:R-HSA-69273	0.000187302344386	0.272727272727	CCNH CDK7 MNAT1	Cyclin A/B1/B2 associated events during G2/M transition
HP:0000320	0.000198570833886	0.272727272727	ERCC2 ERCC3 GTF2H5	Bird-like facies
HP:0003139	0.000238187118297	0.272727272727	ERCC2 ERCC3 GTF2H5	Panhypogammaglobulinemia
HP:0007266	0.000238187118297	0.272727272727	ERCC2 ERCC3 GTF2H5	Cerebral dysmyelination
HP:0007485	0.000238187118297	0.272727272727	ERCC2 ERCC3 GTF2H5	Absence of subcutaneous fat
HP:0025546	0.000238187118297	0.272727272727	ERCC2 ERCC3 GTF2H5	Abnormal mean corpuscular hemoglobin concentration
HP:0003254	0.000282731012242	0.272727272727	ERCC2 ERCC3 GTF2H5	Abnormality of DNA repair
HP:0100275	0.000332488077726	0.272727272727	ERCC2 ERCC3 GTF2H5	Diffuse cerebellar atrophy
HP:0025427	0.000332488077726	0.272727272727	ERCC2 ERCC3 GTF2H5	Abnormal bronchus physiology
HP:0007479	0.000387743402168	0.272727272727	ERCC2 ERCC3 GTF2H5	Congenital nonbullous ichthyosiform erythroderma
KEGG:05203	0.000398417613823	0.363636363636	GTF2H1 GTF2H3 GTF2H2 GTF2H4	Viral carcinogenesis
HP:0007633	0.000515886807433	0.272727272727	ERCC2 ERCC3 GTF2H5	Bilateral microphthalmos
GO:0016251	0.000566266067171	0.363636363636	CCNH GTF2H3 GTF2H2 GTF2H4	RNA polymerase II general transcription initiation factor activity
GO:0034654	0.000568973562955	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	nucleobase-containing compound biosynthetic process
GO:0018130	0.000695422418697	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	heterocycle biosynthetic process
GO:0019438	0.00070360086061	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	aromatic compound biosynthetic process
GO:0033554	0.000739581768862	0.818181818182	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 GTF2H2 GTF2H1 ERCC3 MNAT1	cellular response to stress
HP:0007431	0.000850644000044	0.272727272727	ERCC2 ERCC3 GTF2H5	Congenital ichthyosiform erythroderma
HP:0001807	0.000850644000044	0.272727272727	ERCC2 ERCC3 GTF2H5	Ridged nail
HP:0001808	0.000952329815823	0.272727272727	ERCC2 ERCC3 GTF2H5	Fragile nails
GO:1901362	0.000967632092806	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	organic cyclic compound biosynthetic process
HP:0000133	0.00106177755968	0.272727272727	ERCC2 ERCC3 GTF2H5	Gonadal dysgenesis
HP:0008391	0.00117926806831	0.272727272727	ERCC2 ERCC3 GTF2H5	Dystrophic fingernails
REAC:R-HSA-69231	0.00122557011999	0.272727272727	CCNH CDK7 MNAT1	Cyclin D associated events in G1
REAC:R-HSA-69236	0.00122557011999	0.272727272727	CCNH CDK7 MNAT1	G1 Phase
WP:WP45	0.00134534612351	0.272727272727	CCNH CDK7 MNAT1	G1 to S cell cycle control
HP:0008887	0.00143949837695	0.272727272727	ERCC2 ERCC3 GTF2H5	Adipose tissue loss
HP:0003328	0.00158279750202	0.272727272727	ERCC2 ERCC3 GTF2H5	Abnormal hairshaft morphology
GO:0140223	0.00166128673178	0.363636363636	CCNH GTF2H3 GTF2H2 GTF2H4	general transcription initiation factor activity
CORUM:3066	0.00187394691988	0.181818181818	ERCC3 GTF2H3	RNA polymerase II complex, chromatin structure modifying
CORUM:1141	0.00265541551617	0.181818181818	GTF2H4 ERCC3	CF IIAm complex (Cleavage factor IIAm complex)
HP:0002293	0.002857973802	0.272727272727	ERCC2 ERCC3 GTF2H5	Alopecia of scalp
HP:0001097	0.00308233584056	0.272727272727	ERCC2 ERCC3 GTF2H5	Keratoconjunctivitis sicca
GO:0016070	0.00308349463476	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	RNA metabolic process
HP:0006970	0.00356546349643	0.272727272727	ERCC2 ERCC3 GTF2H5	Periventricular leukomalacia
HP:0002299	0.00409629201445	0.272727272727	ERCC2 ERCC3 GTF2H5	Brittle hair
HP:0001096	0.00438027839181	0.272727272727	ERCC2 ERCC3 GTF2H5	Keratoconjunctivitis
HP:0040063	0.0046770102126	0.272727272727	ERCC2 ERCC3 GTF2H5	Decreased adipose tissue
GO:0044271	0.0050969753096	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	cellular nitrogen compound biosynthetic process
HP:0002942	0.0056464004799	0.272727272727	ERCC2 ERCC3 GTF2H5	Thoracic kyphosis
HP:0001338	0.00674028008009	0.272727272727	ERCC2 ERCC3 GTF2H5	Partial agenesis of the corpus callosum
REAC:R-HSA-69202	0.0070448571977	0.272727272727	CCNH CDK7 MNAT1	Cyclin E associated events during G1/S transition
REAC:R-HSA-69656	0.00757350751073	0.272727272727	CCNH CDK7 MNAT1	Cyclin A:Cdk2-associated events at S phase entry
HP:0012760	0.0079659428127	0.272727272727	ERCC2 ERCC3 GTF2H5	Reduced social reciprocity
HP:0001019	0.00840503749443	0.272727272727	ERCC2 ERCC3 GTF2H5	Erythroderma
GO:0150005	0.00883419058623	0.272727272727	CCNH CDK7 MNAT1	enzyme activator complex
HP:0000656	0.00933064528	0.272727272727	ERCC2 ERCC3 GTF2H5	Ectropion
HP:0002860	0.00981769270471	0.272727272727	ERCC2 ERCC3 GTF2H5	Squamous cell carcinoma
HP:0004337	0.00999375104824	0.181818181818	ERCC2 ERCC3	Abnormality of amino acid metabolism
HP:0002828	0.0103212579368	0.272727272727	ERCC2 ERCC3 GTF2H5	Multiple joint contractures
GO:0005654	0.0105448660706	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	nucleoplasm
GO:0019908	0.0107228250299	0.272727272727	CCNH CDK7 MNAT1	nuclear cyclin-dependent protein kinase holoenzyme complex
GO:0090304	0.0119029444692	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	nucleic acid metabolic process
HP:0008619	0.0125060104917	0.272727272727	ERCC2 ERCC3 GTF2H5	Bilateral sensorineural hearing impairment
HP:0010649	0.0133195302426	0.181818181818	ERCC2 ERCC3	Flat nasal alae
HP:0000491	0.0184911445467	0.272727272727	ERCC2 ERCC3 GTF2H5	Keratitis
REAC:R-HSA-8939236	0.0193759565403	0.272727272727	CCNH CDK7 MNAT1	RUNX1 regulates transcription of genes involved in differentiation of HSCs
GO:0031981	0.0214587900711	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	nuclear lumen
HP:0000608	0.0216651030937	0.272727272727	ERCC2 ERCC3 GTF2H5	Macular degeneration
REAC:R-HSA-69206	0.027902357559	0.272727272727	CCNH CDK7 MNAT1	G1/S Transition
HP:0006297	0.0290488213855	0.272727272727	ERCC2 ERCC3 GTF2H5	Enamel hypoplasia
HP:0009886	0.031344503338	0.181818181818	ERCC2 GTF2H5	Trichorrhexis nodosa
HP:0002080	0.032194928133	0.272727272727	ERCC2 ERCC3 GTF2H5	Intention tremor
HP:0000509	0.0332913902948	0.272727272727	ERCC2 ERCC3 GTF2H5	Conjunctivitis
HP:0011001	0.0344121544227	0.272727272727	ERCC2 ERCC3 GTF2H5	Increased bone mineral density
HP:0000992	0.0367275982991	0.272727272727	ERCC2 ERCC3 GTF2H5	Cutaneous photosensitivity
GO:1901990	0.0376968406374	0.454545454545	ERCC2 CCNH MNAT1 CDK7 ERCC3	regulation of mitotic cell cycle phase transition
HP:0030186	0.0379227818031	0.272727272727	ERCC2 ERCC3 GTF2H5	Kinetic tremor
HP:0025337	0.0379227818031	0.272727272727	ERCC2 ERCC3 GTF2H5	Red eye
GO:0006139	0.0379532315546	1.0	ERCC2 GTF2H2C GTF2H5 GTF2H4 GTF2H3 CCNH CDK7 MNAT1 GTF2H1 ERCC3 GTF2H2	nucleobase-containing compound metabolic process
HP:0011495	0.0391432747849	0.272727272727	ERCC2 ERCC3 GTF2H5	Abnormal corneal epithelium morphology
REAC:R-HSA-453279	0.0401691573103	0.272727272727	CCNH CDK7 MNAT1	Mitotic G1 phase and G1/S transition
HP:0100711	0.0416611918368	0.272727272727	ERCC2 ERCC3 GTF2H5	Abnormal thoracic spine morphology
HP:0009755	0.0431819390176	0.181818181818	ERCC2 ERCC3	Ankyloblepharon

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
GTF2H4	ERCC3	1.0	0.256
GTF2H2	GTF2H1	1.0	0.404
CDK7	CCNH	1.0	0.344
GTF2H2	GTF2H3	1.0	0.648
GTF2H2	ERCC3	1.0	0.286	structurally_consistent (dimer)
GTF2H4	GTF2H1	1.0	0.162
CCNH	MNAT1	1.0	0.476
GTF2H1	GTF2H3	1.0	0.354	mutually_exclusive (Q6P1K8) structurally_consistent (dimer)
CDK7	MNAT1	1.0	0.376
GTF2H4	GTF2H3	1.0	0.402	structurally_consistent (dimer)
GTF2H1	ERCC3	1.0	0.296	structurally_consistent (Q6P1K8)
GTF2H4	GTF2H2C	1.0	0.122	structurally_consistent (dimer)
GTF2H4	GTF2H5	1.0	0.264
ERCC3	GTF2H2C	1.0	0.26	structurally_consistent (dimer)
GTF2H5	GTF2H3	1.0	0.434
GTF2H2	GTF2H5	1.0	0.41	structurally_consistent (P19447)
ERCC3	GTF2H3	1.0	0.456
GTF2H1	GTF2H2C	1.0	0.118	mutually_exclusive (Q13889) structurally_consistent (dimer)
GTF2H2	GTF2H4	1.0	0.26
ERCC3	GTF2H5	1.0	0.196	structurally_consistent (dimer)
GTF2H2C	GTF2H3	1.0	0.124	structurally_consistent (Q92759) structurally_consistent (dimer)
GTF2H1	GTF2H5	1.0	0.428
ERCC2	CCNH	0.999	0.172	structurally_consistent (dimer)
CDK7	ERCC2	0.999	0.278	structurally_consistent (dimer)
ERCC2	MNAT1	0.999	0.388
ERCC3	MNAT1	0.998	0.120086956522
GTF2H5	CCNH	0.998	0.196
GTF2H2C	GTF2H5	0.997	0.166
GTF2H4	MNAT1	0.995	0.218	structurally_consistent (Q13889)
ERCC2	GTF2H1	0.992	0.224	structurally_consistent (dimer)
CDK7	ERCC3	0.99	0.262
CDK7	GTF2H5	0.989	0.354
GTF2H5	MNAT1	0.989	0.444
GTF2H4	CDK7	0.986	0.31	structurally_consistent (Q6P1K8)
ERCC2	GTF2H5	0.986	0.318
GTF2H2	MNAT1	0.984	0.618
ERCC2	ERCC3	0.975	0.248
GTF2H3	MNAT1	0.975	0.458	structurally_consistent (dimer)
GTF2H4	ERCC2	0.972	0.326
CDK7	GTF2H3	0.971	0.464
GTF2H2	CDK7	0.969	0.522	structurally_consistent (P18074)
GTF2H4	CCNH	0.968	0.12
GTF2H1	CCNH	0.968	0.064
CCNH	GTF2H3	0.968	0.234
GTF2H1	MNAT1	0.959	0.316
CDK7	GTF2H1	0.946	0.248
ERCC3	CCNH	0.944	0.212
ERCC2	GTF2H3	0.935	0.426
CDK7	GTF2H2C	0.924	0.132	structurally_consistent (dimer)
GTF2H2	ERCC2	0.921	0.262	structurally_consistent (dimer)
GTF2H2	CCNH	0.91	0.304	structurally_consistent (P18074)
GTF2H2C	MNAT1	0.544	0.064
GTF2H2	GTF2H2C	0.079	0.138	mutually_exclusive (P19447)
ERCC2	GTF2H2C	0.008	0.27	structurally_consistent (dimer)

Related Complexes

Genename	Complexes
GTF2H2C	huMAP3_05174.1 huMAP3_09908.1 huMAP3_12429.1 huMAP3_15000.1
GTF2H2	huMAP3_05174.1 huMAP3_09908.1 huMAP3_12429.1
GTF2H4	huMAP3_05174.1 huMAP3_09908.1 huMAP3_12429.1
CDK7	huMAP3_05174.1 huMAP3_09908.1 huMAP3_12429.1
ERCC2	huMAP3_05174.1 huMAP3_09908.1 huMAP3_12429.1
GTF2H1	huMAP3_05174.1 huMAP3_09908.1 huMAP3_12429.1
ERCC3	huMAP3_05174.1 huMAP3_09908.1 huMAP3_12429.1
GTF2H5	huMAP3_05174.1 huMAP3_09908.1 huMAP3_12429.1
CCNH	huMAP3_05174.1 huMAP3_09908.1 huMAP3_12429.1 huMAP3_14722.1
GTF2H3	huMAP3_05174.1 huMAP3_09908.1 huMAP3_12429.1
MNAT1	huMAP3_05174.1 huMAP3_09908.1 huMAP3_12429.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05174.1

Complex Portal: CPX-23353