hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05180.1
Complex Portal: CPX-12794
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZFYVE9 | Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation) | 5 | UniProt NCBI |
| SMAD9 | Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9) | 5 | UniProt NCBI |
| SMAD2 | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | 5 | UniProt NCBI |
| SMAD3 | Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1827 | 2.80628050973e-09 | 0.75 | ZFYVE9 SMAD2 SMAD3 | PML-SMAD2/3-SARA complex |
| WP:WP560 | 2.95203799349e-09 | 1.0 | ZFYVE9 SMAD2 SMAD3 SMAD9 | TGF beta receptor signaling |
| WP:WP4816 | 3.56404587019e-09 | 1.0 | ZFYVE9 SMAD2 SMAD3 SMAD9 | TGF beta receptor signaling in skeletal dysplasias |
| KEGG:04350 | 5.22938873215e-08 | 1.0 | ZFYVE9 SMAD2 SMAD3 SMAD9 | TGF-beta signaling pathway |
| WP:WP4331 | 1.73107546211e-06 | 0.75 | SMAD9 SMAD2 SMAD3 | Neovascularisation processes |
| GO:0071141 | 1.34540429244e-05 | 0.75 | SMAD9 SMAD2 SMAD3 | SMAD protein complex |
| GO:0071144 | 1.34540429244e-05 | 0.75 | SMAD9 SMAD2 SMAD3 | heteromeric SMAD protein complex |
| CORUM:2834 | 1.53774525569e-05 | 0.5 | SMAD3 SMAD2 | SMAD4-SMAD2-SMAD3 complex |
| CORUM:2830 | 1.53774525569e-05 | 0.5 | SMAD3 SMAD2 | TIF1gamma-SMAD2-SMAD3 complex |
| WP:WP5353 | 2.2575194708e-05 | 0.75 | SMAD9 SMAD2 SMAD3 | A network map of Macrophage stimulating protein MSP signaling |
| REAC:R-HSA-3311021 | 3.07549051138e-05 | 0.5 | SMAD3 SMAD2 | SMAD4 MH2 Domain Mutants in Cancer |
| REAC:R-HSA-3315487 | 3.07549051138e-05 | 0.5 | SMAD3 SMAD2 | SMAD2/3 MH2 Domain Mutants in Cancer |
| REAC:R-HSA-3304347 | 3.07549051138e-05 | 0.5 | SMAD3 SMAD2 | Loss of Function of SMAD4 in Cancer |
| REAC:R-HSA-3656532 | 6.15041976665e-05 | 0.5 | SMAD3 SMAD2 | TGFBR1 KD Mutants in Cancer |
| REAC:R-HSA-3304356 | 6.15041976665e-05 | 0.5 | SMAD3 SMAD2 | SMAD2/3 Phosphorylation Motif Mutants in Cancer |
| WP:WP366 | 9.51374072337e-05 | 0.75 | ZFYVE9 SMAD2 SMAD3 | TGF beta signaling pathway |
| KEGG:04550 | 9.58294361569e-05 | 0.75 | SMAD9 SMAD2 SMAD3 | Signaling pathways regulating pluripotency of stem cells |
| REAC:R-HSA-3304349 | 0.000102497642323 | 0.5 | SMAD3 SMAD2 | Loss of Function of SMAD2/3 in Cancer |
| REAC:R-HSA-3656534 | 0.000102497642323 | 0.5 | SMAD3 SMAD2 | Loss of Function of TGFBR1 in Cancer |
| REAC:R-HSA-3304351 | 0.000153732433522 | 0.5 | SMAD3 SMAD2 | Signaling by TGF-beta Receptor Complex in Cancer |
| WP:WP5382 | 0.000168398502686 | 0.5 | SMAD3 SMAD2 | TGF Smad signaling pathway |
| GO:0070411 | 0.000174830724535 | 0.75 | SMAD9 SMAD2 SMAD3 | I-SMAD binding |
| CORUM:2829 | 0.000184428417548 | 0.5 | SMAD3 SMAD2 | RSmad complex |
| WP:WP3859 | 0.000267833349503 | 0.5 | SMAD3 SMAD2 | TGF beta signaling in thyroid cells for epithelial mesenchymal transition |
| WP:WP3874 | 0.000267833349503 | 0.5 | SMAD3 SMAD2 | Canonical and non canonical TGF B signaling |
| REAC:R-HSA-9006936 | 0.000284930280132 | 0.75 | SMAD9 SMAD2 SMAD3 | Signaling by TGFB family members |
| HP:0008419 | 0.000334337547576 | 0.5 | SMAD3 SMAD2 | Intervertebral disc degeneration |
| REAC:R-HSA-9823730 | 0.000368856835097 | 0.5 | SMAD3 SMAD2 | Formation of definitive endoderm |
| REAC:R-HSA-9796292 | 0.000368856835097 | 0.5 | SMAD3 SMAD2 | Formation of axial mesoderm |
| WP:WP5103 | 0.000436026474737 | 0.5 | SMAD3 SMAD2 | Progeria associated lipodystrophy |
| REAC:R-HSA-1502540 | 0.000461028962628 | 0.5 | SMAD3 SMAD2 | Signaling by Activin |
| GO:0007179 | 0.000518885109813 | 1.0 | ZFYVE9 SMAD2 SMAD3 SMAD9 | transforming growth factor beta receptor signaling pathway |
| REAC:R-HSA-9754189 | 0.000676052383047 | 0.5 | SMAD3 SMAD2 | Germ layer formation at gastrulation |
| KEGG:04144 | 0.000687966939719 | 0.75 | ZFYVE9 SMAD2 SMAD3 | Endocytosis |
| WP:WP3668 | 0.00070344077777 | 0.5 | SMAD3 SMAD2 | Hypothesized pathways in pathogenesis of cardiovascular disease |
| GO:0071560 | 0.000883719448116 | 1.0 | ZFYVE9 SMAD2 SMAD3 SMAD9 | cellular response to transforming growth factor beta stimulus |
| WP:WP2870 | 0.00096305612306 | 0.5 | SMAD3 SMAD2 | Extracellular vesicle mediated signaling in recipient cells |
| GO:0071559 | 0.000993378785041 | 1.0 | ZFYVE9 SMAD2 SMAD3 SMAD9 | response to transforming growth factor beta |
| WP:WP3850 | 0.00110807642161 | 0.5 | SMAD3 SMAD2 | Factors and pathways affecting insulin like growth factor IGF1 Akt signaling |
| HP:0005086 | 0.00120317586686 | 0.5 | SMAD3 SMAD2 | Knee osteoarthritis |
| HP:0100718 | 0.00120317586686 | 0.5 | SMAD3 SMAD2 | Uterine rupture |
| REAC:R-HSA-9617828 | 0.00122873738811 | 0.5 | SMAD3 SMAD2 | FOXO-mediated transcription of cell cycle genes |
| REAC:R-HSA-1181150 | 0.00156635412759 | 0.5 | SMAD3 SMAD2 | Signaling by NODAL |
| WP:WP4535 | 0.00178944501344 | 0.5 | SMAD3 SMAD2 | Envelope proteins and their potential roles in EDMD physiopathology |
| WP:WP1971 | 0.00198508114189 | 0.5 | SMAD3 SMAD2 | Integrated cancer pathway |
| HP:0005294 | 0.00220521848756 | 0.5 | SMAD3 SMAD2 | Arterial dissection |
| HP:0008843 | 0.00220521848756 | 0.5 | SMAD3 SMAD2 | Hip osteoarthritis |
| KEGG:05321 | 0.00225645669975 | 0.5 | SMAD3 SMAD2 | Inflammatory bowel disease |
| GO:0141091 | 0.00254488754804 | 1.0 | ZFYVE9 SMAD2 SMAD3 SMAD9 | transforming growth factor beta receptor superfamily signaling pathway |
| REAC:R-HSA-2173788 | 0.00258893271292 | 0.5 | SMAD3 SMAD2 | Downregulation of TGF-beta receptor signaling |
| WP:WP5144 | 0.0027493593259 | 0.5 | SMAD3 SMAD2 | NRP1 triggered signaling pathways in pancreatic cancer |
| WP:WP4879 | 0.0027493593259 | 0.5 | SMAD3 SMAD2 | Overlap between signal transduction pathways contributing to LMNA laminopathies |
| REAC:R-HSA-9615017 | 0.00306932002175 | 0.5 | SMAD3 SMAD2 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
| GO:0007178 | 0.00314873966928 | 1.0 | ZFYVE9 SMAD2 SMAD3 SMAD9 | transmembrane receptor protein serine/threonine kinase signaling pathway |
| WP:WP5356 | 0.00405547408869 | 0.5 | SMAD3 SMAD2 | Affected pathways in Duchenne muscular dystrophy |
| REAC:R-HSA-2173795 | 0.00415229579539 | 0.5 | SMAD3 SMAD2 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| WP:WP5158 | 0.00434689671613 | 0.5 | SMAD3 SMAD2 | Urotensin II mediated signaling pathway |
| WP:WP2324 | 0.00449637847065 | 0.5 | SMAD3 SMAD2 | AGE RAGE pathway |
| HP:0012180 | 0.0051092979876 | 0.5 | SMAD3 SMAD2 | Cystic medial necrosis |
| HP:0004959 | 0.0051092979876 | 0.5 | SMAD3 SMAD2 | Descending thoracic aorta aneurysm |
| HP:0200146 | 0.0051092979876 | 0.5 | SMAD3 SMAD2 | Mucoid extracellular matrix accumulation |
| HP:0032079 | 0.0051092979876 | 0.5 | SMAD3 SMAD2 | Medial degeneration |
| WP:WP4216 | 0.00561306746582 | 0.5 | SMAD3 SMAD2 | Chromosomal and microsatellite instability in colorectal cancer |
| HP:0012432 | 0.0057098705025 | 0.5 | SMAD3 SMAD2 | Chronic fatigue |
| HP:0012763 | 0.0057098705025 | 0.5 | SMAD3 SMAD2 | Paroxysmal dyspnea |
| WP:WP5345 | 0.00578263137464 | 0.5 | SMAD3 SMAD2 | 1p36 copy number variation syndrome |
| HP:0012499 | 0.00634372129255 | 0.5 | SMAD3 SMAD2 | Descending aortic dissection |
| KEGG:05212 | 0.00637013094617 | 0.5 | SMAD3 SMAD2 | Pancreatic cancer |
| REAC:R-HSA-2173796 | 0.00643909852192 | 0.5 | SMAD3 SMAD2 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| REAC:R-HSA-9758941 | 0.0068064250699 | 0.5 | SMAD3 SMAD2 | Gastrulation |
| KEGG:05210 | 0.00748004798883 | 0.5 | SMAD3 SMAD2 | Colorectal cancer |
| HP:0100775 | 0.00771122114953 | 0.5 | SMAD3 SMAD2 | Dural ectasia |
| HP:0004933 | 0.00771122114953 | 0.5 | SMAD3 SMAD2 | Ascending aortic dissection |
| WP:WP4263 | 0.00821485966847 | 0.5 | SMAD3 SMAD2 | Pancreatic adenocarcinoma pathway |
| REAC:R-HSA-2173789 | 0.00837722051003 | 0.5 | SMAD3 SMAD2 | TGF-beta receptor signaling activates SMADs |
| WP:WP4540 | 0.00841946044435 | 0.5 | SMAD3 SMAD2 | Hippo signaling regulation pathways |
| HP:0012163 | 0.00844485194452 | 0.5 | SMAD3 SMAD2 | Carotid artery dilatation |
| HP:0010303 | 0.00844485194452 | 0.5 | SMAD3 SMAD2 | Abnormal spinal meningeal morphology |
| HP:0005116 | 0.00844485194452 | 0.5 | SMAD3 SMAD2 | Arterial tortuosity |
| HP:0005112 | 0.00844485194452 | 0.5 | SMAD3 SMAD2 | Abdominal aortic aneurysm |
| HP:0031784 | 0.00844485194452 | 0.5 | SMAD3 SMAD2 | Abnormal ascending aorta morphology |
| KEGG:04933 | 0.00931062778609 | 0.5 | SMAD3 SMAD2 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:04659 | 0.00996493530849 | 0.5 | SMAD3 SMAD2 | Th17 cell differentiation |
| GO:0046332 | 0.0106287970558 | 0.75 | SMAD9 SMAD2 SMAD3 | SMAD binding |
| HP:0002619 | 0.0108451581837 | 0.5 | SMAD3 SMAD2 | Varicose veins |
| WP:WP2263 | 0.0113062844995 | 0.5 | SMAD3 SMAD2 | Androgen receptor network in prostate cancer |
| HP:0004948 | 0.0117117011059 | 0.5 | SMAD3 SMAD2 | Vascular tortuosity |
| GO:0060395 | 0.0124631389739 | 0.75 | SMAD9 SMAD2 SMAD3 | SMAD protein signal transduction |
| REAC:R-HSA-2173793 | 0.012504459305 | 0.5 | SMAD3 SMAD2 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| HP:0004950 | 0.0126114492305 | 0.5 | SMAD3 SMAD2 | Peripheral arterial stenosis |
| HP:0011106 | 0.0126114492305 | 0.5 | SMAD3 SMAD2 | Hypovolemia |
| HP:0011104 | 0.0126114492305 | 0.5 | SMAD3 SMAD2 | Abnormality of blood volume homeostasis |
| HP:0002647 | 0.0145105245688 | 0.5 | SMAD3 SMAD2 | Aortic dissection |
| HP:0002138 | 0.0145105245688 | 0.5 | SMAD3 SMAD2 | Subarachnoid hemorrhage |
| KEGG:04371 | 0.015160801965 | 0.5 | SMAD3 SMAD2 | Apelin signaling pathway |
| WP:WP5083 | 0.0154364529098 | 0.5 | SMAD3 SMAD2 | Neuroinflammation and glutamatergic signaling |
| HP:0030163 | 0.0158129816731 | 0.75 | SMAD9 SMAD2 SMAD3 | Abnormal vascular physiology |
| HP:0001065 | 0.0165423111708 | 0.5 | SMAD3 SMAD2 | Striae distensae |
| WP:WP2853 | 0.0165681999049 | 0.5 | SMAD3 SMAD2 | Endoderm differentiation |
| WP:WP179 | 0.0168573248614 | 0.5 | SMAD3 SMAD2 | Cell cycle |
| REAC:R-HSA-9614085 | 0.0180511544442 | 0.5 | SMAD3 SMAD2 | FOXO-mediated transcription |
| HP:0005293 | 0.018706736024 | 0.5 | SMAD3 SMAD2 | Venous insufficiency |
| HP:0002140 | 0.0198386649826 | 0.5 | SMAD3 SMAD2 | Ischemic stroke |
| WP:WP2857 | 0.0202008249203 | 0.5 | SMAD3 SMAD2 | Mesodermal commitment pathway |
| HP:0025722 | 0.021003726131 | 0.5 | SMAD3 SMAD2 | Cerebral infarct |
| KEGG:05226 | 0.0211069184789 | 0.5 | SMAD3 SMAD2 | Gastric cancer |
| WP:WP4239 | 0.0218193051527 | 0.5 | SMAD3 SMAD2 | Epithelial to mesenchymal transition in colorectal cancer |
| WP:WP4666 | 0.023499356813 | 0.5 | SMAD3 SMAD2 | Hepatitis B infection |
| KEGG:04218 | 0.0240987471983 | 0.5 | SMAD3 SMAD2 | Cellular senescence |
| HP:0001519 | 0.0246976114972 | 0.5 | SMAD3 SMAD2 | Disproportionate tall stature |
| CORUM:3199 | 0.0249718442456 | 0.25 | SMAD3 | SKI-SMAD3 complex |
| CORUM:3198 | 0.0249718442456 | 0.25 | SMAD2 | SKI-SMAD2 complex |
| CORUM:3039 | 0.0249718442456 | 0.25 | SMAD2 | SMAD2-FAST1 complex |
| CORUM:3729 | 0.0249718442456 | 0.25 | SMAD2 | SKI-SMAD2 complex |
| CORUM:3733 | 0.0249718442456 | 0.25 | SMAD3 | SKI-SMAD3 complex |
| HP:0005108 | 0.0259951101914 | 0.5 | SMAD3 SMAD2 | Abnormal intervertebral disk morphology |
| KEGG:04390 | 0.02620193588 | 0.5 | SMAD3 SMAD2 | Hippo signaling pathway |
| KEGG:04110 | 0.0280208578488 | 0.5 | SMAD3 SMAD2 | Cell cycle |
| GO:0071363 | 0.0296421612139 | 1.0 | ZFYVE9 SMAD2 SMAD3 SMAD9 | cellular response to growth factor stimulus |
| KEGG:05225 | 0.0310562109 | 0.5 | SMAD3 SMAD2 | Hepatocellular carcinoma |
| HP:0001677 | 0.0315158796726 | 0.5 | SMAD3 SMAD2 | Coronary artery atherosclerosis |
| HP:0004944 | 0.0329787201379 | 0.5 | SMAD3 SMAD2 | Dilatation of the cerebral artery |
| HP:0002758 | 0.0329787201379 | 0.5 | SMAD3 SMAD2 | Osteoarthritis |
| GO:0070848 | 0.0339527319479 | 1.0 | ZFYVE9 SMAD2 SMAD3 SMAD9 | response to growth factor |
| HP:0002326 | 0.034474601612 | 0.5 | SMAD3 SMAD2 | Transient ischemic attack |
| REAC:R-HSA-170834 | 0.0380580405855 | 0.5 | SMAD3 SMAD2 | Signaling by TGF-beta Receptor Complex |
| KEGG:05415 | 0.0406374666322 | 0.5 | SMAD3 SMAD2 | Diabetic cardiomyopathy |
| HP:0100679 | 0.0424493051949 | 0.5 | SMAD3 SMAD2 | Lack of skin elasticity |
| KEGG:05166 | 0.0480473295333 | 0.5 | SMAD3 SMAD2 | Human T-cell leukemia virus 1 infection |
| CORUM:6513 | 0.049938562206 | 0.25 | SMAD2 | MAN1-SMAD2 complex |
| CORUM:3972 | 0.049938562206 | 0.25 | SMAD3 | Ubiquitin E3 ligase (SMURF2, SMAD3) - SnoN complex, TGF(beta)-dependent |
| CORUM:3959 | 0.049938562206 | 0.25 | SMAD3 | SKI-SMAD3-SMAD4 complex, TGF(beta)-dependent |
| CORUM:3749 | 0.049938562206 | 0.25 | SMAD2 | CREBBP-SMAD2 hexameric complex |
| CORUM:1831 | 0.049938562206 | 0.25 | SMAD3 | PIAS3-SMAD3-P300 complex |
| CORUM:3739 | 0.049938562206 | 0.25 | SMAD2 | SKI-SMAD2-SMAD4 pentameric complex |
| CORUM:2813 | 0.049938562206 | 0.25 | SMAD3 | BRCA1-SMAD3 complex |
| CORUM:3205 | 0.049938562206 | 0.25 | SMAD3 | SMAD3-SKI-NCOR complex |
| CORUM:3204 | 0.049938562206 | 0.25 | SMAD2 | SMAD2-SKI-NCOR complex |
| CORUM:3038 | 0.049938562206 | 0.25 | SMAD2 | SMAD2-SMAD4-FAST1 complex |
| CORUM:2968 | 0.049938562206 | 0.25 | SMAD3 | Axin-SMAD3 complex |
| CORUM:3740 | 0.049938562206 | 0.25 | SMAD3 | SKI-SMAD3-SMAD4 complex |
| CORUM:3750 | 0.049938562206 | 0.25 | SMAD3 | CREBBP-SMAD3 hexameric complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ZFYVE9 | SMAD2 | 0.998 | 0.088 |
mutually_exclusive (Q99717)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ZFYVE9 | SMAD3 | 0.996 | 0.212 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| SMAD2 | SMAD3 | 0.993 | 0.29 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SMAD3 | SMAD9 | 0.989 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SMAD2 | SMAD9 | 0.965 |
mutually_exclusive (P84022)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| ZFYVE9 | SMAD9 | 0.353 |
mutually_exclusive (P84022)
|
bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes