hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05182.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PPFIA3 | Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) | 5 | UniProt NCBI |
| IGBP1 | Immunoglobulin-binding protein 1 (B-cell signal transduction molecule alpha 4) (Protein alpha-4) (CD79a-binding protein 1) (Protein phosphatase 2/4/6 regulatory subunit) (Renal carcinoma antigen NY-REN-16) | 5 | UniProt NCBI |
| PPP4R1 | Serine/threonine-protein phosphatase 4 regulatory subunit 1 | 4 | UniProt NCBI |
| ANKLE2 | Ankyrin repeat and LEM domain-containing protein 2 (LEM domain-containing protein 4) | 5 | UniProt NCBI |
| PRR14 | Proline-rich protein 14 | 5 | UniProt NCBI |
| PPP4C | Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) (Protein phosphatase X) (PP-X) | 5 | UniProt NCBI |
| PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta) | 5 | UniProt NCBI |
| FECH | Ferrochelatase, mitochondrial (EC 4.98.1.1) (Heme synthase) (Protoheme ferro-lyase) | 5 | UniProt NCBI |
| CCDC6 | Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4) | 5 | UniProt NCBI |
| PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4949 | 8.02558195695e-11 | 0.666666666667 | IGBP1 PPP2CB CCDC6 PPP4C PPP4R1 PPP2R5D | 16p11 2 proximal deletion syndrome |
| GO:0008287 | 0.000753968512946 | 0.444444444444 | PPP4R1 PPP2R5D PPP2CB PPP4C | protein serine/threonine phosphatase complex |
| GO:1903293 | 0.000753968512946 | 0.444444444444 | PPP4R1 PPP2R5D PPP2CB PPP4C | phosphatase complex |
| REAC:R-HSA-163767 | 0.00167485737707 | 0.222222222222 | PPP2R5D PPP2CB | PP2A-mediated dephosphorylation of key metabolic factors |
| GO:0019888 | 0.00182029811799 | 0.444444444444 | IGBP1 PPP2R5D ANKLE2 PPP4R1 | protein phosphatase regulator activity |
| GO:0019208 | 0.00334782846127 | 0.444444444444 | IGBP1 PPP2R5D ANKLE2 PPP4R1 | phosphatase regulator activity |
| REAC:R-HSA-9634600 | 0.00525543712779 | 0.222222222222 | PPP2R5D PPP2CB | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism |
| REAC:R-HSA-202670 | 0.00620898744994 | 0.222222222222 | PPP2R5D PPP2CB | ERKs are inactivated |
| REAC:R-HSA-4839735 | 0.00724150508664 | 0.222222222222 | PPP2R5D PPP2CB | Signaling by AXIN mutants |
| REAC:R-HSA-4839744 | 0.00724150508664 | 0.222222222222 | PPP2R5D PPP2CB | Signaling by APC mutants |
| REAC:R-HSA-4839748 | 0.00724150508664 | 0.222222222222 | PPP2R5D PPP2CB | Signaling by AMER1 mutants |
| REAC:R-HSA-5467340 | 0.00724150508664 | 0.222222222222 | PPP2R5D PPP2CB | AXIN missense mutants destabilize the destruction complex |
| REAC:R-HSA-5467337 | 0.00724150508664 | 0.222222222222 | PPP2R5D PPP2CB | APC truncation mutants have impaired AXIN binding |
| REAC:R-HSA-5467348 | 0.00724150508664 | 0.222222222222 | PPP2R5D PPP2CB | Truncations of AMER1 destabilize the destruction complex |
| KEGG:04136 | 0.0073475567725 | 0.222222222222 | IGBP1 PPP2CB | Autophagy - other |
| REAC:R-HSA-5339716 | 0.00835291407054 | 0.222222222222 | PPP2R5D PPP2CB | Signaling by GSK3beta mutants |
| REAC:R-HSA-4839743 | 0.00835291407054 | 0.222222222222 | PPP2R5D PPP2CB | Signaling by CTNNB1 phospho-site mutants |
| REAC:R-HSA-5358751 | 0.00835291407054 | 0.222222222222 | PPP2R5D PPP2CB | CTNNB1 S45 mutants aren't phosphorylated |
| REAC:R-HSA-5358752 | 0.00835291407054 | 0.222222222222 | PPP2R5D PPP2CB | CTNNB1 T41 mutants aren't phosphorylated |
| REAC:R-HSA-5358749 | 0.00835291407054 | 0.222222222222 | PPP2R5D PPP2CB | CTNNB1 S37 mutants aren't phosphorylated |
| REAC:R-HSA-5358747 | 0.00835291407054 | 0.222222222222 | PPP2R5D PPP2CB | CTNNB1 S33 mutants aren't phosphorylated |
| REAC:R-HSA-432142 | 0.00954313848115 | 0.222222222222 | PPP2R5D PPP2CB | Platelet sensitization by LDL |
| REAC:R-HSA-196299 | 0.0108121024449 | 0.222222222222 | PPP2R5D PPP2CB | Beta-catenin phosphorylation cascade |
| REAC:R-HSA-389513 | 0.0121597301349 | 0.222222222222 | PPP2R5D PPP2CB | CTLA4 inhibitory signaling |
| WP:WP5117 | 0.0141704493256 | 0.222222222222 | PPP2R5D PPP2CB | Cohesin complex Cornelia de Lange syndrome |
| REAC:R-HSA-180024 | 0.0150906736209 | 0.222222222222 | PPP2R5D PPP2CB | DARPP-32 events |
| REAC:R-HSA-198753 | 0.0166738379974 | 0.222222222222 | PPP2R5D PPP2CB | ERK/MAPK targets |
| WP:WP500 | 0.0202568688475 | 0.222222222222 | PPP2R5D PPP2CB | Glycogen synthesis and degradation |
| REAC:R-HSA-450282 | 0.0344394959621 | 0.222222222222 | PPP2R5D PPP2CB | MAPK targets/ Nuclear events mediated by MAP kinases |
| REAC:R-HSA-5673000 | 0.0344394959621 | 0.222222222222 | PPP2R5D PPP2CB | RAF activation |
| REAC:R-HSA-4641262 | 0.0368028731299 | 0.222222222222 | PPP2R5D PPP2CB | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| GO:0004721 | 0.041079120868 | 0.444444444444 | PPP4R1 PPP2R5D PPP2CB PPP4C | phosphoprotein phosphatase activity |
| REAC:R-HSA-4791275 | 0.0417623735111 | 0.222222222222 | PPP2R5D PPP2CB | Signaling by WNT in cancer |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PPP4R1 | CCDC6 | 1.0 | 0.072 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 boldt_WMM |
| PPP2R5D | PPP2CB | 1.0 | 0.204 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 fraction boldt_WMM |
| PPP4C | CCDC6 | 1.0 | 0.142 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM |
| PPP4R1 | PPP4C | 1.0 | 0.18 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 boldt_WMM |
| PPP4C | PPP2CB | 0.999 | 0.354 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM treiber_WMM |
| IGBP1 | PPP4C | 0.999 | 0.282 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| PRR14 | PPP2R5D | 0.998 | 0.084 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PRR14 | PPP2CB | 0.995 | 0.199142857143 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ANKLE2 | PPP2CB | 0.994 | 0.084 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM |
| IGBP1 | PPP2CB | 0.993 | 0.27 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () bioplex3_HCT116 fraction boldt_WMM |
| PPP4R1 | PPP2CB | 0.993 | 0.234 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| CCDC6 | PPP2CB | 0.992 | 0.122 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| PPFIA3 | PPP2CB | 0.992 | 0.098 | hein_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| ANKLE2 | PPP4R1 | 0.989 | 0.04 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PPP4C | PPP2R5D | 0.986 | 0.172 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| FECH | PPP2CB | 0.985 | 0.108 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| IGBP1 | CCDC6 | 0.985 | 0.102 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| IGBP1 | PPP4R1 | 0.983 | 0.154 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| FECH | PPP4R1 | 0.983 | 0.018 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PRR14 | CCDC6 | 0.981 | 0.062 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PPFIA3 | PPP2R5D | 0.981 | 0.094 | hein_WMM bioplex3_WMM WMM_only |
| PPP4R1 | PPP2R5D | 0.976 | 0.106 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ANKLE2 | FECH | 0.971 | 0.026 | hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| PPFIA3 | CCDC6 | 0.969 | 0.09 | hein_WMM bioplex3_WMM WMM_only |
| PPP4R1 | PRR14 | 0.961 | 0.056 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| FECH | PPFIA3 | 0.961 | 0.062 | hein_WMM bioplex3_WMM WMM_only |
| PPFIA3 | PRR14 | 0.961 | 0.054 | hein_WMM bioplex3_WMM WMM_only |
| PPP2R5D | CCDC6 | 0.96 | 0.072 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| FECH | CCDC6 | 0.959 | 0.012 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ANKLE2 | PPFIA3 | 0.959 | 0.156 | hein_WMM bioplex3_WMM WMM_only |
| FECH | PPP2R5D | 0.95 | 0.054 | hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| FECH | PPP4C | 0.948 | 0.046 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PPFIA3 | PPP4C | 0.946 | 0.094 | hein_WMM bioplex3_WMM WMM_only |
| ANKLE2 | PPP2R5D | 0.941 | 0.074 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| ANKLE2 | CCDC6 | 0.94 | 0.046 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM fraction |
| ANKLE2 | PRR14 | 0.939 | 0.064 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PPFIA3 | PPP4R1 | 0.929 | 0.064 | hein_WMM bioplex3_WMM WMM_only |
| FECH | IGBP1 | 0.927 | 0.026 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| FECH | PRR14 | 0.861 | 0.034 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PRR14 | PPP4C | 0.806 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| IGBP1 | PPP2R5D | 0.771 | 0.112 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| ANKLE2 | IGBP1 | 0.533 | 0.054 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| IGBP1 | PRR14 | 0.298 | 0.04 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ANKLE2 | PPP4C | 0.277 | 0.144 | hein_WMM bioplex3_WMM youn_WMM WMM_only |
| PPFIA3 | IGBP1 | 0.179 | 0.06 | hein_WMM bioplex3_WMM WMM_only |
Related Complexes