hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05193.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TP73 | Tumor protein p73 (p53-like transcription factor) (p53-related protein) | 5 | UniProt NCBI |
| TP63 | Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6803207 | 4.78453290596e-05 | 1.0 | TP63 TP73 | TP53 Regulates Transcription of Caspase Activators and Caspases |
| REAC:R-HSA-139915 | 6.15154230766e-05 | 1.0 | TP63 TP73 | Activation of PUMA and translocation to mitochondria |
| WP:WP1742 | 7.2783930122e-05 | 1.0 | TP63 TP73 | TP53 network |
| REAC:R-HSA-6804759 | 9.39818963671e-05 | 1.0 | TP63 TP73 | Regulation of TP53 Activity through Association with Co-factors |
| REAC:R-HSA-6803211 | 0.000112778275641 | 1.0 | TP63 TP73 | TP53 Regulates Transcription of Death Receptors and Ligands |
| REAC:R-HSA-6803205 | 0.000133283416666 | 1.0 | TP63 TP73 | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain |
| REAC:R-HSA-6803204 | 0.000292198259614 | 1.0 | TP63 TP73 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release |
| REAC:R-HSA-114452 | 0.000743311362176 | 1.0 | TP63 TP73 | Activation of BH3-only proteins |
| WP:WP254 | 0.00111857408398 | 1.0 | TP63 TP73 | Apoptosis |
| REAC:R-HSA-5633008 | 0.00120125951175 | 1.0 | TP63 TP73 | TP53 Regulates Transcription of Cell Death Genes |
| REAC:R-HSA-109606 | 0.00226581808332 | 1.0 | TP63 TP73 | Intrinsic Pathway for Apoptosis |
| REAC:R-HSA-5633007 | 0.0196097498674 | 1.0 | TP63 TP73 | Regulation of TP53 Activity |
| GO:0097371 | 0.0210690324038 | 1.0 | TP63 TP73 | MDM2/MDM4 family protein binding |
| REAC:R-HSA-109581 | 0.0234014921954 | 1.0 | TP63 TP73 | Apoptosis |
| HP:0000389 | 0.0291002126388 | 1.0 | TP63 TP73 | Chronic otitis media |
| REAC:R-HSA-5357801 | 0.0319897287616 | 1.0 | TP63 TP73 | Programmed Cell Death |
| WP:WP3655 | 0.0435328773163 | 0.5 | TP63 | Hypothetical craniofacial development pathway |
| HP:0002287 | 0.0499436884913 | 0.5 | TP63 | Progressive alopecia |
| HP:0007717 | 0.0499436884913 | 0.5 | TP63 | Chronic irritative conjunctivitis |
| HP:0031088 | 0.0499436884913 | 0.5 | TP63 | Vaginal dryness |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TP73 | TP63 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| TP73 | huMAP3_05193.1 huMAP3_09433.1 |
| TP63 | huMAP3_05193.1 huMAP3_09433.1 huMAP3_11513.1 |