hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05213.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MPZL2 | Myelin protein zero-like protein 2 (Epithelial V-like antigen 1) | 5 | UniProt NCBI |
| HLA-DRB5 | HLA class II histocompatibility antigen, DR beta 5 chain (DR beta-5) (DR2-beta-2) (Dw2) (MHC class II antigen DRB5) | 5 | UniProt NCBI |
| HLA-DRB1 | HLA class II histocompatibility antigen, DRB1 beta chain (Human leukocyte antigen DRB1) (HLA-DRB1) | 5 | UniProt NCBI |
| HLA-DPB1 | HLA class II histocompatibility antigen, DP beta 1 chain (HLA class II histocompatibility antigen, DP(W4) beta chain) (MHC class II antigen DPB1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05310 | 2.33266642449e-07 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Asthma |
| REAC:R-HSA-202430 | 4.0111272408e-07 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Translocation of ZAP-70 to Immunological synapse |
| REAC:R-HSA-202427 | 9.53498684462e-07 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Phosphorylation of CD3 and TCR zeta chains |
| KEGG:05330 | 1.0028742148e-06 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Allograft rejection |
| KEGG:04672 | 1.12316139724e-06 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Intestinal immune network for IgA production |
| REAC:R-HSA-389948 | 1.14413965008e-06 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | PD-1 signaling |
| KEGG:05332 | 1.54085228371e-06 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Graft-versus-host disease |
| KEGG:04940 | 2.24311561366e-06 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Type I diabetes mellitus |
| REAC:R-HSA-202433 | 2.8370403595e-06 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Generation of second messenger molecules |
| KEGG:05320 | 3.38522311544e-06 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Autoimmune thyroid disease |
| KEGG:05321 | 4.22779284136e-06 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Inflammatory bowel disease |
| KEGG:05150 | 7.13131503768e-06 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Staphylococcus aureus infection |
| KEGG:05416 | 8.49257304271e-06 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Viral myocarditis |
| KEGG:04640 | 1.11278026553e-05 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Hematopoietic cell lineage |
| KEGG:04612 | 1.231807766e-05 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Antigen processing and presentation |
| KEGG:05140 | 1.2943754201e-05 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Leishmaniasis |
| WP:WP2328 | 1.66891072317e-05 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Allograft rejection |
| KEGG:05323 | 1.71467161414e-05 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Rheumatoid arthritis |
| KEGG:04658 | 2.21720662311e-05 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Th1 and Th2 cell differentiation |
| KEGG:04659 | 4.01491324891e-05 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Th17 cell differentiation |
| REAC:R-HSA-388841 | 4.09441910601e-05 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Costimulation by the CD28 family |
| KEGG:05145 | 4.15157123412e-05 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Toxoplasmosis |
| GO:0002399 | 4.61210427592e-05 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | MHC class II protein complex assembly |
| GO:0002503 | 4.61210427592e-05 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | peptide antigen assembly with MHC class II protein complex |
| KEGG:04514 | 6.21896513057e-05 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Cell adhesion molecules |
| GO:0042613 | 6.34131776058e-05 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | MHC class II protein complex |
| KEGG:05322 | 6.9706157818e-05 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Systemic lupus erythematosus |
| WP:WP4217 | 8.8077388901e-05 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Ebola virus infection in host |
| REAC:R-HSA-877300 | 9.82762051365e-05 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Interferon gamma signaling |
| GO:0002396 | 0.000109904886398 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | MHC protein complex assembly |
| GO:0002501 | 0.000109904886398 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | peptide antigen assembly with MHC protein complex |
| KEGG:04145 | 0.000127763882829 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Phagosome |
| REAC:R-HSA-202424 | 0.000158650980172 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Downstream TCR signaling |
| KEGG:05164 | 0.000166087532962 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Influenza A |
| KEGG:05152 | 0.000173136486645 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Tuberculosis |
| GO:0042611 | 0.000215165225046 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | MHC protein complex |
| REAC:R-HSA-202403 | 0.000269276548599 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | TCR signaling |
| WP:WP4884 | 0.000306067313039 | 0.5 | HLA-DRB1 HLA-DRB5 | Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex |
| KEGG:05169 | 0.000325152133201 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Epstein-Barr virus infection |
| REAC:R-HSA-2132295 | 0.000362881762367 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | MHC class II antigen presentation |
| KEGG:05166 | 0.000433035444638 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Human T-cell leukemia virus 1 infection |
| GO:0023026 | 0.000437924933217 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | MHC class II protein complex binding |
| GO:0019886 | 0.000510886175237 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| GO:0098553 | 0.000591522022343 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | lumenal side of endoplasmic reticulum membrane |
| GO:0002495 | 0.000777349058504 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | antigen processing and presentation of peptide antigen via MHC class II |
| GO:0002504 | 0.000883305813556 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| GO:0042605 | 0.000883305813556 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | peptide antigen binding |
| GO:0023023 | 0.00112321912057 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | MHC protein complex binding |
| GO:0002478 | 0.00112321912057 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | antigen processing and presentation of exogenous peptide antigen |
| REAC:R-HSA-913531 | 0.00122110889015 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Interferon Signaling |
| GO:0098576 | 0.00155882617412 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | lumenal side of membrane |
| GO:0019884 | 0.00172575455775 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | antigen processing and presentation of exogenous antigen |
| KEGG:05168 | 0.00275266829871 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | Herpes simplex virus 1 infection |
| HP:0025439 | 0.00400802433742 | 0.5 | HLA-DRB1 HLA-DPB1 | Pharyngitis |
| HP:0025389 | 0.0057098705025 | 0.5 | HLA-DRB1 HLA-DPB1 | Pulmonary interstitial high-resolution computed tomography abnormality |
| GO:0003823 | 0.00582352741409 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | antigen binding |
| GO:0012507 | 0.00663460918661 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | ER to Golgi transport vesicle membrane |
| GO:0048002 | 0.0079870728422 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | antigen processing and presentation of peptide antigen |
| HP:0100721 | 0.0092117244708 | 0.5 | HLA-DRB1 HLA-DPB1 | Mediastinal lymphadenopathy |
| HP:0001701 | 0.0117117011059 | 0.5 | HLA-DRB1 HLA-DPB1 | Pericarditis |
| GO:0030669 | 0.0131184183431 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | clathrin-coated endocytic vesicle membrane |
| GO:0045334 | 0.0238272099283 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | clathrin-coated endocytic vesicle |
| GO:0030134 | 0.0238272099283 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | COPII-coated ER to Golgi transport vesicle |
| HP:0045026 | 0.0259951101914 | 0.5 | HLA-DRB1 HLA-DPB1 | Abnormal mediastinum morphology |
| GO:0019882 | 0.0269276802074 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | antigen processing and presentation |
| HP:0003565 | 0.03008608933 | 0.5 | HLA-DRB1 HLA-DPB1 | Elevated erythrocyte sedimentation rate |
| HP:0011227 | 0.03008608933 | 0.5 | HLA-DRB1 HLA-DPB1 | Elevated circulating C-reactive protein concentration |
| GO:0031902 | 0.0302857026499 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | late endosome membrane |
| HP:0032436 | 0.0329787201379 | 0.5 | HLA-DRB1 HLA-DPB1 | Abnormal circulating C-reactive protein concentration |
| HP:0025021 | 0.0329787201379 | 0.5 | HLA-DRB1 HLA-DPB1 | Abnormal erythrocyte sedimentation rate |
| HP:0045027 | 0.036003514982 | 0.5 | HLA-DRB1 HLA-DPB1 | Abnormality of the thoracic cavity |
| HP:0100758 | 0.036003514982 | 0.5 | HLA-DRB1 HLA-DPB1 | Gangrene |
| WP:WP5115 | 0.0365498826325 | 0.5 | HLA-DRB1 HLA-DRB5 | Network map of SARS CoV 2 signaling pathway |
| HP:0002113 | 0.0375654511359 | 0.5 | HLA-DRB1 HLA-DPB1 | Pulmonary infiltrates |
| HP:0002633 | 0.0458701548093 | 0.5 | HLA-DRB1 HLA-DPB1 | Vasculitis |
| HPA:0211093 | 0.046121259966 | 0.5 | HLA-DRB1 HLA-DPB1 | fallopian tube; non-ciliated cells[High] |
| GO:0032588 | 0.0464975978221 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | trans-Golgi network membrane |
| HP:0000873 | 0.0476300363671 | 0.5 | HLA-DRB1 HLA-DPB1 | Diabetes insipidus |
| GO:0030665 | 0.048062454325 | 0.75 | HLA-DRB1 HLA-DRB5 HLA-DPB1 | clathrin-coated vesicle membrane |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HLA-DRB5 | HLA-DRB1 | 0.999 | 0.31 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| HLA-DPB1 | HLA-DRB1 | 0.992 | 0.274 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MPZL2 | HLA-DRB1 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HLA-DPB1 | HLA-DRB5 | 0.832 | 0.282 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MPZL2 | HLA-DRB5 | 0.042 | 0.086 | bioplex3_WMM WMM_only |
| MPZL2 | HLA-DPB1 | 0.026 | 0.092 | bioplex3_WMM WMM_only |
Related Complexes