hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05216.1
Complex Portal: CPX-21922
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IL6R | Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126) [Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)] | 5 | UniProt NCBI |
| CDH16 | Cadherin-16 (Kidney-specific cadherin) (Ksp-cadherin) | 5 | UniProt NCBI |
| FANCB | Fanconi anemia group B protein (Protein FACB) (Fanconi anemia-associated polypeptide of 95 kDa) (FAAP95) | 5 | UniProt NCBI |
| FANCL | E3 ubiquitin-protein ligase FANCL (EC 2.3.2.27) (Fanconi anemia group L protein) (Fanconi anemia-associated polypeptide of 43 kDa) (FAAP43) (RING-type E3 ubiquitin transferase FANCL) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6885 | 1.53774525569e-05 | 0.5 | FANCL FANCB | L-B-P100 subcomplex |
| CORUM:1152 | 0.000107602882996 | 0.5 | FANCL FANCB | FA complex (Fanconi anemia complex) |
| CORUM:245 | 0.000143457417375 | 0.5 | FANCL FANCB | FA core complex (Fanconi anemia core complex) |
| CORUM:1624 | 0.000143457417375 | 0.5 | FANCL FANCB | FA core complex (Fanconi anemia core complex) |
| CORUM:6884 | 0.000184428417548 | 0.5 | FANCL FANCB | Fanconi anemia FAAP100 complex |
| CORUM:2739 | 0.000230514481314 | 0.5 | FANCL FANCB | FA complex (Fanconi anemia complex) |
| HP:0009892 | 0.00260592941411 | 0.5 | FANCL FANCB | Anotia |
| KEGG:03460 | 0.0029370300722 | 0.5 | FANCL FANCB | Fanconi anemia pathway |
| HP:0008517 | 0.00400802433742 | 0.5 | FANCL FANCB | Aplasia/Hypoplasia of the sacrum |
| REAC:R-HSA-6783310 | 0.006081926491 | 0.5 | FANCL FANCB | Fanconi Anemia Pathway |
| HP:0005522 | 0.00771122114953 | 0.5 | FANCL FANCB | Pyridoxine-responsive sideroblastic anemia |
| HP:0010469 | 0.00844485194452 | 0.5 | FANCL FANCB | Absent testis |
| HP:0003974 | 0.0092117244708 | 0.5 | FANCL FANCB | Absent radius |
| HP:0009822 | 0.0100118295947 | 0.5 | FANCL FANCB | Aplasia involving forearm bones |
| HP:0003953 | 0.0100118295947 | 0.5 | FANCL FANCB | Absent forearm bone |
| HP:0100867 | 0.0117117011059 | 0.5 | FANCL FANCB | Duodenal stenosis |
| HP:0002032 | 0.0117117011059 | 0.5 | FANCL FANCB | Esophageal atresia |
| HP:0012848 | 0.0117117011059 | 0.5 | FANCL FANCB | Small intestinal stenosis |
| HP:0010293 | 0.0117117011059 | 0.5 | FANCL FANCB | Aplasia/Hypoplasia of the uvula |
| HP:0100760 | 0.0126114492305 | 0.5 | FANCL FANCB | Clubbing of toes |
| HP:0002245 | 0.0126114492305 | 0.5 | FANCL FANCB | Meckel diverticulum |
| HP:0100587 | 0.0145105245688 | 0.5 | FANCL FANCB | Abnormal preputium morphology |
| WP:WP4946 | 0.0159973744593 | 0.5 | FANCL FANCB | DNA repair pathways full network |
| HP:0001924 | 0.0165423111708 | 0.5 | FANCL FANCB | Sideroblastic anemia |
| HP:0001549 | 0.0222019103471 | 0.5 | FANCL FANCB | Abnormal ileum morphology |
| HP:0000813 | 0.0329787201379 | 0.5 | FANCL FANCB | Bicornuate uterus |
| HP:0007874 | 0.0375654511359 | 0.5 | FANCL FANCB | Almond-shaped palpebral fissure |
| HP:0100026 | 0.0391604009626 | 0.5 | FANCL FANCB | Arteriovenous malformation |
| HP:0003022 | 0.0424493051949 | 0.5 | FANCL FANCB | Hypoplasia of the ulna |
| HP:0003220 | 0.0441432413831 | 0.5 | FANCL FANCB | Abnormality of chromosome stability |
| HP:0200005 | 0.0458701548093 | 0.5 | FANCL FANCB | Abnormal shape of the palpebral fissure |
| HP:0009777 | 0.0458701548093 | 0.5 | FANCL FANCB | Absent thumb |
| HP:0006495 | 0.049422876951 | 0.5 | FANCL FANCB | Aplasia/Hypoplasia of the ulna |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FANCL | FANCB | 0.991 | 0.226 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM | |
| CDH16 | FANCL | 0.975 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| IL6R | FANCL | 0.96 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| IL6R | FANCB | 0.96 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes