hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05226.1

Complex Portal: CPX-15504

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
BOD1L1	Biorientation of chromosomes in cell division protein 1-like 1	5	UniProt NCBI
SETD1A	Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)	5	UniProt NCBI
SETD1B	Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B)	5	UniProt NCBI
KMT2A	Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]	5	UniProt NCBI
HCFC2	Host cell factor 2 (HCF-2) (C2 factor)	5	UniProt NCBI
KDM6A	Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A)	5	UniProt NCBI
DPY30	Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L)	5	UniProt NCBI
ASH2L	Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2-like protein)	5	UniProt NCBI
RBBP5	Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)	5	UniProt NCBI
KMT2C	Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)	5	UniProt NCBI
BOD1	Biorientation of chromosomes in cell division protein 1 (Biorientation defective protein 1) (Protein FAM44B)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9772755	3.6928926222e-27	1.0	KMT2A BOD1L1 ASH2L SETD1A RBBP5 BOD1 SETD1B HCFC2 KDM6A DPY30 KMT2C	Formation of WDR5-containing histone-modifying complexes
GO:0035097	2.2925054484e-22	1.0	KMT2A BOD1L1 ASH2L SETD1A RBBP5 BOD1 SETD1B HCFC2 KDM6A DPY30 KMT2C	histone methyltransferase complex
GO:0034708	1.45904000817e-20	1.0	KMT2A BOD1L1 ASH2L SETD1A RBBP5 BOD1 SETD1B HCFC2 KDM6A DPY30 KMT2C	methyltransferase complex
REAC:R-HSA-212165	1.05337327685e-19	1.0	KMT2A BOD1L1 ASH2L SETD1A RBBP5 BOD1 SETD1B HCFC2 KDM6A DPY30 KMT2C	Epigenetic regulation of gene expression
GO:0048188	4.8028121718e-19	0.727272727273	BOD1L1 HCFC2 RBBP5 BOD1 SETD1B SETD1A ASH2L DPY30	Set1C/COMPASS complex
CORUM:6470	6.14266278829e-19	0.636363636364	BOD1L1 HCFC2 RBBP5 BOD1 SETD1B ASH2L DPY30	Set1B complex
CORUM:6461	6.95147910138e-13	0.454545454545	KMT2C KDM6A RBBP5 DPY30 ASH2L	MLL3 complex
CORUM:6469	1.38981992441e-12	0.454545454545	SETD1A ASH2L RBBP5 DPY30 HCFC2	Set1A complex
CORUM:5195	1.38981992441e-12	0.454545454545	KMT2C KDM6A RBBP5 DPY30 ASH2L	PTIP-HMT complex
REAC:R-HSA-3214841	2.89436471634e-12	0.636363636364	KMT2A KMT2C SETD1A RBBP5 SETD1B ASH2L DPY30	PKMTs methylate histone lysines
REAC:R-HSA-8936459	9.45704500561e-12	0.636363636364	KMT2A KMT2C SETD1A RBBP5 SETD1B ASH2L DPY30	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
CORUM:6851	5.76350611564e-11	0.363636363636	KMT2A RBBP5 DPY30 ASH2L	MWRAD complex (MLL1, WDR5, RBBP5, ASH2L, DPY30)
REAC:R-HSA-3247509	2.68161417525e-10	0.727272727273	KMT2A KMT2C SETD1A RBBP5 SETD1B ASH2L KDM6A DPY30	Chromatin modifying enzymes
REAC:R-HSA-4839726	2.68161417525e-10	0.727272727273	KMT2A KMT2C SETD1A RBBP5 SETD1B ASH2L KDM6A DPY30	Chromatin organization
GO:1990234	4.48299201665e-10	1.0	KMT2A BOD1L1 ASH2L SETD1A RBBP5 BOD1 SETD1B HCFC2 KDM6A DPY30 KMT2C	transferase complex
REAC:R-HSA-74160	6.70090981098e-10	1.0	KMT2A BOD1L1 ASH2L SETD1A RBBP5 BOD1 SETD1B HCFC2 KDM6A DPY30 KMT2C	Gene expression (Transcription)
CORUM:6462	8.05963357471e-10	0.363636363636	KMT2A RBBP5 DPY30 ASH2L	MLL1 complex
WP:WP5351	1.0229231024e-09	0.454545454545	KMT2C KDM6A RBBP5 DPY30 ASH2L	Kleefstra syndrome
CORUM:6467	1.45017792512e-09	0.363636363636	KDM6A RBBP5 DPY30 ASH2L	MLL4 complex
GO:0044666	1.91798962418e-09	0.454545454545	KMT2C KDM6A RBBP5 DPY30 ASH2L	MLL3/4 complex
CORUM:6460	2.41603666192e-09	0.363636363636	HCFC2 RBBP5 DPY30 ASH2L	MLL2 complex
CORUM:3075	5.69057779739e-09	0.363636363636	KMT2C KDM6A RBBP5 ASH2L	UTX-MLL2/3 complex
REAC:R-HSA-8878171	9.6362550819e-09	0.636363636364	KMT2A KMT2C SETD1A RBBP5 SETD1B ASH2L DPY30	Transcriptional regulation by RUNX1
GO:0140513	2.22565858581e-08	1.0	KMT2A BOD1L1 ASH2L SETD1A RBBP5 BOD1 SETD1B HCFC2 KDM6A DPY30 KMT2C	nuclear protein-containing complex
CORUM:6457	8.42140472852e-08	0.272727272727	KMT2A RBBP5 ASH2L	MLL1 core complex
CORUM:6849	8.42140472852e-08	0.272727272727	ASH2L DPY30 RBBP5	WRAD complex (WDR5, RBBP5, ASH2L, DPY30)
CORUM:2731	4.20724492332e-07	0.272727272727	SETD1A RBBP5 ASH2L	Set1A complex
CORUM:2730	4.20724492332e-07	0.272727272727	ASH2L SETD1B RBBP5	Set1B complex
GO:0071339	7.00568210819e-07	0.454545454545	KMT2A ASH2L RBBP5 DPY30 HCFC2	MLL1 complex
CORUM:1400	7.35965509424e-07	0.272727272727	ASH2L RBBP5 KMT2C	ASCOM complex
CORUM:1256	7.35965509424e-07	0.272727272727	KMT2A RBBP5 ASH2L	MLL-HCF complex
CORUM:1254	7.35965509424e-07	0.272727272727	ASH2L DPY30 RBBP5	Menin-associated histone methyltransferase complex
GO:1902494	7.89780451133e-07	1.0	KMT2A BOD1L1 ASH2L SETD1A RBBP5 BOD1 SETD1B HCFC2 KDM6A DPY30 KMT2C	catalytic complex
GO:0044665	8.3001854745e-07	0.454545454545	KMT2A ASH2L RBBP5 DPY30 HCFC2	MLL1/2 complex
REAC:R-HSA-5617472	2.10995286644e-06	0.454545454545	KMT2C KDM6A RBBP5 DPY30 ASH2L	Activation of anterior HOX genes in hindbrain development during early embryogenesis
REAC:R-HSA-5619507	2.10995286644e-06	0.454545454545	KMT2C KDM6A RBBP5 DPY30 ASH2L	Activation of HOX genes during differentiation
CORUM:1401	2.52020279376e-06	0.272727272727	SETD1A RBBP5 KMT2A	MOF complex
GO:0042800	2.85776567317e-06	0.363636363636	KMT2C SETD1A SETD1B KMT2A	histone H3K4 methyltransferase activity
KEGG:00310	3.67833724774e-06	0.363636363636	KMT2C SETD1A SETD1B KMT2A	Lysine degradation
WP:WP2369	9.88982940917e-06	0.363636363636	KMT2C SETD1A SETD1B KMT2A	Histone modifications
CORUM:5386	5.42466075419e-05	0.272727272727	KMT2A RBBP5 ASH2L	MLL1-WDR5 complex
CORUM:6850	0.000102551658964	0.181818181818	ASH2L RBBP5	WRA complex (WDR5, RBBP5, ASH2L)
CORUM:7367	0.000102551658964	0.181818181818	ASH2L RBBP5	ASH2L-KDM6B-KDM6B-WDR5 complex
CORUM:1399	0.000205019103882	0.181818181818	ASH2L RBBP5	WDR5-ASH2L-RBBP5-MLL2 complex
CORUM:6845	0.000205019103882	0.181818181818	ASH2L RBBP5	NIF1-ASH2L-RBBP5-WDR5 complex
GO:0045815	0.000308911252354	0.363636363636	KMT2A RBBP5 DPY30 ASH2L	transcription initiation-coupled chromatin remodeling
CORUM:6340	0.000341558207359	0.181818181818	ASH2L RBBP5	PITX2-MLL4-ASH2L-RBBP5-PTIP complex
GO:0141137	0.00035138481807	0.363636363636	KMT2A RBBP5 DPY30 ASH2L	positive regulation of gene expression, epigenetic
GO:0006325	0.000401078542902	0.636363636364	KMT2A ASH2L SETD1A RBBP5 HCFC2 KDM6A DPY30	chromatin organization
GO:0140938	0.00044927642714	0.363636363636	KMT2C SETD1A SETD1B KMT2A	histone H3 methyltransferase activity
REAC:R-HSA-212436	0.000544477779925	0.636363636364	KMT2A KMT2C SETD1A RBBP5 SETD1B ASH2L DPY30	Generic Transcription Pathway
GO:0071824	0.001108873533	0.636363636364	KMT2A ASH2L SETD1A RBBP5 HCFC2 KDM6A DPY30	protein-DNA complex organization
REAC:R-HSA-73857	0.0011419141294	0.636363636364	KMT2A KMT2C SETD1A RBBP5 SETD1B ASH2L DPY30	RNA Polymerase II Transcription
GO:0042054	0.00139431270595	0.363636363636	KMT2C SETD1A SETD1B KMT2A	histone methyltransferase activity
GO:0016279	0.00152343109181	0.363636363636	KMT2C SETD1A SETD1B KMT2A	protein-lysine N-methyltransferase activity
GO:0016278	0.00166128673178	0.363636363636	KMT2C SETD1A SETD1B KMT2A	lysine N-methyltransferase activity
GO:0140993	0.00355126244096	0.454545454545	KMT2C SETD1A KDM6A SETD1B KMT2A	histone modifying activity
REAC:R-HSA-1266738	0.00363268138211	0.545454545455	KMT2A KMT2C RBBP5 KDM6A ASH2L DPY30	Developmental Biology
CORUM:2721	0.00408022457695	0.181818181818	SETD1A ASH2L	HCF-1 complex
KEGG:04934	0.00488559896554	0.272727272727	KMT2A RBBP5 ASH2L	Cushing syndrome
HP:0007655	0.00714132578593	0.181818181818	KMT2A KDM6A	Eversion of lateral third of lower eyelids
GO:0006338	0.0079647250948	0.545454545455	KMT2A HCFC2 RBBP5 ASH2L KDM6A DPY30	chromatin remodeling
GO:0008170	0.0102701755771	0.363636363636	KMT2C SETD1A SETD1B KMT2A	N-methyltransferase activity
GO:0005654	0.0105448660706	1.0	KMT2A BOD1L1 ASH2L SETD1A RBBP5 BOD1 SETD1B HCFC2 KDM6A DPY30 KMT2C	nucleoplasm
GO:0008276	0.0120389546625	0.363636363636	KMT2C SETD1A SETD1B KMT2A	protein methyltransferase activity
CORUM:1257	0.0127895235697	0.181818181818	KMT2A RBBP5	ALL-1 supercomplex
GO:0031981	0.0214587900711	1.0	KMT2A BOD1L1 ASH2L SETD1A RBBP5 BOD1 SETD1B HCFC2 KDM6A DPY30 KMT2C	nuclear lumen

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
RBBP5	ASH2L	1.0	0.438	structurally_consistent (dimer)
RBBP5	SETD1A	1.0	0.208	mutually_exclusive (P61964)
SETD1B	RBBP5	1.0	0.106
KMT2A	HCFC2	1.0	0.144
HCFC2	ASH2L	0.999	0.276
HCFC2	SETD1A	0.999	0.462
SETD1B	ASH2L	0.999	0.22
BOD1L1	SETD1A	0.999	0.392
BOD1L1	HCFC2	0.999	0.188
SETD1A	ASH2L	0.999	0.566
KMT2A	RBBP5	0.999	0.156
BOD1L1	RBBP5	0.999	0.324
BOD1	ASH2L	0.999	0.182
RBBP5	BOD1	0.998	0.134
DPY30	RBBP5	0.998	0.466
BOD1L1	ASH2L	0.998	0.386
KMT2A	ASH2L	0.997	0.196
DPY30	ASH2L	0.997	0.414
SETD1B	BOD1	0.996	0.166
HCFC2	RBBP5	0.996	0.348
KDM6A	RBBP5	0.993	0.316	mutually_exclusive (P61964)
BOD1L1	KDM6A	0.98	0.15
SETD1B	KDM6A	0.976	0.28
KMT2A	KDM6A	0.976	0.284
KDM6A	ASH2L	0.973	0.204
RBBP5	KMT2C	0.972	0.094
SETD1B	SETD1A	0.96	0.304
KMT2C	ASH2L	0.955	0.082
BOD1L1	BOD1	0.955	0.132
BOD1L1	KMT2A	0.947	0.18
SETD1B	KMT2A	0.946	0.222
HCFC2	DPY30	0.945	0.34
BOD1L1	SETD1B	0.945	0.196
KMT2A	SETD1A	0.941	0.204
BOD1	SETD1A	0.94	0.062
KDM6A	SETD1A	0.93	0.228
SETD1B	HCFC2	0.842	0.154
KDM6A	DPY30	0.824	0.212
KDM6A	BOD1	0.798	0.152
HCFC2	KDM6A	0.769	0.22
DPY30	BOD1	0.673	0.104
DPY30	SETD1A	0.606	0.154
BOD1L1	DPY30	0.499	0.362
SETD1B	DPY30	0.452	0.212
KMT2A	BOD1	0.373	0.15
KMT2A	DPY30	0.362	0.078
HCFC2	BOD1	0.276	0.236
KDM6A	KMT2C	0.266	0.166
KMT2C	SETD1A	0.095	0.144
HCFC2	KMT2C	0.082	0.112
SETD1B	KMT2C	0.079	0.104
KMT2C	BOD1	0.079	0.096
BOD1L1	KMT2C	0.079	0.096
DPY30	KMT2C	0.078	0.1
KMT2A	KMT2C	0.071	0.07

Related Complexes

Genename	Complexes
BOD1L1	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
SETD1A	huMAP3_02698.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
SETD1B	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
KMT2A	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
HCFC2	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
KDM6A	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
DPY30	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1 huMAP3_13844.1
ASH2L	huMAP3_05226.1 huMAP3_06804.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
RBBP5	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1
KMT2C	huMAP3_00564.1 huMAP3_05226.1 huMAP3_06804.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1 huMAP3_12999.1
BOD1	huMAP3_00564.1 huMAP3_05226.1 huMAP3_07065.1 huMAP3_08776.1 huMAP3_08895.1 huMAP3_09051.1 huMAP3_09422.1 huMAP3_10027.1 huMAP3_10650.1 huMAP3_11602.1 huMAP3_11792.1 huMAP3_15215.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05226.1

Complex Portal: CPX-15504