hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05229.1

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
COL5A2	Collagen alpha-2(V) chain	5	UniProt NCBI
PRSS23	Serine protease 23 (EC 3.4.21.-) (Putative secreted protein Zsig13)	4	UniProt NCBI
COL5A1	Collagen alpha-1(V) chain	5	UniProt NCBI
CHI3L1	Chitinase-3-like protein 1 (39 kDa synovial protein) (Cartilage glycoprotein 39) (CGP-39) (GP-39) (hCGP-39) (YKL-40)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
HP:0025509	0.000100319571443	0.5	COL5A2 COL5A1	Piezogenic pedal papules
HP:0025014	0.000100319571443	0.5	COL5A2 COL5A1	Subcutaneous spheroids
HP:0030009	0.000200620835246	0.5	COL5A2 COL5A1	Cervical insufficiency
HP:0004872	0.000200620835246	0.5	COL5A2 COL5A1	Incisional hernia
HP:0000993	0.000334337547576	0.5	COL5A2 COL5A1	Molluscoid pseudotumors
HP:0003771	0.000334337547576	0.5	COL5A2 COL5A1	Pulp calcification
WP:WP2911	0.000390164573598	0.5	COL5A2 COL5A1	miRNA targets in ECM and membrane receptors
HP:0010749	0.000501460556964	0.5	COL5A2 COL5A1	Blepharochalasis
HP:0006243	0.000501460556964	0.5	COL5A2 COL5A1	Phalangeal dislocation
HP:0000139	0.000501460556964	0.5	COL5A2 COL5A1	Uterine prolapse
HP:0100823	0.000501460556964	0.5	COL5A2 COL5A1	Genital hernia
HP:0010750	0.000701980712879	0.5	COL5A2 COL5A1	Dermatochalasis
HP:0025019	0.000935888865729	0.5	COL5A2 COL5A1	Arterial rupture
HP:0004947	0.00120317586686	0.5	COL5A2 COL5A1	Arteriovenous fistula
HP:0001073	0.00150383256857	0.5	COL5A2 COL5A1	Cigarette-paper scars
HP:0005294	0.00220521848756	0.5	COL5A2 COL5A1	Arterial dissection
HP:0012888	0.00220521848756	0.5	COL5A2 COL5A1	Abnormal uterine cervix morphology
HP:0001027	0.00220521848756	0.5	COL5A2 COL5A1	Soft, doughy skin
REAC:R-HSA-3000170	0.00236402400204	0.5	COL5A2 COL5A1	Syndecan interactions
HP:0001704	0.00260592941411	0.5	COL5A2 COL5A1	Tricuspid valve prolapse
GO:0005588	0.0028092043205	0.5	COL5A2 COL5A1	collagen type V trimer
GO:1903225	0.0028092043205	0.5	COL5A2 COL5A1	negative regulation of endodermal cell differentiation
REAC:R-HSA-8874081	0.00282403231951	0.5	COL5A2 COL5A1	MET activates PTK2 signaling
HP:0010754	0.00303997345979	0.5	COL5A2 COL5A1	Abnormality of the temporomandibular joint
HP:0003834	0.00350734148159	0.5	COL5A2 COL5A1	Shoulder dislocation
REAC:R-HSA-419037	0.00359044851421	0.5	COL5A2 COL5A1	NCAM1 interactions
HP:0001788	0.00400802433742	0.5	COL5A2 COL5A1	Premature rupture of membranes
REAC:R-HSA-8948216	0.00444848198459	0.5	COL5A2 COL5A1	Collagen chain trimerization
REAC:R-HSA-8875878	0.00573491177379	0.5	COL5A2 COL5A1	MET promotes cell motility
KEGG:04974	0.00584836845565	0.5	COL5A2 COL5A1	Protein digestion and absorption
REAC:R-HSA-375165	0.008795277704	0.5	COL5A2 COL5A1	NCAM signaling for neurite out-growth
REAC:R-HSA-2022090	0.0110375739361	0.5	COL5A2 COL5A1	Assembly of collagen fibrils and other multimeric structures
REAC:R-HSA-186797	0.0115164156767	0.5	COL5A2 COL5A1	Signaling by PDGF
REAC:R-HSA-3000171	0.0115164156767	0.5	COL5A2 COL5A1	Non-integrin membrane-ECM interactions
REAC:R-HSA-1442490	0.0120053783973	0.5	COL5A2 COL5A1	Collagen degradation
REAC:R-HSA-1650814	0.0135329645116	0.5	COL5A2 COL5A1	Collagen biosynthesis and modifying enzymes
HP:0001030	0.0155098335254	0.5	COL5A2 COL5A1	Fragile skin
HP:0001063	0.0155098335254	0.5	COL5A2 COL5A1	Acrocyanosis
HP:0002036	0.0165423111708	0.5	COL5A2 COL5A1	Hiatus hernia
HP:0001065	0.0165423111708	0.5	COL5A2 COL5A1	Striae distensae
GO:1903224	0.0168521501606	0.5	COL5A2 COL5A1	regulation of endodermal cell differentiation
REAC:R-HSA-3000178	0.0168610262513	0.5	COL5A2 COL5A1	ECM proteoglycans
HP:0001075	0.0176079483787	0.5	COL5A2 COL5A1	Atrophic scars
HP:0000015	0.0176079483787	0.5	COL5A2 COL5A1	Bladder diverticulum
HP:0034033	0.0176079483787	0.5	COL5A2 COL5A1	Peripheral cyanosis
HP:0000977	0.018706736024	0.5	COL5A2 COL5A1	Soft skin
HP:0001278	0.018706736024	0.5	COL5A2 COL5A1	Orthostatic hypotension
HP:0100540	0.0198386649826	0.5	COL5A2 COL5A1	Palpebral edema
REAC:R-HSA-216083	0.0199119958937	0.5	COL5A2 COL5A1	Integrin cell surface interactions
HP:0002761	0.0222019103471	0.5	COL5A2 COL5A1	Generalized joint hypermobility
HP:0001058	0.0222019103471	0.5	COL5A2 COL5A1	Poor wound healing
HP:0003010	0.0234332085093	0.5	COL5A2 COL5A1	Prolonged bleeding time
REAC:R-HSA-6806834	0.0239057396727	0.5	COL5A2 COL5A1	Signaling by MET
HP:0001702	0.0259951101914	0.5	COL5A2 COL5A1	Abnormal tricuspid valve morphology
HP:0001386	0.0259951101914	0.5	COL5A2 COL5A1	Joint swelling
REAC:R-HSA-1474290	0.0260384914588	0.5	COL5A2 COL5A1	Collagen formation
HP:0003083	0.0273256954732	0.5	COL5A2 COL5A1	Dislocated radial head
HP:0003995	0.0315158796726	0.5	COL5A2 COL5A1	Abnormality of the radial head
HP:0004944	0.0329787201379	0.5	COL5A2 COL5A1	Dilatation of the cerebral artery
HP:0002758	0.0329787201379	0.5	COL5A2 COL5A1	Osteoarthritis
HP:0006479	0.036003514982	0.5	COL5A2 COL5A1	Abnormal dental pulp morphology
HP:0031364	0.0391604009626	0.5	COL5A2 COL5A1	Ecchymosis
HP:0100026	0.0391604009626	0.5	COL5A2 COL5A1	Arteriovenous malformation
HP:0002035	0.0391604009626	0.5	COL5A2 COL5A1	Rectal prolapse
HP:0100744	0.0391604009626	0.5	COL5A2 COL5A1	Abnormality of the humeroradial joint
HP:0009763	0.0391604009626	0.5	COL5A2 COL5A1	Limb pain
HP:0100679	0.0424493051949	0.5	COL5A2 COL5A1	Lack of skin elasticity

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
PRSS23	COL5A1	0.996	0.178	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
COL5A2	COL5A1	0.991	0.444	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
PRSS23	CHI3L1	0.99		bioplex3_WMM bioplex3_HCT116 WMM_only
PRSS23	COL5A2	0.988	0.16	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CHI3L1	COL5A1	0.675	0.13	bioplex3_WMM WMM_only
CHI3L1	COL5A2	0.108		bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
COL5A2	huMAP3_01608.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_05229.1 huMAP3_05718.1 huMAP3_06555.1 huMAP3_07100.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10095.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_13038.1 huMAP3_14646.1
PRSS23	huMAP3_00851.1 huMAP3_01608.1 huMAP3_05229.1 huMAP3_10095.1 huMAP3_11407.1 huMAP3_12644.1 huMAP3_13422.1
COL5A1	huMAP3_01608.1 huMAP3_02991.1 huMAP3_03159.1 huMAP3_05229.1 huMAP3_05718.1 huMAP3_06555.1 huMAP3_07100.1 huMAP3_07149.1 huMAP3_08295.1 huMAP3_09435.1 huMAP3_10095.1 huMAP3_10699.1 huMAP3_10984.1 huMAP3_12884.1 huMAP3_13038.1
CHI3L1	huMAP3_00851.1 huMAP3_03784.1 huMAP3_04714.1 huMAP3_05229.1 huMAP3_11660.1 huMAP3_14699.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05229.1