hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05259.1
Complex Portal: CPX-19790
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FUS | RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein) | 5 | UniProt NCBI |
| TAF15 | TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1332 | 0.000324664732905 | 1.0 | TAF15 FUS | Large Drosha complex |
| HP:0009067 | 0.00180445241025 | 1.0 | TAF15 FUS | Progressive spinal muscular atrophy |
| KEGG:05202 | 0.00194026930354 | 1.0 | TAF15 FUS | Transcriptional misregulation in cancer |
| HP:0008955 | 0.00203342648503 | 1.0 | TAF15 FUS | Progressive distal muscular atrophy |
| HP:0033683 | 0.00240251902349 | 1.0 | TAF15 FUS | Jaw hyperreflexia |
| HP:0025425 | 0.00240251902349 | 1.0 | TAF15 FUS | Laryngospasm |
| HP:0030195 | 0.00266566833332 | 1.0 | TAF15 FUS | Fatigable weakness of swallowing muscles |
| HP:0025424 | 0.00323297723503 | 1.0 | TAF15 FUS | Abnormal larynx physiology |
| HP:0012473 | 0.00323297723503 | 1.0 | TAF15 FUS | Tongue atrophy |
| HP:0007354 | 0.00353713682691 | 1.0 | TAF15 FUS | Amyotrophic lateral sclerosis |
| HP:0002145 | 0.0038549665128 | 1.0 | TAF15 FUS | Frontotemporal dementia |
| HP:0000217 | 0.00418646629272 | 1.0 | TAF15 FUS | Xerostomia |
| HP:0007269 | 0.00418646629272 | 1.0 | TAF15 FUS | Spinal muscular atrophy |
| HP:0030196 | 0.00470934738887 | 1.0 | TAF15 FUS | Fatigable weakness of respiratory muscles |
| HP:0030192 | 0.0054543675128 | 1.0 | TAF15 FUS | Fatigable weakness of bulbar muscles |
| HP:0007373 | 0.00604901660254 | 1.0 | TAF15 FUS | Motor neuron atrophy |
| HP:0002450 | 0.00849254590808 | 1.0 | TAF15 FUS | Abnormal motor neuron morphology |
| HP:0002180 | 0.009230730985 | 1.0 | TAF15 FUS | Neurodegeneration |
| HP:0012757 | 0.00973994198714 | 1.0 | TAF15 FUS | Abnormal neuron morphology |
| HP:0004326 | 0.0122005589102 | 1.0 | TAF15 FUS | Cachexia |
| HP:0000713 | 0.0159119894358 | 1.0 | TAF15 FUS | Agitation |
| HP:0003473 | 0.0193807757926 | 1.0 | TAF15 FUS | Fatigable weakness |
| HP:0003398 | 0.0197464508076 | 1.0 | TAF15 FUS | Abnormal synaptic transmission at the neuromuscular junction |
| HP:0012535 | 0.0197464508076 | 1.0 | TAF15 FUS | Abnormal synaptic transmission |
| HP:0030191 | 0.0197464508076 | 1.0 | TAF15 FUS | Abnormal peripheral nervous system synaptic transmission |
| HPA:0381203 | 0.0220168680517 | 1.0 | TAF15 FUS | placenta; hofbauer cells[High] |
| HP:0003324 | 0.0224018665704 | 1.0 | TAF15 FUS | Generalized muscle weakness |
| HP:0002380 | 0.0224018665704 | 1.0 | TAF15 FUS | Fasciculations |
| HP:0009027 | 0.0244011178204 | 1.0 | TAF15 FUS | Foot dorsiflexor weakness |
| HP:0003484 | 0.0282150740512 | 1.0 | TAF15 FUS | Upper limb muscle weakness |
| HP:0000711 | 0.0286559345832 | 1.0 | TAF15 FUS | Restlessness |
| HPA:0381213 | 0.0307158929988 | 1.0 | TAF15 FUS | placenta; syncytiotrophoblasts - cell body[High] |
| HP:0003470 | 0.0318376489657 | 1.0 | TAF15 FUS | Paralysis |
| HP:0003394 | 0.0361744862926 | 1.0 | TAF15 FUS | Muscle spasm |
| HPA:0381202 | 0.0376010915058 | 1.0 | TAF15 FUS | placenta; hofbauer cells[>=Medium] |
| HP:0000712 | 0.0387034536857 | 1.0 | TAF15 FUS | Emotional lability |
| HPA:0381201 | 0.047783554467 | 1.0 | TAF15 FUS | placenta; hofbauer cells[>=Low] |
| HP:0100755 | 0.0496737041344 | 1.0 | TAF15 FUS | Abnormality of salivation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FUS | TAF15 | 0.955 | 0.666 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () treiber_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| FUS | huMAP3_05259.1 huMAP3_09409.1 huMAP3_14523.1 |
| TAF15 | huMAP3_05259.1 huMAP3_06354.1 huMAP3_08869.1 huMAP3_09409.1 huMAP3_09539.1 huMAP3_12158.1 huMAP3_14523.1 |