hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05263.1

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
PCMTD1	Protein-L-isoaspartate O-methyltransferase domain-containing protein 1	5	UniProt NCBI
LRRC41	Leucine-rich repeat-containing protein 41 (Protein Muf1)	5	UniProt NCBI
TULP4	Tubby-related protein 4 (Tubby superfamily protein) (Tubby-like protein 4)	5	UniProt NCBI
SOCS2	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)	5	UniProt NCBI
ASB2	Ankyrin repeat and SOCS box protein 2 (ASB-2)	5	UniProt NCBI
PCMTD2	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2	5	UniProt NCBI
SOCS5	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2 protein 6) (CIS-6) (Cytokine-inducible SH2-containing protein 5)	5	UniProt NCBI
SOCS4	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7)	5	UniProt NCBI
RNF7	RING-box protein 2 (Rbx2) (CKII beta-binding protein 1) (CKBBP1) (RING finger protein 7) (Regulator of cullins 2) (Sensitive to apoptosis gene protein)	5	UniProt NCBI
LRRC28	Leucine-rich repeat-containing protein 28	2	UniProt NCBI
ASB13	Ankyrin repeat and SOCS box protein 13 (ASB-13)	5	UniProt NCBI
WSB1	WD repeat and SOCS box-containing protein 1 (WSB-1) (SOCS box-containing WD protein SWiP-1)	5	UniProt NCBI
CUL5	Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)	5	UniProt NCBI
CISH	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)	5	UniProt NCBI
ASB1	Ankyrin repeat and SOCS box protein 1 (ASB-1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-8951664	3.49058608157e-15	0.733333333333	ASB1 SOCS2 WSB1 SOCS5 ASB13 LRRC41 ASB2 CUL5 TULP4 RNF7 CISH	Neddylation
CORUM:208	4.2408504662e-07	0.2	CUL5 RNF7 ASB1	Ubiquitin E3 ligase (ASB1, TCEB1, TCEB2, CUL5, RNF7)
CORUM:207	4.2408504662e-07	0.2	ASB2 RNF7 CUL5	Ubiquitin E3 ligase (ASB2, TCEB1, TCEB2, CUL5, RNF7)
REAC:R-HSA-597592	4.35617616317e-07	0.733333333333	ASB1 SOCS2 WSB1 SOCS5 ASB13 LRRC41 ASB2 CUL5 TULP4 RNF7 CISH	Post-translational protein modification
REAC:R-HSA-983168	1.56070649097e-06	0.466666666667	ASB1 WSB1 CUL5 LRRC41 ASB2 ASB13 RNF7	Antigen processing: Ubiquitination & Proteasome degradation
REAC:R-HSA-983169	6.42147366902e-06	0.466666666667	ASB1 WSB1 CUL5 LRRC41 ASB2 ASB13 RNF7	Class I MHC mediated antigen processing & presentation
REAC:R-HSA-392499	1.4066078217e-05	0.733333333333	ASB1 SOCS2 WSB1 SOCS5 ASB13 LRRC41 ASB2 CUL5 TULP4 RNF7 CISH	Metabolism of proteins
KEGG:04917	2.20608123943e-05	0.266666666667	SOCS2 SOCS4 CISH SOCS5	Prolactin signaling pathway
GO:0046935	3.57366752742e-05	0.266666666667	SOCS2 SOCS4 CISH SOCS5	1-phosphatidylinositol-3-kinase regulator activity
REAC:R-HSA-168256	0.000212704739192	0.666666666667	ASB1 CISH WSB1 SOCS5 ASB13 ASB2 LRRC41 SOCS2 CUL5 RNF7	Immune System
CORUM:211	0.000286035615974	0.133333333333	CUL5 RNF7	Ubiquitin E3 ligase (ASB12, TCEB1, TCEB2, CUL5, RNF7)
KEGG:04630	0.000444431259365	0.266666666667	SOCS2 SOCS4 CISH SOCS5	JAK-STAT signaling pathway
GO:0005942	0.000448632865791	0.266666666667	SOCS2 SOCS4 CISH SOCS5	phosphatidylinositol 3-kinase complex
CORUM:214	0.000476443303259	0.133333333333	WSB1 CUL5	Ubiquitin E3 ligase (WSB1, TCEB1, TCEB2, CUL5, RBX1)
CORUM:209	0.000476443303259	0.133333333333	CUL5 RNF7	Ubiquitin E3 ligase (ASB6, TCEB1, TCEB2, CUL5, RNF7)
CORUM:210	0.000476443303259	0.133333333333	CUL5 RNF7	Ubiquitin E3 ligase (ASB7, TCEB1, TCEB2, CUL5, RNF7)
REAC:R-HSA-1280218	0.000542048782842	0.466666666667	ASB1 WSB1 CUL5 LRRC41 ASB2 ASB13 RNF7	Adaptive Immune System
GO:1990234	0.000607667975081	0.6	ASB1 PCMTD1 SOCS5 CUL5 ASB2 SOCS2 SOCS4 RNF7 CISH	transferase complex
GO:0031466	0.00366015186856	0.2	CUL5 PCMTD1 RNF7	Cul5-RING ubiquitin ligase complex
GO:0046854	0.00624235062122	0.266666666667	SOCS2 SOCS4 CISH SOCS5	phosphatidylinositol phosphate biosynthetic process
WP:WP5358	0.0436496232857	0.133333333333	SOCS2 CISH	JAK STAT signaling in the regulation of Beta cells
KEGG:04930	0.0449150412235	0.133333333333	SOCS2 SOCS4	Type II diabetes mellitus

Edges

Protein 1	Protein 2	Score	ProteomeHD
CISH	CUL5	1.0
RNF7	CUL5	1.0	0.544
SOCS2	CUL5	0.999
TULP4	CUL5	0.999
LRRC41	CUL5	0.999	0.018
SOCS5	CUL5	0.998
ASB1	CUL5	0.998	0.096
LRRC28	CUL5	0.998
WSB1	CUL5	0.997
SOCS4	CUL5	0.997
RNF7	SOCS2	0.997
SOCS5	RNF7	0.997
ASB1	RNF7	0.997	0.138
ASB13	RNF7	0.997
WSB1	RNF7	0.997
SOCS4	RNF7	0.997
ASB13	CUL5	0.993
LRRC41	RNF7	0.992	0.03
RNF7	CISH	0.991
PCMTD1	CUL5	0.991	0.034
RNF7	PCMTD1	0.99	0.082
PCMTD2	RNF7	0.98	0.128
PCMTD2	CUL5	0.976	0.06
TULP4	RNF7	0.974
ASB2	CUL5	0.961
PCMTD2	PCMTD1	0.941	0.136
ASB13	SOCS5	0.925
SOCS4	SOCS2	0.925
WSB1	SOCS2	0.925
ASB13	SOCS4	0.925
SOCS5	SOCS2	0.925
ASB13	WSB1	0.925
SOCS5	SOCS4	0.913
WSB1	SOCS5	0.913
WSB1	SOCS4	0.913
ASB13	SOCS2	0.912
WSB1	CISH	0.907
SOCS4	CISH	0.907
SOCS5	CISH	0.907
SOCS5	LRRC28	0.877
WSB1	LRRC28	0.877
SOCS4	LRRC28	0.877
ASB13	CISH	0.873
LRRC28	SOCS2	0.868
ASB13	LRRC28	0.868
ASB13	ASB1	0.844
ASB1	WSB1	0.841
ASB1	SOCS5	0.841
ASB1	SOCS4	0.841
ASB1	SOCS2	0.823
SOCS5	TULP4	0.821
TULP4	SOCS4	0.821
WSB1	TULP4	0.821
ASB1	PCMTD2	0.816	0.076
LRRC41	SOCS4	0.812
LRRC41	WSB1	0.812
LRRC41	SOCS5	0.812
PCMTD1	SOCS2	0.802
ASB13	TULP4	0.8
LRRC41	LRRC28	0.788
CISH	SOCS2	0.787
ASB1	CISH	0.786
TULP4	SOCS2	0.786
PCMTD2	SOCS5	0.785
PCMTD2	WSB1	0.785
PCMTD2	SOCS4	0.785
ASB13	PCMTD2	0.783
WSB1	PCMTD1	0.778
SOCS5	PCMTD1	0.778
SOCS4	PCMTD1	0.778
LRRC41	TULP4	0.777
LRRC41	ASB13	0.765
ASB13	PCMTD1	0.763
LRRC41	SOCS2	0.759
LRRC41	ASB1	0.757	0.11
ASB1	TULP4	0.754
ASB1	PCMTD1	0.745	0.074
ASB1	LRRC28	0.741
RNF7	LRRC28	0.741
LRRC41	PCMTD2	0.728	0.07
TULP4	LRRC28	0.716
PCMTD2	TULP4	0.685
PCMTD2	LRRC28	0.68
LRRC28	PCMTD1	0.644
LRRC41	PCMTD1	0.631	0.014
LRRC41	CISH	0.625
TULP4	PCMTD1	0.512
CISH	PCMTD1	0.459
PCMTD2	SOCS2	0.356
LRRC28	CISH	0.333
TULP4	CISH	0.265
PCMTD2	CISH	0.133

Related Complexes

Genename	Complexes
PCMTD1	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1 huMAP3_14346.1
LRRC41	huMAP3_00145.1 huMAP3_02336.1 huMAP3_02504.1 huMAP3_04750.1 huMAP3_05263.1 huMAP3_06952.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_10962.1 huMAP3_13601.1
TULP4	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
SOCS2	huMAP3_04750.1 huMAP3_05263.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
ASB2	huMAP3_01110.1 huMAP3_05263.1 huMAP3_10502.1 huMAP3_14158.1
PCMTD2	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1 huMAP3_14346.1
SOCS5	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
SOCS4	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
RNF7	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
LRRC28	huMAP3_04750.1 huMAP3_05263.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
ASB13	huMAP3_01436.1 huMAP3_04750.1 huMAP3_05263.1 huMAP3_06301.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09431.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
WSB1	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
CUL5	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_06706.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
CISH	huMAP3_04750.1 huMAP3_05263.1 huMAP3_05894.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_13601.1
ASB1	huMAP3_01555.1 huMAP3_02310.1 huMAP3_04750.1 huMAP3_05263.1 huMAP3_05980.1 huMAP3_06706.1 huMAP3_07874.1 huMAP3_08919.1 huMAP3_09980.1 huMAP3_10502.1 huMAP3_12652.1 huMAP3_13601.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05263.1