hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05269.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TICRR | Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein) | 5 | UniProt NCBI |
| HELB | DNA helicase B (hDHB) (EC 3.6.4.12) | 5 | UniProt NCBI |
| RBL1 | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | 5 | UniProt NCBI |
| SCAPER | S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291) | 5 | UniProt NCBI |
| CCNA2 | Cyclin-A2 (Cyclin-A) (Cyclin A) | 5 | UniProt NCBI |
| CCNA1 | Cyclin-A1 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04110 | 8.36690855792e-06 | 0.666666666667 | TICRR CCNA1 RBL1 CCNA2 | Cell cycle |
| REAC:R-HSA-1538133 | 1.83108883385e-05 | 0.5 | CCNA1 RBL1 CCNA2 | G0 and Early G1 |
| CORUM:5144 | 5.12534978153e-05 | 0.333333333333 | RBL1 CCNA2 | E2F1-p107-cyclinA complex |
| CORUM:1661 | 5.12534978153e-05 | 0.333333333333 | RBL1 CCNA2 | E2F4-p107-cyclinA complex |
| REAC:R-HSA-170145 | 7.74455426548e-05 | 0.333333333333 | CCNA1 CCNA2 | Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes |
| REAC:R-HSA-6791312 | 9.96428056205e-05 | 0.5 | CCNA1 RBL1 CCNA2 | TP53 Regulates Transcription of Cell Cycle Genes |
| REAC:R-HSA-68911 | 0.00025805759528 | 0.333333333333 | CCNA1 CCNA2 | G2 Phase |
| WP:WP179 | 0.000686980450846 | 0.5 | CCNA1 RBL1 CCNA2 | Cell cycle |
| KEGG:04218 | 0.000872061762815 | 0.5 | CCNA1 RBL1 CCNA2 | Cellular senescence |
| REAC:R-HSA-6804116 | 0.00200991204249 | 0.333333333333 | CCNA1 CCNA2 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest |
| KEGG:05203 | 0.00204140619094 | 0.5 | CCNA1 RBL1 CCNA2 | Viral carcinogenesis |
| REAC:R-HSA-69206 | 0.00247941542207 | 0.5 | CCNA1 RBL1 CCNA2 | G1/S Transition |
| REAC:R-HSA-1362300 | 0.00270466310657 | 0.333333333333 | RBL1 CCNA2 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| REAC:R-HSA-453279 | 0.00358509487789 | 0.5 | CCNA1 RBL1 CCNA2 | Mitotic G1 phase and G1/S transition |
| REAC:R-HSA-171319 | 0.00650743774508 | 0.333333333333 | CCNA1 CCNA2 | Telomere Extension By Telomerase |
| REAC:R-HSA-69273 | 0.00771351163082 | 0.333333333333 | CCNA1 CCNA2 | Cyclin A/B1/B2 associated events during G2/M transition |
| KEGG:05165 | 0.00797489844932 | 0.5 | CCNA1 RBL1 CCNA2 | Human papillomavirus infection |
| REAC:R-HSA-69205 | 0.00902151290218 | 0.333333333333 | CCNA1 RBL1 | G1/S-Specific Transcription |
| KEGG:05221 | 0.0123104747863 | 0.333333333333 | CCNA1 CCNA2 | Acute myeloid leukemia |
| REAC:R-HSA-6804757 | 0.0152705482636 | 0.333333333333 | CCNA1 CCNA2 | Regulation of TP53 Degradation |
| REAC:R-HSA-6806003 | 0.0161658624528 | 0.333333333333 | CCNA1 CCNA2 | Regulation of TP53 Expression and Degradation |
| WP:WP5293 | 0.0170615762461 | 0.333333333333 | CCNA1 CCNA2 | Acute myeloid leukemia |
| WP:WP1403 | 0.0182415379951 | 0.333333333333 | CCNA1 CCNA2 | AMP activated protein kinase signaling |
| GO:0097124 | 0.0210651876021 | 0.333333333333 | CCNA1 CCNA2 | cyclin A2-CDK2 complex |
| KEGG:04914 | 0.0237939838034 | 0.333333333333 | CCNA1 CCNA2 | Progesterone-mediated oocyte maturation |
| REAC:R-HSA-180786 | 0.0326270815028 | 0.333333333333 | CCNA1 CCNA2 | Extension of Telomeres |
| REAC:R-HSA-3700989 | 0.0427993747798 | 0.5 | CCNA1 RBL1 CCNA2 | Transcriptional Regulation by TP53 |
| KEGG:04152 | 0.045081780015 | 0.333333333333 | CCNA1 CCNA2 | AMPK signaling pathway |
| REAC:R-HSA-187577 | 0.0452196184553 | 0.333333333333 | CCNA1 CCNA2 | SCF(Skp2)-mediated degradation of p27/p21 |
| CORUM:5556 | 0.0499436884912 | 0.166666666667 | CCNA2 | CDK2-CCNA2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RBL1 | CCNA2 | 1.0 | 0.296 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| SCAPER | CCNA2 | 0.999 | 0.176 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| CCNA2 | CCNA1 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TICRR | CCNA2 | 0.955 | 0.152 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| CCNA2 | HELB | 0.952 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RBL1 | SCAPER | 0.625 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only |
| TICRR | HELB | 0.572 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only |
| CCNA1 | HELB | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| TICRR | CCNA1 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | |
| SCAPER | HELB | 0.502 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only |
| SCAPER | CCNA1 | 0.487 | bioplex_WMM bioplex3_WMM WMM_only | |
| TICRR | SCAPER | 0.487 | 0.156 | bioplex_WMM bioplex3_WMM WMM_only |
| TICRR | RBL1 | 0.172 | 0.196 | bioplex_WMM bioplex3_WMM WMM_only |
| RBL1 | HELB | 0.172 | 0.158 | bioplex_WMM bioplex3_WMM WMM_only |
| RBL1 | CCNA1 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes