hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05292.1

Complex Portal: CPX-11355

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
UBOX5	RING finger protein 37 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF37) (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (hUIP5) (Ubiquitin-conjugating enzyme 7-interacting protein 5)	5	UniProt NCBI
TAB1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1)	5	UniProt NCBI
UBXN1	UBX domain-containing protein 1 (SAPK substrate protein 1) (UBA/UBX 33.3 kDa protein)	5	UniProt NCBI
TAB3	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3)	5	UniProt NCBI
DGKQ	Diacylglycerol kinase theta (DAG kinase theta) (DGKtheta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase theta) (DGK-theta)	5	UniProt NCBI
EMILIN1	EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1)	5	UniProt NCBI
TAB2	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)	5	UniProt NCBI
TAX1BP1	Tax1-binding protein 1 (TRAF6-binding protein)	5	UniProt NCBI
MAP3K7	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:5268	3.76336611262e-10	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	TNF-alpha/NF-kappa B signaling complex 7
REAC:R-HSA-937042	3.29426179613e-09	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	IRAK2 mediated activation of TAK1 complex
REAC:R-HSA-9645460	5.17527951477e-09	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Alpha-protein kinase 1 signaling pathway
REAC:R-HSA-9014325	5.17527951477e-09	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	TICAM1,TRAF6-dependent induction of TAK1 complex
REAC:R-HSA-975163	1.12069648133e-08	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
REAC:R-HSA-937072	1.12069648133e-08	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	TRAF6-mediated induction of TAK1 complex within TLR4 complex
CORUM:2758	1.31072783286e-08	0.333333333333	MAP3K7 TAB1 TAB2	TAK1 complex
REAC:R-HSA-75893	1.52620946243e-08	0.555555555556	TAB2 MAP3K7 TAB1 TAX1BP1 TAB3	TNF signaling
REAC:R-HSA-450321	3.72634490188e-08	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
REAC:R-HSA-450302	7.57954108849e-08	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	activated TAK1 mediates p38 MAPK activation
REAC:R-HSA-168638	5.60712805559e-07	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	NOD1/2 Signaling Pathway
REAC:R-HSA-5357956	5.60712805559e-07	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	TNFR1-induced NF-kappa-B signaling pathway
WP:WP2637	7.38691399834e-07	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Interleukin 1 IL 1 structural pathway
REAC:R-HSA-445989	9.17480125108e-07	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	TAK1-dependent IKK and NF-kappa-B activation
WP:WP195	1.16309507957e-06	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	IL 1 signaling pathway
REAC:R-HSA-73887	1.32936452512e-06	0.555555555556	TAB2 MAP3K7 TAB1 TAX1BP1 TAB3	Death Receptor Signaling
REAC:R-HSA-168643	2.534741312e-06	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
CORUM:6344	4.75490888667e-06	0.333333333333	MAP3K7 TAB1 TAB2	TNF-R1-associated signaling complex
KEGG:04064	5.19250512427e-06	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	NF-kappa B signaling pathway
REAC:R-HSA-450294	5.6894576648e-06	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	MAP kinase activation
REAC:R-HSA-448424	8.62700529853e-06	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Interleukin-17 signaling
KEGG:04668	1.0408935525e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	TNF signaling pathway
WP:WP75	1.08792566126e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Toll like receptor signaling pathway
WP:WP231	1.14200808527e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	TNF alpha signaling pathway
REAC:R-HSA-2871837	1.87298045635e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	FCERI mediated NF-kB activation
REAC:R-HSA-168176	2.69008286706e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Toll Like Receptor 5 (TLR5) Cascade
REAC:R-HSA-975871	2.69008286706e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	MyD88 cascade initiated on plasma membrane
REAC:R-HSA-168142	2.69008286706e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Toll Like Receptor 10 (TLR10) Cascade
REAC:R-HSA-975138	2.96597360535e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
KEGG:04936	3.04292378738e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Alcoholic liver disease
REAC:R-HSA-975155	3.11158623875e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	MyD88 dependent cascade initiated on endosome
REAC:R-HSA-168181	3.11158623875e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Toll Like Receptor 7/8 (TLR7/8) Cascade
WP:WP3851	3.36586385976e-05	0.333333333333	MAP3K7 TAB1 TAB2	TLR4 signaling and tolerance
REAC:R-HSA-168138	3.74804354083e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Toll Like Receptor 9 (TLR9) Cascade
REAC:R-HSA-5607764	3.92129315961e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	CLEC7A (Dectin-1) signaling
REAC:R-HSA-168164	4.10045520825e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Toll Like Receptor 3 (TLR3) Cascade
REAC:R-HSA-166166	4.47704432732e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	MyD88-independent TLR4 cascade
REAC:R-HSA-937061	4.47704432732e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	TRIF(TICAM1)-mediated TLR4 signaling
REAC:R-HSA-166058	4.87888020581e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	MyD88:MAL(TIRAP) cascade initiated on plasma membrane
REAC:R-HSA-168188	4.87888020581e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Toll Like Receptor TLR6:TLR2 Cascade
REAC:R-HSA-181438	5.30705425561e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Toll Like Receptor 2 (TLR2) Cascade
REAC:R-HSA-168179	5.30705425561e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Toll Like Receptor TLR1:TLR2 Cascade
REAC:R-HSA-9020702	5.76267992814e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Interleukin-1 signaling
KEGG:04621	5.85607695532e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	NOD-like receptor signaling pathway
WP:WP4329	6.56591297121e-05	0.333333333333	MAP3K7 TAB1 TAB2	miRNA role in immune response in sepsis
CORUM:5215	8.20609246787e-05	0.222222222222	TAB1 TAB2	CS-MAP3K7IP1-MAP3K7IP2 complex
REAC:R-HSA-2454202	9.13803206472e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Fc epsilon receptor (FCERI) signaling
REAC:R-HSA-9705671	9.47387065173e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	SARS-CoV-2 activates/modulates innate and adaptive immune responses
KEGG:05130	9.54866913048e-05	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Pathogenic Escherichia coli infection
REAC:R-HSA-5621481	0.000125027974441	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	C-type lectin receptors (CLRs)
REAC:R-HSA-166016	0.000138065138157	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Toll Like Receptor 4 (TLR4) Cascade
REAC:R-HSA-446652	0.000167151000677	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Interleukin-1 family signaling
WP:WP2018	0.00022071317957	0.333333333333	MAP3K7 TAB1 TAB2	RANKL RANK signaling pathway
REAC:R-HSA-168898	0.000245601040752	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Toll-like Receptor Cascades
KEGG:05140	0.000303192388334	0.333333333333	MAP3K7 TAB1 TAB2	Leishmaniasis
KEGG:05132	0.000322205998393	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Salmonella infection
KEGG:05131	0.000339656530832	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Shigellosis
KEGG:04657	0.000583713911688	0.333333333333	MAP3K7 TAB3 TAB2	IL-17 signaling pathway
REAC:R-HSA-9705683	0.0007529287167	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	SARS-CoV-2-host interactions
KEGG:04620	0.000843198484996	0.333333333333	MAP3K7 TAB1 TAB2	Toll-like receptor signaling pathway
KEGG:05145	0.000965229215008	0.333333333333	MAP3K7 TAB1 TAB2	Toxoplasmosis
KEGG:05135	0.00194722583522	0.333333333333	MAP3K7 TAB1 TAB2	Yersinia infection
KEGG:04380	0.00194722583522	0.333333333333	MAP3K7 TAB1 TAB2	Osteoclast differentiation
REAC:R-HSA-9694516	0.00330310163066	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	SARS-CoV-2 Infection
KEGG:05161	0.00413269570012	0.333333333333	MAP3K7 TAB1 TAB2	Hepatitis B
WP:WP4666	0.00592637242666	0.333333333333	MAP3K7 TAB1 TAB2	Hepatitis B infection
KEGG:05169	0.00738827422101	0.333333333333	MAP3K7 TAB1 TAB2	Epstein-Barr virus infection
KEGG:05417	0.00738827422101	0.333333333333	MAP3K7 TAB1 TAB2	Lipid and atherosclerosis
KEGG:05170	0.00908112215612	0.333333333333	MAP3K7 TAB1 TAB2	Human immunodeficiency virus 1 infection
REAC:R-HSA-9679506	0.0116205979875	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	SARS-CoV Infections
WP:WP4496	0.0132604628613	0.222222222222	MAP3K7 TAB1	Signal transduction through IL1R
REAC:R-HSA-449147	0.0142295083868	0.444444444444	TAB2 MAP3K7 TAB1 TAB3	Signaling by Interleukins
KEGG:04010	0.0179039523177	0.333333333333	MAP3K7 TAB1 TAB2	MAPK signaling pathway
WP:WP382	0.0184784380745	0.333333333333	MAP3K7 TAB1 TAB2	MAPK signaling pathway
REAC:R-HSA-168249	0.0199047475117	0.555555555556	TAB2 MAP3K7 TAB1 TAX1BP1 TAB3	Innate Immune System
REAC:R-HSA-168256	0.0342353908338	0.666666666667	TAB3 TAX1BP1 MAP3K7 TAB1 UBOX5 TAB2	Immune System

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
TAB1	TAB2	0.999	0.156		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
TAB1	MAP3K7	0.999	0.266		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only
UBXN1	EMILIN1	0.999	0.038		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TAX1BP1	EMILIN1	0.999	0.082		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TAB1	TAB3	0.998	0.172		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
TAB2	EMILIN1	0.998	0.056		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TAB3	EMILIN1	0.998	0.03		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TAB1	EMILIN1	0.996	0.024		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
DGKQ	EMILIN1	0.996	0.0881385641925		bioplex3_WMM bioplex3_HCT116 WMM_only
MAP3K7	EMILIN1	0.995	0.062		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
UBOX5	EMILIN1	0.991	0.068		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
TAB2	MAP3K7	0.982	0.428	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
TAB3	TAB2	0.865	0.118	mutually_exclusive (O43318)	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
TAB3	MAP3K7	0.848	0.142	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
TAB3	TAX1BP1	0.775	0.118361581921		bioplex_WMM bioplex3_WMM WMM_only
TAB3	UBXN1	0.745	0.096		bioplex_WMM bioplex3_WMM WMM_only
MAP3K7	UBXN1	0.72	0.154		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
TAB2	TAX1BP1	0.53	0.126		bioplex_WMM bioplex3_WMM WMM_only
TAB1	TAX1BP1	0.506	0.038		bioplex_WMM bioplex3_WMM WMM_only
TAB1	UBXN1	0.434	0.126		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
DGKQ	TAB3	0.356	0.09		bioplex3_WMM WMM_only
DGKQ	TAB2	0.335	0.09		bioplex3_WMM WMM_only
DGKQ	MAP3K7	0.272	0.094		bioplex3_WMM WMM_only
DGKQ	UBXN1	0.261	0.102		bioplex3_WMM WMM_only
UBXN1	TAX1BP1	0.259	0.08		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
DGKQ	TAX1BP1	0.249	0.072		bioplex3_WMM WMM_only
TAX1BP1	UBOX5	0.248	0.078		bioplex_WMM bioplex3_WMM WMM_only
MAP3K7	UBOX5	0.237	0.098		bioplex_WMM bioplex3_WMM WMM_only
DGKQ	TAB1	0.22	0.092		bioplex3_WMM WMM_only
TAB2	UBOX5	0.213	0.13		bioplex_WMM bioplex3_WMM WMM_only
MAP3K7	TAX1BP1	0.197	0.038		bioplex_WMM bioplex3_WMM WMM_only
UBXN1	UBOX5	0.19	0.148		bioplex_WMM bioplex3_WMM WMM_only
TAB3	UBOX5	0.164	0.118		bioplex_WMM bioplex3_WMM WMM_only
TAB1	UBOX5	0.143	0.114		bioplex_WMM bioplex3_WMM WMM_only
TAB2	UBXN1	0.12	0.364		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
DGKQ	UBOX5	0.046	0.102		bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
UBOX5	huMAP3_05292.1 huMAP3_12717.1
TAB1	huMAP3_01078.1 huMAP3_05292.1 huMAP3_11701.1 huMAP3_12513.1 huMAP3_12717.1 huMAP3_13193.1
UBXN1	huMAP3_01770.1 huMAP3_05292.1 huMAP3_08795.1
TAB3	huMAP3_01078.1 huMAP3_05292.1 huMAP3_11701.1 huMAP3_12513.1 huMAP3_12717.1 huMAP3_13193.1
DGKQ	huMAP3_00421.1 huMAP3_00691.1 huMAP3_05292.1 huMAP3_06096.1 huMAP3_06627.1 huMAP3_11516.1 huMAP3_12385.1 huMAP3_15245.1
EMILIN1	huMAP3_05292.1 huMAP3_12717.1
TAB2	huMAP3_01078.1 huMAP3_05292.1 huMAP3_11701.1 huMAP3_12513.1 huMAP3_12717.1 huMAP3_13193.1
TAX1BP1	huMAP3_03002.1 huMAP3_05292.1 huMAP3_07091.1 huMAP3_10850.1 huMAP3_11282.1 huMAP3_11869.1 huMAP3_11874.1 huMAP3_12462.1
MAP3K7	huMAP3_01078.1 huMAP3_05292.1 huMAP3_11701.1 huMAP3_12513.1 huMAP3_12717.1 huMAP3_13193.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05292.1

Complex Portal: CPX-11355