hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05297.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RFXAP | Regulatory factor X-associated protein (RFX-associated protein) (RFX DNA-binding complex 36 kDa subunit) | 5 | UniProt NCBI |
| RFX5 | DNA-binding protein RFX5 (Regulatory factor X 5) | 5 | UniProt NCBI |
| ANKRA2 | Ankyrin repeat family A protein 2 (RFXANK-like protein 2) | 5 | UniProt NCBI |
| RFX7 | DNA-binding protein RFX7 (Regulatory factor X 7) (Regulatory factor X domain-containing protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6133 | 5.12628525639e-06 | 0.5 | RFXAP RFX5 | RFX5-RFXANK-RFXAP complex |
| HP:0031389 | 3.34429085774e-05 | 0.5 | RFXAP RFX5 | Abnormal MHC II surface expression |
| HP:0031390 | 3.34429085774e-05 | 0.5 | RFXAP RFX5 | Reduced MHC II surface expression |
| HP:0200124 | 3.34429085774e-05 | 0.5 | RFXAP RFX5 | Chronic hepatitis due to cryptosporidium infection |
| HP:0025347 | 0.000100319571443 | 0.5 | RFXAP RFX5 | Decreased circulating beta-2-microglobulin level |
| HP:0005386 | 0.000100319571443 | 0.5 | RFXAP RFX5 | Recurrent protozoan infections |
| HP:0025345 | 0.000100319571443 | 0.5 | RFXAP RFX5 | Abnormality of circulating beta-2-microglobulin level |
| HP:0007041 | 0.000100319571443 | 0.5 | RFXAP RFX5 | Chronic lymphocytic meningitis |
| HP:0000371 | 0.000100319571443 | 0.5 | RFXAP RFX5 | Acute otitis media |
| HP:0030991 | 0.000200620835246 | 0.5 | RFXAP RFX5 | Sclerosing cholangitis |
| HP:0002965 | 0.000200620835246 | 0.5 | RFXAP RFX5 | Cutaneous anergy |
| HP:0005354 | 0.000334337547576 | 0.5 | RFXAP RFX5 | Lack of T cell function |
| HP:0025465 | 0.000501460556964 | 0.5 | RFXAP RFX5 | Abnormal circulating beta globulin level |
| KEGG:05340 | 0.000878377582941 | 0.5 | RFXAP RFX5 | Primary immunodeficiency |
| HP:0032179 | 0.000935888865729 | 0.5 | RFXAP RFX5 | Abnormal circulating globulin concentration |
| HP:0002963 | 0.000935888865729 | 0.5 | RFXAP RFX5 | Abnormal delayed hypersensitivity skin test |
| HP:0200123 | 0.000935888865729 | 0.5 | RFXAP RFX5 | Chronic hepatitis |
| HP:0004385 | 0.00150383256857 | 0.5 | RFXAP RFX5 | Protracted diarrhea |
| HP:0030151 | 0.00183784982408 | 0.5 | RFXAP RFX5 | Cholangitis |
| HP:0006562 | 0.00220521848756 | 0.5 | RFXAP RFX5 | Viral hepatitis |
| HP:0031394 | 0.00260592941411 | 0.5 | RFXAP RFX5 | Abnormal CD4:CD8 ratio |
| HP:0005401 | 0.00260592941411 | 0.5 | RFXAP RFX5 | Recurrent candida infections |
| HP:0001904 | 0.00303997345979 | 0.5 | RFXAP RFX5 | Neutropenia in presence of anti-neutropil antibodies |
| HP:0004432 | 0.00454201288615 | 0.5 | RFXAP RFX5 | Agammaglobulinemia |
| KEGG:04612 | 0.00456536626645 | 0.5 | RFXAP RFX5 | Antigen processing and presentation |
| HP:0002783 | 0.00510067960952 | 0.75 | RFX7 RFXAP RFX5 | Recurrent lower respiratory tract infections |
| HP:0005353 | 0.0051092979876 | 0.5 | RFXAP RFX5 | Recurrent herpes |
| HP:0003139 | 0.0051092979876 | 0.5 | RFXAP RFX5 | Panhypogammaglobulinemia |
| HP:0034318 | 0.0057098705025 | 0.5 | RFXAP RFX5 | Unusual virus reactivation |
| HP:0034317 | 0.0057098705025 | 0.5 | RFXAP RFX5 | Unusual viral infection |
| HP:0031381 | 0.00771122114953 | 0.5 | RFXAP RFX5 | Decreased lymphocyte proliferation in response to mitogen |
| HP:0011472 | 0.00771122114953 | 0.5 | RFXAP RFX5 | Abnormal small intestinal villus morphology |
| HP:0011473 | 0.00771122114953 | 0.5 | RFXAP RFX5 | Villous atrophy |
| HP:0002726 | 0.00844485194452 | 0.5 | RFXAP RFX5 | Recurrent Staphylococcus aureus infections |
| HP:0005407 | 0.0092117244708 | 0.5 | RFXAP RFX5 | Decreased proportion of CD4-positive helper T cells |
| HP:0500267 | 0.0092117244708 | 0.5 | RFXAP RFX5 | Abnormal proportion of CD4-positive helper T cells |
| HP:0007499 | 0.0092117244708 | 0.5 | RFXAP RFX5 | Recurrent staphylococcal infections |
| HP:0025129 | 0.0092117244708 | 0.5 | RFXAP RFX5 | Abnormal small intestinal mucosa morphology |
| HP:0001890 | 0.0108451581837 | 0.5 | RFXAP RFX5 | Autoimmune hemolytic anemia |
| HP:0032218 | 0.0145105245688 | 0.5 | RFXAP RFX5 | Decreased proportion of CD4-positive T cells |
| HP:0004798 | 0.0155098335254 | 0.5 | RFXAP RFX5 | Recurrent infection of the gastrointestinal tract |
| HP:0031377 | 0.0155098335254 | 0.5 | RFXAP RFX5 | Abnormal cell proliferation |
| HP:0031378 | 0.0155098335254 | 0.5 | RFXAP RFX5 | Abnormal lymphocyte proliferation |
| HP:0001973 | 0.018706736024 | 0.5 | RFXAP RFX5 | Autoimmune thrombocytopenia |
| HP:0031392 | 0.021003726131 | 0.5 | RFXAP RFX5 | Abnormal proportion of CD4-positive T cells |
| HP:0002383 | 0.0234332085093 | 0.5 | RFXAP RFX5 | Infectious encephalitis |
| KEGG:05152 | 0.02620193588 | 0.5 | RFXAP RFX5 | Tuberculosis |
| HP:0002728 | 0.028689358225 | 0.5 | RFXAP RFX5 | Chronic mucocutaneous candidiasis |
| HP:0011840 | 0.034474601612 | 0.5 | RFXAP RFX5 | Abnormality of T cell physiology |
| HP:0004429 | 0.034474601612 | 0.5 | RFXAP RFX5 | Recurrent viral infections |
| HP:0005403 | 0.0375654511359 | 0.5 | RFXAP RFX5 | T lymphocytopenia |
| HP:0002583 | 0.040788355352 | 0.5 | RFXAP RFX5 | Colitis |
| HP:0011370 | 0.0424493051949 | 0.5 | RFXAP RFX5 | Recurrent cutaneous fungal infections |
| HP:0011123 | 0.046066142944 | 0.75 | RFX7 RFXAP RFX5 | Inflammatory abnormality of the skin |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RFXAP | RFX5 | 1.0 | 0.226 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| RFX5 | RFX7 | 0.996 | 0.056 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RFX5 | ANKRA2 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RFXAP | RFX7 | 0.786 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only |
| RFXAP | ANKRA2 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | |
| ANKRA2 | RFX7 | 0.487 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| RFXAP | huMAP3_05297.1 huMAP3_12081.1 huMAP3_14895.1 |
| RFX5 | huMAP3_05297.1 |
| ANKRA2 | huMAP3_05297.1 |
| RFX7 | huMAP3_05297.1 |