hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05326.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| POLA1 | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | 5 | UniProt NCBI |
| POLA2 | DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1100 | 1.02525705128e-05 | 1.0 | POLA1 POLA2 | DNA polymerase alpha-primase complex |
| REAC:R-HSA-68952 | 4.78453290596e-05 | 1.0 | POLA1 POLA2 | DNA replication initiation |
| CORUM:1003 | 4.78453290596e-05 | 1.0 | POLA1 POLA2 | RC complex (Replication competent complex) |
| CORUM:1107 | 6.15154230766e-05 | 1.0 | POLA1 POLA2 | DNA synthesome core complex |
| CORUM:1098 | 7.68942788458e-05 | 1.0 | POLA1 POLA2 | DNA synthesome complex (13 subunits) |
| KEGG:03030 | 0.000102418907518 | 1.0 | POLA1 POLA2 | DNA replication |
| REAC:R-HSA-113501 | 0.000133283416666 | 1.0 | POLA1 POLA2 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| CORUM:1108 | 0.000133283416666 | 1.0 | POLA1 POLA2 | DNA synthesome complex (15 subunits) |
| REAC:R-HSA-174430 | 0.000133283416666 | 1.0 | POLA1 POLA2 | Telomere C-strand synthesis initiation |
| REAC:R-HSA-69166 | 0.000155497319444 | 1.0 | POLA1 POLA2 | Removal of the Flap Intermediate |
| REAC:R-HSA-69091 | 0.000155497319444 | 1.0 | POLA1 POLA2 | Polymerase switching |
| CORUM:1099 | 0.000155497319444 | 1.0 | POLA1 POLA2 | DNA synthesome complex (17 subunits) |
| CORUM:1111 | 0.000155497319444 | 1.0 | POLA1 POLA2 | DNA synthesome complex (17 subunits) |
| REAC:R-HSA-69109 | 0.000155497319444 | 1.0 | POLA1 POLA2 | Leading Strand Synthesis |
| REAC:R-HSA-69183 | 0.000179419983974 | 1.0 | POLA1 POLA2 | Processive synthesis on the lagging strand |
| REAC:R-HSA-69186 | 0.000324664732905 | 1.0 | POLA1 POLA2 | Lagging Strand Synthesis |
| WP:WP466 | 0.00036647347272 | 1.0 | POLA1 POLA2 | DNA replication |
| REAC:R-HSA-113510 | 0.000394723964742 | 1.0 | POLA1 POLA2 | E2F mediated regulation of DNA replication |
| REAC:R-HSA-174411 | 0.000555347569442 | 1.0 | POLA1 POLA2 | Polymerase switching on the C-strand of the telomere |
| REAC:R-HSA-69190 | 0.000847545829056 | 1.0 | POLA1 POLA2 | DNA strand elongation |
| REAC:R-HSA-68962 | 0.000902226205124 | 1.0 | POLA1 POLA2 | Activation of the pre-replicative complex |
| REAC:R-HSA-174417 | 0.000958615342944 | 1.0 | POLA1 POLA2 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-180786 | 0.00217867123396 | 1.0 | POLA1 POLA2 | Extension of Telomeres |
| REAC:R-HSA-9710421 | 0.0031270340064 | 1.0 | POLA1 POLA2 | Defective pyroptosis |
| GO:0005658 | 0.00468200720083 | 1.0 | POLA1 POLA2 | alpha DNA polymerase:primase complex |
| GO:0006269 | 0.00468200720083 | 1.0 | POLA1 POLA2 | DNA replication, synthesis of RNA primer |
| REAC:R-HSA-9645723 | 0.00699737937497 | 1.0 | POLA1 POLA2 | Diseases of programmed cell death |
| REAC:R-HSA-157579 | 0.00845837067304 | 1.0 | POLA1 POLA2 | Telomere Maintenance |
| REAC:R-HSA-69239 | 0.0119972162617 | 1.0 | POLA1 POLA2 | Synthesis of DNA |
| REAC:R-HSA-73886 | 0.0136718027788 | 1.0 | POLA1 POLA2 | Chromosome Maintenance |
| REAC:R-HSA-69206 | 0.0143279672916 | 1.0 | POLA1 POLA2 | G1/S Transition |
| REAC:R-HSA-453279 | 0.0183367223621 | 1.0 | POLA1 POLA2 | Mitotic G1 phase and G1/S transition |
| REAC:R-HSA-69002 | 0.0183367223621 | 1.0 | POLA1 POLA2 | DNA Replication Pre-Initiation |
| REAC:R-HSA-69242 | 0.0214637563685 | 1.0 | POLA1 POLA2 | S Phase |
| REAC:R-HSA-69306 | 0.0257185731313 | 1.0 | POLA1 POLA2 | DNA Replication |
| HPA:0320892 | 0.0269907484521 | 1.0 | POLA1 POLA2 | nasopharynx; goblet cells[>=Medium] |
| HPA:0320891 | 0.0318803767949 | 1.0 | POLA1 POLA2 | nasopharynx; goblet cells[>=Low] |
| HP:0008757 | 0.0499436884913 | 0.5 | POLA1 | Unilateral vocal cord paralysis |
| HP:0033253 | 0.0499436884913 | 0.5 | POLA1 | Reduced circulating interferon gamma concentration |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| POLA1 | POLA2 | 0.979 | 0.84 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
Related Complexes