hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05354.1

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
NELFCD	Negative elongation factor C/D (NELF-C/D) (TH1-like protein)	5	UniProt NCBI
NELFE	Negative elongation factor E (NELF-E) (RNA-binding protein RD)	5	UniProt NCBI
GPR137B	Integral membrane protein GPR137B (Transmembrane 7 superfamily member 1 protein)	5	UniProt NCBI
XYLT1	Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (XT-I) (XylT-I)	5	UniProt NCBI
TMEM141	Transmembrane protein 141	2	UniProt NCBI
IGHMBP2	DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2)	5	UniProt NCBI
NELFB	Negative elongation factor B (NELF-B) (Cofactor of BRCA1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:2598	2.80877722849e-08	0.428571428571	NELFE NELFCD NELFB	NELF complex (Negative elongation factor complex)
CORUM:281	2.80877722849e-08	0.428571428571	NELFE NELFCD NELFB	NELF complex (Negative elongation factor complex)
GO:0032021	1.34540429244e-05	0.428571428571	NELFE NELFCD NELFB	NELF complex
WP:WP5365	1.77389368121e-05	0.428571428571	NELFE NELFCD NELFB	4p16 3 copy number variation
REAC:R-HSA-167242	2.00026744108e-05	0.428571428571	NELFE NELFCD NELFB	Abortive elongation of HIV-1 transcript in the absence of Tat
WP:WP3414	2.21509180757e-05	0.428571428571	NELFE NELFCD NELFB	Initiation of transcription and translation elongation at the HIV 1 LTR
REAC:R-HSA-167243	5.26476903505e-05	0.428571428571	NELFE NELFCD NELFB	Tat-mediated HIV elongation arrest and recovery
REAC:R-HSA-167238	5.26476903505e-05	0.428571428571	NELFE NELFCD NELFB	Pausing and recovery of Tat-mediated HIV elongation
REAC:R-HSA-167158	6.42919230078e-05	0.428571428571	NELFE NELFCD NELFB	Formation of the HIV-1 Early Elongation Complex
REAC:R-HSA-167290	6.42919230078e-05	0.428571428571	NELFE NELFCD NELFB	Pausing and recovery of HIV elongation
REAC:R-HSA-167287	6.42919230078e-05	0.428571428571	NELFE NELFCD NELFB	HIV elongation arrest and recovery
REAC:R-HSA-113418	6.42919230078e-05	0.428571428571	NELFE NELFCD NELFB	Formation of the Early Elongation Complex
KEGG:03250	0.000101617882229	0.428571428571	NELFE NELFCD NELFB	Viral life cycle - HIV-1
REAC:R-HSA-167246	0.00014849904315	0.428571428571	NELFE NELFCD NELFB	Tat-mediated elongation of the HIV-1 transcript
REAC:R-HSA-167169	0.00014849904315	0.428571428571	NELFE NELFCD NELFB	HIV Transcription Elongation
REAC:R-HSA-167200	0.00014849904315	0.428571428571	NELFE NELFCD NELFB	Formation of HIV-1 elongation complex containing HIV-1 Tat
REAC:R-HSA-167152	0.000171246735353	0.428571428571	NELFE NELFCD NELFB	Formation of HIV elongation complex in the absence of HIV Tat
REAC:R-HSA-75955	0.000377325314633	0.428571428571	NELFE NELFCD NELFB	RNA Polymerase II Transcription Elongation
REAC:R-HSA-112382	0.000377325314633	0.428571428571	NELFE NELFCD NELFB	Formation of RNA Pol II elongation complex
REAC:R-HSA-6796648	0.000463730815151	0.428571428571	NELFE NELFCD NELFB	TP53 Regulates Transcription of DNA Repair Genes
REAC:R-HSA-167172	0.000644814393069	0.428571428571	NELFE NELFCD NELFB	Transcription of the HIV genome
REAC:R-HSA-674695	0.00101516292409	0.428571428571	NELFE NELFCD NELFB	RNA Polymerase II Pre-transcription Events
GO:0034244	0.00122180600483	0.428571428571	NELFE NELFCD NELFB	negative regulation of transcription elongation by RNA polymerase II
GO:0032785	0.00273674384085	0.428571428571	NELFE NELFCD NELFB	negative regulation of DNA-templated transcription, elongation
REAC:R-HSA-162599	0.00454464074576	0.428571428571	NELFE NELFCD NELFB	Late Phase of HIV Life Cycle
REAC:R-HSA-162587	0.00591992337161	0.428571428571	NELFE NELFCD NELFB	HIV Life Cycle
REAC:R-HSA-162906	0.0221229571183	0.428571428571	NELFE NELFCD NELFB	HIV Infection

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
NELFE	NELFB	1.0		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction
NELFCD	NELFE	1.0	0.56	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction
NELFCD	NELFB	1.0		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction
NELFE	IGHMBP2	1.0	0.05	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
NELFCD	IGHMBP2	0.988	0.16	bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
NELFCD	TMEM141	0.984	0.046	bioplex3_HEK293 bioplex3_WMM WMM_only
NELFCD	XYLT1	0.979		bioplex3_HEK293 bioplex3_WMM WMM_only
XYLT1	IGHMBP2	0.977		bioplex3_HEK293 bioplex3_WMM WMM_only
XYLT1	NELFB	0.977		bioplex3_HEK293 bioplex3_WMM WMM_only
IGHMBP2	NELFB	0.966		bioplex_WMM bioplex3_WMM WMM_only
NELFCD	GPR137B	0.95		bioplex3_HEK293 bioplex3_WMM WMM_only
NELFE	XYLT1	0.934		bioplex3_HEK293 bioplex3_WMM WMM_only
TMEM141	GPR137B	0.415		bioplex3_WMM WMM_only
TMEM141	NELFB	0.25		bioplex3_WMM WMM_only
NELFB	GPR137B	0.25		bioplex3_WMM WMM_only
IGHMBP2	GPR137B	0.25		bioplex3_WMM WMM_only
TMEM141	IGHMBP2	0.25	0.128	bioplex3_WMM WMM_only
NELFE	GPR137B	0.093		bioplex3_WMM WMM_only
NELFE	TMEM141	0.093	0.036	bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
NELFCD	huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1
NELFE	huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1
GPR137B	huMAP3_03084.1 huMAP3_05354.1 huMAP3_09446.1 huMAP3_09855.1 huMAP3_11452.1 huMAP3_11457.1 huMAP3_14385.1 huMAP3_14663.1
XYLT1	huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1
TMEM141	huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1
IGHMBP2	huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1
NELFB	huMAP3_01088.1 huMAP3_05354.1 huMAP3_09446.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05354.1