hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05374.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATP6V0A2 | V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) | 5 | UniProt NCBI |
| TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 (V-ATPase 116 kDa subunit a 3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T-cell immune response cDNA7 protein) (TIRC7) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3) | 5 | UniProt NCBI |
| AQP5 | Aquaporin-5 (AQP-5) | 5 | UniProt NCBI |
| ATP6AP2 | Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (ER-localized type I transmembrane adapter) (Embryonic liver differentiation factor 10) (N14F) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (ATP6M8-9) (V-ATPase M8.9 subunit) [Cleaved into: Renin receptor N-terminal fragment; Renin receptor C-terminal fragment] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016471 | 0.000591522022343 | 0.75 | ATP6V0A2 ATP6AP2 TCIRG1 | vacuolar proton-transporting V-type ATPase complex |
| KEGG:04966 | 0.000633363895839 | 0.5 | ATP6V0A2 TCIRG1 | Collecting duct acid secretion |
| GO:0033176 | 0.000680215375943 | 0.75 | ATP6V0A2 ATP6AP2 TCIRG1 | proton-transporting V-type ATPase complex |
| GO:0007035 | 0.00125794076491 | 0.75 | ATP6V0A2 ATP6AP2 TCIRG1 | vacuolar acidification |
| KEGG:05110 | 0.00247340401034 | 0.5 | ATP6V0A2 TCIRG1 | Vibrio cholerae infection |
| REAC:R-HSA-917977 | 0.00386628370571 | 0.5 | ATP6V0A2 TCIRG1 | Transferrin endocytosis and recycling |
| REAC:R-HSA-77387 | 0.00386628370571 | 0.5 | ATP6V0A2 TCIRG1 | Insulin receptor recycling |
| GO:0051452 | 0.00409056451107 | 0.75 | ATP6V0A2 ATP6AP2 TCIRG1 | intracellular pH reduction |
| KEGG:04721 | 0.00441608599796 | 0.5 | ATP6V0A2 TCIRG1 | Synaptic vesicle cycle |
| REAC:R-HSA-1222556 | 0.00475483947495 | 0.5 | ATP6V0A2 TCIRG1 | ROS and RNS production in phagocytes |
| KEGG:05120 | 0.00487132756685 | 0.5 | ATP6V0A2 TCIRG1 | Epithelial cell signaling in Helicobacter pylori infection |
| GO:0016469 | 0.00508133939815 | 0.75 | ATP6V0A2 ATP6AP2 TCIRG1 | proton-transporting two-sector ATPase complex |
| KEGG:05323 | 0.0056793701001 | 0.5 | ATP6V0A2 TCIRG1 | Rheumatoid arthritis |
| HP:0011354 | 0.00770335684353 | 1.0 | ATP6V0A2 ATP6AP2 AQP5 TCIRG1 | Generalized abnormality of skin |
| GO:1902600 | 0.0100599149475 | 0.75 | ATP6V0A2 ATP6AP2 TCIRG1 | proton transmembrane transport |
| GO:0051453 | 0.0131184183431 | 0.75 | ATP6V0A2 ATP6AP2 TCIRG1 | regulation of intracellular pH |
| REAC:R-HSA-917937 | 0.0135329645116 | 0.5 | ATP6V0A2 TCIRG1 | Iron uptake and transport |
| GO:0030641 | 0.0144970047051 | 0.75 | ATP6V0A2 ATP6AP2 TCIRG1 | regulation of cellular pH |
| GO:0006885 | 0.0167406494658 | 0.75 | ATP6V0A2 ATP6AP2 TCIRG1 | regulation of pH |
| KEGG:00190 | 0.0183110737362 | 0.5 | ATP6V0A2 TCIRG1 | Oxidative phosphorylation |
| KEGG:04142 | 0.0186120295723 | 0.5 | ATP6V0A2 TCIRG1 | Lysosome |
| REAC:R-HSA-74752 | 0.019281632575 | 0.5 | ATP6V0A2 TCIRG1 | Signaling by Insulin receptor |
| KEGG:04145 | 0.0214296747035 | 0.5 | ATP6V0A2 TCIRG1 | Phagosome |
| HP:0001350 | 0.0259951101914 | 0.5 | ATP6V0A2 ATP6AP2 | Slurred speech |
| HP:0003160 | 0.0259951101914 | 0.5 | ATP6V0A2 ATP6AP2 | Abnormal isoelectric focusing of serum transferrin |
| KEGG:05152 | 0.02620193588 | 0.5 | ATP6V0A2 TCIRG1 | Tuberculosis |
| HP:0012347 | 0.028689358225 | 0.5 | ATP6V0A2 ATP6AP2 | Abnormal protein N-linked glycosylation |
| HP:0012346 | 0.03008608933 | 0.5 | ATP6V0A2 ATP6AP2 | Abnormal protein glycosylation |
| REAC:R-HSA-382551 | 0.0342552713859 | 0.75 | ATP6V0A2 AQP5 TCIRG1 | Transport of small molecules |
| HP:0005425 | 0.0375654511359 | 0.5 | ATP6V0A2 TCIRG1 | Recurrent sinopulmonary infections |
| HP:0012345 | 0.0375654511359 | 0.5 | ATP6V0A2 ATP6AP2 | Abnormal glycosylation |
| HP:0002812 | 0.0441432413831 | 0.5 | ATP6V0A2 TCIRG1 | Coxa vara |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ATP6V0A2 | ATP6AP2 | 0.999 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| TCIRG1 | ATP6AP2 | 0.997 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TCIRG1 | ATP6V0A2 | 0.992 | 0.062 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATP6V0A2 | AQP5 | 0.954 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes