hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_05382.1

Complex Portal: CPX-22353

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
EXOSC3	Exosome complex component RRP40 (Exosome component 3) (Ribosomal RNA-processing protein 40) (p10)	5	UniProt NCBI
DIS3	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44)	5	UniProt NCBI
EXOSC7	Exosome complex component RRP42 (Exosome component 7) (Ribosomal RNA-processing protein 42) (p8)	5	UniProt NCBI
MTREX	Exosome RNA helicase MTR4 (EC 3.6.4.13) (ATP-dependent RNA helicase DOB1) (ATP-dependent RNA helicase SKIV2L2) (Superkiller viralicidic activity 2-like 2) (TRAMP-like complex helicase)	5	UniProt NCBI
DIS3L	DIS3-like exonuclease 1 (EC 3.1.13.1)	5	UniProt NCBI
EXOSC8	Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9)	5	UniProt NCBI
EXOSC4	Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A)	5	UniProt NCBI
EXOSC1	Exosome complex component CSL4 (Exosome component 1)	5	UniProt NCBI
MPHOSPH6	M-phase phosphoprotein 6	5	UniProt NCBI
EXOSC6	Exosome complex component MTR3 (Exosome component 6) (mRNA transport regulator 3 homolog) (hMtr3) (p11)	5	UniProt NCBI
EXOSC5	Exosome complex component RRP46 (Chronic myelogenous leukemia tumor antigen 28) (Exosome component 5) (Ribosomal RNA-processing protein 46) (p12B)	5	UniProt NCBI
EXOSC2	Exosome complex component RRP4 (Exosome component 2) (Ribosomal RNA-processing protein 4)	5	UniProt NCBI
EXOSC10	Exosome complex component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2)	5	UniProt NCBI
ZCCHC8	Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8)	5	UniProt NCBI
RBM7	RNA-binding protein 7 (RNA-binding motif protein 7)	5	UniProt NCBI
C1D	Nuclear nucleic acid-binding protein C1D (hC1D)	5	UniProt NCBI
HBS1L	HBS1-like protein (EC 3.6.5.-) (ERFS)	5	UniProt NCBI
EXOSC9	Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0000176	7.93561129389e-38	0.777777777778	DIS3 EXOSC10 EXOSC9 MTREX EXOSC7 EXOSC1 EXOSC4 MPHOSPH6 EXOSC8 EXOSC6 EXOSC2 EXOSC3 C1D EXOSC5	nuclear exosome (RNase complex)
GO:1905354	8.87367353689e-38	0.833333333333	DIS3 C1D EXOSC10 EXOSC9 MTREX EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	exoribonuclease complex
GO:0000178	8.87367353689e-38	0.833333333333	DIS3 C1D EXOSC10 EXOSC9 MTREX EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	exosome (RNase complex)
CORUM:7443	3.79256257707e-36	0.666666666667	DIS3L EXOSC9 EXOSC10 EXOSC1 EXOSC7 EXOSC4 MPHOSPH6 EXOSC8 EXOSC6 EXOSC2 EXOSC3 EXOSC5	Exosome
CORUM:789	7.91236912508e-33	0.611111111111	DIS3 EXOSC9 EXOSC10 EXOSC1 EXOSC7 EXOSC4 EXOSC8 EXOSC6 EXOSC2 EXOSC3 EXOSC5	Exosome
KEGG:03018	3.06665996634e-31	0.833333333333	DIS3 C1D EXOSC10 EXOSC9 MTREX EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	RNA degradation
GO:0000177	8.54607668716e-30	0.666666666667	DIS3 EXOSC10 EXOSC9 DIS3L EXOSC7 EXOSC1 EXOSC4 EXOSC8 EXOSC6 EXOSC2 EXOSC3 EXOSC5	cytoplasmic exosome (RNase complex)
CORUM:788	1.4445018884e-29	0.555555555556	DIS3 EXOSC9 EXOSC1 EXOSC7 EXOSC4 EXOSC8 EXOSC6 EXOSC2 EXOSC3 EXOSC5	Exosome
GO:0034661	2.24143487516e-28	0.777777777778	DIS3 EXOSC10 RBM7 EXOSC9 MTREX ZCCHC8 EXOSC7 DIS3L EXOSC4 EXOSC8 EXOSC6 EXOSC2 EXOSC3 EXOSC5	ncRNA catabolic process
REAC:R-HSA-429958	2.63962005712e-28	0.611111111111	DIS3 EXOSC9 HBS1L EXOSC1 EXOSC7 EXOSC4 EXOSC8 EXOSC6 EXOSC2 EXOSC3 EXOSC5	mRNA decay by 3' to 5' exoribonuclease
GO:0101019	1.79118234161e-26	0.555555555556	EXOSC9 EXOSC10 EXOSC1 EXOSC3 EXOSC4 EXOSC8 EXOSC2 EXOSC7 EXOSC6 EXOSC5	nucleolar exosome (RNase complex)
GO:0016075	3.11276777535e-25	0.611111111111	DIS3 EXOSC10 EXOSC9 DIS3L EXOSC7 EXOSC6 EXOSC4 EXOSC8 EXOSC2 EXOSC3 EXOSC5	rRNA catabolic process
REAC:R-HSA-450513	8.82776501204e-25	0.555555555556	DIS3 EXOSC9 EXOSC1 EXOSC7 EXOSC4 EXOSC8 EXOSC6 EXOSC2 EXOSC3 EXOSC5	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
REAC:R-HSA-450385	2.14281784057e-24	0.555555555556	DIS3 EXOSC9 EXOSC1 EXOSC7 EXOSC4 EXOSC8 EXOSC6 EXOSC2 EXOSC3 EXOSC5	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
REAC:R-HSA-450604	2.14281784057e-24	0.555555555556	DIS3 EXOSC9 EXOSC1 EXOSC7 EXOSC4 EXOSC8 EXOSC6 EXOSC2 EXOSC3 EXOSC5	KSRP (KHSRP) binds and destabilizes mRNA
GO:0006401	2.15735911719e-22	0.888888888889	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	RNA catabolic process
REAC:R-HSA-380994	5.8263773628e-22	0.555555555556	DIS3 EXOSC9 EXOSC1 EXOSC7 EXOSC4 EXOSC8 EXOSC6 EXOSC2 EXOSC3 EXOSC5	ATF4 activates genes in response to endoplasmic reticulum stress
GO:0016073	9.55923379011e-22	0.666666666667	MTREX RBM7 EXOSC9 EXOSC10 ZCCHC8 EXOSC7 EXOSC6 EXOSC4 EXOSC8 EXOSC2 EXOSC3 EXOSC5	snRNA metabolic process
REAC:R-HSA-6791226	1.00165072425e-21	0.777777777778	DIS3 EXOSC10 EXOSC9 MTREX EXOSC7 EXOSC1 EXOSC4 MPHOSPH6 EXOSC8 EXOSC6 EXOSC2 EXOSC3 C1D EXOSC5	Major pathway of rRNA processing in the nucleolus and cytosol
REAC:R-HSA-8868773	2.19018122976e-21	0.777777777778	DIS3 EXOSC10 EXOSC9 MTREX EXOSC7 EXOSC1 EXOSC4 MPHOSPH6 EXOSC8 EXOSC6 EXOSC2 EXOSC3 C1D EXOSC5	rRNA processing in the nucleus and cytosol
REAC:R-HSA-72312	4.59338796312e-21	0.777777777778	DIS3 EXOSC10 EXOSC9 MTREX EXOSC7 EXOSC1 EXOSC4 MPHOSPH6 EXOSC8 EXOSC6 EXOSC2 EXOSC3 C1D EXOSC5	rRNA processing
REAC:R-HSA-381042	4.85282144747e-21	0.555555555556	DIS3 EXOSC9 EXOSC1 EXOSC7 EXOSC4 EXOSC8 EXOSC6 EXOSC2 EXOSC3 EXOSC5	PERK regulates gene expression
REAC:R-HSA-429914	7.107716399e-21	0.611111111111	DIS3 EXOSC9 HBS1L EXOSC1 EXOSC7 EXOSC4 EXOSC8 EXOSC6 EXOSC2 EXOSC3 EXOSC5	Deadenylation-dependent mRNA decay
GO:0034475	4.2460941064e-20	0.444444444444	EXOSC9 EXOSC7 EXOSC6 EXOSC4 EXOSC8 EXOSC2 EXOSC3 EXOSC5	U4 snRNA 3'-end processing
GO:0071027	5.80347292239e-20	0.5	EXOSC9 EXOSC10 EXOSC7 EXOSC6 EXOSC4 EXOSC8 EXOSC2 EXOSC3 EXOSC5	nuclear RNA surveillance
GO:0071025	3.31259193036e-19	0.5	EXOSC9 EXOSC10 EXOSC7 EXOSC6 EXOSC4 EXOSC8 EXOSC2 EXOSC3 EXOSC5	RNA surveillance
GO:0034655	3.70625050928e-19	0.888888888889	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	nucleobase-containing compound catabolic process
GO:0016072	6.92218913145e-19	0.777777777778	DIS3 EXOSC10 EXOSC9 MTREX EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC6 EXOSC2 EXOSC3 C1D EXOSC5	rRNA metabolic process
GO:0046700	1.14041828745e-18	0.888888888889	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	heterocycle catabolic process
GO:0044270	1.18542643987e-18	0.888888888889	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	cellular nitrogen compound catabolic process
GO:0019439	1.43654049555e-18	0.888888888889	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	aromatic compound catabolic process
GO:0000460	1.63903999371e-18	0.555555555556	MTREX EXOSC9 EXOSC10 MPHOSPH6 EXOSC7 EXOSC4 EXOSC8 EXOSC2 EXOSC3 C1D	maturation of 5.8S rRNA
GO:1901361	2.61667558916e-18	0.888888888889	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	organic cyclic compound catabolic process
GO:0000291	4.85270251669e-18	0.5	DIS3 EXOSC9 EXOSC7 EXOSC6 EXOSC4 EXOSC8 EXOSC2 EXOSC3 EXOSC5	nuclear-transcribed mRNA catabolic process, exonucleolytic
GO:0034427	6.99327205182e-18	0.444444444444	EXOSC9 EXOSC7 EXOSC6 EXOSC4 EXOSC8 EXOSC2 EXOSC3 EXOSC5	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
REAC:R-HSA-8953854	1.93563116758e-17	0.888888888889	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L EXOSC7 EXOSC1 EXOSC4 MPHOSPH6 EXOSC8 EXOSC6 EXOSC2 EXOSC3 C1D EXOSC5	Metabolism of RNA
GO:0034660	3.12671114308e-17	0.888888888889	DIS3 EXOSC10 RBM7 EXOSC9 MTREX ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC6 EXOSC2 EXOSC3 C1D EXOSC5	ncRNA metabolic process
GO:0006396	1.25620432614e-16	0.944444444444	DIS3 C1D EXOSC10 RBM7 EXOSC9 MTREX ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	RNA processing
REAC:R-HSA-450531	2.59312368793e-16	0.555555555556	DIS3 EXOSC9 EXOSC1 EXOSC7 EXOSC4 EXOSC8 EXOSC6 EXOSC2 EXOSC3 EXOSC5	Regulation of mRNA stability by proteins that bind AU-rich elements
REAC:R-HSA-381119	2.94207373984e-16	0.555555555556	DIS3 EXOSC9 EXOSC1 EXOSC7 EXOSC4 EXOSC8 EXOSC6 EXOSC2 EXOSC3 EXOSC5	Unfolded Protein Response (UPR)
GO:0000175	2.02307052552e-15	0.5	DIS3 EXOSC10 DIS3L EXOSC7 EXOSC9 EXOSC4 EXOSC5 EXOSC2 EXOSC3	3'-5'-RNA exonuclease activity
GO:0034470	2.30471205352e-15	0.777777777778	DIS3 EXOSC10 EXOSC9 MTREX ZCCHC8 EXOSC7 MPHOSPH6 EXOSC4 C1D EXOSC8 EXOSC6 EXOSC2 EXOSC3 EXOSC5	ncRNA processing
GO:0006364	2.69787238713e-15	0.666666666667	DIS3 EXOSC10 EXOSC9 MTREX EXOSC7 MPHOSPH6 EXOSC4 C1D EXOSC8 EXOSC2 EXOSC3 EXOSC5	rRNA processing
GO:0000956	4.92460004172e-15	0.611111111111	DIS3 EXOSC9 EXOSC10 HBS1L EXOSC7 EXOSC6 EXOSC4 EXOSC8 EXOSC2 EXOSC3 EXOSC5	nuclear-transcribed mRNA catabolic process
GO:0016896	6.05839034698e-15	0.5	DIS3 EXOSC10 DIS3L EXOSC7 EXOSC9 EXOSC4 EXOSC5 EXOSC2 EXOSC3	RNA exonuclease activity, producing 5'-phosphomonoesters
GO:0071028	6.75320850932e-15	0.388888888889	EXOSC10 EXOSC7 EXOSC9 EXOSC4 EXOSC5 EXOSC6 EXOSC8	nuclear mRNA surveillance
GO:0004532	7.81293528955e-15	0.5	DIS3 EXOSC10 DIS3L EXOSC7 EXOSC9 EXOSC4 EXOSC5 EXOSC2 EXOSC3	RNA exonuclease activity
GO:0034472	8.57225015028e-15	0.444444444444	EXOSC9 EXOSC7 EXOSC6 EXOSC4 EXOSC8 EXOSC2 EXOSC3 EXOSC5	snRNA 3'-end processing
GO:0016180	6.56124649302e-14	0.444444444444	EXOSC9 EXOSC7 EXOSC6 EXOSC4 EXOSC8 EXOSC2 EXOSC3 EXOSC5	snRNA processing
GO:0043928	9.6380081533e-14	0.388888888889	DIS3 EXOSC7 EXOSC9 EXOSC8 EXOSC2 EXOSC3 EXOSC5	exonucleolytic catabolism of deadenylated mRNA
GO:0008408	1.04422891962e-13	0.5	DIS3 EXOSC10 DIS3L EXOSC7 EXOSC9 EXOSC4 EXOSC5 EXOSC2 EXOSC3	3'-5' exonuclease activity
GO:0016796	1.25712195078e-13	0.5	DIS3 EXOSC10 DIS3L EXOSC7 EXOSC9 EXOSC4 EXOSC5 EXOSC2 EXOSC3	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
GO:0071046	4.80196613796e-13	0.333333333333	EXOSC9 EXOSC7 EXOSC10 EXOSC8 EXOSC2 EXOSC3	nuclear polyadenylation-dependent ncRNA catabolic process
GO:0071029	4.80196613796e-13	0.333333333333	EXOSC9 EXOSC7 EXOSC10 EXOSC8 EXOSC2 EXOSC3	nuclear ncRNA surveillance
GO:0071035	4.80196613796e-13	0.333333333333	EXOSC9 EXOSC7 EXOSC10 EXOSC8 EXOSC2 EXOSC3	nuclear polyadenylation-dependent rRNA catabolic process
GO:0071038	4.80196613796e-13	0.333333333333	EXOSC9 EXOSC7 EXOSC10 EXOSC8 EXOSC2 EXOSC3	nuclear polyadenylation-dependent tRNA catabolic process
GO:0042254	4.95752969623e-13	0.666666666667	DIS3 EXOSC10 EXOSC9 MTREX EXOSC7 MPHOSPH6 EXOSC4 C1D EXOSC8 EXOSC2 EXOSC3 EXOSC5	ribosome biogenesis
GO:0016071	1.43354447292e-12	0.777777777778	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 EXOSC6 EXOSC4 EXOSC8 EXOSC2 EXOSC3 EXOSC5	mRNA metabolic process
GO:0043633	1.91943403175e-12	0.333333333333	EXOSC9 EXOSC7 EXOSC10 EXOSC8 EXOSC2 EXOSC3	polyadenylation-dependent RNA catabolic process
GO:0106354	1.91943403175e-12	0.333333333333	EXOSC9 EXOSC7 EXOSC10 EXOSC8 EXOSC2 EXOSC3	tRNA surveillance
GO:0043634	1.91943403175e-12	0.333333333333	EXOSC9 EXOSC7 EXOSC10 EXOSC8 EXOSC2 EXOSC3	polyadenylation-dependent ncRNA catabolic process
GO:0071051	1.91943403175e-12	0.333333333333	EXOSC10 EXOSC6 EXOSC4 EXOSC5 EXOSC2 EXOSC3	polyadenylation-dependent snoRNA 3'-end processing
GO:0004527	2.38902308173e-12	0.5	DIS3 EXOSC10 DIS3L EXOSC7 EXOSC9 EXOSC4 EXOSC5 EXOSC2 EXOSC3	exonuclease activity
GO:0009057	2.97216395219e-12	0.888888888889	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	macromolecule catabolic process
GO:0006402	4.13449853282e-12	0.611111111111	DIS3 EXOSC9 EXOSC10 HBS1L EXOSC7 EXOSC6 EXOSC4 EXOSC8 EXOSC2 EXOSC3 EXOSC5	mRNA catabolic process
GO:0000467	5.75424749836e-12	0.333333333333	EXOSC9 EXOSC7 EXOSC10 EXOSC8 EXOSC2 EXOSC3	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0031123	1.02643496282e-11	0.5	EXOSC9 EXOSC10 EXOSC7 EXOSC6 EXOSC4 EXOSC8 EXOSC2 EXOSC3 EXOSC5	RNA 3'-end processing
GO:0031125	1.43754889331e-11	0.333333333333	EXOSC9 EXOSC7 EXOSC10 EXOSC8 EXOSC2 EXOSC3	rRNA 3'-end processing
GO:0044248	1.99605943164e-11	0.888888888889	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	cellular catabolic process
GO:0031126	6.31630970508e-11	0.333333333333	EXOSC10 EXOSC6 EXOSC4 EXOSC5 EXOSC2 EXOSC3	sno(s)RNA 3'-end processing
GO:0004540	6.32236288067e-11	0.5	DIS3 EXOSC10 DIS3L EXOSC7 EXOSC9 EXOSC4 EXOSC5 EXOSC2 EXOSC3	RNA nuclease activity
GO:0022613	9.42457014282e-11	0.666666666667	DIS3 EXOSC10 EXOSC9 MTREX EXOSC7 MPHOSPH6 EXOSC4 C1D EXOSC8 EXOSC2 EXOSC3 EXOSC5	ribonucleoprotein complex biogenesis
GO:0043144	1.17220283024e-10	0.333333333333	EXOSC10 EXOSC6 EXOSC4 EXOSC5 EXOSC2 EXOSC3	sno(s)RNA processing
GO:0016074	3.4141106807e-10	0.333333333333	EXOSC10 EXOSC6 EXOSC4 EXOSC5 EXOSC2 EXOSC3	sno(s)RNA metabolic process
GO:0016078	3.4141106807e-10	0.333333333333	EXOSC9 EXOSC7 EXOSC10 EXOSC8 EXOSC2 EXOSC3	tRNA catabolic process
GO:0140513	4.59311953737e-10	0.833333333333	DIS3 EXOSC10 EXOSC9 MTREX ZCCHC8 EXOSC7 EXOSC1 EXOSC4 MPHOSPH6 EXOSC8 EXOSC6 EXOSC2 EXOSC3 C1D EXOSC5	nuclear protein-containing complex
GO:1901575	9.01346602197e-10	0.888888888889	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	organic substance catabolic process
GO:1902494	1.18339565857e-09	0.888888888889	DIS3 C1D EXOSC10 EXOSC9 MTREX ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	catalytic complex
GO:0004518	4.02456007246e-09	0.5	DIS3 EXOSC10 DIS3L EXOSC7 EXOSC9 EXOSC4 EXOSC5 EXOSC2 EXOSC3	nuclease activity
GO:0000466	5.06460633388e-09	0.333333333333	EXOSC9 EXOSC7 EXOSC10 EXOSC8 EXOSC2 EXOSC3	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000288	2.67428639577e-08	0.388888888889	DIS3 EXOSC7 EXOSC9 EXOSC8 EXOSC2 EXOSC3 EXOSC5	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0009056	2.96768591454e-08	0.888888888889	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	catabolic process
GO:0140098	3.63899771998e-08	0.555555555556	DIS3 EXOSC10 EXOSC9 MTREX EXOSC7 DIS3L EXOSC4 EXOSC5 EXOSC2 EXOSC3	catalytic activity, acting on RNA
CORUM:7349	6.32531883213e-08	0.166666666667	MTREX RBM7 ZCCHC8	MTR4-RBM7-ZCCHC8 complex
GO:0016070	7.83970113024e-08	1.0	DIS3 C1D EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	RNA metabolic process
GO:0061157	3.68047434671e-07	0.388888888889	DIS3 EXOSC7 EXOSC9 EXOSC8 EXOSC2 EXOSC3 EXOSC5	mRNA destabilization
GO:0005730	3.76973261247e-07	0.666666666667	EXOSC9 EXOSC10 MPHOSPH6 EXOSC1 EXOSC4 C1D EXOSC8 EXOSC6 EXOSC2 EXOSC7 EXOSC3 EXOSC5	nucleolus
GO:0016076	4.02274655956e-07	0.222222222222	MTREX RBM7 ZCCHC8 EXOSC10	snRNA catabolic process
GO:0071034	4.02274655956e-07	0.222222222222	DIS3 EXOSC10 EXOSC3 EXOSC2	CUT catabolic process
GO:0071043	4.02274655956e-07	0.222222222222	DIS3 EXOSC10 EXOSC3 EXOSC2	CUT metabolic process
GO:0050779	4.67021511839e-07	0.388888888889	DIS3 EXOSC7 EXOSC9 EXOSC8 EXOSC2 EXOSC3 EXOSC5	RNA destabilization
GO:0061014	5.04700702078e-07	0.388888888889	DIS3 EXOSC7 EXOSC9 EXOSC8 EXOSC2 EXOSC3 EXOSC5	positive regulation of mRNA catabolic process
GO:0090304	7.16456735392e-07	1.0	DIS3 C1D EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	nucleic acid metabolic process
REAC:R-HSA-2262752	7.77248508899e-07	0.555555555556	DIS3 EXOSC9 EXOSC1 EXOSC7 EXOSC4 EXOSC8 EXOSC6 EXOSC2 EXOSC3 EXOSC5	Cellular responses to stress
REAC:R-HSA-8953897	8.53270543113e-07	0.555555555556	DIS3 EXOSC9 EXOSC1 EXOSC7 EXOSC4 EXOSC8 EXOSC6 EXOSC2 EXOSC3 EXOSC5	Cellular responses to stimuli
GO:1903313	2.4464943099e-06	0.388888888889	DIS3 EXOSC7 EXOSC9 EXOSC8 EXOSC2 EXOSC3 EXOSC5	positive regulation of mRNA metabolic process
GO:0140640	3.05227842408e-06	0.555555555556	DIS3 EXOSC10 EXOSC9 MTREX EXOSC7 DIS3L EXOSC4 EXOSC5 EXOSC2 EXOSC3	catalytic activity, acting on a nucleic acid
GO:0006139	4.78635215296e-06	1.0	DIS3 C1D EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	nucleobase-containing compound metabolic process
GO:0010629	5.98989777901e-06	0.611111111111	DIS3 EXOSC9 EXOSC10 HBS1L EXOSC7 EXOSC6 EXOSC4 EXOSC8 EXOSC2 EXOSC3 EXOSC5	negative regulation of gene expression
CORUM:822	7.54956890187e-06	0.166666666667	EXOSC4 EXOSC10 EXOSC2	mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN)
GO:0046483	8.09121800114e-06	1.0	DIS3 C1D EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	heterocycle metabolic process
GO:0006725	8.55697619319e-06	1.0	DIS3 C1D EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	cellular aromatic compound metabolic process
GO:1903311	8.6453392527e-06	0.444444444444	DIS3 RBM7 EXOSC7 EXOSC9 EXOSC8 EXOSC2 EXOSC3 EXOSC5	regulation of mRNA metabolic process
GO:0043488	8.81640211506e-06	0.388888888889	DIS3 EXOSC7 EXOSC9 EXOSC8 EXOSC2 EXOSC3 EXOSC5	regulation of mRNA stability
GO:0043487	1.4392966413e-05	0.388888888889	DIS3 EXOSC7 EXOSC9 EXOSC8 EXOSC2 EXOSC3 EXOSC5	regulation of RNA stability
GO:0003723	1.46843876871e-05	0.722222222222	MTREX RBM7 EXOSC9 EXOSC10 ZCCHC8 EXOSC1 EXOSC7 EXOSC4 EXOSC8 EXOSC6 EXOSC2 EXOSC3 C1D	RNA binding
GO:1901360	1.6392699489e-05	1.0	DIS3 C1D EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	organic cyclic compound metabolic process
GO:0045006	1.68308738937e-05	0.222222222222	EXOSC4 EXOSC5 EXOSC3 EXOSC6	DNA deamination
GO:0061013	1.73452616973e-05	0.388888888889	DIS3 EXOSC7 EXOSC9 EXOSC8 EXOSC2 EXOSC3 EXOSC5	regulation of mRNA catabolic process
GO:0010467	1.75873712133e-05	1.0	DIS3 C1D EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	gene expression
HPA:0460642	3.05937511824e-05	0.722222222222	DIS3 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 MPHOSPH6 EXOSC1 EXOSC10 C1D EXOSC2 EXOSC7 EXOSC3	skin 1; Langerhans[>=Medium]
GO:0034641	3.61502183153e-05	1.0	DIS3 C1D EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	cellular nitrogen compound metabolic process
HPA:0470682	4.49468399004e-05	0.833333333333	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 C1D EXOSC1 EXOSC2 EXOSC3	skin 2; epidermal cells[>=Medium]
HP:0004886	6.67498497768e-05	0.166666666667	EXOSC3 EXOSC9 EXOSC8	Congenital laryngeal stridor
GO:0009059	7.71105965449e-05	1.0	DIS3 C1D EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	macromolecule biosynthetic process
GO:0034476	7.84339535184e-05	0.166666666667	EXOSC7 EXOSC9 EXOSC8	U5 snRNA 3'-end processing
GO:0034473	7.84339535184e-05	0.166666666667	EXOSC7 EXOSC9 EXOSC8	U1 snRNA 3'-end processing
HPA:0460672	0.000199977804641	0.777777777778	DIS3 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC1 DIS3L EXOSC10 MPHOSPH6 C1D EXOSC2 EXOSC7 EXOSC3	skin 1; melanocytes[>=Medium]
HPA:0050092	0.000271887920189	0.777777777778	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC1 EXOSC7 EXOSC4 MPHOSPH6 C1D EXOSC2 EXOSC3	breast; myoepithelial cells[>=Medium]
GO:0071047	0.000313494264121	0.166666666667	EXOSC7 EXOSC9 EXOSC8	polyadenylation-dependent mRNA catabolic process
GO:0071042	0.000313494264121	0.166666666667	EXOSC7 EXOSC9 EXOSC8	nuclear polyadenylation-dependent mRNA catabolic process
GO:0016788	0.000337520174924	0.5	DIS3 EXOSC10 DIS3L EXOSC7 EXOSC9 EXOSC4 EXOSC5 EXOSC2 EXOSC3	hydrolase activity, acting on ester bonds
HPA:0460662	0.000415694717284	0.722222222222	DIS3 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 MPHOSPH6 EXOSC1 EXOSC10 C1D EXOSC2 EXOSC7 EXOSC3	skin 1; keratinocytes[>=Medium]
HP:0005348	0.000542926757632	0.166666666667	EXOSC3 EXOSC9 EXOSC8	Inspiratory stridor
HPA:0460651	0.000556530328871	0.777777777778	DIS3 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 C1D EXOSC1 EXOSC2 EXOSC3	skin 1; fibroblasts[>=Low]
HPA:0620222	0.000666426017857	0.777777777778	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC1 EXOSC7 EXOSC4 MPHOSPH6 C1D EXOSC2 EXOSC3	vagina; squamous epithelial cells[>=Medium]
HPA:0090162	0.000784869037228	0.777777777778	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC1 EXOSC7 EXOSC4 MPHOSPH6 C1D EXOSC2 EXOSC3	cerebellum; Purkinje cells[>=Medium]
GO:0044249	0.000790228697705	1.0	DIS3 C1D EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	cellular biosynthetic process
GO:0005654	0.000871515982599	0.888888888889	DIS3 EXOSC10 RBM7 EXOSC9 MTREX ZCCHC8 EXOSC7 EXOSC1 EXOSC4 MPHOSPH6 EXOSC8 EXOSC6 EXOSC2 EXOSC3 C1D EXOSC5	nucleoplasm
GO:0031331	0.000908801163488	0.388888888889	DIS3 EXOSC7 EXOSC9 EXOSC8 EXOSC2 EXOSC3 EXOSC5	positive regulation of cellular catabolic process
GO:1901576	0.000914898997088	1.0	DIS3 C1D EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	organic substance biosynthetic process
GO:0009058	0.0010203541129	1.0	DIS3 C1D EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	biosynthetic process
HPA:0190222	0.00121574399119	0.833333333333	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 C1D EXOSC1 EXOSC2 EXOSC3	esophagus; squamous epithelial cells[>=Medium]
HPA:0460661	0.00124934639677	0.833333333333	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 C1D EXOSC1 EXOSC2 EXOSC3	skin 1; keratinocytes[>=Low]
HP:0002398	0.00154309552699	0.166666666667	EXOSC3 EXOSC9 EXOSC8	Degeneration of anterior horn cells
HP:0006802	0.00183101505694	0.166666666667	EXOSC3 EXOSC9 EXOSC8	Abnormal anterior horn cell morphology
HPA:0460671	0.00215963901866	0.833333333333	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 C1D EXOSC1 EXOSC2 EXOSC3	skin 1; melanocytes[>=Low]
GO:0031981	0.00235324229769	0.888888888889	DIS3 EXOSC10 RBM7 EXOSC9 MTREX ZCCHC8 EXOSC7 EXOSC1 EXOSC4 MPHOSPH6 EXOSC8 EXOSC6 EXOSC2 EXOSC3 C1D EXOSC5	nuclear lumen
GO:0006399	0.00246614601801	0.333333333333	EXOSC9 EXOSC7 EXOSC10 EXOSC8 EXOSC2 EXOSC3	tRNA metabolic process
HP:0012110	0.00264657296537	0.222222222222	EXOSC9 EXOSC3 EXOSC1 EXOSC8	Hypoplasia of the pons
HPA:0460641	0.00357026683852	0.722222222222	DIS3 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 MPHOSPH6 EXOSC1 EXOSC10 C1D EXOSC2 EXOSC7 EXOSC3	skin 1; Langerhans[>=Low]
HPA:0090161	0.00389527610148	0.833333333333	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 C1D EXOSC1 EXOSC2 EXOSC3	cerebellum; Purkinje cells[>=Low]
GO:0032991	0.00435794847069	0.944444444444	DIS3 C1D EXOSC10 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	protein-containing complex
HPA:0030071	0.0044341950427	0.777777777778	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 EXOSC5 EXOSC1 EXOSC2 EXOSC3	appendix; lymphoid tissue[>=Low]
HPA:0470681	0.00460225107398	0.833333333333	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 C1D EXOSC1 EXOSC2 EXOSC3	skin 2; epidermal cells[>=Low]
HPA:0100131	0.00519151940949	0.888888888889	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC5 EXOSC1 EXOSC2 EXOSC3 C1D	cerebral cortex; neuronal cells[>=Low]
HPA:0050091	0.00561675265018	0.833333333333	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 C1D EXOSC1 EXOSC2 EXOSC3	breast; myoepithelial cells[>=Low]
HP:0007361	0.00659996895778	0.222222222222	EXOSC9 EXOSC3 EXOSC1 EXOSC8	Abnormal pons morphology
HPA:0460652	0.00682735201903	0.611111111111	DIS3 DIS3L HBS1L ZCCHC8 EXOSC1 EXOSC9 EXOSC4 MTREX C1D EXOSC2 EXOSC3	skin 1; fibroblasts[>=Medium]
GO:0000791	0.0079257196095	0.222222222222	EXOSC4 EXOSC10 EXOSC3 EXOSC5	euchromatin
HP:0001308	0.00841557073161	0.166666666667	EXOSC3 EXOSC9 EXOSC8	Tongue fasciculations
GO:0010558	0.0102556939731	0.611111111111	DIS3 EXOSC9 EXOSC10 HBS1L EXOSC7 EXOSC6 EXOSC4 EXOSC8 EXOSC2 EXOSC3 EXOSC5	negative regulation of macromolecule biosynthetic process
HPA:0620221	0.0117947505188	0.833333333333	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 C1D EXOSC1 EXOSC2 EXOSC3	vagina; squamous epithelial cells[>=Low]
HPA:0620000	0.0117947505188	0.833333333333	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 C1D EXOSC1 EXOSC2 EXOSC3	vagina
HPA:0050052	0.0118068976667	0.777777777778	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC1 EXOSC7 EXOSC4 MPHOSPH6 C1D EXOSC2 EXOSC3	breast; glandular cells[>=Medium]
GO:0010608	0.0122904059214	0.388888888889	DIS3 EXOSC7 EXOSC9 EXOSC8 EXOSC2 EXOSC3 EXOSC5	post-transcriptional regulation of gene expression
WP:WP4352	0.0125585215046	0.222222222222	EXOSC4 EXOSC7 EXOSC9 EXOSC2	Ciliary landscape
GO:0031327	0.0129221723315	0.611111111111	DIS3 EXOSC9 EXOSC10 HBS1L EXOSC7 EXOSC6 EXOSC4 EXOSC8 EXOSC2 EXOSC3 EXOSC5	negative regulation of cellular biosynthetic process
HPA:0470683	0.013434475854	0.388888888889	MTREX ZCCHC8 MPHOSPH6 EXOSC9 EXOSC10 EXOSC2 EXOSC3	skin 2; epidermal cells[High]
GO:0009890	0.0137246478108	0.611111111111	DIS3 EXOSC9 EXOSC10 HBS1L EXOSC7 EXOSC6 EXOSC4 EXOSC8 EXOSC2 EXOSC3 EXOSC5	negative regulation of biosynthetic process
HP:0010307	0.0183696141885	0.166666666667	EXOSC3 EXOSC9 EXOSC8	Stridor
HPA:0570732	0.0191651021509	0.777777777778	DIS3 EXOSC10 RBM7 EXOSC9 DIS3L HBS1L ZCCHC8 EXOSC1 MPHOSPH6 EXOSC4 MTREX C1D EXOSC2 EXOSC3	testis; Leydig cells[>=Medium]
GO:0009896	0.0192389037494	0.388888888889	DIS3 EXOSC7 EXOSC9 EXOSC8 EXOSC2 EXOSC3 EXOSC5	positive regulation of catabolic process
HPA:0500000	0.019363157111	0.777777777778	DIS3 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 C1D EXOSC1 EXOSC2 EXOSC3	soft tissue 1
HPA:0241101	0.0195311745161	0.833333333333	DIS3 EXOSC10 RBM7 EXOSC9 DIS3L HBS1L EXOSC7 EXOSC1 EXOSC4 MTREX MPHOSPH6 EXOSC5 EXOSC2 ZCCHC8 C1D	heart muscle; cardiomyocytes[>=Low]
HPA:0240000	0.0195311745161	0.833333333333	DIS3 EXOSC10 RBM7 EXOSC9 DIS3L HBS1L EXOSC7 EXOSC1 EXOSC4 MTREX MPHOSPH6 EXOSC5 EXOSC2 ZCCHC8 C1D	heart muscle
HPA:0550052	0.0205850357082	0.833333333333	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 C1D EXOSC1 EXOSC2 EXOSC3	stomach 2; glandular cells[>=Medium]
GO:0043170	0.0218804672791	1.0	DIS3 C1D EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC8 EXOSC1 EXOSC2 EXOSC3 EXOSC6 EXOSC5	macromolecule metabolic process
HPA:0340000	0.023792249411	0.777777777778	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 EXOSC5 EXOSC2 EXOSC3	ovary
HPA:0490000	0.0240329177873	0.777777777778	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 C1D EXOSC1 EXOSC2 EXOSC3	smooth muscle
HPA:0490691	0.0240329177873	0.777777777778	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 C1D EXOSC1 EXOSC2 EXOSC3	smooth muscle; smooth muscle cells[>=Low]
HPA:0620223	0.0240386754493	0.388888888889	MTREX RBM7 ZCCHC8 HBS1L EXOSC9 EXOSC10 EXOSC3	vagina; squamous epithelial cells[High]
HPA:0100201	0.0244227505724	0.722222222222	DIS3 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC1 EXOSC7 EXOSC4 MPHOSPH6 C1D EXOSC2 EXOSC3	cerebral cortex; endothelial cells[>=Low]
HPA:0330223	0.0282571840891	0.388888888889	DIS3 ZCCHC8 HBS1L MPHOSPH6 EXOSC10 MTREX EXOSC3	oral mucosa; squamous epithelial cells[High]
GO:0006304	0.0305373630844	0.222222222222	EXOSC4 EXOSC5 EXOSC3 EXOSC6	DNA modification
HP:0002120	0.0320166605612	0.277777777778	EXOSC2 EXOSC5 EXOSC3 EXOSC9 EXOSC8	Cerebral cortical atrophy
HP:0030810	0.0361621092544	0.166666666667	EXOSC3 EXOSC9 EXOSC8	Abnormal tongue physiology
HPA:0130201	0.0361779324088	0.777777777778	DIS3 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 C1D EXOSC1 EXOSC2 EXOSC3	colon; endothelial cells[>=Low]
HPA:0590052	0.0367053925786	0.777777777778	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 C1D EXOSC1 EXOSC2 EXOSC3	thyroid gland; glandular cells[>=Medium]
HPA:0510651	0.0453089047952	0.666666666667	DIS3 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 EXOSC1 EXOSC2 EXOSC3	soft tissue 2; fibroblasts[>=Low]
HPA:0190000	0.0460006119896	0.833333333333	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 C1D EXOSC1 EXOSC2 EXOSC3	esophagus
HPA:0190221	0.0460006119896	0.833333333333	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 C1D EXOSC1 EXOSC2 EXOSC3	esophagus; squamous epithelial cells[>=Low]
HPA:0170051	0.047552030999	0.833333333333	DIS3 EXOSC10 RBM7 EXOSC9 MTREX HBS1L ZCCHC8 EXOSC7 DIS3L EXOSC4 MPHOSPH6 C1D EXOSC1 EXOSC2 EXOSC3	endometrium 2; glandular cells[>=Low]
HP:0000565	0.0480869650528	0.222222222222	EXOSC5 EXOSC3 EXOSC9 EXOSC8	Esotropia
HP:0010546	0.0482176471165	0.166666666667	EXOSC3 EXOSC9 EXOSC8	Muscle fibrillation
CORUM:2004	0.0496617483143	0.0555555555556	C1D	C1D homodimer protein

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
EXOSC6	EXOSC2	1.0	0.946	structurally_consistent (Q06265) structurally_consistent (dimer)
EXOSC5	EXOSC2	1.0	0.972	structurally_consistent (dimer)
EXOSC1	EXOSC2	1.0	0.944
EXOSC7	EXOSC10	1.0	0.906
EXOSC1	EXOSC4	1.0	0.842	structurally_consistent (dimer)
EXOSC7	MPHOSPH6	1.0	0.208
EXOSC4	EXOSC6	1.0	0.764	structurally_consistent (Q15024) structurally_consistent (dimer)
EXOSC1	MPHOSPH6	1.0	0.416	structurally_consistent (Q9NQT5) structurally_consistent (dimer)
EXOSC2	EXOSC10	1.0	0.894
EXOSC4	EXOSC2	1.0	0.97	structurally_consistent (dimer)
MPHOSPH6	EXOSC5	1.0	0.236
MPHOSPH6	EXOSC2	1.0	0.166
EXOSC4	EXOSC5	1.0	0.966
EXOSC8	MPHOSPH6	1.0	0.136
EXOSC2	EXOSC9	1.0	0.992	structurally_consistent (Q15024) structurally_consistent (dimer)
EXOSC3	MPHOSPH6	1.0	0.246	structurally_consistent (dimer)
EXOSC4	EXOSC10	1.0	0.786
MPHOSPH6	EXOSC6	1.0	0.322	structurally_consistent (Q9Y3B2)
MPHOSPH6	EXOSC9	1.0	0.132
EXOSC3	EXOSC10	1.0	0.952
EXOSC1	EXOSC9	1.0	0.978
EXOSC8	EXOSC10	1.0	0.856
EXOSC3	EXOSC7	1.0	0.982	structurally_consistent (Q06265) structurally_consistent (dimer)
EXOSC5	EXOSC10	1.0	0.884
EXOSC2	C1D	1.0	0.356	structurally_consistent (dimer)
EXOSC4	MPHOSPH6	1.0	0.426
EXOSC6	EXOSC5	1.0	0.634	structurally_consistent (Q06265) structurally_consistent (dimer)
EXOSC3	EXOSC6	1.0	0.946
EXOSC8	EXOSC2	1.0	0.902	structurally_consistent (Q06265) structurally_consistent (dimer)
MTREX	C1D	1.0	0.334	structurally_consistent (Q13868)
EXOSC4	C1D	1.0	0.438	structurally_consistent (Q13868)
EXOSC1	C1D	1.0	0.528
EXOSC3	EXOSC9	1.0	0.994	structurally_consistent (Q15024) structurally_consistent (dimer)
MPHOSPH6	EXOSC10	1.0	0.27
EXOSC3	EXOSC2	1.0	0.982
EXOSC1	EXOSC10	1.0	0.844
EXOSC3	EXOSC5	1.0	0.982
EXOSC6	C1D	1.0	0.256	structurally_consistent (Q13868)
EXOSC1	EXOSC5	1.0	0.962
EXOSC4	EXOSC9	1.0	0.97	structurally_consistent (dimer)
EXOSC5	EXOSC9	1.0	0.982	structurally_consistent (dimer)
EXOSC1	EXOSC7	1.0	0.932
EXOSC10	C1D	1.0	0.424
C1D	EXOSC9	1.0	0.3
EXOSC7	EXOSC2	1.0	0.988	structurally_consistent (dimer)
MPHOSPH6	C1D	1.0	0.314
EXOSC7	EXOSC4	1.0	0.974	structurally_consistent (dimer)
MTREX	EXOSC2	1.0	0.81	structurally_consistent (dimer)
EXOSC5	C1D	1.0	0.366	structurally_consistent (Q13868)
EXOSC7	EXOSC5	1.0	0.95
EXOSC1	DIS3L	1.0	0.136	structurally_consistent (Q9NPD3)
EXOSC3	C1D	1.0	0.546
MTREX	MPHOSPH6	1.0	0.128
DIS3L	EXOSC4	1.0	0.23	structurally_consistent (dimer)
EXOSC10	EXOSC9	1.0	0.95
EXOSC8	EXOSC5	1.0	0.712	structurally_consistent (Q06265)
RBM7	C1D	1.0	0.174	structurally_consistent (Q13868)
EXOSC3	EXOSC4	1.0	0.974	structurally_consistent (dimer)
EXOSC1	EXOSC3	1.0	0.966	structurally_consistent (dimer)
EXOSC6	EXOSC9	1.0	0.688	structurally_consistent (dimer)
EXOSC6	EXOSC10	1.0	0.836
ZCCHC8	C1D	1.0	0.13
EXOSC1	EXOSC8	1.0	0.884
ZCCHC8	RBM7	1.0	0.234	structurally_consistent (Q9Y3B2)
EXOSC1	EXOSC6	1.0	0.928	structurally_consistent (dimer)
DIS3L	EXOSC2	1.0	0.132
EXOSC7	C1D	1.0	0.501428571429
DIS3L	EXOSC5	1.0	0.17
EXOSC7	EXOSC9	1.0	0.982	structurally_consistent (Q9NPD3) structurally_consistent (dimer)
EXOSC7	DIS3L	1.0	0.108
EXOSC3	DIS3L	1.0	0.202	structurally_consistent (Q9NPD3) structurally_consistent (dimer)
EXOSC3	HBS1L	1.0	0.092	structurally_consistent (dimer)
EXOSC7	EXOSC6	0.999	0.788	structurally_consistent (Q9NPD3) structurally_consistent (dimer)
MTREX	RBM7	0.999	0.47
EXOSC3	MTREX	0.999	0.746
EXOSC8	EXOSC4	0.999	0.778	structurally_consistent (dimer)
DIS3L	MPHOSPH6	0.999	0.09	mutually_exclusive (Q9NQT5)
EXOSC3	EXOSC8	0.999	0.856	structurally_consistent (Q15024)
MTREX	EXOSC5	0.999	0.576
EXOSC3	ZCCHC8	0.999	0.192
EXOSC7	EXOSC8	0.999	0.944	structurally_consistent (dimer)
EXOSC4	ZCCHC8	0.999	0.156
EXOSC7	MTREX	0.999	0.79
EXOSC1	HBS1L	0.999	0.084
EXOSC8	EXOSC9	0.999	0.934	structurally_consistent (Q9NPD3) structurally_consistent (dimer)
MTREX	EXOSC4	0.999	0.588
DIS3L	C1D	0.999	0.132
EXOSC7	HBS1L	0.999	0.1	structurally_consistent (dimer)
EXOSC8	EXOSC6	0.999	0.706	structurally_consistent (Q9NPD3)
EXOSC7	ZCCHC8	0.999	0.154
DIS3L	EXOSC9	0.999	0.186
EXOSC8	C1D	0.998	0.56
MTREX	EXOSC8	0.998	0.66	structurally_consistent (Q13868)
EXOSC5	RBM7	0.998	0.264
EXOSC4	HBS1L	0.998	0.126
EXOSC7	RBM7	0.998	0.154	structurally_consistent (dimer)
MPHOSPH6	RBM7	0.998	0.062
MTREX	ZCCHC8	0.998	0.266
MTREX	EXOSC6	0.998	0.472
EXOSC4	RBM7	0.998	0.23	structurally_consistent (dimer)
EXOSC10	RBM7	0.998	0.176
DIS3	C1D	0.998	0.256
MPHOSPH6	ZCCHC8	0.998	0.1
EXOSC1	MTREX	0.997	0.636
EXOSC2	ZCCHC8	0.997	0.272
EXOSC8	RBM7	0.997	0.12
MTREX	DIS3L	0.997	0.13
EXOSC2	RBM7	0.997	0.128	mutually_exclusive (Q15024) structurally_consistent (dimer)
EXOSC5	ZCCHC8	0.997	0.278
EXOSC2	HBS1L	0.996	0.102
EXOSC1	RBM7	0.996	0.122	structurally_consistent (dimer)
DIS3	MPHOSPH6	0.996	0.178	structurally_consistent (dimer)
MTREX	EXOSC10	0.996	0.832
EXOSC3	RBM7	0.996	0.222	structurally_consistent (Q15024) structurally_consistent (dimer)
EXOSC5	HBS1L	0.996	0.064	structurally_consistent (Q5RKV6)
DIS3L	EXOSC6	0.996	0.13
DIS3L	EXOSC8	0.996	0.126
MTREX	EXOSC9	0.995	0.824	structurally_consistent (Q13868)
DIS3L	EXOSC10	0.995	0.184
EXOSC8	ZCCHC8	0.994	0.27
EXOSC10	ZCCHC8	0.994	0.176
C1D	HBS1L	0.991	0.084
EXOSC8	HBS1L	0.991	0.05
EXOSC1	ZCCHC8	0.988	0.17	structurally_consistent (dimer)
DIS3L	HBS1L	0.987	0.13
DIS3	EXOSC5	0.986	0.37
DIS3L	ZCCHC8	0.985	0.09
DIS3L	RBM7	0.985	0.06
DIS3	EXOSC4	0.977	0.322	structurally_consistent (dimer)
RBM7	EXOSC9	0.977	0.088
DIS3	EXOSC7	0.968	0.24	structurally_consistent (dimer)
MPHOSPH6	HBS1L	0.962	0.14	structurally_consistent (Q9Y2L1)
EXOSC6	ZCCHC8	0.96	0.194	mutually_exclusive (Q9Y3B2)
DIS3	EXOSC3	0.955	0.19
ZCCHC8	EXOSC9	0.954	0.226
EXOSC10	HBS1L	0.944	0.052
MTREX	HBS1L	0.943	0.118
EXOSC6	HBS1L	0.942	0.09	structurally_consistent (dimer)
RBM7	HBS1L	0.932	0.046	structurally_consistent (Q9NQT5)
DIS3	EXOSC10	0.929	0.446
EXOSC6	RBM7	0.91	0.114
HBS1L	EXOSC9	0.9	0.112
DIS3	EXOSC2	0.896	0.446
ZCCHC8	HBS1L	0.817	0.058
DIS3	EXOSC1	0.616	0.188
DIS3	EXOSC9	0.352	0.426
DIS3	DIS3L	0.332	0.084	mutually_exclusive (Q9NPD3)
DIS3	EXOSC6	0.33	0.252
DIS3	EXOSC8	0.254	0.264	structurally_consistent (Q15024)
DIS3	RBM7	0.162	0.112	structurally_consistent (Q9NPD3)
DIS3	HBS1L	0.043	0.12	structurally_consistent (Q15024) structurally_consistent (dimer)
DIS3	MTREX	0.041	0.464
DIS3	ZCCHC8	0.03	0.238

Related Complexes

Genename	Complexes
EXOSC3	huMAP3_05382.1 huMAP3_14264.1
DIS3	huMAP3_01165.1 huMAP3_05382.1 huMAP3_10791.1
EXOSC7	huMAP3_05382.1 huMAP3_14264.1
MTREX	huMAP3_05382.1 huMAP3_14264.1
DIS3L	huMAP3_05382.1 huMAP3_14264.1
EXOSC8	huMAP3_05382.1 huMAP3_14264.1
EXOSC4	huMAP3_05382.1 huMAP3_14264.1
EXOSC1	huMAP3_05194.1 huMAP3_05382.1 huMAP3_14264.1
MPHOSPH6	huMAP3_05382.1 huMAP3_14264.1
EXOSC6	huMAP3_05382.1 huMAP3_14264.1
EXOSC5	huMAP3_05382.1 huMAP3_14264.1
EXOSC2	huMAP3_05382.1 huMAP3_14264.1
EXOSC10	huMAP3_05382.1
ZCCHC8	huMAP3_05382.1 huMAP3_14264.1
RBM7	huMAP3_05382.1 huMAP3_13336.1
C1D	huMAP3_05382.1 huMAP3_14264.1
HBS1L	huMAP3_05382.1 huMAP3_14264.1
EXOSC9	huMAP3_05382.1 huMAP3_14264.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_05382.1

Complex Portal: CPX-22353