hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05402.1
Complex Portal: CPX-13648
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MKNK2 | MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) | 5 | UniProt NCBI |
| RHBDF1 | Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho) | 5 | UniProt NCBI |
| MAPK14 | Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) | 5 | UniProt NCBI |
| DUSP16 | Dual specificity protein phosphatase 16 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7) | 5 | UniProt NCBI |
| MKNK1 | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | 5 | UniProt NCBI |
| MAPKAPK3 | MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK) | 5 | UniProt NCBI |
| RNF138 | E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138) | 5 | UniProt NCBI |
| MAPK11 | Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP382 | 1.56845834741e-08 | 0.75 | MAPK11 DUSP16 MKNK2 MAPK14 MAPKAPK3 MKNK1 | MAPK signaling pathway |
| KEGG:04010 | 2.67869322364e-08 | 0.75 | MAPK11 DUSP16 MKNK2 MAPK14 MAPKAPK3 MKNK1 | MAPK signaling pathway |
| WP:WP2637 | 4.11262197767e-07 | 0.5 | MAPK11 MKNK1 MKNK2 MAPK14 | Interleukin 1 IL 1 structural pathway |
| REAC:R-HSA-171007 | 2.74368957961e-06 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | p38MAPK events |
| REAC:R-HSA-167044 | 8.313982098e-06 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Signalling to RAS |
| REAC:R-HSA-450302 | 2.59982063947e-05 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | activated TAK1 mediates p38 MAPK activation |
| REAC:R-HSA-187687 | 5.92028436306e-05 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Signalling to ERKs |
| KEGG:04370 | 0.00010962516806 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | VEGF signaling pathway |
| GO:0009931 | 0.000301045822538 | 0.375 | MKNK1 MKNK2 MAPKAPK3 | calcium-dependent protein serine/threonine kinase activity |
| GO:0010857 | 0.00045145282213 | 0.375 | MKNK1 MKNK2 MAPKAPK3 | calcium-dependent protein kinase activity |
| REAC:R-HSA-450294 | 0.000626344972097 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | MAP kinase activation |
| REAC:R-HSA-448424 | 0.000853240910983 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Interleukin-17 signaling |
| REAC:R-HSA-376172 | 0.00155943355885 | 0.25 | MAPK14 MAPK11 | DSCAM interactions |
| KEGG:04148 | 0.00160212912447 | 0.375 | DUSP16 MAPK14 MAPK11 | Efferocytosis |
| REAC:R-HSA-168176 | 0.00198770799356 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 0.00198770799356 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975871 | 0.00198770799356 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-2151209 | 0.00200443712543 | 0.25 | MAPK14 MAPK11 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation |
| REAC:R-HSA-975138 | 0.00213752571158 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-975155 | 0.00221515749645 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 0.00221515749645 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-4420097 | 0.00237597190289 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-450341 | 0.00250486048439 | 0.25 | MAPK14 MAPK11 | Activation of the AP-1 family of transcription factors |
| REAC:R-HSA-168138 | 0.00254432714295 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168164 | 0.00272039056422 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166166 | 0.0029043291557 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 0.0029043291557 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-168188 | 0.00309630954826 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-166058 | 0.00309630954826 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-194138 | 0.00309630954826 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Signaling by VEGF |
| REAC:R-HSA-187037 | 0.00329649801499 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-168179 | 0.00329649801499 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.00329649801499 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Toll Like Receptor 2 (TLR2) Cascade |
| WP:WP4767 | 0.00407177869695 | 0.25 | MAPK14 MAPK11 | FGFR3 signaling in chondrocyte proliferation and terminal differentiation |
| WP:WP5272 | 0.00407177869695 | 0.25 | MAPK14 MAPK11 | LDL influence on CD14 and TLR4 |
| REAC:R-HSA-2559580 | 0.00442635602723 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Oxidative Stress Induced Senescence |
| WP:WP4864 | 0.0045229597893 | 0.25 | MAPK14 MAPK11 | Host pathogen interaction of human coronaviruses apoptosis |
| WP:WP1528 | 0.00499769201238 | 0.25 | MAPK14 MAPK11 | Physiological and pathological hypertrophy of the heart |
| WP:WP3879 | 0.00499769201238 | 0.25 | MKNK1 MKNK2 | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| REAC:R-HSA-166520 | 0.00535285250311 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Signaling by NTRKs |
| WP:WP3612 | 0.0054959559122 | 0.25 | MAPK14 MAPK11 | Photodynamic therapy induced NFE2L2 NRF2 survival signaling |
| REAC:R-HSA-166016 | 0.00672088844441 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Toll Like Receptor 4 (TLR4) Cascade |
| GO:0051019 | 0.00712601113833 | 0.375 | DUSP16 MAPK14 MAPKAPK3 | mitogen-activated protein kinase binding |
| WP:WP3869 | 0.00713174328203 | 0.25 | MAPK14 MAPK11 | Cannabinoid receptor signaling |
| REAC:R-HSA-450604 | 0.00755574884395 | 0.25 | MAPK14 MAPK11 | KSRP (KHSRP) binds and destabilizes mRNA |
| WP:WP722 | 0.0077239395488 | 0.25 | MAPKAPK3 MAPK14 | Serotonin HTR1 group and FOS pathway |
| GO:0004683 | 0.00824905178996 | 0.375 | MKNK1 MKNK2 MAPKAPK3 | calmodulin-dependent protein kinase activity |
| WP:WP2643 | 0.00833957037235 | 0.25 | MAPK14 MAPK11 | Nanoparticle mediated activation of receptor signaling |
| REAC:R-HSA-9006934 | 0.010203163963 | 0.5 | MAPK11 MKNK1 MAPK14 MAPKAPK3 | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-168898 | 0.0103248470282 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Toll-like Receptor Cascades |
| WP:WP4877 | 0.0103268762936 | 0.25 | MAPK14 MAPK11 | Host pathogen interaction of human coronaviruses MAPK signaling |
| WP:WP400 | 0.0103268762936 | 0.25 | MKNK1 MAPK14 | p38 MAPK signaling pathway |
| REAC:R-HSA-198753 | 0.0116541924374 | 0.25 | MAPK14 MAPK11 | ERK/MAPK targets |
| REAC:R-HSA-5668599 | 0.0116541924374 | 0.25 | MAPK14 MAPK11 | RHO GTPases Activate NADPH Oxidases |
| WP:WP2371 | 0.01330352589 | 0.25 | MAPK14 MAPK11 | Parkinson 39 s disease pathway |
| REAC:R-HSA-525793 | 0.0153043597228 | 0.25 | MAPK14 MAPK11 | Myogenesis |
| GO:0004674 | 0.0153100939664 | 0.625 | MAPK11 MKNK1 MAPKAPK3 MKNK2 MAPK14 | protein serine/threonine kinase activity |
| KEGG:04664 | 0.0176380965856 | 0.25 | MAPK14 MAPK11 | Fc epsilon RI signaling pathway |
| REAC:R-HSA-2559583 | 0.0192389562496 | 0.375 | MAPKAPK3 MAPK14 MAPK11 | Cellular Senescence |
| WP:WP3611 | 0.021360968316 | 0.25 | MAPK14 MAPK11 | Photodynamic therapy induced AP 1 survival signaling |
| KEGG:05133 | 0.021864446587 | 0.25 | MAPK14 MAPK11 | Pertussis |
| REAC:R-HSA-450282 | 0.0240813966337 | 0.25 | MAPK14 MAPK11 | MAPK targets/ Nuclear events mediated by MAP kinases |
| KEGG:05140 | 0.0241447644056 | 0.25 | MAPK14 MAPK11 | Leishmaniasis |
| KEGG:04917 | 0.0241447644056 | 0.25 | MAPK14 MAPK11 | Prolactin signaling pathway |
| KEGG:05120 | 0.0249295632697 | 0.25 | MAPK14 MAPK11 | Epithelial cell signaling in Helicobacter pylori infection |
| WP:WP395 | 0.0255436500108 | 0.25 | MAPK14 MAPK11 | IL 4 signaling pathway |
| KEGG:04622 | 0.0265361384039 | 0.25 | MAPK14 MAPK11 | RIG-I-like receptor signaling pathway |
| REAC:R-HSA-168638 | 0.0274432906045 | 0.25 | MAPK14 MAPK11 | NOD1/2 Signaling Pathway |
| KEGG:04912 | 0.0290382898495 | 0.25 | MAPK14 MAPK11 | GnRH signaling pathway |
| KEGG:04750 | 0.0298969094283 | 0.25 | MAPK14 MAPK11 | Inflammatory mediator regulation of TRP channels |
| WP:WP3865 | 0.0337492362996 | 0.25 | MAPK14 MAPK11 | Novel intracellular components of RIG I like receptor pathway |
| KEGG:04658 | 0.0343738123186 | 0.25 | MAPK14 MAPK11 | Th1 and Th2 cell differentiation |
| REAC:R-HSA-373752 | 0.0367988237757 | 0.25 | MAPK14 MAPK11 | Netrin-1 signaling |
| KEGG:04657 | 0.0372066280408 | 0.25 | MAPK14 MAPK11 | IL-17 signaling pathway |
| KEGG:05235 | 0.040149110607 | 0.25 | MAPK14 MAPK11 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| WP:WP4538 | 0.0416757621985 | 0.25 | MAPK14 MAPK11 | Regulatory circuits of the STAT3 signaling pathway |
| KEGG:01522 | 0.0421715550792 | 0.25 | MAPK14 MAPK11 | Endocrine resistance |
| KEGG:04914 | 0.0421715550792 | 0.25 | MAPK14 MAPK11 | Progesterone-mediated oocyte maturation |
| KEGG:04625 | 0.0452962013273 | 0.25 | MAPK14 MAPK11 | C-type lectin receptor signaling pathway |
| WP:WP4341 | 0.0459468228145 | 0.25 | MAPK14 MAPK11 | Non genomic actions of 1 25 dihydroxyvitamin D3 |
| WP:WP3303 | 0.0459468228145 | 0.25 | MAPK14 MAPK11 | RAC1 PAK1 p38 MMP2 pathway |
| KEGG:04670 | 0.0463619704146 | 0.25 | MAPK14 MAPK11 | Leukocyte transendothelial migration |
| KEGG:04933 | 0.0474398326563 | 0.25 | MAPK14 MAPK11 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:04620 | 0.0474398326563 | 0.25 | MAPK14 MAPK11 | Toll-like receptor signaling pathway |
| KEGG:05142 | 0.0485297778512 | 0.25 | MAPK14 MAPK11 | Chagas disease |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAPKAPK3 | MAPK14 | 1.0 | 0.286 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| MAPK14 | MKNK1 | 0.999 | 0.154 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MAPKAPK3 | MAPK11 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MAPK14 | DUSP16 | 0.986 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MKNK2 | MAPK14 | 0.975 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RHBDF1 | MAPK14 | 0.968 | 0.04 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MAPK11 | MAPK14 | 0.964 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MAPK14 | RNF138 | 0.955 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MAPKAPK3 | MKNK1 | 0.884 | 0.224 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only |
| MKNK2 | RHBDF1 | 0.568 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| MKNK2 | MKNK1 | 0.551 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| MAPKAPK3 | RHBDF1 | 0.541 | 0.058 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only |
| RHBDF1 | DUSP16 | 0.527 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| MKNK2 | MAPKAPK3 | 0.513 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| MKNK2 | DUSP16 | 0.498 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| MAPKAPK3 | DUSP16 | 0.378 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| RHBDF1 | MKNK1 | 0.364 | 0.108 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only |
| MKNK2 | RNF138 | 0.242 | bioplex_WMM bioplex3_WMM WMM_only | ||
| DUSP16 | MKNK1 | 0.214 |
mutually_exclusive (Q16539)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| MAPKAPK3 | RNF138 | 0.19 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only | |
| RHBDF1 | RNF138 | 0.188 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only | |
| MKNK1 | RNF138 | 0.186 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only | |
| DUSP16 | RNF138 | 0.185 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes