hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05415.1
Complex Portal: CPX-22951
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GIT2 | ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2) | 5 | UniProt NCBI |
| ARHGEF7 | Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85) | 5 | UniProt NCBI |
| ARHGEF6 | Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6) | 5 | UniProt NCBI |
| NT5DC3 | 5'-nucleotidase domain-containing protein 3 (EC 3.1.3.-) (GRP94-neighboring nucleotidase) | 4 | UniProt NCBI |
| FBXO28 | F-box only protein 28 | 5 | UniProt NCBI |
| PAK1 | Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK) | 5 | UniProt NCBI |
| GIT1 | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1) | 5 | UniProt NCBI |
| PAK2 | Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9013420 | 1.02057957089e-12 | 0.75 | GIT2 PAK1 ARHGEF6 PAK2 GIT1 ARHGEF7 | RHOU GTPase cycle |
| REAC:R-HSA-9013424 | 6.93001958826e-10 | 0.625 | GIT1 GIT2 PAK2 ARHGEF7 PAK1 | RHOV GTPase cycle |
| REAC:R-HSA-9013148 | 2.13958130543e-09 | 0.75 | GIT2 PAK1 ARHGEF6 PAK2 GIT1 ARHGEF7 | CDC42 GTPase cycle |
| REAC:R-HSA-9013406 | 6.1071250098e-09 | 0.625 | GIT1 GIT2 PAK2 ARHGEF7 PAK1 | RHOQ GTPase cycle |
| REAC:R-HSA-9013409 | 6.1071250098e-09 | 0.625 | GIT1 GIT2 PAK2 ARHGEF7 PAK1 | RHOJ GTPase cycle |
| REAC:R-HSA-9013149 | 8.49488982498e-09 | 0.75 | GIT2 PAK1 ARHGEF6 PAK2 GIT1 ARHGEF7 | RAC1 GTPase cycle |
| CORUM:6928 | 9.82248594942e-09 | 0.375 | GIT2 ARHGEF7 PAK1 | ARHGEF7-GIT2-PAK1 complex |
| REAC:R-HSA-3928664 | 1.42273501904e-08 | 0.5 | GIT1 PAK2 ARHGEF7 PAK1 | Ephrin signaling |
| CORUM:6778 | 3.92798604902e-08 | 0.375 | GIT1 ARHGEF7 PAK1 | SCRIB-GIT1-ARHGEF7-PAK1 complex |
| CORUM:6341 | 3.92798604902e-08 | 0.375 | GIT1 ARHGEF7 PAK1 | GIT1-ARHGEF7-PAK1-PXN complex |
| CORUM:6779 | 3.92798604902e-08 | 0.375 | GIT1 ARHGEF7 PAK1 | SCRIB-GIT1-ARHGEF7-PAK1 complex |
| WP:WP51 | 2.38355350544e-07 | 0.625 | GIT1 PAK1 PAK2 ARHGEF7 ARHGEF6 | Regulation of actin cytoskeleton |
| KEGG:04810 | 1.07813908024e-06 | 0.625 | GIT1 PAK1 PAK2 ARHGEF7 ARHGEF6 | Regulation of actin cytoskeleton |
| REAC:R-HSA-9012999 | 2.10417246333e-06 | 0.75 | GIT2 PAK1 ARHGEF6 PAK2 GIT1 ARHGEF7 | RHO GTPase cycle |
| WP:WP185 | 6.37238794528e-06 | 0.5 | GIT2 PAK2 ARHGEF7 PAK1 | Integrin mediated cell adhesion |
| REAC:R-HSA-2682334 | 1.34761418673e-05 | 0.5 | GIT1 PAK2 ARHGEF7 PAK1 | EPH-Ephrin signaling |
| REAC:R-HSA-9013404 | 1.41553656517e-05 | 0.5 | GIT2 PAK2 PAK1 GIT1 | RAC2 GTPase cycle |
| REAC:R-HSA-9013423 | 1.63471640191e-05 | 0.5 | GIT2 PAK2 PAK1 GIT1 | RAC3 GTPase cycle |
| REAC:R-HSA-194315 | 3.46737483099e-05 | 0.75 | GIT2 PAK1 ARHGEF6 PAK2 GIT1 ARHGEF7 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 3.95146816329e-05 | 0.75 | GIT2 PAK1 ARHGEF6 PAK2 GIT1 ARHGEF7 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| CORUM:930 | 7.17483486175e-05 | 0.25 | GIT1 ARHGEF7 | SCRIB-GIT1-ARHGEF7 complex |
| WP:WP4263 | 0.000821419342632 | 0.375 | PAK2 ARHGEF6 PAK1 | Pancreatic adenocarcinoma pathway |
| REAC:R-HSA-389359 | 0.00250486048439 | 0.25 | PAK2 PAK1 | CD28 dependent Vav1 pathway |
| GO:0010968 | 0.00364711882004 | 0.375 | GIT1 ARHGEF7 PAK1 | regulation of microtubule nucleation |
| REAC:R-HSA-428540 | 0.00433819320746 | 0.25 | PAK2 PAK1 | Activation of RAC1 |
| REAC:R-HSA-399954 | 0.00583667819665 | 0.25 | PAK2 PAK1 | Sema3A PAK dependent Axon repulsion |
| REAC:R-HSA-8964616 | 0.00849789009901 | 0.25 | ARHGEF6 PAK1 | G beta:gamma signalling through CDC42 |
| WP:WP4874 | 0.0103268762936 | 0.25 | GIT1 ARHGEF7 | CAMKK2 pathway |
| REAC:R-HSA-5627123 | 0.0105471572959 | 0.25 | PAK2 PAK1 | RHO GTPases activate PAKs |
| REAC:R-HSA-5621575 | 0.0105471572959 | 0.25 | PAK2 PAK1 | CD209 (DC-SIGN) signaling |
| REAC:R-HSA-2871796 | 0.0116541924374 | 0.25 | PAK2 PAK1 | FCERI mediated MAPK activation |
| GO:0043015 | 0.0123105223466 | 0.375 | GIT1 ARHGEF7 PAK1 | gamma-tubulin binding |
| WP:WP4564 | 0.01330352589 | 0.25 | PAK2 PAK1 | Neural crest cell migration during development |
| WP:WP4565 | 0.0149316061259 | 0.25 | PAK2 PAK1 | Neural crest cell migration in cancer |
| REAC:R-HSA-202433 | 0.0153043597228 | 0.25 | PAK2 PAK1 | Generation of second messenger molecules |
| REAC:R-HSA-5218920 | 0.0153043597228 | 0.25 | PAK2 PAK1 | VEGFR2 mediated vascular permeability |
| REAC:R-HSA-422475 | 0.0156587020597 | 0.5 | GIT1 PAK2 ARHGEF7 PAK1 | Axon guidance |
| WP:WP314 | 0.016652650636 | 0.25 | PAK2 PAK1 | Fas ligand pathway and stress induction of heat shock proteins |
| REAC:R-HSA-9675108 | 0.0180671751641 | 0.5 | GIT1 PAK2 ARHGEF7 PAK1 | Nervous system development |
| WP:WP4534 | 0.0184665051061 | 0.25 | PAK2 PAK1 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| REAC:R-HSA-397795 | 0.0194471683576 | 0.25 | ARHGEF6 PAK1 | G-protein beta:gamma signalling |
| REAC:R-HSA-389356 | 0.0224821270291 | 0.25 | PAK2 PAK1 | CD28 co-stimulation |
| KEGG:05120 | 0.0249295632697 | 0.25 | GIT1 PAK1 | Epithelial cell signaling in Helicobacter pylori infection |
| KEGG:05211 | 0.0265361384039 | 0.25 | PAK2 PAK1 | Renal cell carcinoma |
| REAC:R-HSA-9013407 | 0.0310226901604 | 0.25 | PAK2 PAK1 | RHOH GTPase cycle |
| REAC:R-HSA-162582 | 0.0324681032361 | 0.75 | GIT2 PAK1 ARHGEF6 PAK2 GIT1 ARHGEF7 | Signal Transduction |
| KEGG:04012 | 0.0362501572582 | 0.25 | PAK2 PAK1 | ErbB signaling pathway |
| REAC:R-HSA-445355 | 0.0367988237757 | 0.25 | PAK2 PAK1 | Smooth Muscle Contraction |
| WP:WP4205 | 0.0376097283422 | 0.25 | PAK2 PAK1 | MET in type 1 papillary renal cell carcinoma |
| REAC:R-HSA-193648 | 0.0498119601581 | 0.25 | ARHGEF7 ARHGEF6 | NRAGE signals death through JNK |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ARHGEF6 | GIT1 | 1.0 | 0.218 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| ARHGEF7 | ARHGEF6 | 1.0 |
mutually_exclusive (Q9Y2X7)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| GIT2 | ARHGEF6 | 1.0 | 0.372 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| ARHGEF6 | PAK1 | 1.0 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GIT2 | PAK2 | 1.0 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| ARHGEF7 | PAK2 | 1.0 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM | ||
| ARHGEF6 | PAK2 | 0.999 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GIT2 | ARHGEF7 | 0.999 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM | ||
| ARHGEF7 | GIT1 | 0.999 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| ARHGEF7 | PAK1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| GIT1 | PAK2 | 0.998 | 0.188 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| GIT2 | GIT1 | 0.997 | 0.216 |
mutually_exclusive (Q15052)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM |
| NT5DC3 | ARHGEF6 | 0.995 | 0.092 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GIT2 | PAK1 | 0.994 | 0.128 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PAK1 | GIT1 | 0.993 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only | |
| FBXO28 | ARHGEF7 | 0.99 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| FBXO28 | ARHGEF6 | 0.984 | 0.038 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FBXO28 | PAK1 | 0.983 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PAK1 | PAK2 | 0.983 | 0.42 | bioplex_WMM bioplex3_WMM fraction | |
| FBXO28 | GIT2 | 0.982 | 0.08 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FBXO28 | GIT1 | 0.972 | 0.056 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FBXO28 | PAK2 | 0.959 | 0.088 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| NT5DC3 | PAK1 | 0.523 | 0.076 | bioplex3_WMM WMM_only | |
| NT5DC3 | GIT1 | 0.489 | 0.046 | bioplex3_WMM WMM_only | |
| NT5DC3 | GIT2 | 0.476 | 0.112 | bioplex3_WMM WMM_only | |
| NT5DC3 | ARHGEF7 | 0.454 | bioplex3_WMM WMM_only | ||
| NT5DC3 | PAK2 | 0.195 | 0.03 | bioplex3_WMM WMM_only | |
| NT5DC3 | FBXO28 | 0.089 | 0.012 | bioplex3_WMM WMM_only |
Related Complexes