hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05423.1
Complex Portal: CPX-16596
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DGKH | Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) | 5 | UniProt NCBI |
| DGKG | Diacylglycerol kinase gamma (DAG kinase gamma) (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) | 5 | UniProt NCBI |
| ZC2HC1A | Zinc finger C2HC domain-containing protein 1A | 4 | UniProt NCBI |
| DGKD | Diacylglycerol kinase delta (DAG kinase delta) (EC 2.7.1.107) (130 kDa diacylglycerol kinase) (Diglyceride kinase delta) (DGK-delta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-114508 | 2.4825378684e-06 | 0.75 | DGKH DGKD DGKG | Effects of PIP2 hydrolysis |
| KEGG:00561 | 8.02117619688e-06 | 0.75 | DGKH DGKD DGKG | Glycerolipid metabolism |
| GO:0046834 | 2.15253635486e-05 | 0.75 | DGKH DGKD DGKG | lipid phosphorylation |
| KEGG:00564 | 2.70408059374e-05 | 0.75 | DGKH DGKD DGKG | Glycerophospholipid metabolism |
| KEGG:05231 | 3.1411932255e-05 | 0.75 | DGKH DGKD DGKG | Choline metabolism in cancer |
| GO:0004143 | 3.22863876272e-05 | 0.75 | DGKH DGKD DGKG | ATP-dependent diacylglycerol kinase activity |
| KEGG:04070 | 3.37636371132e-05 | 0.75 | DGKH DGKD DGKG | Phosphatidylinositol signaling system |
| KEGG:04072 | 8.65045783849e-05 | 0.75 | DGKH DGKD DGKG | Phospholipase D signaling pathway |
| REAC:R-HSA-416476 | 0.000510403660163 | 0.75 | DGKH DGKD DGKG | G alpha (q) signalling events |
| GO:0046339 | 0.000510886175237 | 0.75 | DGKH DGKD DGKG | diacylglycerol metabolic process |
| GO:0006654 | 0.00112321912057 | 0.75 | DGKH DGKD DGKG | phosphatidic acid biosynthetic process |
| GO:0046473 | 0.00172575455775 | 0.75 | DGKH DGKD DGKG | phosphatidic acid metabolic process |
| REAC:R-HSA-76002 | 0.00233091981852 | 0.75 | DGKH DGKD DGKG | Platelet activation, signaling and aggregation |
| GO:0001727 | 0.00274053853655 | 0.75 | DGKH DGKD DGKG | lipid kinase activity |
| REAC:R-HSA-388396 | 0.0112517828268 | 0.75 | DGKH DGKD DGKG | GPCR downstream signalling |
| REAC:R-HSA-372790 | 0.0165968987372 | 0.75 | DGKH DGKD DGKG | Signaling by GPCR |
| GO:0090038 | 0.0168521501606 | 0.5 | DGKG DGKD | negative regulation of protein kinase C signaling |
| REAC:R-HSA-109582 | 0.0327468558633 | 0.75 | DGKH DGKD DGKG | Hemostasis |
| GO:0030168 | 0.0391800710576 | 0.75 | DGKH DGKD DGKG | platelet activation |
| GO:0006639 | 0.0449670283878 | 0.75 | DGKH DGKD DGKG | acylglycerol metabolic process |
| GO:0006638 | 0.0449670283878 | 0.75 | DGKH DGKD DGKG | neutral lipid metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ZC2HC1A | DGKG | 0.987 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DGKG | DGKD | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DGKH | DGKG | 0.984 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ZC2HC1A | DGKD | 0.415 | 0.082 | bioplex3_WMM WMM_only | |
| DGKH | DGKD | 0.21 | 0.17 | bioplex3_WMM WMM_only | |
| DGKH | ZC2HC1A | 0.078 | 0.102 | bioplex3_WMM WMM_only |
Related Complexes