hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05444.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATP6V0A1 | V-type proton ATPase 116 kDa subunit a 1 (V-ATPase 116 kDa subunit a 1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1) | 5 | UniProt NCBI |
| ATP6V0D1 | V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (32 kDa accessory protein) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (p39) (Vacuolar proton pump subunit d 1) | 5 | UniProt NCBI |
| ATP6V1F | V-type proton ATPase subunit F (V-ATPase subunit F) (V-ATPase 14 kDa subunit) (Vacuolar proton pump subunit F) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04966 | 9.25155395361e-08 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | Collecting duct acid secretion |
| KEGG:05110 | 7.41273577649e-07 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | Vibrio cholerae infection |
| REAC:R-HSA-917977 | 1.5285886144e-06 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | Transferrin endocytosis and recycling |
| REAC:R-HSA-77387 | 1.5285886144e-06 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | Insulin receptor recycling |
| KEGG:04721 | 1.78762380741e-06 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | Synaptic vesicle cycle |
| KEGG:05120 | 2.07446899521e-06 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | Epithelial cell signaling in Helicobacter pylori infection |
| REAC:R-HSA-1222556 | 2.09737662446e-06 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | ROS and RNS production in phagocytes |
| KEGG:05323 | 2.61801737967e-06 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | Rheumatoid arthritis |
| REAC:R-HSA-917937 | 1.03119073194e-05 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | Iron uptake and transport |
| KEGG:00190 | 1.54230874605e-05 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | Oxidative phosphorylation |
| REAC:R-HSA-74752 | 1.76468929782e-05 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | Signaling by Insulin receptor |
| KEGG:04145 | 1.95719209727e-05 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | Phagosome |
| REAC:R-HSA-983712 | 0.000144704522421 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | Ion channel transport |
| GO:0016471 | 0.000148024863258 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | vacuolar proton-transporting V-type ATPase complex |
| GO:0033176 | 0.000170228592746 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | proton-transporting V-type ATPase complex |
| KEGG:05165 | 0.000218999274719 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | Human papillomavirus infection |
| GO:0007035 | 0.000314889254566 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | vacuolar acidification |
| GO:0051452 | 0.00102463963787 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | intracellular pH reduction |
| GO:0016469 | 0.00127301382402 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | proton-transporting two-sector ATPase complex |
| GO:1902600 | 0.00252170927764 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | proton transmembrane transport |
| GO:0051453 | 0.00328922780564 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | regulation of intracellular pH |
| GO:0030641 | 0.00363525995351 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | regulation of cellular pH |
| HPA:0271153 | 0.00413784397738 | 0.666666666667 | ATP6V0A1 ATP6V1F | kidney; proximal tubules (microvilli)[High] |
| GO:0006885 | 0.00419852339422 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | regulation of pH |
| KEGG:04142 | 0.00569595332742 | 0.666666666667 | ATP6V0A1 ATP6V0D1 | Lysosome |
| REAC:R-HSA-9006934 | 0.00622622698696 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | Signaling by Receptor Tyrosine Kinases |
| KEGG:05152 | 0.00802719593767 | 0.666666666667 | ATP6V0A1 ATP6V0D1 | Tuberculosis |
| GO:0033179 | 0.00842684400117 | 0.666666666667 | ATP6V0A1 ATP6V0D1 | proton-transporting V-type ATPase, V0 domain |
| GO:0000220 | 0.00842684400117 | 0.666666666667 | ATP6V0A1 ATP6V0D1 | vacuolar proton-transporting V-type ATPase, V0 domain |
| REAC:R-HSA-9639288 | 0.00937397262456 | 0.666666666667 | ATP6V1F ATP6V0D1 | Amino acids regulate mTORC1 |
| HPA:0271152 | 0.0113321357931 | 0.666666666667 | ATP6V0A1 ATP6V1F | kidney; proximal tubules (microvilli)[>=Medium] |
| REAC:R-HSA-382551 | 0.0117092435511 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | Transport of small molecules |
| HPA:0090992 | 0.0123978177618 | 0.666666666667 | ATP6V0A1 ATP6V1F | cerebellum; molecular layer - neuropil[>=Medium] |
| HPA:0271151 | 0.0126166695908 | 0.666666666667 | ATP6V0A1 ATP6V1F | kidney; proximal tubules (microvilli)[>=Low] |
| KEGG:01100 | 0.0189521995452 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | Metabolic pathways |
| HPA:0090991 | 0.0420544039627 | 0.666666666667 | ATP6V0A1 ATP6V1F | cerebellum; molecular layer - neuropil[>=Low] |
| GO:1904949 | 0.042099520671 | 1.0 | ATP6V0A1 ATP6V0D1 ATP6V1F | ATPase complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ATP6V0A1 | ATP6V0D1 | 1.0 | 0.412 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 fraction |
| ATP6V1F | ATP6V0A1 | 1.0 | 0.104 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| ATP6V1F | ATP6V0D1 | 0.999 | 0.272 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes