hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_05473.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DST | Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein) | 5 | UniProt NCBI |
| SPTBN1 | Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1) | 5 | UniProt NCBI |
| SPTAN1 | Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit) | 5 | UniProt NCBI |
| GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | 5 | UniProt NCBI |
| ARPC3 | Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC) | 5 | UniProt NCBI |
| SPTBN2 | Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein) | 5 | UniProt NCBI |
| BASP1 | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-445095 | 2.29983491089e-05 | 0.428571428571 | SPTBN1 SPTAN1 SPTBN2 | Interaction between L1 and Ankyrins |
| GO:0008091 | 6.72425931667e-05 | 0.428571428571 | SPTBN1 SPTAN1 SPTBN2 | spectrin |
| REAC:R-HSA-9013424 | 8.47845144152e-05 | 0.428571428571 | DST SPTAN1 SPTBN1 | RHOV GTPase cycle |
| REAC:R-HSA-9013420 | 0.000100611892471 | 0.428571428571 | DST SPTAN1 SPTBN1 | RHOU GTPase cycle |
| REAC:R-HSA-375165 | 0.00014849904315 | 0.428571428571 | SPTBN1 SPTAN1 SPTBN2 | NCAM signaling for neurite out-growth |
| REAC:R-HSA-162582 | 0.000187648625697 | 1.0 | SPTBN1 BASP1 SPTBN2 SPTAN1 DST ARPC3 GNAI2 | Signal Transduction |
| REAC:R-HSA-194315 | 0.000554819347598 | 0.714285714286 | BASP1 DST SPTAN1 ARPC3 SPTBN1 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.000618457686161 | 0.714285714286 | BASP1 DST SPTAN1 ARPC3 SPTBN1 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| HPA:0100213 | 0.00120677556938 | 0.571428571429 | BASP1 SPTBN1 SPTAN1 SPTBN2 | cerebral cortex; neuropil[High] |
| REAC:R-HSA-6807878 | 0.00182778376728 | 0.428571428571 | SPTBN1 SPTAN1 SPTBN2 | COPI-mediated anterograde transport |
| REAC:R-HSA-373760 | 0.00219374690011 | 0.428571428571 | SPTBN1 SPTAN1 SPTBN2 | L1CAM interactions |
| REAC:R-HSA-1500931 | 0.00225909350547 | 0.428571428571 | DST SPTAN1 SPTBN1 | Cell-Cell communication |
| GO:0005200 | 0.0023201010514 | 0.571428571429 | SPTBN1 SPTBN2 SPTAN1 ARPC3 | structural constituent of cytoskeleton |
| REAC:R-HSA-9012999 | 0.00330867736449 | 0.571428571429 | BASP1 DST SPTAN1 SPTBN1 | RHO GTPase cycle |
| REAC:R-HSA-199977 | 0.00604553029649 | 0.428571428571 | SPTBN1 SPTAN1 SPTBN2 | ER to Golgi Anterograde Transport |
| GO:0005856 | 0.00665123557963 | 1.0 | SPTBN1 BASP1 SPTBN2 SPTAN1 DST ARPC3 GNAI2 | cytoskeleton |
| REAC:R-HSA-422475 | 0.00732241318188 | 0.571428571429 | SPTBN1 SPTBN2 SPTAN1 ARPC3 | Axon guidance |
| REAC:R-HSA-373753 | 0.00796834465067 | 0.285714285714 | SPTBN1 SPTAN1 | Nephrin family interactions |
| REAC:R-HSA-9675108 | 0.00845717716544 | 0.571428571429 | SPTBN1 SPTBN2 SPTAN1 ARPC3 | Nervous system development |
| REAC:R-HSA-948021 | 0.0104945039722 | 0.428571428571 | SPTBN1 SPTAN1 SPTBN2 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-199991 | 0.0144304646027 | 0.571428571429 | SPTBN1 SPTBN2 SPTAN1 ARPC3 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0178473234243 | 0.571428571429 | SPTBN1 SPTBN2 SPTAN1 ARPC3 | Vesicle-mediated transport |
| REAC:R-HSA-5673001 | 0.0198290408707 | 0.428571428571 | SPTBN1 SPTAN1 SPTBN2 | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.0209553984355 | 0.428571428571 | SPTBN1 SPTAN1 SPTBN2 | MAPK1/MAPK3 signaling |
| REAC:R-HSA-9662361 | 0.0238233224402 | 0.285714285714 | SPTBN1 SPTAN1 | Sensory processing of sound by outer hair cells of the cochlea |
| GO:0051015 | 0.0293914725345 | 0.571428571429 | SPTBN1 SPTBN2 SPTAN1 ARPC3 | actin filament binding |
| REAC:R-HSA-5683057 | 0.0315073113812 | 0.428571428571 | SPTBN1 SPTAN1 SPTBN2 | MAPK family signaling cascades |
| REAC:R-HSA-446203 | 0.0459981559702 | 0.428571428571 | SPTBN1 SPTAN1 SPTBN2 | Asparagine N-linked glycosylation |
| REAC:R-HSA-9662360 | 0.0480490075434 | 0.285714285714 | SPTBN1 SPTAN1 | Sensory processing of sound by inner hair cells of the cochlea |
| GO:0005198 | 0.0497964309081 | 0.714285714286 | DST SPTBN2 SPTAN1 ARPC3 SPTBN1 | structural molecule activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SPTBN1 | SPTAN1 | 0.998 | hein_WMM bioplex_WMM bioplex3_WMM Malo gupta_WMM fraction treiber_WMM | |
| GNAI2 | BASP1 | 0.994 | 0.098 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| SPTBN2 | BASP1 | 0.994 | 0.19 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| SPTBN1 | BASP1 | 0.989 | 0.196842105263 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| SPTBN1 | SPTBN2 | 0.983 | 0.66 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only boldt_WMM treiber_WMM |
| SPTAN1 | SPTBN2 | 0.979 | hein_WMM bioplex_WMM bioplex3_WMM fraction boldt_WMM treiber_WMM | |
| ARPC3 | BASP1 | 0.978 | 0.164 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| SPTAN1 | BASP1 | 0.977 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| DST | BASP1 | 0.965 | 0.042 | hein_WMM gupta_WMM WMM_only |
| ARPC3 | GNAI2 | 0.962 | 0.172 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| GNAI2 | SPTBN2 | 0.954 | 0.09 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| DST | SPTAN1 | 0.943 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM | |
| DST | GNAI2 | 0.936 | 0.078 | hein_WMM bioplex3_WMM youn_WMM WMM_only |
| SPTBN1 | GNAI2 | 0.867 | 0.19 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| SPTAN1 | GNAI2 | 0.854 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction | |
| ARPC3 | SPTBN2 | 0.843 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| DST | SPTBN2 | 0.825 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM fraction boldt_WMM |
| DST | SPTBN1 | 0.266 | 0.264 | hein_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| DST | ARPC3 | 0.235 | 0.072 | hein_WMM bioplex3_WMM gupta_WMM WMM_only |
| ARPC3 | SPTBN1 | 0.068 | 0.182 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| ARPC3 | SPTAN1 | 0.044 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction |
Related Complexes