hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05480.1
Complex Portal: CPX-18054
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAC3 | Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3) | 5 | UniProt NCBI |
| TGFA | Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1)] | 5 | UniProt NCBI |
| RAB5B | Ras-related protein Rab-5B (EC 3.6.5.2) | 5 | UniProt NCBI |
| RAB5C | Ras-related protein Rab-5C (EC 3.6.5.2) (L1880) (RAB5L) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04014 | 1.08581012416e-06 | 1.0 | RAB5B RAB5C RAC3 TGFA | Ras signaling pathway |
| WP:WP4223 | 0.000179947709834 | 0.75 | RAB5C RAC3 RAB5B | Ras signaling |
| WP:WP4301 | 0.000390164573598 | 0.5 | RAB5C RAB5B | Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells |
| REAC:R-HSA-8856828 | 0.000546477733259 | 0.75 | RAB5C TGFA RAB5B | Clathrin-mediated endocytosis |
| KEGG:04962 | 0.00194963326435 | 0.5 | RAB5C RAB5B | Vasopressin-regulated water reabsorption |
| WP:WP5085 | 0.00198508114189 | 0.5 | RAB5C RAB5B | Vasopressin regulated water reabsorption |
| KEGG:05212 | 0.00637013094617 | 0.5 | RAC3 TGFA | Pancreatic cancer |
| KEGG:05210 | 0.00748004798883 | 0.5 | RAC3 TGFA | Colorectal cancer |
| REAC:R-HSA-8854214 | 0.007571530532 | 0.5 | RAB5C RAB5B | TBC/RABGAPs |
| WP:WP4263 | 0.00821485966847 | 0.5 | RAC3 TGFA | Pancreatic adenocarcinoma pathway |
| KEGG:05146 | 0.00909742323246 | 0.5 | RAB5C RAB5B | Amoebiasis |
| KEGG:04137 | 0.0118173906169 | 0.5 | RAB5C RAB5B | Mitophagy - animal |
| KEGG:04148 | 0.0189154103852 | 0.5 | RAB5C RAB5B | Efferocytosis |
| REAC:R-HSA-8873719 | 0.019281632575 | 0.5 | RAB5C RAB5B | RAB geranylgeranylation |
| KEGG:04145 | 0.0214296747035 | 0.5 | RAB5C RAB5B | Phagosome |
| KEGG:05152 | 0.02620193588 | 0.5 | RAB5C RAB5B | Tuberculosis |
| REAC:R-HSA-8876198 | 0.0329793636325 | 0.5 | RAB5C RAB5B | RAB GEFs exchange GTP for GDP on RABs |
| REAC:R-HSA-199991 | 0.0424877030349 | 0.75 | RAB5C TGFA RAB5B | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0499402458571 | 0.75 | RAB5C TGFA RAB5B | Vesicle-mediated transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RAB5C | RAB5B | 0.985 | 0.498 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM treiber_WMM | |
| RAB5C | RAC3 | 0.968 | 0.49 | hein_WMM bioplex3_WMM WMM_only | |
| TGFA | RAB5C | 0.951 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TGFA | RAB5B | 0.95 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TGFA | RAC3 | 0.865 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| RAC3 | RAB5B | 0.447 | 0.154123076923 | bioplex3_WMM WMM_only |
Related Complexes