hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05489.1
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GAB2 | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | 5 | UniProt NCBI |
| GAB1 | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1) | 5 | UniProt NCBI |
| GRAP2 | GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3676 | 0.000459327445001 | 0.666666666667 | GAB2 GAB1 | BDNF TrkB signaling |
| WP:WP69 | 0.00206734131669 | 0.666666666667 | GAB2 GRAP2 | T cell receptor signaling pathway |
| REAC:R-HSA-109704 | 0.00239054881557 | 0.666666666667 | GAB2 GAB1 | PI3K Cascade |
| REAC:R-HSA-9680350 | 0.00257431960226 | 0.666666666667 | GAB2 GRAP2 | Signaling by CSF1 (M-CSF) in myeloid cells |
| REAC:R-HSA-5655302 | 0.00276488364952 | 0.666666666667 | GAB2 GAB1 | Signaling by FGFR1 in disease |
| REAC:R-HSA-112399 | 0.00296224002415 | 0.666666666667 | GAB2 GAB1 | IRS-mediated signalling |
| REAC:R-HSA-8853659 | 0.00296224002415 | 0.666666666667 | GAB2 GAB1 | RET signaling |
| WP:WP23 | 0.00321742070882 | 0.666666666667 | GAB2 GAB1 | B cell receptor signaling pathway |
| REAC:R-HSA-9607240 | 0.0033773260227 | 0.666666666667 | GAB2 GRAP2 | FLT3 Signaling |
| REAC:R-HSA-2428928 | 0.00359505378021 | 0.666666666667 | GAB2 GAB1 | IRS-related events triggered by IGF1R |
| REAC:R-HSA-2404192 | 0.00359505378021 | 0.666666666667 | GAB2 GAB1 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| REAC:R-HSA-2428924 | 0.00359505378021 | 0.666666666667 | GAB2 GAB1 | IGF1R signaling cascade |
| REAC:R-HSA-74751 | 0.00428896488724 | 0.666666666667 | GAB2 GAB1 | Insulin receptor signalling cascade |
| REAC:R-HSA-1433557 | 0.00428896488724 | 0.666666666667 | GAB2 GRAP2 | Signaling by SCF-KIT |
| KEGG:04072 | 0.00506520175959 | 0.666666666667 | GAB2 GAB1 | Phospholipase D signaling pathway |
| REAC:R-HSA-9006934 | 0.00622622698696 | 1.0 | GAB2 GAB1 GRAP2 | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-2219530 | 0.00833431912959 | 0.666666666667 | GAB2 GAB1 | Constitutive Signaling by Aberrant PI3K in Cancer |
| REAC:R-HSA-1226099 | 0.00833431912959 | 0.666666666667 | GAB2 GAB1 | Signaling by FGFR in disease |
| WP:WP437 | 0.0115871748317 | 0.666666666667 | GAB2 GAB1 | EGF EGFR signaling pathway |
| WP:WP4223 | 0.0120750625641 | 0.666666666667 | GAB2 GAB1 | Ras signaling |
| KEGG:04014 | 0.0127453972967 | 0.666666666667 | GAB2 GAB1 | Ras signaling pathway |
| REAC:R-HSA-74752 | 0.0128584085686 | 0.666666666667 | GAB2 GAB1 | Signaling by Insulin receptor |
| REAC:R-HSA-6811558 | 0.0183561585619 | 0.666666666667 | GAB2 GAB1 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-2219528 | 0.0193669984414 | 0.666666666667 | GAB2 GAB1 | PI3K/AKT Signaling in Cancer |
| REAC:R-HSA-199418 | 0.0220121799777 | 0.666666666667 | GAB2 GAB1 | Negative regulation of the PI3K/AKT network |
| REAC:R-HSA-2454202 | 0.041419681818 | 0.666666666667 | GAB2 GRAP2 | Fc epsilon receptor (FCERI) signaling |
| CORUM:904 | 0.0499402709677 | 0.333333333333 | GAB1 | SHC3-GAB1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GAB1 | GRAP2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GAB2 | GRAP2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GAB2 | GAB1 | 0.855 | 0.12 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes