hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_05492.1
Complex Portal: CPX-22874
Confidence: Very High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EDA | Ectodysplasin-A (Ectodermal dysplasia protein) (EDA protein) [Cleaved into: Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form] | 5 | UniProt NCBI |
| PRKCSH | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH) | 5 | UniProt NCBI |
| PPIB | Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) | 5 | UniProt NCBI |
| LRRC59 | Leucine-rich repeat-containing protein 59 (Ribosome-binding protein p34) (p34) [Cleaved into: Leucine-rich repeat-containing protein 59, N-terminally processed] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3930 | 0.049750157242 | 0.5 | EDA | EDA signaling in hair follicle development |
| HP:0007411 | 0.0499436884913 | 0.5 | EDA | Hypoplastic-absent sebaceous glands |
| HP:0010667 | 0.0499436884913 | 0.5 | EDA | Aplasia of the maxilla |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EDA | PPIB | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| EDA | LRRC59 | 0.97 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| EDA | PRKCSH | 0.966 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PPIB | LRRC59 | 0.032 | 0.316 |
structurally_consistent (P14314)
|
bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only |
| LRRC59 | PRKCSH | 0.009 | 0.298 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| PPIB | PRKCSH | 0.004 | 0.504 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
Related Complexes